A woman in her fifties with a post-operative infection, generalised rash and organ failure
This article presents a case of a middle-aged woman who developed symptoms of toxic shock syndrome five days after elective breast cancer surgery, with high fever, multiorgan failure and a characteristic desquamation of the palms.INTERPRETATION: Toxic shock syndrome is a potentially lethal, toxin-mediated disease. Symptoms develop quickly, within hours. Early recognition and appropriate surgical management, intensive care and antibiotics are therefore important to reduce mortality and sequelae.PMID:38651709 | DOI:10.4045/tidsskr.23.0623 (Source: Tidsskrift for den Norske Laegeforening)
Source: Tidsskrift for den Norske Laegeforening - April 23, 2024 Category: General Medicine Authors: Naima Borg Tahri Berit Gravdehaug Nazli Bahrami Laurens Reitsma Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
Association of CovRS two-component regulatory system with NADase induction by Clindamycin treatment in Streptococcus pyogenes
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.451. Online ahead of print.ABSTRACTThe administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome (STSS). However, CLI-resistant strains have been identified worldwide. Firstly, in this study, some CLI-resistant strains showed increased extracellular activities of the NAD- glycohydrolase (NADase) exotoxin after CLI treatment. This result supported our previous conclusion that not only CLI-susceptible but also CLI-resistant S. pyogenes strains show the CLI-dependent NADase induction. Se...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Ichiro Tatsuno Masanori Isaka Tadao Hasegawa Source Type: research
