Review and future directions for PIMS-TS (MIS-C)
Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C), is a novel hyperinflammatory condition that shares features with Kawasaki disease (KD) and toxic shock syndrome (TSS).1–3 The median age of children with PIMS-TS is approximately 8 years with male sex, obesity and black or Asian ethnicity associated with an increased risk.1 2 Children with PIMS-TS typically have a history of SARS-CoV-2 infection in the weeks preceding presentatio...
Source: Archives of Disease in Childhood - March 17, 2023 Category: Pediatrics Authors: Roarty, C., Waterfield, T. Tags: COVID-19 Viewpoint Source Type: research
Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: common inflammatory pathways of two distinct diseases
Multisystem inflammatory syndrome in children (MIS-C) is a delayed post-inflammatory disorder associated with the previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially, MIS-C was described as highly similar to Kawasaki disease (KD), a pediatric febrile systemic vasculitis that can lead to the development of coronary artery aneurysms (CAAs). While KD and MIS-C are both inflammatory disorders, the two entities differ in their epidemiological, clinical, immunological, and pathological features. MIS-C clinical and laboratory characteristics are more closely related to toxic shock syndr...
Source: Rheumatic Disease Clinics of North America - March 16, 2023 Category: Rheumatology Authors: Magali Noval Rivas, Moshe Arditi Source Type: research
Kawasaki Disease and Multisystem Inflammatory Syndrome in Children
Multisystem inflammatory syndrome in children (MIS-C) is a delayed postinflammatory disorder associated with the previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially, MIS-C was described as highly similar to Kawasaki disease (KD), a pediatric febrile systemic vasculitis that can lead to the development of coronary artery aneurysms (CAAs). While KD and MIS-C are both inflammatory disorders, the 2 entities differ in their epidemiological, clinical, immunological, and pathological features. MIS-C clinical and laboratory characteristics are more closely related to toxic shock syndrome...
Source: Rheumatic Disease Clinics of North America - March 16, 2023 Category: Rheumatology Authors: Magali Noval Rivas, Moshe Arditi Source Type: research
Probable enterotoxin-associated toxic shock syndrome caused by Staphylococcus epidermidis
We describe a case of a toxic shock-like syndrome in a child, which was associated with Staphylococcus epidermidis instead of Staphylococcus aureus or Streptococcus pyogenes, the usual causes of toxic shock syndr... (Source: BMC Pediatrics)
Source: BMC Pediatrics - March 7, 2023 Category: Pediatrics Authors: William F. Pomputius, Samuel H. Kilgore and Patrick M. Schlievert Tags: Case report Source Type: research
Outcomes and management of pregnancy and puerperal group A streptococcal infections: A systematic review
ConclusionsGroup A streptococcus infection remains an important contributor to pregnancy and puerperal morbidity and mortality. Early recognition, diagnosis and aggressive management are important for favorable outcomes given the serious risk of sepsis and streptococcal toxic shock syndrome. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 1, 2023 Category: OBGYN Authors: Kristin Harris,
Leslie K. Proctor,
Shiri Shinar,
Eleni Philippopoulos,
Mark H. Yudin,
Kellie E. Murphy Tags: SYSTEMATIC REVIEW Source Type: research
Necrotizing fasciitis and septic shock due to streptococcal toxic shock syndrome in an elderly patient: A case report
We report an elderly patient with STSS, necrotizing fasciitis and septic shock caused by group G streptococcus who was successfully treated with multidisciplinary therapy. (Source: Clinical Case Reports)
Source: Clinical Case Reports - January 19, 2023 Category: General Medicine Authors: Akiko Kurachi,
Yusuke Ishida,
Koichi Nakazawa,
Toshio Okada,
Takumi Kishida,
Hiroyuki Uchino Tags: CASE REPORT Source Type: research
Outcomes and management of pregnancy and puerperal group A streptococcal infections: A systematic review
ConclusionsGroup A streptococcus infection remains an important contributor to pregnancy and puerperal morbidity and mortality. Early recognition, diagnosis and aggressive management are important for favorable outcomes given the serious risk of sepsis and streptococcal toxic shock syndrome. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 13, 2023 Category: OBGYN Authors: Kristin Harris,
Leslie K. Proctor,
Shiri Shinar,
Eleni Philippopoulos,
Mark H. Yudin,
Kellie E. Murphy Tags: SYSTEMATIC REVIEW Source Type: research
Toxic Shock Syndrome: A Diagnostic and Therapeutic Challenge!
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - January 13, 2023 Category: Pediatrics Source Type: research
Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis
Conclusions
Treatment with clindamycin and within clindamycin-treated patients, IVIG, was each significantly associated with mortality, but the certainty of evidence was low. Future research should focus on morbidity post-infection in STSS survivors.
PROSPERO registration number
CRD42020166961. (Source: BMJ Open)
Source: BMJ Open - December 1, 2022 Category: General Medicine Authors: Bartoszko, J. J., Elias, Z., Rudziak, P., Lo, C. K. L., Thabane, L., Mertz, D., Loeb, M. Tags: Open access, Infectious diseases Source Type: research
Modulation of sensitization and inflammation through S. aureus nasal carriage in allergic asthma patients and a mouse model
Conclusion: In allergic asthma patients, S. aureus colonization was associated with toxin-specific IgE-sensitization. S. aureus colonization in mice provides a valuable model to assess its immunological interplay with allergic airway inflammation in common mouse models. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Stegemann-Koniszewski, S., Görges, S., Asari, A., Lücke, E., Holtfreter, S., Wiles, S., Schreiber, J. Tags: 05.03 - Allergy and immunology Source Type: research
Fifteen-minute consultation: An approach to the management of PIMS-TS in a district general hospital
The COVID-19 pandemic has caused significant disease across the globe but children seem to be much less affected than adults. Coincidentally with the first wave of the pandemic, a cluster of children with fever, hyperinflammation and shock were identified, and this was first described as paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) by the Royal College of Paediatrics and Child Health. Patients with this novel condition were transferred to tertiary centres for management, increasing the pressure in these hospitals that were already extremely busy. There are multiple challenges...
Source: Archives of Disease in Childhood - Education and Practice - November 17, 2022 Category: Pediatrics Authors: Freitas, J., Sanpera, J., Dessouki, T., Rainsley, V., Nyirenda, M., Canet Tarres, A., Thomas, J. Tags: Best practice and Fifteen Minute Consultations, COVID-19 Best practice and Fifteen-minute consultations Source Type: research
Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report
Exp Ther Med. 2022 Oct 7;24(6):714. doi: 10.3892/etm.2022.11650. eCollection 2022 Dec.ABSTRACTDisseminated intravascular coagulation (DIC) is a common and morbid complication of streptococcal toxic shock syndrome (STSS). Because DIC with STSS progresses rapidly, prompt and proper care is critical. The present report describes the case of a 10-year-old boy who survived STSS with DIC without sequelae after treatment with combination anticoagulant therapy of recombinant human soluble thrombomodulin (rhTM) and danaparoid. RhTM and antithrombin-III were administered on day 1. RhTM administration was continued. Despite this, on ...
Source: Experimental and Therapeutic Medicine - November 16, 2022 Category: General Medicine Authors: Yutaka Kato Hiroshi Kawaguchi Shinichiro Iwataki Hirotaka Kihara Satoshi Okada Source Type: research
