General Phenotype of NADase Induction by CLI Treatment in < em > Streptococcus pyogenes < /em >
In this study, we examine NADase induction by CLI treatment using an extracellular NADase activity assay instead of the previous two-dimensional gel electrophoresis assay. The examination revealed that CLI administration can induce NADase expression in a dose-dependent manner. We analyzed 23 CLI-susceptible strains (5 emm1 strains, 6 emm3 strains, 3 emm4 strains, 1 emm6 strain, 3 emm12 strains, 1 emm28 strain, and 4 emm89 strains), and 19 of the 23 strains showed similar NADase induction phenotypes to that shown in strain 1529. These results indicate that NADase induction by CLI treatment is not restricted to specific stra...
Source: International Journal of Microbiology - November 7, 2022 Category: Microbiology Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
ICU Management of Invasive β-Hemolytic Streptococcal Infections
β-hemolytic streptococci (BHS) are a leading cause of invasive bacterial disease worldwide. They are subtyped based on the presence of the surface polysaccharide antigens and include Group A Streptococcus (GAS; Streptococcus pyogenes), Group B Streptococcus (GBS; Streptococcus agalactiae), and non- group A, non-group B Streptococci (NABS). Invasive BHS infection is defined as isolation from the normally sterile site in patients with a compatible clinical syndrome which include, but is not limited to, streptococcal toxic shock syndrome (STSS), Necrotizing soft tissue infection (NSTI), bacteremi a, meningitis lower respirat...
Source: Infectious Diseases Clinics of North America - November 1, 2022 Category: Infectious Diseases Authors: Ahmed Babiker, Sameer S. Kadri Source Type: research
Acute heart failure associated with toxic shock syndrome due to methicillin-susceptible Staphylococcus aureus during the postpartum period: case report and systematic literature review
We present a case of acute heart failure as the initial presentation of TSS due to methi... (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - October 29, 2022 Category: Cardiology Authors: Takahiro Suzuki, Takahiro Matsuo, Yasufumi Kijima, Ryo Hasegawa, Kazuhiro Ishikawa, Michiko Yamanaka, Fujimi Kawai, Nobuyuki Komiyama and Nobuyoshi Mori Tags: Case report Source Type: research
Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion
Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose r... (Source: BMC Biotechnology)
Source: BMC Biotechnology - October 28, 2022 Category: Biotechnology Authors: Mahdieh Soezi, Somayeh Piri-Gavgani, Mostafa Ghanei, Mir Davood Omrani, Behnoush Soltanmohammadi, Kamran Pooshang Bagheri, Reza Ahangari Cohan, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh, Shohreh Khatami, Masoumeh Azizi and Fatemeh Rahimi-Jamnani Tags: Research Source Type: research
Maternal death due to serious group A streptococcal toxic shock syndrome reduced after the coronavirus disease pandemic in Japan
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - October 5, 2022 Category: Perinatology & Neonatology Authors: Junichi Hasegawa Hiroaki Tanaka Shinji Katsuragi Masafumi Nii Akihiko Sekizawa Isamu Ishiwata Tomoaki Ikeda Source Type: research
High-progesterone environment preserves T cell competency by evading glucocorticoid effects on immune regulation
Progesterone (P4) and glucocorticoid (GC) play crucial roles in the immunoregulation of a mother to accept and maintain a semi-allogenic fetus. P4 concentration increases during pregnancy and becomes much higher in the placenta than in the other peripheral tissues, wherein the concentration of cortisol (COR), the most abundant GC and a strong immunosuppressor, remains uniform throughout the rest of the body. Here, we evaluated the effect of a high-P4 environment on pregnant immunity by comparing it with COR. Naïve T cell proportion increased transiently in peripheral blood of pregnant women just after delivery and decreas...
Source: Frontiers in Immunology - September 20, 2022 Category: Allergy & Immunology Source Type: research
Low rate of asymptomatic carriage and salivary immunoglobulin A response to Group A Streptococci in the healthy adult population in Finland
This study aims to investigate IgA responses against GAS and oral streptococci from saliva samples collected from healthy Finnish adults. In addition, asymptomatic throat GAS carriage was studied. The study participants consisted of healthy adult volunteers who provided one saliva sample, a throat swab, and a background questionnaire. Total salivary IgA, and GAS specific IgA were analysed from the saliva samples using enzyme-linked immunosorbent assays (ELISA) and the results were compared to oral streptococci specific IgA levels. Asymptomatic GAS throat carriers were identified by bacterial culture, and the isolates weree...
Source: Medical Microbiology and Immunology - September 2, 2022 Category: Microbiology Source Type: research
Increasing Incidence of Invasive Group A Streptococcus Disease, Idaho, USA, 2008-2019
We examined changes in distribution of clinical syndrome, patient demographics, and risk factors by comparing 2008-2013 baseline with 2014-2019 data. Incidence was higher among all age groups during 2014-2019. Streptococcal toxic shock syndrome increased from 0% to 6.4% of cases (p = 0.02). We identified no differences in distribution of demographic or risk factors between periods. Results indicated that invasive group A Streptococcus is increasing among the general population of Idaho. Ongoing surveillance of state-level invasive group A Streptococcus cases could help identify outbreaks, track regional trends in incidence...
Source: Emerging Infectious Diseases - August 23, 2022 Category: Infectious Diseases Authors: Eileen M Dunne Scott Hutton Erin Peterson Anna J Blackstock Christine G Hahn Kathryn Turner Kris K Carter Source Type: research
Increasing Incidence of Invasive Group A Streptococcus Disease, Idaho, USA, 2008-2019
We examined changes in distribution of clinical syndrome, patient demographics, and risk factors by comparing 2008-2013 baseline with 2014-2019 data. Incidence was higher among all age groups during 2014-2019. Streptococcal toxic shock syndrome increased from 0% to 6.4% of cases (p = 0.02). We identified no differences in distribution of demographic or risk factors between periods. Results indicated that invasive group A Streptococcus is increasing among the general population of Idaho. Ongoing surveillance of state-level invasive group A Streptococcus cases could help identify outbreaks, track regional trends in incidence...
Source: Emerging Infectious Diseases - August 23, 2022 Category: Infectious Diseases Authors: Eileen M Dunne Scott Hutton Erin Peterson Anna J Blackstock Christine G Hahn Kathryn Turner Kris K Carter Source Type: research
