Group A Streptococcus interactions with the host across time and space
Curr Opin Microbiol. 2024 Feb;77:102420. doi: 10.1016/j.mib.2023.102420. Epub 2024 Jan 14.ABSTRACTGroup A Streptococcus (GAS) has a fantastically wide tissue tropism in humans, manifesting as different diseases depending on the strain's virulence factor repertoire and the tissue involved. Activation of immune cells and pro-inflammatory signaling has historically been considered an exclusively host-protective response that a pathogen would seek to avoid. However, recent advances in human and animal models suggest that in some tissues, GAS will activate and manipulate specific pro-inflammatory pathways to promote growth, nut...
Source: Current Opinion in Microbiology - January 14, 2024 Category: Microbiology Authors: Stephanie Guerra Christopher LaRock Source Type: research
Interplay between Staphylococcus aureus and the vaginal microbiota
Trends Microbiol. 2024 Jan 4:S0966-842X(23)00340-2. doi: 10.1016/j.tim.2023.12.005. Online ahead of print.ABSTRACTStaphylococcus aureus is a proficient colonizer and opportunistic pathogen which can lead to vaginal dysbiosis, aerobic vaginitis, or life-threatening menstrual toxic shock syndrome. Here we explore the complex but underappreciated interactions that S. aureus may impose on the vaginal environment leading to additional disease outcomes.PMID:38182522 | DOI:10.1016/j.tim.2023.12.005 (Source: Trends in Microbiology)
Source: Trends in Microbiology - January 5, 2024 Category: Microbiology Authors: Carla S Maduta Stephen W Tuffs John K McCormick Karine Dufresne Source Type: research
Interplay between Staphylococcus aureus and the vaginal microbiota
Trends Microbiol. 2024 Jan 4:S0966-842X(23)00340-2. doi: 10.1016/j.tim.2023.12.005. Online ahead of print.ABSTRACTStaphylococcus aureus is a proficient colonizer and opportunistic pathogen which can lead to vaginal dysbiosis, aerobic vaginitis, or life-threatening menstrual toxic shock syndrome. Here we explore the complex but underappreciated interactions that S. aureus may impose on the vaginal environment leading to additional disease outcomes.PMID:38182522 | DOI:10.1016/j.tim.2023.12.005 (Source: Trends in Microbiology)
Source: Trends in Microbiology - January 5, 2024 Category: Microbiology Authors: Carla S Maduta Stephen W Tuffs John K McCormick Karine Dufresne Source Type: research
Interplay between Staphylococcus aureus and the vaginal microbiota
Trends Microbiol. 2024 Jan 4:S0966-842X(23)00340-2. doi: 10.1016/j.tim.2023.12.005. Online ahead of print.ABSTRACTStaphylococcus aureus is a proficient colonizer and opportunistic pathogen which can lead to vaginal dysbiosis, aerobic vaginitis, or life-threatening menstrual toxic shock syndrome. Here we explore the complex but underappreciated interactions that S. aureus may impose on the vaginal environment leading to additional disease outcomes.PMID:38182522 | DOI:10.1016/j.tim.2023.12.005 (Source: Trends in Microbiology)
Source: Trends in Microbiology - January 5, 2024 Category: Microbiology Authors: Carla S Maduta Stephen W Tuffs John K McCormick Karine Dufresne Source Type: research
Interplay between Staphylococcus aureus and the vaginal microbiota
Trends Microbiol. 2024 Jan 4:S0966-842X(23)00340-2. doi: 10.1016/j.tim.2023.12.005. Online ahead of print.ABSTRACTStaphylococcus aureus is a proficient colonizer and opportunistic pathogen which can lead to vaginal dysbiosis, aerobic vaginitis, or life-threatening menstrual toxic shock syndrome. Here we explore the complex but underappreciated interactions that S. aureus may impose on the vaginal environment leading to additional disease outcomes.PMID:38182522 | DOI:10.1016/j.tim.2023.12.005 (Source: Trends in Microbiology)
Source: Trends in Microbiology - January 5, 2024 Category: Microbiology Authors: Carla S Maduta Stephen W Tuffs John K McCormick Karine Dufresne Source Type: research
Biofilms: A developmental niche for vancomycin-intermediate Staphylococcus aureus
Infect Genet Evol. 2023 Dec 29:105545. doi: 10.1016/j.meegid.2023.105545. Online ahead of print.ABSTRACTStaphylococcus aureus are gram-positive bacteria responsible for a wide array of diseases, ranging from skin and soft tissue infections to more chronic illnesses such as toxic shock syndrome, osteomyelitis, and endocarditis. Vancomycin is currently one of the most effective antibiotics available in treating patients infected with methicillin-resistant S. aureus (MRSA), however the emergence of vancomycin-resistant S. aureus (VRSA), and more commonly vancomycin-intermediate S. aureus (VISA), threaten the future efficacy o...
Source: Infection, Genetics and Evolution - December 31, 2023 Category: Genetics & Stem Cells Authors: Jenelle E Chapman Shilpa E George Christiane Wolz Michael E Olson Source Type: research
Biofilms: A developmental niche for vancomycin-intermediate Staphylococcus aureus
Infect Genet Evol. 2023 Dec 29:105545. doi: 10.1016/j.meegid.2023.105545. Online ahead of print.ABSTRACTStaphylococcus aureus are gram-positive bacteria responsible for a wide array of diseases, ranging from skin and soft tissue infections to more chronic illnesses such as toxic shock syndrome, osteomyelitis, and endocarditis. Vancomycin is currently one of the most effective antibiotics available in treating patients infected with methicillin-resistant S. aureus (MRSA), however the emergence of vancomycin-resistant S. aureus (VRSA), and more commonly vancomycin-intermediate S. aureus (VISA), threaten the future efficacy o...
Source: Infection, Genetics and Evolution - December 31, 2023 Category: Genetics & Stem Cells Authors: Jenelle E Chapman Shilpa E George Christiane Wolz Michael E Olson Source Type: research
Biofilms: A developmental niche for vancomycin-intermediate Staphylococcus aureus
Infect Genet Evol. 2023 Dec 29:105545. doi: 10.1016/j.meegid.2023.105545. Online ahead of print.ABSTRACTStaphylococcus aureus are gram-positive bacteria responsible for a wide array of diseases, ranging from skin and soft tissue infections to more chronic illnesses such as toxic shock syndrome, osteomyelitis, and endocarditis. Vancomycin is currently one of the most effective antibiotics available in treating patients infected with methicillin-resistant S. aureus (MRSA), however the emergence of vancomycin-resistant S. aureus (VRSA), and more commonly vancomycin-intermediate S. aureus (VISA), threaten the future efficacy o...
Source: Infection, Genetics and Evolution - December 31, 2023 Category: Genetics & Stem Cells Authors: Jenelle E Chapman Shilpa E George Christiane Wolz Michael E Olson Source Type: research
Stimulation Strength Determined by Superantigen Dose Controls Subcellular Localization of FOXP3 Isoforms and Suppressive Function of CD4+CD25+FOXP3+ T Cells
In this study, we demonstrate that stimulation strength plays a critical role in superantigen-mediated induction of immunosuppressive human CD4+CD25+FOXP3+ T cells. Suboptimal stimulation by a low dose (1 ng/ml) of staphylococcal enterotoxin C1 (SEC1) led to de novo generation of Treg-like CD4+CD25+FOXP3+ T cells with strong suppressive activity. In contrast, CD4+CD25+ T cells induced by optimal stimulation with high-dose SEC1 (1 µg/ml) were not immunosuppressive, despite high FOXP3 expression. Signal transduction pathway analysis revealed differential activation of the PI3K signaling pathway and expression of PTEN in opt...
Source: Journal of Immunology - December 18, 2023 Category: Allergy & Immunology Authors: Juyeun Lee Nogi Park Michael Nicosia Joo Youn Park Stephen B Pruett Keun Seok Seo Source Type: research
Stimulation Strength Determined by Superantigen Dose Controls Subcellular Localization of FOXP3 Isoforms and Suppressive Function of CD4+CD25+FOXP3+ T Cells
In this study, we demonstrate that stimulation strength plays a critical role in superantigen-mediated induction of immunosuppressive human CD4+CD25+FOXP3+ T cells. Suboptimal stimulation by a low dose (1 ng/ml) of staphylococcal enterotoxin C1 (SEC1) led to de novo generation of Treg-like CD4+CD25+FOXP3+ T cells with strong suppressive activity. In contrast, CD4+CD25+ T cells induced by optimal stimulation with high-dose SEC1 (1 µg/ml) were not immunosuppressive, despite high FOXP3 expression. Signal transduction pathway analysis revealed differential activation of the PI3K signaling pathway and expression of PTEN in opt...
Source: Journal of Immunology - December 18, 2023 Category: Allergy & Immunology Authors: Juyeun Lee Nogi Park Michael Nicosia Joo Youn Park Stephen B Pruett Keun Seok Seo Source Type: research
Stimulation Strength Determined by Superantigen Dose Controls Subcellular Localization of FOXP3 Isoforms and Suppressive Function of CD4+CD25+FOXP3+ T Cells
In this study, we demonstrate that stimulation strength plays a critical role in superantigen-mediated induction of immunosuppressive human CD4+CD25+FOXP3+ T cells. Suboptimal stimulation by a low dose (1 ng/ml) of staphylococcal enterotoxin C1 (SEC1) led to de novo generation of Treg-like CD4+CD25+FOXP3+ T cells with strong suppressive activity. In contrast, CD4+CD25+ T cells induced by optimal stimulation with high-dose SEC1 (1 µg/ml) were not immunosuppressive, despite high FOXP3 expression. Signal transduction pathway analysis revealed differential activation of the PI3K signaling pathway and expression of PTEN in opt...
Source: Journal of Immunology - December 18, 2023 Category: Allergy & Immunology Authors: Juyeun Lee Nogi Park Michael Nicosia Joo Youn Park Stephen B Pruett Keun Seok Seo Source Type: research
Sensitization to Staphylococcus aureus toxins in Severe Asthma. The Belgian IgE (BEIgE) study.
Conclusion: Patients with SA and StA-monosensitization display a ‘Type 2’ (T2) airways inflammatory profile and may therefore represent a T2 SA subgroup which is incorrectly considered as ‘non-sensitized’; testing for StA toxins may therefore be indicated in this group of patients. Further prospective studies are needed to establish whether they might benefit from anti-IgE therapy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Schleich, F., Maury, E., Bachert, C., Jansen, M., Gurdain, S., Van Schoor, J. Tags: Allergy and immunology Source Type: research
Molecules, Vol. 28, Pages 6742: Potential of Natural Phenolic Compounds as Antimicrobial Agents against Multidrug-Resistant Staphylococcus aureus in Chicken Meat
This study aimed to determine the prevalence of S. aureus in chicken meat in Egyptian markets. Thus, this study might be the first to assess the efficiency of different natural phenolic compounds as novel antibacterial agents against MDR S. aureus pathogens isolated from raw chicken meat in the Egyptian market. The incidence and quantification of pathogenic S. aureus were detected in retail raw chicken meat parts (breast, thigh, fillet, and giblets). In total, 73 out of 80 (91.3%) of the chicken meat parts were contaminated, with S. aureus as the only species isolated. Of the 192 identified S. aureus isolates, 143 were coa...
Source: Molecules - September 21, 2023 Category: Chemistry Authors: Alaa Eldin M. A. Morshdy Karima M. E. Abdallah Heba E. Abdallah Fahad D. Algahtani Mohamed Tharwat Elabbasy Suleman Atique Khursheed Ahmad Mohammad A. A. Al-Najjar Hossam M. Abdallah Abdallah Fikry A. Mahmoud Tags: Article Source Type: research
Microvascular endothelial activation/dysfunction and dysregulation of the angiopoietin-tie2 system in the pathogenesis of life-threatening infections
Trans Am Clin Climatol Assoc. 2023;133:234-246.ABSTRACTMicrovascular endothelial activation/dysfunction has emerged as an important mechanistic pathophysiological process in the development of morbidity and mortality in life-threatening infections. The angiopoietin-Tie2 system plays an integral role in the regulation of microvascular endothelial integrity. Angiopoietin-1 (Ang-1), produced by platelets and pericytes, is the cognate agonistic ligand for Tie2, promoting endothelial quiescence and inhibiting microvascular leak. Angiopoietin-2 (Ang-2), released from activated endothelial cells in Weibel-Palade bodies, competes ...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: W Conrad Liles Source Type: research
