Distinguishing Multisystem Inflammatory Syndrome in Children From COVID-19, Kawasaki Disease and Toxic Shock Syndrome
Background:
Distinguishing multisystem inflammatory syndrome in children (MIS-C) from coronavirus disease 2019 (COVID-19), Kawasaki disease (KD), and toxic shock syndrome (TSS) can be challenging. Because clinical management of these conditions can vary, timely and accurate diagnosis is essential.
Methods:
Data were collected from patients (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - March 23, 2022 Category: Infectious Diseases Tags: COVID Reports Source Type: research
Multisystem Inflammatory Syndrome in Children (MIS-C)
AbstractPurpose of ReviewThe novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed into a pandemic. A unique challenge of this pandemic has been the emergence of multisystem inflammatory syndrome in children (MIS-C), a rare post-infectious hyperinflammatory disorder associated with SARS-CoV-2. This syndrome is characterized by overwhelming systemic inflammation, fever, hypotension, and cardiac dysfunction. This disorder may also have features overlapping with Kawasaki disease (KD), macrophage activation syndrome (MAS), and toxic shock syndrome ...
Source: Current Allergy and Asthma Reports - March 22, 2022 Category: Allergy & Immunology Source Type: research
Clinical Snippets
Broad-based immunosuppression and/or other immunomodulatory agents are the primary treatments for the autoimmune blistering disease bullous pemphigoid (BP), which is characterized by autoantibodies to the epidermal attachment proteins BP180 and BP230. Such therapies can result in increased infections. Messingham et al. showed that most patients with BP were colonized with Staphylococcus aureus that produces toxic shock syndrome toxin 1, even in the presence of neutralizing antibodies against this factor. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 21, 2022 Category: Dermatology Tags: Clinical Snippets Source Type: research
The Association Between Onset of Staphylococcal Non-menstrual Toxic Shock Syndrome With Inducibility of Toxic Shock Syndrome Toxin-1 Production
Non-menstrual toxic shock syndrome (non-mTSS) is a life-threatening disease caused by Staphylococcus aureus strains producing superantigens, such as staphylococcal enterotoxins A, B, C, and toxic shock syndrome toxin-1 (TSST-1). However, little is known about why the TSS cases are rare, although S. aureus strains frequently carry a tst gene, which encodes TSST-1. To answer this question, the amount of TSST-1 produced by 541 clinical isolates was measured in both the presence and absence of serum supplementation to growth media. Then a set of S. aureus strains with similar genetic backgrounds isolated from patients presenti...
Source: Frontiers in Microbiology - March 14, 2022 Category: Microbiology Source Type: research
