Genes, Vol. 15, Pages 558: Genetic Mechanisms Driving Uterine Leiomyoma Pathobiology, Epidemiology, and Treatment
Borahay
Uterine leiomyomas (ULs) are the most common benign tumor of the uterus. They can be associated with symptoms including abnormal uterine bleeding, pelvic pain, urinary frequency, and pregnancy complications. Despite the high prevalence of UL, its underlying pathophysiology mechanisms have historically been poorly understood. Several mechanisms of pathogenesis have been suggested, implicating various genes, growth factors, cytokines, chemokines, and microRNA aberrations. The purpose of this study is to summarize the current research on the relationship of genetics with UL. Specifically, we performed a literature...
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Malini S. Ramaiyer Eslam Saad Irem Kurt Mostafa A. Borahay Tags: Review Source Type: research
Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF- κB
Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022.ABSTRACTNuclear factor κB (NF-κB) plays roles in various diseases. Many inflammatory signals, such as circulating lipopolysaccharides (LPSs), activate NF-κB via specific receptors. Using whole-genome CRISPR-Cas9 screens of LPS-treated cells that express an NF-κB-driven suicide gene, we discovered that the LPS receptor Toll-like receptor 4 (TLR4) is specifically dependent on the oligosaccharyltransferase complex OST-A for N-glycosylation and cell-surface localization. The tool compound NGI-1 inhibits OST complexes in vivo, but the underlying molecul...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Benjamin L Lampson Ana S Ram ίrez Marta Baro Lixia He Mudra Hegde Vidyasagar Koduri Jamie L Pfaff Ruth E Hanna Julia Kowal Nitin H Shirole Yanfeng He John G Doench Joseph N Contessa Kaspar P Locher William G Kaelin Source Type: research
A Longitudinal Investigation of Alexithymia as a Predictor of Empathy, Emotional Functioning, Resilience, and Life Satisfaction Two Years after Brain Injury
CONCLUSIONS: Compared to those with lower alexithymia scores, persons with TBI who had higher alexithymia scores at 1-year post-injury reported poorer emotional health at 2 years after TBI, even after controlling for Year 1 outcome scores, sociodemographics, and injury-related factors. These results support the need to assess for elevated alexithymia and to provide interventions targeting alexithymia early in the TBI recovery process.PMID:38670209 | DOI:10.1016/j.apmr.2024.04.008 (Source: Health Physics)
Source: Health Physics - April 26, 2024 Category: Physics Authors: Dawn Neumann Flora M Hammond Angelle M Sander Jennifer Bogner Tamara Bushnik Jacob A Finn Joyce S Chung Daniel W Klyce Mitch Sevigny Jessica M Ketchum Source Type: research
Psychosocial characteristics pattern correlated with suicidal ideation and non-suicidal self-injury among nurse staff: a latent profile analysis
This study aimed to investigate the impact of latent psychosocial characteristic patterns... (Source: BMC Nursing)
Source: BMC Nursing - April 26, 2024 Category: Nursing Authors: Xuehua Li, Changmian Ding, Guizhi Li and Zhizhou Duan Tags: Research Source Type: research
Empathy and mental health in veterinary medicine
AbstractIn veterinary medicine, the relationship between empathy and mental health presents a complex and important aspect of professional well-being. Veterinarians are frequently exposed to numerous work-related stressors and are therefore more likely to experience mental health disorders and commit suicide. Due to the specific nature of the profession, veterinarians deal with negative patient outcomes, inform owners of unfavourable news, handle heavy workloads, and professional isolation. Psychological stress is a result of all these factors coming together, and it can lead to anxiety, depression, burnout, and even frequ...
Source: Veterinary Research Communications - April 26, 2024 Category: Veterinary Research Source Type: research
Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
Cell Stem Cell. 2024 Apr 17:S1934-5909(24)00124-3. doi: 10.1016/j.stem.2024.03.018. Online ahead of print.ABSTRACTDue to the limitations of autologous chimeric antigen receptor (CAR)-T cells, alternative sources of cellular immunotherapy, including CAR macrophages, are emerging for solid tumors. Human induced pluripotent stem cells (iPSCs) offer an unlimited source for immune cell generation. Here, we develop human iPSC-derived CAR macrophages targeting prostate stem cell antigen (PSCA) (CAR-iMacs), which express membrane-bound interleukin (IL)-15 and truncated epidermal growth factor receptor (EGFR) for immune cell activa...
Source: Cell Stem Cell - April 25, 2024 Category: Stem Cells Authors: Zahir Shah Lei Tian Zhixin Li Lewei Jin Jianying Zhang Zhenlong Li Tasha Barr Hejun Tang Mingye Feng Michael A Caligiuri Jianhua Yu Source Type: research
Sleep Quality and Suicidal Ideation in Adolescent Depression: A Chain Mediation Effect of Perceived Social Support and Resilience
CONCLUSIONS: This study establishes that sleep quality indirectly predicts suicide ideation in major depressive adolescents, mediated independently by perceived social support and resilience.PMID:38659274 | DOI:10.1002/cpp.2990 (Source: Clinical Psychology and Psychotherapy)
Source: Clinical Psychology and Psychotherapy - April 25, 2024 Category: Psychiatry Authors: Yan Wu Zixuan Guo Dawei Zhang Yongna Wang Shufen Wang Source Type: research
Daily Levels and Dynamic Metrics of Affective-Cognitive Constructs Associate With Suicidal Thoughts and Behaviours in Adults After Psychiatric Hospitalization
Clin Psychol Psychother. 2024 Mar-Apr;31(2):e2982. doi: 10.1002/cpp.2982.ABSTRACTThe period after psychiatric hospitalization is an extraordinarily high-risk period for suicidal thoughts and behaviours (STBs). Affective-cognitive constructs (ACCs) are salient risk factors for STBs, and intensive longitudinal metrics of these constructs may improve personalized risk detection and intervention. However, limited research has examined how within-person daily levels and between-person dynamic metrics of ACCs relate to STBs after hospital discharge. Adult psychiatric inpatients (N = 95) completed a 65-day ecological momentary as...
Source: Clinical Psychology and Psychotherapy - April 25, 2024 Category: Psychiatry Authors: Gemma T Wallace Leslie A Brick Emily Mower Provost Jessica R Peters Ivan W Miller Heather T Schatten Source Type: research
Lives Cut Short: < em > suicide among adolescent females < /em >
Perspect Biol Med. 2023;66(3):437-450. doi: 10.1353/pbm.2023.a902036.ABSTRACTSuicide is a worldwide public health issue, and suicide ideation and behavior among adolescents, females in particular, have been increasing. Focusing on the risk factors that are unique to adolescents and adolescent females can help tailor and inform prevention strategies. There are unique biological, psychological, social, and societal factors that contribute to suicide ideation and behavior among adolescent females. Some of these include hormonal fluctuations and sensitivity, developing brain systems, impacts of social media, maladaptive coping...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Meaghan Stacy Jay Schulkin Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
Sleep Quality and Suicidal Ideation in Adolescent Depression: A Chain Mediation Effect of Perceived Social Support and Resilience
CONCLUSIONS: This study establishes that sleep quality indirectly predicts suicide ideation in major depressive adolescents, mediated independently by perceived social support and resilience.PMID:38659274 | DOI:10.1002/cpp.2990 (Source: Clinical Psychology and Psychotherapy)
Source: Clinical Psychology and Psychotherapy - April 25, 2024 Category: Psychiatry Authors: Yan Wu Zixuan Guo Dawei Zhang Yongna Wang Shufen Wang Source Type: research
Daily Levels and Dynamic Metrics of Affective-Cognitive Constructs Associate With Suicidal Thoughts and Behaviours in Adults After Psychiatric Hospitalization
Clin Psychol Psychother. 2024 Mar-Apr;31(2):e2982. doi: 10.1002/cpp.2982.ABSTRACTThe period after psychiatric hospitalization is an extraordinarily high-risk period for suicidal thoughts and behaviours (STBs). Affective-cognitive constructs (ACCs) are salient risk factors for STBs, and intensive longitudinal metrics of these constructs may improve personalized risk detection and intervention. However, limited research has examined how within-person daily levels and between-person dynamic metrics of ACCs relate to STBs after hospital discharge. Adult psychiatric inpatients (N = 95) completed a 65-day ecological momentary as...
Source: Clinical Psychology and Psychotherapy - April 25, 2024 Category: Psychiatry Authors: Gemma T Wallace Leslie A Brick Emily Mower Provost Jessica R Peters Ivan W Miller Heather T Schatten Source Type: research
Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
Cell Stem Cell. 2024 Apr 17:S1934-5909(24)00124-3. doi: 10.1016/j.stem.2024.03.018. Online ahead of print.ABSTRACTDue to the limitations of autologous chimeric antigen receptor (CAR)-T cells, alternative sources of cellular immunotherapy, including CAR macrophages, are emerging for solid tumors. Human induced pluripotent stem cells (iPSCs) offer an unlimited source for immune cell generation. Here, we develop human iPSC-derived CAR macrophages targeting prostate stem cell antigen (PSCA) (CAR-iMacs), which express membrane-bound interleukin (IL)-15 and truncated epidermal growth factor receptor (EGFR) for immune cell activa...
Source: Cell Stem Cell - April 25, 2024 Category: Stem Cells Authors: Zahir Shah Lei Tian Zhixin Li Lewei Jin Jianying Zhang Zhenlong Li Tasha Barr Hejun Tang Mingye Feng Michael A Caligiuri Jianhua Yu Source Type: research
Lives Cut Short: < em > suicide among adolescent females < /em >
Perspect Biol Med. 2023;66(3):437-450. doi: 10.1353/pbm.2023.a902036.ABSTRACTSuicide is a worldwide public health issue, and suicide ideation and behavior among adolescents, females in particular, have been increasing. Focusing on the risk factors that are unique to adolescents and adolescent females can help tailor and inform prevention strategies. There are unique biological, psychological, social, and societal factors that contribute to suicide ideation and behavior among adolescent females. Some of these include hormonal fluctuations and sensitivity, developing brain systems, impacts of social media, maladaptive coping...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Meaghan Stacy Jay Schulkin Source Type: research
Relationship of Major Depressive Disorder and Schizophrenia Polygenic Risk Scores to Suicide: A Comparison Between European and Asian Ancestry Populations
. (Source: Archives of Suicide Research)
Source: Archives of Suicide Research - April 25, 2024 Category: Psychiatry & Psychology Authors: Ikuo OtsukaHanga GalfalvyJia GuoMasato AkiyamaSatoshi OkazakiChikashi TeraoDan RujescuGustavo TureckiAkitoyo HishimotoJ. John MannIkuo Otsuka, Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan, and Laboratory for Statistic Source Type: research
