President's address from budapest to vienna and back.
PRESIDENT'S ADDRESS FROM BUDAPEST TO VIENNA AND BACK. Trans Am Clin Climatol Assoc. 2018;129:1-23 Authors: Schafer AI PMID: 30166693 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Disordered histone methylation in hematological malignancies the case of utx/kdm6a.
DISORDERED HISTONE METHYLATION IN HEMATOLOGICAL MALIGNANCIES THE CASE OF UTX/KDM6A. Trans Am Clin Climatol Assoc. 2018;129:24-36 Authors: Licht JD Abstract Alterations of epigenetic proteins that modulate the gene repressive lysine 27 on histone H3 (H3K27me) are recurrent features in cancers, including multiple myeloma (MM). The histone demethylase UTX/KDM6A, mutated in up to 10% of cases of MM activates genes by removing the H3K27me3 repressive histone mark, counteracting EZH2. RNA-sequencing studies showed that UTX upregulated genes in association with loss of H3K27me. Treatment of MM cell lines with...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The theodore e. woodward award.
THE THEODORE E. WOODWARD AWARD. Trans Am Clin Climatol Assoc. 2018;129:37 Authors: PMID: 30166695 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Winners of the theodore e. woodward award.
WINNERS OF THE THEODORE E. WOODWARD AWARD. Trans Am Clin Climatol Assoc. 2018;129:38 Authors: PMID: 30166696 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Is "ovarian" cancer a misnomer? exploring ovarian cancer origins in the mouse.
IS "OVARIAN" CANCER A MISNOMER? EXPLORING OVARIAN CANCER ORIGINS IN THE MOUSE. Trans Am Clin Climatol Assoc. 2018;129:40-47 Authors: Cho KR Abstract Ovarian cancer is a generic term that encompasses several different tumor types. The most common and lethal type is known as high-grade serous carcinoma. The cellular origin of high-grade serous carcinoma has been debated for many years, but recent studies suggest that many, if not most, arise from epithelium in the fallopian tube rather than from the ovarian surface epithelium. Genetically engineered mice have been used to study the consequences...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Targeting the prostacyclin/peroxisome proliferator-activated receptor gamma axis in lung cancer chemoprevention.
TARGETING THE PROSTACYCLIN/PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AXIS IN LUNG CANCER CHEMOPREVENTION. Trans Am Clin Climatol Assoc. 2018;129:48-55 Authors: Geraci MW Abstract Lung cancer remains an important target of cancer research, and accounts for most deaths of any cancer type in the United States. Chemoprevention refers to the use of agents to prevent the development of cancer in high-risk populations, often in patients with predisposing lesions. In the following, we describe our ongoing work examining the role of the eicosanoid prostacyclin in lung cancer chemoprevention. Our findings...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Molecular features and mouse models of colorectal cancer.
MOLECULAR FEATURES AND MOUSE MODELS OF COLORECTAL CANCER. Trans Am Clin Climatol Assoc. 2018;129:56-62 Authors: Fearon ER Abstract Colorectal cancers (CRCs) harbor accumulated defects in key signaling pathways that regulate cell phenotypes, including proliferation, survival, metabolism, and differentiation. To study the functional contributions of the accumulated molecular defects in CRC, we have developed approaches to inactivate selected tumor suppressor and/or activate oncogenes in mouse colon epithelium. Conditional inactivation of the CDX2 tumor suppressor protein in conjunction with oncogenic act...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Biomedical prevention of hiv in women: challenges and approaches, with particular reference to the vaginal microbiome.
BIOMEDICAL PREVENTION OF HIV IN WOMEN: CHALLENGES AND APPROACHES, WITH PARTICULAR REFERENCE TO THE VAGINAL MICROBIOME. Trans Am Clin Climatol Assoc. 2018;129:63-73 Authors: Marrazzo JM Abstract Although great progress has been made in treating HIV-1 infection globally, incidence remains high in many locales, especially sub-Saharan Africa. Two-thirds of the burden of disease is there, and among those infected, 60% are women. Pre-exposure prophylaxis, the administration of a drug to prevent acquisition of infection, has proven to be a promising prevention modality for HIV-1 when administered as a daily o...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

New strategies to predict and prevent serious immunologically mediated adverse drug reactions.
NEW STRATEGIES TO PREDICT AND PREVENT SERIOUS IMMUNOLOGICALLY MEDIATED ADVERSE DRUG REACTIONS. Trans Am Clin Climatol Assoc. 2018;129:74-87 Authors: Phillips EJ Abstract Preventive efforts for serious immunologically mediated adverse drug reactions (IM-ADRs) have been fueled by discovery of strong class I human leukocyte antigen (HLA) associations; however, the low positive predictive value of HLA for IM-ADRs has limited translation. Studies were undertaken to explain why most patients carrying an HLA risk allele do not develop IM-ADR on exposure to the risk drug. Tissue-specific approaches defined the...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

A decade of excellent outcomes after surgical intervention: 538 patients with thoracic outlet syndrome.
A DECADE OF EXCELLENT OUTCOMES AFTER SURGICAL INTERVENTION: 538 PATIENTS WITH THORACIC OUTLET SYNDROME. Trans Am Clin Climatol Assoc. 2018;129:88-94 Authors: Ann Freischlag J Abstract This review describes the outcomes for patients who underwent first rib resection for all three forms of thoracic outlet syndrome during a period of 10 years. The data were previously published in 2014 and the ACCA presentation, and this manuscript are derived largely from this work (1). Patients treated with first rib section from August 2003 through July 2013 were retrospectively reviewed using a prospectively maintaine...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The gordon wilson memorial lecture.
THE GORDON WILSON MEMORIAL LECTURE. Trans Am Clin Climatol Assoc. 2018;129:95 Authors: PMID: 30166703 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The gordon wilson lectures.
THE GORDON WILSON LECTURES. Trans Am Clin Climatol Assoc. 2018;129:96-98 Authors: PMID: 30166704 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The gordon wilson lecture: cancer gene variant (re)classification: from truthiness to truth.
THE GORDON WILSON LECTURE: CANCER GENE VARIANT (RE)CLASSIFICATION: FROM TRUTHINESS TO TRUTH. Trans Am Clin Climatol Assoc. 2018;129:99-120 Authors: Ross T Abstract The new genetics, defined as that which followed the completion of the human genome project and includes development of rapid and cheaper next-generation sequencing (NGS), is impacting our medical world in several ways (1). As is the case in any new area of medicine, the field is infused with "truthiness," where instead, what is needed for good patient care and scientific rigor is an effort to close in on the truth. Today, I'll dis...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Cell fate determination in 3d: regulation of gene expression via chromatin interactions with the nuclear membrane.
CELL FATE DETERMINATION IN 3D: REGULATION OF GENE EXPRESSION VIA CHROMATIN INTERACTIONS WITH THE NUCLEAR MEMBRANE. Trans Am Clin Climatol Assoc. 2018;129:121-131 Authors: Epstein JA Abstract In the nucleus of all cells, DNA is packaged in association with histone proteins to form chromatin. It is becoming increasingly clear that the organization of chromatin in three dimensions within the nucleus is highly regulated and can contribute to gene expression and cell function. The regions of the genome that are near the nuclear periphery are termed "lamin associated domains" or LADs (1-3). Here, I...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Cd39 as a critical ectonucleotidase defense against pathological vascular remodeling.
CD39 AS A CRITICAL ECTONUCLEOTIDASE DEFENSE AGAINST PATHOLOGICAL VASCULAR REMODELING. Trans Am Clin Climatol Assoc. 2018;129:132-139 Authors: Pinsky DJ Abstract A common thread underlying vascular or tissue injury is the loss of plasmalemmal integrity and the passive (or even active) spillage of intracellular contents into the circulation. Purinergic nucleotides, which serve as energy shuttling moieties within cells, are among the contents released into the bloodstream, where they signal danger and trigger thrombosis and inflammation. To regain vascular homeostasis, vascular cells have evolved highly c...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Novel mechanisms and anti-inflammatory strategies to reduce cardiovascular risk in human immunodeficiency virus.
NOVEL MECHANISMS AND ANTI-INFLAMMATORY STRATEGIES TO REDUCE CARDIOVASCULAR RISK IN HUMAN IMMUNODEFICIENCY VIRUS. Trans Am Clin Climatol Assoc. 2018;129:140-154 Authors: Grinspoon S Abstract Cardiovascular disease (CVD) rates are 50% to 100% higher in human immunodeficiency virus (HIV) patients. Traditional risks account for only 25% of this excess risk. Excess CVD risk in HIV may relate in part to increases in ectopic adipose depots. CVD in HIV-infection is characterized by atypical highly vulnerable plaque lesions, which are inflamed, in tight relationship to immune, and monocyte activation pathways. ...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The electronic health record and development of medical students' mental patient models.
THE ELECTRONIC HEALTH RECORD AND DEVELOPMENT OF MEDICAL STUDENTS' MENTAL PATIENT MODELS. Trans Am Clin Climatol Assoc. 2018;129:155-168 Authors: Woolliscroft JO, Grum C Abstract Medical practitioners routinely use dual process clinical reasoning: pattern recognition, termed system 1 thinking, and system 2 thinking or analytic reasoning. System 1 thinking, a hallmark of expertise developed through experience with multiple similar patients and deliberate practice, is rapid and automatic. For decades, the structured written medical write-up and progress notes served an educational as well as a patient car...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The mary allen engle award.
THE MARY ALLEN ENGLE AWARD. Trans Am Clin Climatol Assoc. 2018;129:169 Authors: PMID: 30166710 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Winners of the mary allen engle award.
WINNERS OF THE MARY ALLEN ENGLE AWARD. Trans Am Clin Climatol Assoc. 2018;129:170 Authors: PMID: 30166711 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Pathogenesis of rheumatoid arthritis: the intersection of genetics and epigenetics.
PATHOGENESIS OF RHEUMATOID ARTHRITIS: THE INTERSECTION OF GENETICS AND EPIGENETICS. Trans Am Clin Climatol Assoc. 2018;129:171-182 Authors: Firestein GS Abstract Rheumatoid arthritis is a synovial inflammatory disease marked by joint infiltration by immune cells and damage to the extracellular matrix. Although genetics plays a critical role in heritability and its pathogenesis, the relative lack of disease concordance in identical twins suggests that noncoding influences can affect risk and severity. Environmental stress, which can be reflected in the genome as altered epigenetic marks, also contribute...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Identifying new sudden death genes.
IDENTIFYING NEW SUDDEN DEATH GENES. Trans Am Clin Climatol Assoc. 2018;129:183-184 Authors: London B, Greiner AM, Mehdi H, Gutmann R Abstract Inherited conditions that lead to cardiac arrhythmias and sudden cardiac death remain an important cause of morbidity and mortality. Identifying the genes responsible for these rare conditions can provide insights into the more common and heritable forms of sudden cardiac death seen in patients with structural heart disease. We and others have used candidate gene approaches and positional cloning in large families to show that mutations in ion channels and ion ch...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The role of mitochondrial fatty acid use in neonatal lung injury and repair.
THE ROLE OF MITOCHONDRIAL FATTY ACID USE IN NEONATAL LUNG INJURY AND REPAIR. Trans Am Clin Climatol Assoc. 2018;129:195-201 Authors: Dennery PA, Carr J, Peterson A, Yao H Abstract In premature neonates, hyperoxic exposure contributes to lung injury characterized by simplified alveolarization and arrested vascularization. These are the hallmarks of bronchopulmonary dysplasia, a disease with long-term consequences on pulmonary and neurodevelopmental function. Lung vascular development and endothelial cell signals are synergistically important for normal alveolarization. It has been shown that metabolism ...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The cardiosplenic axis is essential for the pathogenesis of ischemic heart failure.
THE CARDIOSPLENIC AXIS IS ESSENTIAL FOR THE PATHOGENESIS OF ISCHEMIC HEART FAILURE. Trans Am Clin Climatol Assoc. 2018;129:202-214 Authors: Prabhu SD Abstract The role of innate and adaptive immunity in heart failure (HF) is poorly understood. We discovered that mice with ischemic HF exhibit robust expansion of proinflammatory monocytes/macrophages, classical and plasmacytoid dendritic cells, and CD4+ and CD8+ T cells. There was profound splenic remodeling indicative of heightened antigen processing, and expanded antigen-experienced effector and memory CD4+ T cell populations. A series of subsequent st...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

DEMOCRATIZING DISCOVERY HEALTH WITH N=Me.
Authors: Ofili EO, Pemu PE, Quarshie A, Mensah EA, Rollins L, Ojutalayo F, McCaslin A, Clair BS Abstract Health 360x is a mobile health application and social platform that integrates self-monitoring and decision support for preventive health. We studied 240 diabetic patients in primary care practices and a church community in metropolitan Atlanta. Health coaches were trained on the Health 360x curriculum, which was adapted from the American Association of Diabetes Educators. Participants worked with the health coaches to set goals for diabetes self-management. The intervention included weekly coaching for 12 weeks...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The bert and peggy dupont lecture.
THE BERT AND PEGGY DUPONT LECTURE. Trans Am Clin Climatol Assoc. 2018;129:235 Authors: PMID: 30166717 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Past as prologue: lessons on life and doctoring from boston's rough sleepers 1985 - 2017.
PAST AS PROLOGUE: LESSONS ON LIFE AND DOCTORING FROM BOSTON'S ROUGH SLEEPERS 1985 - 2017. Trans Am Clin Climatol Assoc. 2018;129:238-246 Authors: O'Connell J PMID: 30166718 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The jeremiah metzger lecture.
THE JEREMIAH METZGER LECTURE. Trans Am Clin Climatol Assoc. 2018;129:247 Authors: PMID: 30166719 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Jeremiah metzger lectures.
JEREMIAH METZGER LECTURES. Trans Am Clin Climatol Assoc. 2018;129:248-249 Authors: PMID: 30166720 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The jeremiah metzger lecture novel therapeutic strategies of allergic and immunologic disorders.
THE JEREMIAH METZGER LECTURE NOVEL THERAPEUTIC STRATEGIES OF ALLERGIC AND IMMUNOLOGIC DISORDERS. Trans Am Clin Climatol Assoc. 2018;129:250-265 Authors: Crystal RG, Pagovich OE Abstract Advances in understanding the immunological basis and mechanisms underlying allergic and immunologic disorders have led to effective but costly long-term and repetitive biologic therapies. Gene therapy is a rapidly advancing technology, in which a single administration of an adeno-associated virus encoding the therapeutic protein or monoclonal antibody may provide effective long-term therapy for allergic and immunologic...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Mitochondrial dynamics and metabolic regulation in cardiac and skeletal muscle.
MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE. Trans Am Clin Climatol Assoc. 2018;129:266-278 Authors: Abel ED Abstract Mitochondria are the metabolic powerhouses of cells. In addition to generating adenosine triphosphate (ATP), they play important roles in cell survival pathways such as apoptosis and necrosis. Mitochondrial size and shape are dynamically regulated by a process known as mitochondrial dynamics. The significance of this process in metabolically active cells such as skeletal and cardiac muscle are only now beginning to be elucidated. In cardiac muscle, mit...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Efficacy-to-effectiveness clinical trials.
EFFICACY-TO-EFFECTIVENESS CLINICAL TRIALS. Trans Am Clin Climatol Assoc. 2018;129:279-300 Authors: Selker HP, Gorman S, Kaitin KI Abstract Efficacy trials, which assess treatments in optimally selected patients under advantageous conditions for relatively short time periods, are necessary to gain regulatory approval for marketing. In contrast, effectiveness trials, which test treatments across a spectrum of patients in real-world conditions with follow-up periods that match typical treatment regimens, provide critical information on drug effects in those patients who may ultimately receive the treatmen...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The future of cardiovascular care: from affordable care to the academic medical center.
THE FUTURE OF CARDIOVASCULAR CARE: FROM AFFORDABLE CARE TO THE ACADEMIC MEDICAL CENTER. Trans Am Clin Climatol Assoc. 2018;129:301-311 Authors: Konstam MA Abstract We are presently seeing exponential advances in medical knowledge and development of therapeutic and diagnostic tools. We have also begun to experience an historic restructuring of our health care system. But health care costs continue to rise, disparities persist, and the chaotic, disjointed, and often thoughtless discourse in Washington threatens to roll back the prior advances. Improvement in patient care will be severely stymied if the t...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

In my own words: the value of storytelling to shape the academic medicine journey.
IN MY OWN WORDS: THE VALUE OF STORYTELLING TO SHAPE THE ACADEMIC MEDICINE JOURNEY. Trans Am Clin Climatol Assoc. 2018;129:312-324 Authors: Golden SH Abstract As young physicians, we are trained to listen to our patients as they relay a set of signs, symptoms, and feelings to us, and then to translate their stories into a diagnosis and treatment plan that improves their health status and overall quality of life. The art of storytelling is crucial in disseminating diverse and innovative perspectives in academic medicine. First, stories from patients play a pivotal role in defining new areas of research f...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

An outcomes-based approach across the medical education continuum.
This article provides three examples across the medical education and practice continuum where an outcomes-based approach is being used. By focusing on outcomes instead of process, a more predictable product of undergraduate medical education will be a medical student capable on day 1 of performing the work required of residency. Assessing the quality of medical education by the quality of care a graduate delivers once they enter practice will allow more effective design of medical education to improve care. A more comprehensive assessment of lifelong physician competence will help ensure the health of patients, their heal...
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Officers and council 2017.
OFFICERS AND COUNCIL 2017. Trans Am Clin Climatol Assoc. 2018;129:iii Authors: PMID: 30166728 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Officers and council 2018.
OFFICERS AND COUNCIL 2018. Trans Am Clin Climatol Assoc. 2018;129:iv Authors: PMID: 30166729 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Secretary-treasurer's report.
SECRETARY-TREASURER'S REPORT. Trans Am Clin Climatol Assoc. 2018;129:lix-lxviii Authors: PMID: 30166730 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Accountants' compilation report.
ACCOUNTANTS' COMPILATION REPORT. Trans Am Clin Climatol Assoc. 2018;129:lxix-lxxxi Authors: Board of Trustees, Baton Rouge, Louisiana October 19, 2016 PMID: 30166731 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Recorder's report.
RECORDER'S REPORT. Trans Am Clin Climatol Assoc. 2018;129:lxxxii-lxxxiii Authors: PMID: 30166732 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

INSTRUCTIONS TO AUTHORS: Transactions of the American Clinical and Climatological Association.
Authors: PMID: 30166733 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

FORMER OFFICERS 1884 through 2017.
Authors: PMID: 30166734 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Constitution and by-laws.
CONSTITUTION AND BY-LAWS. Trans Am Clin Climatol Assoc. 2018;129:xlix-lviii Authors: PMID: 30166735 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

American clinical and climatological association meeting locations 1884 - 2017.
AMERICAN CLINICAL AND CLIMATOLOGICAL ASSOCIATION MEETING LOCATIONS 1884 - 2017. Trans Am Clin Climatol Assoc. 2018;129:xlvii-xlviii Authors: PMID: 30166736 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

ACCA Presidents, Past and Present (and Spouses).
Authors: PMID: 30166737 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

DECEASED MEMBERS 1884 through 2017.
Authors: PMID: 30166738 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Present Members.
Authors: PMID: 30166739 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 1, 2018 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

President's Address: Physicians and the Pharmaceutical Industry.
Authors: Dale DC PMID: 28790483 [PubMed - in process] (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - August 11, 2017 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Inherited Predisposition to Prostate Cancer: From Gene Discovery to Clinical Impact.
Authors: Cooney KA Abstract Family history of prostate cancer is one of the three most important risk factors for the disease in addition to age and race. Yet despite the recognition of this significant heritable component, it has been challenging to identify the genes associated with prostate cancer predisposition. Initial approaches focused on the collection of multiplex prostate cancer families. However, despite more than 20 years of linkage studies, few genes have been identified that account for a significant number of hereditary prostate cancer families. Our research team studied a large number of families wi...
Source: Transactions of the American Clinical and Climatological Association - August 11, 2017 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Bone Wasn't Built in a Day: Destruction and Formation of Bone in the Rheumatic Diseases.
Authors: Gravallese EM Abstract The hallmark of rheumatoid arthritis is synovitis, or inflammation of synovial tissues lining joints. Synovitis in rheumatoid arthritis promotes destruction of articular bone by inducing the differentiation and function of osteoclasts, leading to significant patient morbidity. The cell types and pathways mediating articular bone destruction have now been elucidated and the critical role of receptor activator of nuclear factor-kappa B ligand has been recognized, leading to the identification of new targets for the protection of articular bone. Synovitis not only promotes bone destruct...
Source: Transactions of the American Clinical and Climatological Association - August 11, 2017 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

The Role of Aging in the Development of Osteoarthritis.
Authors: Loeser RF Abstract Osteoarthritis (OA) is the most common form of arthritis and a significant cause of pain and disability in older adults. Among the risk factors for OA, age is the most prominent. This review will discuss the relationship between aging and the development of OA, with a particular focus on mechanisms relevant to cartilage degeneration and the role of excessive levels of reactive oxygen species. Rather than just causing random oxidative damage, an increase in reactive oxygen species that leads to oxidative stress disrupts specific cell signaling pathways. This disruption in cell signaling a...
Source: Transactions of the American Clinical and Climatological Association - August 11, 2017 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research