Association of ambient ozone exposure and greenness exposure with hemorrhagic stroke mortality at different times: A cohort study in Shandong Province, China
This study aimed to investigate the association between long-term exposure to ambient ozone, greenness, and mortality from HS using exposure metrics at different times. We also examined whether greenness exposure modified the relationship between ozone exposure and mortality due to HS. The study population consisted of 45771 participants aged ≥40 y residing in 20 counties in Shandong Province who were followed up from 2013 to 2019. Ozone exposure metrics (annual mean and warm season) and the normalized difference a measure of greenness exposure, were calculated. The relationship between environmental exposures (ozone and...
Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Chengrong Liu Bingyin Zhang Chao Liu Yingying Zhang Ke Zhao Peiyao Zhang Meihui Tian Zilong Lu Xiaolei Guo Xianjie Jia Source Type: research
Comparison of the efficacy and safety of warfarin anticoagulation and left atrial appendage transcatheter occlusion in the treatment of non-valvular atrial fibrillation and investigation of ET-1, hs-CRP and PDGFs
This study compared the therapeutic effect and safety between warfarin anticoagulation and percutaneous left atrial appendage transcatheter occlusion (PLAATO) in non-valvular atrial fibrillation (NVAF). A total of 110 patients were selected and assigned to Control group (n=55) and Observation group (n=55). The control patients were used warfarin, while the observation patients were performed PLAATO. The coagulation function, stroke and bleeding scores were compared between the two groups at different times. Left ventricular function before therapy and 1 year after therapy and adverse events during follow-up were compared b...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yujie Zhang Yali Yao Ling Tao Tao Du Binbin Jia Mi Zhou Zhen Zhang Source Type: research
Association of ambient ozone exposure and greenness exposure with hemorrhagic stroke mortality at different times: A cohort study in Shandong Province, China
This study aimed to investigate the association between long-term exposure to ambient ozone, greenness, and mortality from HS using exposure metrics at different times. We also examined whether greenness exposure modified the relationship between ozone exposure and mortality due to HS. The study population consisted of 45771 participants aged ≥40 y residing in 20 counties in Shandong Province who were followed up from 2013 to 2019. Ozone exposure metrics (annual mean and warm season) and the normalized difference a measure of greenness exposure, were calculated. The relationship between environmental exposures (ozone and...
Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Chengrong Liu Bingyin Zhang Chao Liu Yingying Zhang Ke Zhao Peiyao Zhang Meihui Tian Zilong Lu Xiaolei Guo Xianjie Jia Source Type: research
High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia
Behav Brain Res. 2024 Apr 27;467:115018. doi: 10.1016/j.bbr.2024.115018. Online ahead of print.ABSTRACTPoststroke cognitive impairment (PSCI) is a common complication of stroke, but effective treatments are currently lacking. Repetitive transcranial magnetic stimulation (rTMS) is gradually being applied to treat PSCI, but there is limited evidence of its efficacy. To determine rTMS effects on PSCI, we constructed a transient middle cerebral artery occlusion (tMCAO) rat model. Rats were then grouped by random digital table method: the sham group (n = 10), tMCAO group (n = 10) and rTMS group (n = 10). The shuttle box and Mor...
Source: Behavioural Brain Research - April 28, 2024 Category: Neurology Authors: Jiena Hong Jiemei Chen Chao Li Fei Zhao Jiantao Zhang Yilong Shan Hongmei Wen Source Type: research
High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia
Behav Brain Res. 2024 Apr 27;467:115018. doi: 10.1016/j.bbr.2024.115018. Online ahead of print.ABSTRACTPoststroke cognitive impairment (PSCI) is a common complication of stroke, but effective treatments are currently lacking. Repetitive transcranial magnetic stimulation (rTMS) is gradually being applied to treat PSCI, but there is limited evidence of its efficacy. To determine rTMS effects on PSCI, we constructed a transient middle cerebral artery occlusion (tMCAO) rat model. Rats were then grouped by random digital table method: the sham group (n = 10), tMCAO group (n = 10) and rTMS group (n = 10). The shuttle box and Mor...
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Jiena Hong Jiemei Chen Chao Li Fei Zhao Jiantao Zhang Yilong Shan Hongmei Wen Source Type: research
Comparison of the efficacy and safety of warfarin anticoagulation and left atrial appendage transcatheter occlusion in the treatment of non-valvular atrial fibrillation and investigation of ET-1, hs-CRP and PDGFs
This study compared the therapeutic effect and safety between warfarin anticoagulation and percutaneous left atrial appendage transcatheter occlusion (PLAATO) in non-valvular atrial fibrillation (NVAF). A total of 110 patients were selected and assigned to Control group (n=55) and Observation group (n=55). The control patients were used warfarin, while the observation patients were performed PLAATO. The coagulation function, stroke and bleeding scores were compared between the two groups at different times. Left ventricular function before therapy and 1 year after therapy and adverse events during follow-up were compared b...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yujie Zhang Yali Yao Ling Tao Tao Du Binbin Jia Mi Zhou Zhen Zhang Source Type: research
Elabela ameliorates neuronal pyroptosis and mitochondrial fission via APJ/ZBP1 signaling in ischemic stroke
Exp Neurol. 2024 Apr 26:114802. doi: 10.1016/j.expneurol.2024.114802. Online ahead of print.ABSTRACTPyroptosis signifies a significant form of programmed neuronal demise subsequent to ischemic stroke. In our prior investigations, we demonstrated that the Elabela (ELA)-Apelin receptor (APJ) axis alleviated neuronal death by improving collateral circulation and mitigating ferroptosis in a murine model of middle cerebral artery occlusion (MCAO). However, the connection between ELA and neuronal pyroptosis remains further elucidation. Here, we observed an upregulation of ELA and APJ expression in both murine brain specimens and...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Nan Shen Lingqi Kong Xinyue Wang Yan Zhang Rui Li Chunrong Tao Guoping Wang Pengfei Xu Wei Hu Source Type: research
Temporarily Reversing Warfarin With Low-Dose 4-Factor Prothrombin Complex Concentrate in Left Ventricular Assist Device Patients Undergoing an Invasive Procedure
CONCLUSIONS AND RELEVANCE: Low-dose PCC4 appears to be a safe and effective temporary reversal strategy for patients with LVADs undergoing low-bleed risk elective procedures.PMID:38678311 | DOI:10.1177/10600280241248172 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 28, 2024 Category: Drugs & Pharmacology Authors: Byron Stevenson A Joshua Roberts William E Dager Source Type: research
In Vitro and In Silico Characterization of the Aggregation of Thrombi on Textured Ventricular Cannula
Ann Biomed Eng. 2024 Apr 28. doi: 10.1007/s10439-024-03504-1. Online ahead of print.ABSTRACTThe unacceptably high stroke rate associated with HeartMate 3 ventricular assist device (VAD) without signs of adherent pump thrombosis is hypothesized to be the result of the emboli produced by the inflow cannula, that are ingested and ejected from the pump. This in vitro and numerical study aimed to emulate the surface features and supraphysiological shear of a ventricular cannula to provide insight into their effect on thrombogenesis. Human whole blood was perfused at calibrated flow rates in a microfluidic channel to achieve she...
Source: Annals of Biomedical Engineering - April 28, 2024 Category: Biomedical Engineering Authors: Wenxuan He Abhishek Karmakar Junhyuk Kang Grant Rowlands Samuel Schirmacher Rodrigo M éndez-Rojano James Antaki Source Type: research
Comparison of the efficacy and safety of warfarin anticoagulation and left atrial appendage transcatheter occlusion in the treatment of non-valvular atrial fibrillation and investigation of ET-1, hs-CRP and PDGFs
This study compared the therapeutic effect and safety between warfarin anticoagulation and percutaneous left atrial appendage transcatheter occlusion (PLAATO) in non-valvular atrial fibrillation (NVAF). A total of 110 patients were selected and assigned to Control group (n=55) and Observation group (n=55). The control patients were used warfarin, while the observation patients were performed PLAATO. The coagulation function, stroke and bleeding scores were compared between the two groups at different times. Left ventricular function before therapy and 1 year after therapy and adverse events during follow-up were compared b...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Yujie Zhang Yali Yao Ling Tao Tao Du Binbin Jia Mi Zhou Zhen Zhang Source Type: research
Association of ambient ozone exposure and greenness exposure with hemorrhagic stroke mortality at different times: A cohort study in Shandong Province, China
This study aimed to investigate the association between long-term exposure to ambient ozone, greenness, and mortality from HS using exposure metrics at different times. We also examined whether greenness exposure modified the relationship between ozone exposure and mortality due to HS. The study population consisted of 45771 participants aged ≥40 y residing in 20 counties in Shandong Province who were followed up from 2013 to 2019. Ozone exposure metrics (annual mean and warm season) and the normalized difference a measure of greenness exposure, were calculated. The relationship between environmental exposures (ozone and...
Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Chengrong Liu Bingyin Zhang Chao Liu Yingying Zhang Ke Zhao Peiyao Zhang Meihui Tian Zilong Lu Xiaolei Guo Xianjie Jia Source Type: research
Elabela ameliorates neuronal pyroptosis and mitochondrial fission via APJ/ZBP1 signaling in ischemic stroke
Exp Neurol. 2024 Apr 26:114802. doi: 10.1016/j.expneurol.2024.114802. Online ahead of print.ABSTRACTPyroptosis signifies a significant form of programmed neuronal demise subsequent to ischemic stroke. In our prior investigations, we demonstrated that the Elabela (ELA)-Apelin receptor (APJ) axis alleviated neuronal death by improving collateral circulation and mitigating ferroptosis in a murine model of middle cerebral artery occlusion (MCAO). However, the connection between ELA and neuronal pyroptosis remains further elucidation. Here, we observed an upregulation of ELA and APJ expression in both murine brain specimens and...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Nan Shen Lingqi Kong Xinyue Wang Yan Zhang Rui Li Chunrong Tao Guoping Wang Pengfei Xu Wei Hu Source Type: research
High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia
Behav Brain Res. 2024 Apr 27;467:115018. doi: 10.1016/j.bbr.2024.115018. Online ahead of print.ABSTRACTPoststroke cognitive impairment (PSCI) is a common complication of stroke, but effective treatments are currently lacking. Repetitive transcranial magnetic stimulation (rTMS) is gradually being applied to treat PSCI, but there is limited evidence of its efficacy. To determine rTMS effects on PSCI, we constructed a transient middle cerebral artery occlusion (tMCAO) rat model. Rats were then grouped by random digital table method: the sham group (n = 10), tMCAO group (n = 10) and rTMS group (n = 10). The shuttle box and Mor...
Source: Behavioural Brain Research - April 28, 2024 Category: Neurology Authors: Jiena Hong Jiemei Chen Chao Li Fei Zhao Jiantao Zhang Yilong Shan Hongmei Wen Source Type: research
High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia
Behav Brain Res. 2024 Apr 27;467:115018. doi: 10.1016/j.bbr.2024.115018. Online ahead of print.ABSTRACTPoststroke cognitive impairment (PSCI) is a common complication of stroke, but effective treatments are currently lacking. Repetitive transcranial magnetic stimulation (rTMS) is gradually being applied to treat PSCI, but there is limited evidence of its efficacy. To determine rTMS effects on PSCI, we constructed a transient middle cerebral artery occlusion (tMCAO) rat model. Rats were then grouped by random digital table method: the sham group (n = 10), tMCAO group (n = 10) and rTMS group (n = 10). The shuttle box and Mor...
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Jiena Hong Jiemei Chen Chao Li Fei Zhao Jiantao Zhang Yilong Shan Hongmei Wen Source Type: research
