Microvascular endothelial activation/dysfunction and dysregulation of the angiopoietin-tie2 system in the pathogenesis of life-threatening infections
Trans Am Clin Climatol Assoc. 2023;133:234-246.ABSTRACTMicrovascular endothelial activation/dysfunction has emerged as an important mechanistic pathophysiological process in the development of morbidity and mortality in life-threatening infections. The angiopoietin-Tie2 system plays an integral role in the regulation of microvascular endothelial integrity. Angiopoietin-1 (Ang-1), produced by platelets and pericytes, is the cognate agonistic ligand for Tie2, promoting endothelial quiescence and inhibiting microvascular leak. Angiopoietin-2 (Ang-2), released from activated endothelial cells in Weibel-Palade bodies, competes ...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: W Conrad Liles Source Type: research
Serious Bacterial Infections Associated with Eculizumab: A Pharmacovigilance Study
Conclusion Careful monitoring of serious bacterial infections associated with eculizumab treatment is warranted.PMID:37690847 | DOI:10.2169/internalmedicine.1893-23 (Source: Internal Medicine)
Source: Internal Medicine - September 10, 2023 Category: Internal Medicine Authors: Shohei Okusa Tsubasa Takizawa Shungo Imai Munenori Oyama Kei Ishizuchi Jin Nakahara Satoko Hori Shigeaki Suzuki Source Type: research
A Case Report of Streptococcus Dysgalactiae Toxic Shock Syndrome Complicated with Symmetric Peripheral Gangrene
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - September 8, 2023 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Staphylococcus epidermidis induced toxic shock syndrome (TSS) secondary to influenza infection
To date, few cases of TSS caused by coagulase negative (CoN) staphylococci have been reported in the literature. Recent data show that CoN staphylococci are capable of secreting a number of enterotoxins and cytot... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 6, 2023 Category: Infectious Diseases Authors: Charis Armeftis, Andreas Ioannou, Theodorakis Lazarou, Achilleas Giannopoulos, Efrosyni Dimitriadou, Kostantinos Makrides and Zoi Dorothea Pana Tags: Case Report Source Type: research
Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies. To identify determinants of the anti-TSST-1 antibody response, we examined 976 participants of the German population-based epidemiological Study of Health in Pomerania (SHIP-TREND-0). We measured anti-TSST-1 antibody levels, analyzed the colonization with TSST-1-encoding S. aureus strains, and performed a genome-wide association analysis of genetic risk factors. TSST-1-specific serum IgG levels varied over a range ...
Source: Frontiers in Immunology - September 4, 2023 Category: Allergy & Immunology Source Type: research
Importance of toxin genes and polymerase chain reaction-based open reading frame type (POT) analysis for severe Staphylococcus aureus infection in children
Jpn J Infect Dis. 2023 Aug 31. doi: 10.7883/yoken.JJID.2023.194. Online ahead of print.ABSTRACTIn the present study, 26 Staphylococcus aureus strains, including 16 methicillin-resistant S. aureus (MRSA) and 10 methicillin-susceptible S. aureus (MSSA), which were collected from eight medical institutions in Chiba Prefecture that requested toxin gene analysis from 2015 to 2021, were analyzed. A total of 14 Panton-Valentine leukocidin (PVL) positive strains were identified, including one of MSSA. PVL-positive strains were classified into seven types based on polymerase chain reaction-based open reading frame typing (POT). Of ...
Source: Japanese Journal of Infectious Diseases - August 30, 2023 Category: Infectious Diseases Authors: Noriko Takeuchi Naruhiko Ishiwada Source Type: research
Importance of toxin genes and polymerase chain reaction-based open reading frame type (POT) analysis for severe Staphylococcus aureus infection in children
Jpn J Infect Dis. 2023 Aug 31. doi: 10.7883/yoken.JJID.2023.194. Online ahead of print.ABSTRACTIn the present study, 26 Staphylococcus aureus strains, including 16 methicillin-resistant S. aureus (MRSA) and 10 methicillin-susceptible S. aureus (MSSA), which were collected from eight medical institutions in Chiba Prefecture that requested toxin gene analysis from 2015 to 2021, were analyzed. A total of 14 Panton-Valentine leukocidin (PVL) positive strains were identified, including one of MSSA. PVL-positive strains were classified into seven types based on polymerase chain reaction-based open reading frame typing (POT). Of ...
Source: Japanese Journal of Infectious Diseases - August 30, 2023 Category: Infectious Diseases Authors: Noriko Takeuchi Naruhiko Ishiwada Source Type: research
Importance of toxin genes and polymerase chain reaction-based open reading frame type (POT) analysis for severe Staphylococcus aureus infection in children
Jpn J Infect Dis. 2023 Aug 31. doi: 10.7883/yoken.JJID.2023.194. Online ahead of print.ABSTRACTIn the present study, 26 Staphylococcus aureus strains, including 16 methicillin-resistant S. aureus (MRSA) and 10 methicillin-susceptible S. aureus (MSSA), which were collected from eight medical institutions in Chiba Prefecture that requested toxin gene analysis from 2015 to 2021, were analyzed. A total of 14 Panton-Valentine leukocidin (PVL) positive strains were identified, including one of MSSA. PVL-positive strains were classified into seven types based on polymerase chain reaction-based open reading frame typing (POT). Of ...
Source: Japanese Journal of Infectious Diseases - August 30, 2023 Category: Infectious Diseases Authors: Noriko Takeuchi Naruhiko Ishiwada Source Type: research
Importance of toxin genes and polymerase chain reaction-based open reading frame type (POT) analysis for severe Staphylococcus aureus infection in children
Jpn J Infect Dis. 2023 Aug 31. doi: 10.7883/yoken.JJID.2023.194. Online ahead of print.ABSTRACTIn the present study, 26 Staphylococcus aureus strains, including 16 methicillin-resistant S. aureus (MRSA) and 10 methicillin-susceptible S. aureus (MSSA), which were collected from eight medical institutions in Chiba Prefecture that requested toxin gene analysis from 2015 to 2021, were analyzed. A total of 14 Panton-Valentine leukocidin (PVL) positive strains were identified, including one of MSSA. PVL-positive strains were classified into seven types based on polymerase chain reaction-based open reading frame typing (POT). Of ...
Source: Japanese Journal of Infectious Diseases - August 30, 2023 Category: Infectious Diseases Authors: Noriko Takeuchi Naruhiko Ishiwada Source Type: research
