NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway
CONCLUSIONS: NEAT1 inhibits the angiogenic activity of mCAECs by inducing M1 polarization of BV-2 cells through the AMPK signaling pathway. This study further clarified the impact and mechanism of NEAT1 on microglia and the angiogenic ability of cerebrovascular endothelial cells.PMID:38684954 | PMC:PMC11059773 | DOI:10.1186/s11658-024-00579-5 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 29, 2024 Category: Biochemistry Authors: Ting Chen Xin Huang Yi-Xuan Zhao Zhi-Wen Zhou Wen-Sheng Zhou Source Type: research
Myocardial biomechanical effects of fetal aortic valvuloplasty
Biomech Model Mechanobiol. 2024 Apr 29. doi: 10.1007/s10237-024-01848-0. Online ahead of print.ABSTRACTFetal critical aortic stenosis with evolving hypoplastic left heart syndrome (CAS-eHLHS) can progress to a univentricular (UV) birth malformation. Catheter-based fetal aortic valvuloplasty (FAV) can resolve stenosis and reduce the likelihood of malformation progression. However, we have limited understanding of the biomechanical impact of FAV and subsequent LV responses. Therefore, we performed image-based finite element (FE) modeling of 4 CAS-eHLHS fetal hearts, by performing iterative simulations to match image-based ch...
Source: Biomechanics and Modeling in Mechanobiology - April 29, 2024 Category: Biomedical Science Authors: Laura Green Wei Xuan Chan Andreas Tulzer Gerald Tulzer Choon Hwai Yap Source Type: research
Music Upper Limb Therapy - Integrated (MULT-I) supports a positive transformation in sense of self post stroke: a thematic analysis
CONCLUSION: MULT-I promotes physical, emotional, and social wellbeing following a stroke. This integrated approach supports a positive transformation in sense of self. These findings have implications for improving psychosocial well-being post stroke.PMID:38682830 | DOI:10.1080/09638288.2024.2346240 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - April 29, 2024 Category: Rehabilitation Authors: Anna Palumbo Caitlin Balagula Alan Turry Viswanath Aluru Preeti Raghavan Source Type: research
Dietary inflammatory index is associated with severe depression in older adults with stroke: a cross-sectional study
In conclusion, an increase in DII score was associated with a higher likelihood of severe depression in older adults with stroke.PMID:38679919 | DOI:10.1017/S0007114524000850 (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - April 29, 2024 Category: Nutrition Authors: Panpan Zhang Yubin Wang Xia Xie Yuan Gao Yurong Zhang Source Type: research
Clinicoradiological application of the use of spectral cranial computed tomography in the management of acute ischemic stroke after mechanical thrombectomy
CONCLUSIONS: Spectral CT provides high diagnostic confidence to the radiologist in identifying the type of detected hyperdensity, thereby offering significant therapeutic confidence to the neurologist in early resuming anticoagulation therapy.PMID:38682762 | DOI:10.33588/rn.7809.2023340 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 29, 2024 Category: Neurology Authors: L Moreno-Navarro M Farrerons-Llopart N L ópez-Hernández S Moliner-Castellano M J Ballesteros-Aparicio J Gallego-Le ón L Concepci ón-Aramendía Source Type: research
Ischemic stroke in a patient with pseudoxanthoma elasticum and carotid rete mirabile
Nervenarzt. 2024 Apr 29. doi: 10.1007/s00115-024-01667-9. Online ahead of print.NO ABSTRACTPMID:38683355 | DOI:10.1007/s00115-024-01667-9 (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 29, 2024 Category: Neurology Authors: Lea Auksutat Volker He ßelmann G ünter Seidel Source Type: research
Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC
Eur Heart J. 2024 Apr 30:ehae150. doi: 10.1093/eurheartj/ehae150. Online ahead of print.ABSTRACTOne in six ischaemic stroke patients has an embolic stroke of undetermined source (ESUS), defined as a stroke with unclear aetiology despite recommended diagnostic evaluation. The overall cardiovascular risk of ESUS is high and it is important to optimize strategies to prevent recurrent stroke and other cardiovascular events. The aim of clinicians when confronted with a patient not only with ESUS but also with any other medical condition of unclear aetiology is to identify the actual cause amongst a list of potential differentia...
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: George Ntaios Helmut Baumgartner Wolfram Doehner Erwan Donal Thor Edvardsen Jeff S Healey Bernard Iung Hooman Kamel Scott E Kasner Eleni Korompoki Babak B Navi Christian Pristipino Luca Saba Renate B Schnabel Emma Svennberg Gregory Y H Lip Source Type: research
The prognostic impact of insulin resistance surrogates in patients with acute myocardial infarction with and without type 2 diabetes
CONCLUSIONS: TyG index was an independent risk factor for in-hospital death in patients with STEMI or NSTEMI. TyG index, TyG-BMI and METS-IR were not independent risk factors for MACCE at 12 month follow-up. TyG index and METS-IR have low predictive value in predicting MACCE within 12 months after STEMI and NSTEMI.PMID:38685054 | DOI:10.1186/s12933-024-02240-z (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Dominika Rokicka Bartosz Hudzik Marta Wr óbel Tomasz Sto łtny Dorota Sto łtny Alicja Nowowiejska-Wiewi óra Sonia Rokicka Mariusz G ąsior Krzysztof Strojek Source Type: research
Cardiovascular Comorbidities and Inflammatory Bowel Disease: Causes and Consequences
This article discusses causes of CVD in IBD and strategies to modify the consequences.PMID:38682122 | PMC:PMC11047149 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Preetika Sinh Raymond K Cross Source Type: research
Added Clinical Value of Intraplaque Neovascularization Detection to Color Doppler Ultrasound for Assessing Ischemic Stroke Risk
CONCLUSION: Further assessment of intraplaque neovascularization after CDUS may help more accurately identify patients at risk of ischemic stroke. Combining multiparametric carotid ultrasound and clinical features may help improve the risk stratification of patients with ischemic stroke with ≥50% carotid stenosis.PMID:38681519 | PMC:PMC11055554 | DOI:10.2147/NDT.S456872 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Liuping Cui Ran Liu Fubo Zhou Yumei Liu Bing Tian Ying Chen Yingqi Xing Source Type: research
Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases: Therapeutic Implications: < em > JACC < /em > Family Series
JACC Basic Transl Sci. 2024 Apr 8;9(4):522-534. doi: 10.1016/j.jacbts.2023.12.003. eCollection 2024 Apr.ABSTRACTThe prevalence of cardiovascular diseases markedly rises with age. Cellular senescence, a hallmark of aging, is characterized by irreversible cell cycle arrest and the manifestation of a senescence-associated secretory phenotype, which has emerged as a significant contributor to aging, mortality, and a spectrum of chronic ailments. An increasing body of preclinical and clinical research has established connections between senescence, senescence-associated secretory phenotype, and age-related cardiac and vascular ...
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Manish Kumar Pengyi Yan George A Kuchel Ming Xu Source Type: research
Acceptance of Telepresence Robotics, Telecare and Teletherapy Among Stroke Patients, Relatives and Therapy Staff
CONCLUSION: Accepted new telecare and teletherapies can be offered with the help of telepresence robotics. This requires knowledge of and experience with the technology.PMID:38682498 | DOI:10.3233/SHTI240005 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Edda Currle Sonja Haug Source Type: research
The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation
This study reviews the current evidence on neuroinflammatory responses, the role of circRNAs in IS and their potential mechanisms in regulating inflammatory cells, and inflammatory factors affecting IS damage. This review lays a foundation for future clinical application of circRNAs as novel biomarkers and therapeutic targets.PMID:38682221 | DOI:10.31083/j.jin2304087 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Xin Gu Lingfei Li Biao Chen Yuyao Zhang Yongji Zhou Keqin Liu Wenqin Xia Xiaoqin Li Zheng Zhang Huanqing Shi Jinyu Huang Beibei Gao Lin Jiang Anwen Shao Congguo Yin Source Type: research
NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway
CONCLUSIONS: NEAT1 inhibits the angiogenic activity of mCAECs by inducing M1 polarization of BV-2 cells through the AMPK signaling pathway. This study further clarified the impact and mechanism of NEAT1 on microglia and the angiogenic ability of cerebrovascular endothelial cells.PMID:38684954 | DOI:10.1186/s11658-024-00579-5 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Ting Chen Xin Huang Yi-Xuan Zhao Zhi-Wen Zhou Wen-Sheng Zhou Source Type: research
NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway
CONCLUSIONS: NEAT1 inhibits the angiogenic activity of mCAECs by inducing M1 polarization of BV-2 cells through the AMPK signaling pathway. This study further clarified the impact and mechanism of NEAT1 on microglia and the angiogenic ability of cerebrovascular endothelial cells.PMID:38684954 | DOI:10.1186/s11658-024-00579-5 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 29, 2024 Category: Biochemistry Authors: Ting Chen Xin Huang Yi-Xuan Zhao Zhi-Wen Zhou Wen-Sheng Zhou Source Type: research
