A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
Am J Vet Res. 2024 Apr 20:1-12. doi: 10.2460/ajvr.23.12.0280. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to assess the efficacy and safety of a third-generation lentivirus-based vector encoding the feline erythropoietin (EPO) (feEPO) gene in vitro and in rodent models in vivo. This vector incorporates a genetic mechanism to facilitate the termination of the therapeutic effect in the event of supraphysiologic polycythemia, the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene."ANIMALS: CFRK cells and replication-defective lentiviral vectors encoding feEPO were used for in vitro experiments...
Source: Herpes - April 16, 2024 Category: Infectious Diseases Authors: Sarah E Cook Diego Castillo Tatiana Wolf Chadwick Hillman Katherine Bauer Sonyia Williams Brian G Murphy Source Type: research
Risk factors for suicide reattempt: a systematic review and meta-analysis
CONCLUSION: Most of the risk factors traditionally associated with suicide are also relevant when talking about suicide reattempts. Knowing the traits that define reattempters can help develop better preventive and intervention plans.PMID:38623694 | DOI:10.1017/S0033291724000904 (Source: Psychological Medicine)
Source: Psychological Medicine - April 16, 2024 Category: Psychiatry Authors: Andres Pemau Carolina Marin-Martin Marina Diaz-Marsa Alejandro de la Torre-Luque Wala Ayad-Ahmed Ana Gonzalez-Pinto Nathalia Garrido-Torres Lucia Garrido-Sanchez Natalia Roberto Purificaci ón Lopez-Peña Lorea Mar-Barrutia Iria Grande Marti Guinovart Dan Source Type: research
A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
Am J Vet Res. 2024 Apr 20:1-12. doi: 10.2460/ajvr.23.12.0280. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to assess the efficacy and safety of a third-generation lentivirus-based vector encoding the feline erythropoietin (EPO) (feEPO) gene in vitro and in rodent models in vivo. This vector incorporates a genetic mechanism to facilitate the termination of the therapeutic effect in the event of supraphysiologic polycythemia, the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene."ANIMALS: CFRK cells and replication-defective lentiviral vectors encoding feEPO were used for in vitro experiments...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Sarah E Cook Diego Castillo Tatiana Wolf Chadwick Hillman Katherine Bauer Sonyia Williams Brian G Murphy Source Type: research
A lentivirus-vectored feline erythropoietin gene therapy strategy in tissue culture and rodent models for the potential treatment of chronic renal disease-associated anemia
Am J Vet Res. 2024 Apr 20:1-12. doi: 10.2460/ajvr.23.12.0280. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to assess the efficacy and safety of a third-generation lentivirus-based vector encoding the feline erythropoietin (EPO) (feEPO) gene in vitro and in rodent models in vivo. This vector incorporates a genetic mechanism to facilitate the termination of the therapeutic effect in the event of supraphysiologic polycythemia, the herpes simplex virus thymidine kinase (HSV-TK) "suicide gene."ANIMALS: CFRK cells and replication-defective lentiviral vectors encoding feEPO were used for in vitro experiments...
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Sarah E Cook Diego Castillo Tatiana Wolf Chadwick Hillman Katherine Bauer Sonyia Williams Brian G Murphy Source Type: research
Psychosocial Distress Among Certified Nursing Assistants in Long-Term Care During the COVID-19 Pandemic: A Social Ecological Model Informed Scoping Review
CONCLUSIONS & CLINICAL IMPLICATIONS: This review identifies specific targets for intervention for psychosocial distress among CNAs in LTC at multiple levels, including job clarity; workload; facility culture; community relations; and policy. These intervention targets remain relevant to the LTC industry beyond the context of the COVID-19 pandemic.PMID:38622883 | DOI:10.1080/07317115.2024.2337137 (Source: Clinical Gerontologist)
Source: Clinical Gerontologist - April 16, 2024 Category: Geriatrics Authors: Evan Plys Nina Ahmad Andrea Wei Roy A Thompson E-Shien Chang Jenna Locke Jessica G Bell Ana-Maria Vranceanu Ruth Palan Lopez Source Type: research
A PRISMA Scoping Review to Explore Interventions to Prevent Firearm-Related Injury and Suicide in Older Adults
CONCLUSIONS: Further research into adapting interventions to meet the clinical needs of older adults and treatment efficacy trials is necessary.CLINICAL IMPLICATIONS: Training healthcare providers to conduct firearm safety interventions with older adults may be an acceptable and impactful avenue to prevent suicide.PMID:38626064 | DOI:10.1080/07317115.2024.2339366 (Source: Clinical Gerontologist)
Source: Clinical Gerontologist - April 16, 2024 Category: Geriatrics Authors: Lakshmi Chennapragada Terra Osterberg Madison Strouse Sarah R Sullivan Chana Silver Mary LaMarca Caroline Boucher Emilia Fonseca Marianne Goodman Source Type: research
Impact of COVID-19 restrictions on self-poisoning behaviour with mild analgesics in Danish youth
CONCLUSION: These findings indicate that the restrictions enforced during the second lockdown greatly impacted youth mental health, especially girls, leading to an 85% increase in self-poisonings. We hope for increased awareness of mental health in children and adolescents during possible future lockdowns.PMID:38625374 | DOI:10.1080/08039488.2024.2339433 (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - April 16, 2024 Category: Psychiatry Authors: Gurbhej Singh Jonathan Pommer Hansen Ditte Hulgaard Mads Damkj ær Erik Christiansen Source Type: research
Risk factors for suicide reattempt: a systematic review and meta-analysis
CONCLUSION: Most of the risk factors traditionally associated with suicide are also relevant when talking about suicide reattempts. Knowing the traits that define reattempters can help develop better preventive and intervention plans.PMID:38623694 | DOI:10.1017/S0033291724000904 (Source: Psychological Medicine)
Source: Psychological Medicine - April 16, 2024 Category: Psychiatry Authors: Andres Pemau Carolina Marin-Martin Marina Diaz-Marsa Alejandro de la Torre-Luque Wala Ayad-Ahmed Ana Gonzalez-Pinto Nathalia Garrido-Torres Lucia Garrido-Sanchez Natalia Roberto Purificaci ón Lopez-Peña Lorea Mar-Barrutia Iria Grande Marti Guinovart Dan Source Type: research
Beyond sleepless nights: Unraveling the complexity of alexithymia and suicide risk among university students
ConclusionThe findings carry profound implications for suicide prevention efforts, providing valuable insights to safeguard the well-being and resilience of university students facing suicide risk challenges. (Source: Brain and Behavior)
Source: Brain and Behavior - April 16, 2024 Category: Neurology Authors: Ahmad Daghigh Tags: ORIGINAL ARTICLE Source Type: research
Impact of SARS-CoV-2 Infection on Long-Term Depression Symptoms among Veterans
ConclusionSARS-COV-2 infection was associated with more depression symptoms among Veterans at 18-months post-infection. Routine evaluation of depression symptoms over time following SARS-COV-2 infection is important to facilitate adequate assessment and treatment. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 16, 2024 Category: Internal Medicine Source Type: research
The association between social connectedness and euthanasia and assisted suicide and related constructs: systematic review
Euthanasia and assisted suicide (EAS) requests are common in countries where they are legal. Loneliness and social isolation are modifiable risk factors for mental illness and suicidal behaviour and are common... (Source: BMC Public Health)
Source: BMC Public Health - April 16, 2024 Category: Consumer Health News Authors: Emma Corcoran, Molly Bird, Rachel Batchelor, Nafiso Ahmed, Rebecca Nowland and Alexandra Pitman Tags: Research Source Type: research
A systematic review of the studies testing the integrated motivational-volitional model of suicidal behaviour
. (Source: Health Psychology Review)
Source: Health Psychology Review - April 16, 2024 Category: Psychiatry & Psychology Authors: Kenvil SouzaEdward M. SosuScott ThomsonSusan Rasmussena Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UKb Strathclyde Institute of Education, University of Strathclyde, Glasgow, UK Source Type: research
Mechanical trauma in children and adolescents in Berlin
This study analyzes trauma mechanisms in deceased pediatric patients. Fatal pediatric trauma cases aged 0 –18 years who underwent forensic autopsy in the Federal State of Berlin, Germany, between 2008 until 2018 were enrolled in this retrospective study. Autopsy protocols were analyzed regarding demographic characteristics, trauma mechanisms, injury patterns, resuscitation measures, survival times as well as place, and cause of death. 71 patients (73% male) were included. Traffic accidents (40%) were the leading cause of trauma, followed by falls from height > 3 m (32%), railway accidents (13%), third party viol...
Source: Forensic Science, Medicine, and Pathology - April 16, 2024 Category: Forensic Medicine Source Type: research
Rapid Response Unit for Children and Adolescents at Risk of Suicide: Promoting Therapeutic Linkage and Reducing the Risk of Relapse
CONCLUSIONS: Rapid Response Unit (RRU) decreases the risk of recurrence of suicidal behavior and ensures therapeutic linkage.PMID:38622005 | PMC:PMC11009870 | DOI:10.62641/aep.v52i2.1620 (Source: Actas Espanolas de Psiquiatria)
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Anna Butjosa Daniel Cruz Teresa Richart Maria Ruiz Terradas Ccamh Group Fernando Lacasa Source Type: research
Rapid Response Unit for Children and Adolescents at Risk of Suicide: Promoting Therapeutic Linkage and Reducing the Risk of Relapse
CONCLUSIONS: Rapid Response Unit (RRU) decreases the risk of recurrence of suicidal behavior and ensures therapeutic linkage.PMID:38622005 | PMC:PMC11009870 | DOI:10.62641/aep.v52i2.1620 (Source: Actas Espanolas de Psiquiatria)
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Anna Butjosa Daniel Cruz Teresa Richart Maria Ruiz Terradas Ccamh Group Fernando Lacasa Source Type: research
