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A man in his 50s with abdominal pain and a computer read of ***Acute MI ***
Submitted by Dr. Arjun J V, Written by Pendell MeyersA man in his 50s with history of diabetes presented with acute onset abdominal pain and nausea.Here is his ECG at triage:What do you think?Sinus bradycardia. The QRS is narrow but very abnormal with significant LVH. There are widespread, dramatic, and discordant ST and T wave deviations which are due to the LVH. Look at leads III and aVF here for a particularly important lesson for your eyes. In these leads, the QRS does not actually have radically large QRS voltage, but yet there is substantial (easily meeting STEMI criteria) ST elevation which is due to LVH ...
Source: Dr. Smith's ECG Blog - January 8, 2022 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice. To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Gene Therapies Make Compensatory Metabolic Adjustment More Precise, But That Still Isn't Damage Repair
Given a suitable delivery system, one that localizes to the desired target tissues to a far greater degree than to all other undesirable off-target tissues, the big advantage of a gene therapy is it precisely achieves the manipulation desired. It dials up or dials down expression for selected genes, alters the amount of proteins produced from those genes, and thereby changes cell behavior as a consequence - and that is all it does. One doesn't have the endless concern about off-target effects that characterize small molecule drug development. There are, of course, different challenges. Setting aside some adventurous...
Source: Fight Aging! - October 13, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Right Heart Catheters
Right heart catheterization was the initial type of cardiac catheterization introduced by Werner Forssmann in 1929, who did self-catheterization [1]. But later, with development of coronary interventions, it became less commonly done. Now there is a renewed interest as it is useful in the evaluation of pulmonary hypertension [2] and heart failure as well as in congenital heart diseases. Though the catheter used by Forssmann was a ureteral catheter, dedicated right heart catheters came into use later. Cournand catheter is a right heart diagnostic catheter named after the Nobel laureate André Cournand, who shared the Nob...
Source: Cardiophile MD - September 16, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Large-renal-calculus
A large left renal calculus in the renal pelvis. Significant obstruction looking to the severe hydronephrosis. see more:https://www.ultrasound-images.com/renal-calculi/ (Source: cochinblogs)
Source: cochinblogs - August 21, 2020 Category: Radiology Source Type: blogs

New Technology to Destroy Cancer Cells, Oncotripsy, May Offer Promise
Many of the readers of this blog will be familiar withlithotripsy which involves the use of shock waves to disintegrate stones in the kidneys, bladder, and ureter (see:Lithotripsy). Scientists are now experimenting with the use of ultrasound to selectively kill cancer cells (see:Ultrasound selectively damages cancer cells when tuned to correct frequencies). They have called this type of treatment oncotripsy. Below is an excerpt from the article:A solid mechanics lab at Caltech first developed the theory of oncotripsy, based on the idea that cells are vulnerable to ultrasound at specific frequencies —like how ...
Source: Lab Soft News - January 28, 2020 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Healthcare Delivery Healthcare Innovations Medical Research Source Type: blogs

Fight Aging! Newsletter, November 11th 2019
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the producti...
Source: Fight Aging! - November 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Assessing Gene Therapy to Upregulate Three Longevity-Associated Genes in Mice
In this study, we developed gene therapies based on 3 longevity associated genes: fibroblast growth factor 21 (FGF21), αKlotho, soluble form of mouse transforming growth factor-β receptor 2 (sTGFβR2). The gene therapies were delivered using adeno-associated viruses, and we explored their ability to mitigate 4 age-related diseases: obesity, type II diabetes, heart failure, and renal failure. Individually and combinatorially, we applied these therapies to disease-specific mouse models and found that this set of diverse pathologies could be effectively treated and in some cases, even reversed with a single dose. We ...
Source: Fight Aging! - November 5, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Rise and Rise of Quantitative Cassandras
By SAURABH JHA, MD Despite an area under the ROC curve of 1, Cassandra’s prophesies were never believed. She neither hedged nor relied on retrospective data – her predictions, such as the Trojan war, were prospectively validated. In medicine, a new type of Cassandra has emerged – one who speaks in probabilistic tongue, forked unevenly between the probability of being right and the possibility of being wrong. One who, by conceding that she may be categorically wrong, is technically never wrong. We call these new Minervas “predictions.” The Owl of Minerva flies above its denominator. Deep learning (DL)...
Source: The Health Care Blog - October 7, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Artificial Intelligence Data Medical Practice Physicians RogueRad @roguerad acute kidney injury AI deep learning machine learning predictions Saurabh Jha Source Type: blogs

Retrocaval ureter-Anatomical Basis
Presenting a DAMS Medicine Unplugged, Integrated learning video discussing the anatomical basis of retrocaval ureter.Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - August 2, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Kidney stones: What are your treatment options?
If you’ve been diagnosed with kidney stones (urolithiasis), you may have several options for treatment. These include medical therapy, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotripsy (PCNL), and ureteroscopy. A brief anatomy of the urinary tract The urinary tract includes kidneys (two organs that filter waste and extra water from the blood) ureters (two tubes bringing urine from each kidney to the bladder) bladder (organ that collects urine) urethra (a single tube through which urine in the bladder passes out of the body). The evaluation for kidney stones If your symptoms suggest kidney sto...
Source: Harvard Health Blog - July 18, 2019 Category: Consumer Health News Authors: Kevin R. Loughlin, MD, MBA Tags: Kidney and urinary tract Men's Health Women's Health Source Type: blogs

Fight Aging! Newsletter, February 18th 2019
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - February 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Prospect of Growing Human Organs in Animals as a Source of Transplants
Farming animals is morally dubious, to say the least, but we live in a world in which most people are accepting of this practice. That doesn't make it right, and I think that this will change in the future. For now, however, anyone who finds farming animals for meat ethical should also consider it ethical to create genetically altered animals that contain either human organs or organs that can be humanized. The purpose in doing this is to provide a large supply of organs for transplantation, alleviating the present shortage of organs for that purpose. This is not the only approach, of course. Many research groups are worki...
Source: Fight Aging! - February 13, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Excellent surgeons are those who are quick to recognize their mistakes
“Dr. Rahman, this is the nurse in OR 12, Dr. H is doing a robotic/laparoscopic hysterectomy. He thinks he’s injured the ureter and is requesting help. Are you available?” I knew what came next was going to be complex — challenging surgically, disruptive to my schedule and potentially risky. I told the nurse that I […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 27, 2018 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/naeem-rahman" rel="tag" > Naeem Rahman, MD < /a > < /span > Tags: Conditions Surgery Source Type: blogs

Excellent surgeons those who are quick to recognize their mistakes
“Dr. Rahman, this is the nurse in OR 12, Dr. H is doing a robotic/laparoscopic hysterectomy. He thinks he’s injured the ureter and is requesting help. Are you available?” I knew what came next was going to be complex — challenging surgically, disruptive to my schedule and potentially risky. I told the nurse that I […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 27, 2018 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/naeem-rahman" rel="tag" > Naeem Rahman, MD < /a > < /span > Tags: Conditions Surgery Source Type: blogs