Enhanced In-Silico Polyethylene Wear Simulation of Total Knee Replacements During Daily Activities.
In this study, an in silico polyethylene wear simulation of total knee replacements was developed considering the various highly demanding daily activities. A good predicted accuracy (error = 8.1%) was found through comparison of the experimental results. A relatively larger averaged wear loss was found under the loading condition (1.53 mg/mc) of daily activities compared with the walking condition (1.32 mg/mc). The squatting movement (2.57 mg/mc) produces the highest overall wear rate. In addition, a relatively larger amount of wear was found on the medial side knee prosthesis than that on the...
Source: Annals of Biomedical Engineering - June 30, 2020 Category: Biomedical Engineering Authors: Shu L, Hashimoto S, Sugita N Tags: Ann Biomed Eng Source Type: research

A Review on Advances in Intra-operative Imaging for Surgery and Therapy: Imagining the Operating Room of the Future.
Abstract With the advent of Minimally Invasive Surgery (MIS), intra-operative imaging has become crucial for surgery and therapy guidance, allowing to partially compensate for the lack of information typical of MIS. This paper reviews the advancements in both classical (i.e. ultrasounds, X-ray, optical coherence tomography and magnetic resonance imaging) and more recent (i.e. multispectral, photoacoustic and Raman imaging) intra-operative imaging modalities. Each imaging modality was analyzed, focusing on benefits and disadvantages in terms of compatibility with the operating room, costs, acquisition time and imag...
Source: Annals of Biomedical Engineering - June 29, 2020 Category: Biomedical Engineering Authors: Zaffino P, Moccia S, De Momi E, Spadea MF Tags: Ann Biomed Eng Source Type: research

The Application of Digital Volume Correlation (DVC) to Evaluate Strain Predictions Generated by Finite Element Models of the Osteoarthritic Humeral Head.
This study quantified mechanical strain distributions within OA trabecular bone and demonstrated the importance of BCs to ensure the accuracy of predictions generated by corresponding FEMs. PMID: 32572730 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - June 22, 2020 Category: Biomedical Engineering Authors: Kusins J, Knowles N, Columbus M, Oliviero S, Dall'Ara E, Athwal GS, Ferreira LM Tags: Ann Biomed Eng Source Type: research

Questioning the Value of the Graduate Record Examinations (GRE) in PhD Admissions in Biomedical Engineering.
PMID: 32572731 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - June 22, 2020 Category: Biomedical Engineering Authors: King MR, Jennings GK, Chalkley RG, Sealy LJ Tags: Ann Biomed Eng Source Type: research

Head Impact Burden Differs Between Seasons in Youth and High School US Football Players.
In conclusion, cumulative head impacts differ significantly from one season to the next, and players have difficulty estimating their cumulative head impacts in relation to their team mates, especially at the youth level. Retrospective estimations of head impact burden should account for this variability. PMID: 32556646 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - June 18, 2020 Category: Biomedical Engineering Authors: Savino AK, Huang L, Yang J, Pizzimenti NM, McCarthy MT, Rose SC Tags: Ann Biomed Eng Source Type: research

Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells.
Abstract We provide an innovative, bioengineering, mechanobiology-based approach to rapidly (2-h) establish the in vivo metastatic likelihood of patient tumor-samples, where results are in direct agreement with clinical histopathology and patient outcomes. Cancer-related mortality is mostly due to local recurrence or to metastatic disease, thus early prediction of tumor-cell-fate may critically affect treatment protocols and survival rates. Metastasis and recurrence risks are currently predicted by lymph-node status, tumor size, histopathology and genetic testing, however, these are not infallible and results may ...
Source: Annals of Biomedical Engineering - June 15, 2020 Category: Biomedical Engineering Authors: Merkher Y, Horesh Y, Abramov Z, Shleifer G, Ben-Ishay O, Kluger Y, Weihs D Tags: Ann Biomed Eng Source Type: research

Development and Evaluation of CT-to-3D Ultrasound Image Registration Algorithm in Vertebral Phantoms for Spine Surgery.
Abstract Posterior spinal fusion surgery requires careful insertion of screws into the spine to avoid neurologic injury. While current systems use CT-scans, three-dimensional ultrasound (3DUS) could provide guidance by reconstructing the vertebral surface, and then registering a pre-operative vertebral model to that surface for localization. The aim of this study was to evaluate the accuracy and processing time of a custom CT-3DUS registration algorithm. A phantom human vertebra was 3D-printed and scanned with a motion capture-based 3D ultrasound (3DUS) system. Image registration was performed that included a pre-...
Source: Annals of Biomedical Engineering - June 12, 2020 Category: Biomedical Engineering Authors: Chan A, Coutts B, Parent E, Lou E Tags: Ann Biomed Eng Source Type: research

In Vitro Assessment of Flow Variability in an Intracranial Aneurysm Model Using 4D Flow MRI and Tomographic PIV.
This study aimed to assess cycle-to-cycle flow dynamics variations in a patient-specific intracranial aneurysm model using tomographic particle image velocimetry (tomo-PIV) at a high image rate under pulsatile flow conditions. Time-resolved and time-averaged velocity flow fields within the aneurysm sac and estimations of wall shear stress (WSS) were compared with those from 4D Flow MRI. A one-way ANOVA showed a significant difference between cardiac cycles (p value 
Source: Annals of Biomedical Engineering - June 10, 2020 Category: Biomedical Engineering Authors: Medero R, Ruedinger K, Rutkowski D, Johnson K, Roldán-Alzate A Tags: Ann Biomed Eng Source Type: research

Effectiveness of low-intensity pulsed ultrasound on osteoarthritis of the temporomandibular joint: A review.
Abstract Loading is indispensable for the growth, development, and maintenance of joint tissues, including mandibular condylar cartilage, but excessive loading or reduced host adaptive capacity can considerably damage the temporomandibular joint (TMJ), leading to temporomandibular joint osteoarthritis (TMJ-OA). TMJ-OA, associated with other pathological conditions and aging processes, is a highly degenerative disease affecting the articular cartilage. Many treatment modalities for TMJ-OA have been developed. Traditional clinical treatment includes mainly nonsurgical options, such as occlusal splints. However, non-...
Source: Annals of Biomedical Engineering - June 8, 2020 Category: Biomedical Engineering Authors: Tanaka E, Liu Y, Xia L, Ogasawara N, Sakamaki T, Kano F, Hashimoto N, Feng X, Yamamoto A Tags: Ann Biomed Eng Source Type: research

A Chemo-poroelastic Analysis of Mechanically Induced Fluid and Solute Transport in an Osteonal Cortical Bone.
Abstract It is well known that transport of nutrients and wastes as solute in bone fluid plays an important role in bone remodeling and damage healing. This work presents a chemo-poroelastic model for fluid and solute transport in the lacunar-canalicular network of an osteonal cortical bone under cyclic axial mechanical loading or vascular pressure. Analytical solutions are obtained for the pore fluid pressure, and fluid and solute velocities. Numerical results for fluid and calcium transport indicate that under a cyclic stress of 20 MPa, the magnitudes of the fluid and calcium velocities increase with an inc...
Source: Annals of Biomedical Engineering - June 8, 2020 Category: Biomedical Engineering Authors: Jin ZH, Janes JG, Peterson ML Tags: Ann Biomed Eng Source Type: research

Stereolithography 3D Bioprinting Method for Fabrication of Human Corneal Stroma Equivalent.
In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print the anatomically similar dome-shaped structure of the human corneal stroma. Two different concentrations of GelMA macromer (7.5 and 12.5%) were tested for corneal stroma bioprinting. Due to high macromer concentrations, 12.5% GelMA was stiffer than 7.5% GelMA, which made it easier to handle. In terms of water content and optical transmittance of the bioprinted scaffolds, we observed that scaffold with 12.5% GelMA concentration was clos...
Source: Annals of Biomedical Engineering - June 5, 2020 Category: Biomedical Engineering Authors: Mahdavi SS, Abdekhodaie MJ, Kumar H, Mashayekhan S, Baradaran-Rafii A, Kim K Tags: Ann Biomed Eng Source Type: research

A Wearable Augmented Reality Navigation System for Surgical Telementoring Based on Microsoft HoloLens.
Abstract This paper reports a new type of augmented reality (AR) system that integrates a Microsoft HoloLens device with a three-dimensional (3D) point tracking module for medical training and telementored surgery. In this system, a stereo camera is used to track the 3D position of a scalpel and transfer its coordinates wirelessly to a HoloLens device. In the scenario of surgical training, a virtual surgical scene with pre-recorded surgical annotations is superimposed with the actual surgical scene so that the surgical trainee is able to operate following virtual instructions. In the scenario of telementored surge...
Source: Annals of Biomedical Engineering - June 5, 2020 Category: Biomedical Engineering Authors: Liu P, Li C, Xiao C, Zhang Z, Ma J, Gao J, Shao P, Valerio I, Pawlik TM, Ding C, Yilmaz A, Xu R Tags: Ann Biomed Eng Source Type: research

Tension Strain-Softening and Compression Strain-Stiffening Behavior of Brain White Matter.
Abstract Brain, the most important component of the central nervous system (CNS), is a soft tissue with a complex structure. Understanding the role of brain tissue microstructure in mechanical properties is essential to have a more profound knowledge of how brain development, disease, and injury occur. While many studies have investigated the mechanical behavior of brain tissue under various loading conditions, there has not been a clear explanation for variation reported for material properties of brain tissue. The current study compares the ex-vivo mechanical properties of brain tissue under two loading modes, n...
Source: Annals of Biomedical Engineering - June 3, 2020 Category: Biomedical Engineering Authors: Eskandari F, Shafieian M, Aghdam MM, Laksari K Tags: Ann Biomed Eng Source Type: research

Ultra-High-Frame-Rate Ultrasound Monitoring of Muscle Contractility Changes Due to Neuromuscular Electrical Stimulation.
In this study, instantaneous strain maps of a contracting muscle were derived from ultra-high-frame-rate (2 kHz) ultrasound images to quantify the contractility. A correlation between strain maps and isometric contraction force values was investigated. When the muscle reached its maximum contraction, the maximum and the mean values of the strain map were correlated with the force values and were further used to stage the contractility change. During the muscle activation period, a novel methodology based on the principal component regression (PCR) was proposed to explore the strain-force correlation. The quadriceps muscle ...
Source: Annals of Biomedical Engineering - June 1, 2020 Category: Biomedical Engineering Authors: Sheng Z, Sharma N, Kim K Tags: Ann Biomed Eng Source Type: research

A Novel Multiplex Based Platform for Osteoarthritis Drug Candidate Evaluation.
In this study an ex vivo model of cartilage degradation, combined with measuring releases of 27 proteins, was utilized to study 9 drug candidates. After an initial single drug evaluation step the 3 most promising compounds were selected and employed in an exhaustive combinatorial experiment. The resulting most and least promising treatment candidates were selected and validated in an independent study. This included estimation of mechanical properties via finite element modelling (FEM) and quantification of cartilage degradation as glycosaminoglycan (GAG) release. The most promising candidate showed increase of Young's mod...
Source: Annals of Biomedical Engineering - May 29, 2020 Category: Biomedical Engineering Authors: Neidlin M, Chantzi E, Macheras G, Gustafsson MG, Alexopoulos LG Tags: Ann Biomed Eng Source Type: research

Computational Tools for the Reliability Assessment and the Engineering Design of Procedures and Devices in Bariatric Surgery.
In conclusion, biomechanics proved to be useful for the investigation of BS effects. Future exploitations of the biomechanical methods may largely improve BS reliability, efficacy and penetration rate. PMID: 32472365 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - May 29, 2020 Category: Biomedical Engineering Authors: Salmaso C, Toniolo I, Fontanella CG, Da Roit P, Albanese A, Polese L, Stefanini C, Foletto M, Carniel EL Tags: Ann Biomed Eng Source Type: research

Thermal Effects on Fluid Mixing in the Eye.
Abstract Age-related macular degeneration (AMD) is the leading cause of central vision loss in the developed world. Wet AMD can be managed through serial intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents. However, sometimes the treatment is ineffective. Given that the half-life of the drug is limited, inefficient mixing of the injected drug in the vitreous chamber of the eye may contribute to the ineffectiveness. Here, we introduce thermal heating as a means of enhancing the mixing-process in the vitreous chamber and investigate parameters that potentially influence its effectiv...
Source: Annals of Biomedical Engineering - May 26, 2020 Category: Biomedical Engineering Authors: Huang J, Gharib M Tags: Ann Biomed Eng Source Type: research

Constructing a Human Atrial Fibre Atlas.
Abstract Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy measurements are not currently available, and consequently assigning fibre fields to atrial models is challenging. We aimed to construct an atrial fibre atlas from a high-resolution DTMRI dataset that optimally reproduces electrophysiology simulation predictions corresponding to patient-specific fibre fields, and to develop a methodology for automatically assigning fibres to patient-specific anatomies. We extended an atr...
Source: Annals of Biomedical Engineering - May 26, 2020 Category: Biomedical Engineering Authors: Roney CH, Bendikas R, Pashakhanloo F, Corrado C, Vigmond EJ, McVeigh ER, Trayanova NA, Niederer SA Tags: Ann Biomed Eng Source Type: research

Eyes in Ears: A Miniature Steerable Digital Endoscope for Trans-Nasal Diagnosis of Middle Ear Disease.
Abstract The aim of this work is to design, fabricate and experimentally validate a miniature steerable digital endoscope that can provide comprehensive, high-resolution imaging of the middle ear using a trans-nasal approach. The motivation for this work comes from the high incidence of middle ear diseases, and the current reliance on invasive surgery to diagnose and survey these diseases which typically consists of the eardrum being lifted surgically to directly visualize the middle ear using a trans-canal approach. To enable less-invasive diagnosis and surveillance of middle ear disease, we propose an endoscope ...
Source: Annals of Biomedical Engineering - May 26, 2020 Category: Biomedical Engineering Authors: Gafford J, Freeman M, Fichera L, Noble J, Labadie R, Webster RJ Tags: Ann Biomed Eng Source Type: research

Improving Freezing Protocols and Organotypic Culture: A Histological Study on Rat Prepubertal Testicular Tissue.
In conclusion, this study highlights the necessity to further improve the organ culture method before applying it into the clinics. PMID: 32440757 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - May 21, 2020 Category: Biomedical Engineering Authors: Saulnier J, Oblette A, Delessard M, Dumont L, Rives A, Rives N, Rondanino C Tags: Ann Biomed Eng Source Type: research

Annals of Biomedical Engineering 2019 Year in Review.
PMID: 32440758 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - May 21, 2020 Category: Biomedical Engineering Authors: Rowson B, Duma SM Tags: Ann Biomed Eng Source Type: research

Electro-Thermal Therapy Algorithms and Active Internal Electrode Cooling Reduce Thermal Injury in High Frequency Pulsed Electric Field Cancer Therapies.
In this study active temperature control measures including internal electrode cooling and dynamic energy delivery were investigated as a process for mitigating thermal injury during treatment. Ex vivo liver was used to examine the extent of thermal injury induced by 5000 V treatments with delivery rates up to five times faster than current clinical practice. Active internal cooling of the electrode resulted in a 36% decrease in peak temperature vs. non-cooled control treatments. A temperature based feedback algorithm (electro-thermal therapy) was demonstrated as capable of maintaining steady state tissue temperatures...
Source: Annals of Biomedical Engineering - May 15, 2020 Category: Biomedical Engineering Authors: Sano MB, Fesmire CC, Petrella RA Tags: Ann Biomed Eng Source Type: research

Influence of Patient-Specific Characteristics on Transcatheter Heart Valve Neo-Sinus Flow: An In Silico Study.
This study investigated the effect of the post-TAVR geometry on flow stasis. Computed tomography angiography of 155 patients who underwent TAVR using a SAPIEN 3 were used to identify patients with and without thrombosis, and quantify thrombus volumes. Six patients with 23-mm SAPIEN 3 valves were then selected from the cohort and used to create patient-specific post-TAVR computational fluid dynamic models. Regions of flow stasis (%Volstasis, velocities below 0.05 m/s) were identified. The results showed that all post-TAVR anatomical measurements were significantly different in patients with and without thrombus, but on...
Source: Annals of Biomedical Engineering - May 15, 2020 Category: Biomedical Engineering Authors: Singh-Gryzbon S, Ncho B, Sadri V, Bhat SS, Kollapaneni SS, Balakumar D, Wei ZA, Ruile P, Neumann FJ, Blanke P, Yoganathan AP Tags: Ann Biomed Eng Source Type: research

Temperature Dependence of High Frequency Irreversible Electroporation Evaluated in a 3D Tumor Model.
In this study, a 3D tumor model was used to investigate the correlation between temperature and the effectiveness of standard clinical IRE and high frequency (H-FIRE) protocols. It was found for human glioblastoma cells that in the range of 2 to 37 °C the H-FIRE lethal electric field threshold value, which describes the minimum electric field to cause cell death, is highly dependent on temperature. Increasing the initial temperature from 2 to 37 °C resulted in a significant decrease in lethal electric field threshold from 1168 to 507 V/cm and a 139% increase in ablation size for H-FIRE burst treatmen...
Source: Annals of Biomedical Engineering - May 14, 2020 Category: Biomedical Engineering Authors: Fesmire CC, Petrella RA, Fogle CA, Gerber DA, Xing L, Sano MB Tags: Ann Biomed Eng Source Type: research

Equestrian Helmet Standards: Do They Represent Real-World Accident Conditions?
Abstract The use of helmets in equestrian sports has reduced the occurrence of traumatic brain injuries although, despite improvements to helmets, concussion remains a common injury. Currently, equestrian helmets are designed to pass certification standards involving a linear drop test to a rigid surface, while most concussions in equestrian sports result from oblique impacts to a compliant surface. The purpose of this study was to: (1) Compare the head kinematics and brain tissue response of the current equestrian helmet standard (EN1) and proposed standard EN13087-11 (EN2) to those associated with reconstruction...
Source: Annals of Biomedical Engineering - May 12, 2020 Category: Biomedical Engineering Authors: Clark JM, Hoshizaki TB, Annaidh AN, Gilchrist MD Tags: Ann Biomed Eng Source Type: research

Efficiently Simulating an Endograft Deployment: A Methodology for Detailed CFD Analyses.
Abstract Numerical models of endografts for the simulation of endovascular aneurysm repair are increasingly important in the improvement of device designs and patient outcomes. Nevertheless, current finite element analysis (FEA) models of complete endograft devices come at a high computational cost, requiring days of runtime, therefore restricting their applicability. In the current study, an efficient FEA model of the Anaconda™ endograft (Terumo Aortic, UK) was developed, able to yield results in just over 4 h, an order of magnitude less than similar models found in the literature. The model was used t...
Source: Annals of Biomedical Engineering - May 11, 2020 Category: Biomedical Engineering Authors: Kyriakou F, Maclean C, Dempster W, Nash D Tags: Ann Biomed Eng Source Type: research

ABME Special Issue Editorial: Engineering Cell Behavior.
PMID: 32394222 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - May 11, 2020 Category: Biomedical Engineering Authors: Auguste D Tags: Ann Biomed Eng Source Type: research

Elastic Modulus of Woven Bone: Correlation with Evolution of Porosity and X-ray Greyscale.
z J, Reina-Romo E Abstract The woven bone created during the healing of bone regeneration processes is characterized as being extremely inhomogeneous and having a variable stiffness that increases with time. Therefore, it is important to study how the mechanical properties of woven bone are dependent on its microarchitecture and especially on its porosity and mineral content. The porosity and the x-ray greyscale of specimens taken from bone transport studies in sheep were assessed by means of ex vivo imaging. Our study demonstrates that the porosity of the woven bone in the distraction area diminishes during the h...
Source: Annals of Biomedical Engineering - May 9, 2020 Category: Biomedical Engineering Authors: Mora-Macías J, García-Florencio P, Pajares A, Miranda P, Domínguez J, Reina-Romo E Tags: Ann Biomed Eng Source Type: research

The Role of Feedback Control Design in Developing Anemia Management Protocols.
Abstract The optimal use of erythropoiesis stimulating agents to treat anemia of end-stage renal disease remains difficult due to reported associations with adverse events. A patient's hemoglobin response to these agents cannot be accurately described using population-level models due to many individual factors including chronic inflammation, red blood cell lifespan, and acute blood loss. As a consequence, it is generally understood that current one-size-fits-all anemia management protocols result in suboptimal outcomes. In this paper, we report on our collaboration with the medical community in designing anemia m...
Source: Annals of Biomedical Engineering - May 7, 2020 Category: Biomedical Engineering Authors: Chait Y, Germain MJ, Hollot CV, Horowitz J Tags: Ann Biomed Eng Source Type: research

Prediction of Knee Kinematics at the Time of Noncontact Anterior Cruciate Ligament Injuries Based on the Bone Bruises.
Abstract Biomechanical risk factors associated with the alignment and position of the knee for anterior cruciate ligament (ACL) injury are still not conclusive. As bone bruises identified on magnetic resonance imaging (MRI) following acute ACL injury could represent the impact footprint at the time of injury. To improve understanding of the ACL injury mechanism, we aimed to determine the knee kinematics during ACL injury based on the bone bruises. Knee MRI scans of patients who underwent acute noncontact ACL injuries were acquired. Numerical optimization was used to match the bone bruises of the femur and tibia an...
Source: Annals of Biomedical Engineering - May 7, 2020 Category: Biomedical Engineering Authors: Shi H, Ding L, Ren S, Jiang Y, Zhang H, Hu X, Huang H, Ao Y Tags: Ann Biomed Eng Source Type: research

An Instrumented Urethral Catheter with a Distributed Array of Iontronic Force Sensors.
Abstract This paper develops a novel instrumented urethral catheter with an array of force sensors for measuring the distributed pressure in a human urethra. The catheter and integrated portions of the force sensors are fabricated by the use of 3D printing using a combination of both soft and hard polymer substrates. Other portions of the force sensors consisting of electrodes and electrolytes are fabricated separately and assembled on top of the 3D-printed catheter to create a soft flexible device. The force sensors use a novel supercapacitive (iontronic) sensing mechanism in which the contact area between a pair...
Source: Annals of Biomedical Engineering - May 6, 2020 Category: Biomedical Engineering Authors: Zhang Y, Ahmadi M, Timm G, Sezen S, Rajamani R Tags: Ann Biomed Eng Source Type: research

Nanoparticle-Mediated TGF- β Release from Microribbon-Based Hydrogels Accelerates Stem Cell-Based Cartilage Formation In Vivo.
Nanoparticle-Mediated TGF-β Release from Microribbon-Based Hydrogels Accelerates Stem Cell-Based Cartilage Formation In Vivo. Ann Biomed Eng. 2020 May 06;: Authors: Barati D, Gegg C, Yang F Abstract Conventional nanoporous hydrogels often lead to slow cartilage deposition by MSCs in 3D due to physical constraints and requirement for degradation. Our group has recently reported macroporous gelatin microribbon (μRB) hydrogels, which substantially accelerate MSC-based cartilage formation in vitro compared to conventional gelatin hydrogels. To facilitate translating the use of μRB-based scaffol...
Source: Annals of Biomedical Engineering - May 6, 2020 Category: Biomedical Engineering Authors: Barati D, Gegg C, Yang F Tags: Ann Biomed Eng Source Type: research

Computational Modelling of the Bioheat Transfer Process in Human Skin Subjected to Direct Heating and/or Cooling Sources: A Systematic Review.
res P Abstract The purpose of this systematic review is to analyze characteristics and methodologies utilized in bioheat transfer models of human skin to provide state-of-the-art knowledge on the topic. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. PubMed, EMBASE and Web of Science databases were searched up to May 30th, 2019 for bioheat transfer models focusing on direct contact between skin and temperature (heat and/or cold) source. Ten studies were included. A 16-item checklist was used to assess their methodological quality. Four studi...
Source: Annals of Biomedical Engineering - May 6, 2020 Category: Biomedical Engineering Authors: Silva M, Freitas B, Andrade R, Espregueira-Mendes J, Silva F, Carvalho Ó, Flores P Tags: Ann Biomed Eng Source Type: research

Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics.
This study conducted in silico patient-specific modeling for twelve Fontan patients, using a Newtonian and a non-Newtonian model for each patient. Differences were quantified by examining clinically relevant metrics: indexed power loss (iPL), indexed viscous dissipation rate (iVDR), hepatic flow distribution (HFD), and regions of low wall shear stress (AWSS). Four sets of "non-Newtonian importance factors" were calculated to explore their effectiveness in identifying the non-Newtonian effect. No statistical differences were observed in iPL, iVDR, and HFD between the two models at the population-level, but large i...
Source: Annals of Biomedical Engineering - May 5, 2020 Category: Biomedical Engineering Authors: Wei Z, Singh-Gryzbon S, Trusty PM, Huddleston C, Zhang Y, Fogel MA, Veneziani A, Yoganathan AP Tags: Ann Biomed Eng Source Type: research

Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning.
In this study, iPSC-CMs were utilized to study their calcium transient signals and drug effects by means of machine learning, a central part of artificial intelligence. Drug effects were assessed in six iPSC-lines carrying different mutations causing catecholaminergic polymorphic ventricular tachycardia (CPVT), a highly malignant inherited arrhythmogenic disorder. The antiarrhythmic effect of dantrolene, an inhibitor of sarcoplasmic calcium release, was studied in iPSC-CMs after adrenaline, an adrenergic agonist, stimulation by machine learning analysis of calcium transient signals. First, beats of transient signals were i...
Source: Annals of Biomedical Engineering - May 4, 2020 Category: Biomedical Engineering Authors: Juhola M, Penttinen K, Joutsijoki H, Aalto-Setälä K Tags: Ann Biomed Eng Source Type: research

Plasma Isolation in a Syringe by Conformal Integration of Inertial Microfluidics.
Abstract A thermoplastic microfluidic substrate is conformally integrated onto the cylindrical barrel of a conventional venipuncture syringe, forming a spiral inertial separation element supporting the isolation of plasma from diluted whole blood. The cylindrical shape of the syringe itself serves to define the flow path required for inertial separation by transforming a linear microchannel to a spiral topology. The hybrid system enables inertial plasma separation by Dean flow focusing within the same syringe used for a patient blood draw, with the seamlessly interconnected microfluidic element operated by automat...
Source: Annals of Biomedical Engineering - May 4, 2020 Category: Biomedical Engineering Authors: Han JY, DeVoe DL Tags: Ann Biomed Eng Source Type: research

Stress Measurements on the Articular Cartilage Surface Using Fiber Optic Technology and In-Vivo Gait Kinematics.
In this study, a novel, repeatable, and reliable method for measuring stress on the surface of articular cartilage in articular joints is presented. Small Fiber Bragg Grating (FBG) sensors capable of measuring normal stress between contact surfaces in diarthrodial joints were developed and validated. The small size of these sensors (diameter of 125-300 μm and sensing length of 1 mm) allows them to be inserted into the joint space without the removal of biomechanically relevant structures. In-vitro stresses on the surface of the cartilage for both healthy and surgically damaged joints were measured after implan...
Source: Annals of Biomedical Engineering - April 27, 2020 Category: Biomedical Engineering Authors: Vakiel P, Shekarforoush M, Dennison CR, Scott M, Frank CB, Hart DA, Shrive NG Tags: Ann Biomed Eng Source Type: research

Optimization of Female Head-Neck Model with Active Reflexive Cervical Muscles in Low Severity Rear Impact Collisions.
In this study, the head-neck model of ViVA OpenHBM was further developed by adding active muscle controllers for the cervical muscles to represent the human neck muscle reflex system as studies have shown that cervical muscles influence head-neck kinematics during impacts. The muscle controller was calibrated by conducting optimization-based parameter identification of published-volunteer data. The effects of different calibration objectives to head-neck kinematics were analyzed and compared. In general, a model with active neck muscles improved the head-neck kinematics agreement with volunteer responses. The current study...
Source: Annals of Biomedical Engineering - April 24, 2020 Category: Biomedical Engineering Authors: Putra IPA, Iraeus J, Sato F, Svensson MY, Linder A, Thomson R Tags: Ann Biomed Eng Source Type: research

Cerebrovascular Reactivity in Special Operations Forces Combat Soldiers.
Abstract The purpose of this study was to investigate how concussion history affects cerebrovascular reactivity (CVR) in Special Operations Forces (SOF) combat soldiers. We studied 104 SOF soldiers [age = 33.5 ± 4.3 years; height = 179.7 ± 6.3 cm; 59 (56.7%) with self-reported concussion history]. We employed transcranial Doppler (TCD) ultrasound to measure middle cerebral artery (MCA) velocity. Baseline TCD data were collected for 2 min. Changes in MCA velocity were measured in response to five breath-holding trials and...
Source: Annals of Biomedical Engineering - April 23, 2020 Category: Biomedical Engineering Authors: Roby PR, Chandran A, Barczak-Scarboro NE, DeLellis SM, Ford CB, Healy ML, Means GE, Kane SF, Lynch JH, Mihalik JP Tags: Ann Biomed Eng Source Type: research

Altered β-Cell Calcium Dynamics via Electric Field Exposure.
Altered β-Cell Calcium Dynamics via Electric Field Exposure. Ann Biomed Eng. 2020 Apr 22;: Authors: Liebman C, Vu TM, Phillips A, Chen B, Cho M Abstract Electric field stimulation has long been investigated with results supporting its therapeutic potential; however, its effects on insulin secreting cells has yet to be fully elucidated. Herein we explored the effects of physiological direct current (DC) electric field stimulation on the intracellular calcium dynamics of mouse derived βTC-6 insulinoma cells. This electrical stimulation resulted in an elevation in intracellular calcium along wi...
Source: Annals of Biomedical Engineering - April 22, 2020 Category: Biomedical Engineering Authors: Liebman C, Vu TM, Phillips A, Chen B, Cho M Tags: Ann Biomed Eng Source Type: research

Muscular Thin Films for Label-Free Mapping of Excitation Propagation in Cardiac Tissue.
Abstract Muscular thin films (MTFs), have already found a variety of applications in cardiac tissue engineering and in building of lab-on-a-chip systems. Here we present a novel approach to label-free mapping of excitation waves in the cardiomyocyte cell cultures with the use of MTFs. Neonatal rat ventricular cardiomyocytes were cultured on polydimethylsiloxane (PDMS) thin films and observed by means of off-axis illumination. Inflexions of the membrane created by the contraction of cardiomyocytes led to formation of patterns of bright and dark areas on the surface of the membrane. These patterns were recorded and ...
Source: Annals of Biomedical Engineering - April 20, 2020 Category: Biomedical Engineering Authors: Balashov VA, Gorbunov VS, Guria KG, Agladze KI Tags: Ann Biomed Eng Source Type: research

Perspectives on Bioengineering Clinical Immersion: History, Innovation, and Impact.
Abstract Opportunities to provide clinical immersion experiences to bioengineering undergraduate students have expanded over the last several years. These programs allow students to observe the clinical environment in order to better understand workflow processes, the context in which medical equipment is used, and identify unmet needs firsthand. While each program focuses on identifying unmet needs, these experiences vary in content and implementation. Here we discuss features of clinical immersion programs, share details of our program after six years, and present data regarding post-graduation employment of our...
Source: Annals of Biomedical Engineering - April 20, 2020 Category: Biomedical Engineering Authors: Kotche M, Felder AE, Wilkens K, Stirling S Tags: Ann Biomed Eng Source Type: research

Enzyme-Mediated Conjugation of Peptides to Silk Fibroin for Facile Hydrogel Functionalization.
Abstract Enzymatic crosslinking of tyrosine is a simple and modular method for adding functional peptides to silk fibroin (SF) hydrogels. Silk fibroin is a naturally derived polymer notable for its robust mechanical properties, biological compatibility, and versatility. Hydrogels fabricated from SF are elastic, optically clear, and have tunable moduli, however, they do not contain native biological epitopes for cell interactions. In this work we demonstrate the attachment of peptides to SF hydrogels through crosslinking of tyrosine with horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The goal was to und...
Source: Annals of Biomedical Engineering - April 20, 2020 Category: Biomedical Engineering Authors: McGill M, Grant JM, Kaplan DL Tags: Ann Biomed Eng Source Type: research

Insertion of Small Diameter Radiopaque Tracking Beads into the Anterior Cruciate Ligament Results in Repeatable Strain Measurement Without Affecting the Material Properties.
Abstract The characterization of ligamentous soft tissue properties is limited by a lack of measurement methods capable of minimally-invasively quantifying regional strain. Previous implementations of radiographic imaging and tissue-embedded radiopaque markers demonstrated promising regional strain measurements, but found error associated with non-repeatable bead positions within the tissue after load application. No study has investigated the effects of cyclic loading on the strains measured within the tissue. The purpose of this study was to quantify the effect of joint loading on strain measurement using radiop...
Source: Annals of Biomedical Engineering - April 20, 2020 Category: Biomedical Engineering Authors: Blokker AM, Getgood A, Nguyen D, Holdsworth DW, Burkhart TA Tags: Ann Biomed Eng Source Type: research

Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues.
Abstract Here we demonstrate a technique to generate proteomic signatures of specific cell types within heterogeneous populations. While our method is broadly applicable across biological systems, we have limited the current work to study neural cell types isolated from human, post-mortem Alzheimer's disease (AD) and aged-matched non-symptomatic (NS) brains. Motivating the need for this tool, we conducted an initial meta-analysis of current, human AD proteomics studies. While the results broadly corroborated major neurodegenerative disease hypotheses, cell type-specific predictions were limited. By adapting our Fo...
Source: Annals of Biomedical Engineering - April 17, 2020 Category: Biomedical Engineering Authors: Sadick JS, Crawford LA, Cramer HC, Franck C, Liddelow SA, Darling EM Tags: Ann Biomed Eng Source Type: research

Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries.
This study evaluates the feasibility of near infrared (NIR) spectroscopy to distinguish between different cartilage injury types associated with post-traumatic osteoarthritis and idiopathic osteoarthritis (OA) induced by mechanical and enzymatic damages. Bovine osteochondral samples (n = 72) were subjected to mechanical (n = 24) and enzymatic (n = 36) damage; NIR spectral measurements were acquired from each sample before and after damage, and from a separate control group (n = 12). Biomechanical measurements were then conducted to determine the functional integrity o...
Source: Annals of Biomedical Engineering - April 16, 2020 Category: Biomedical Engineering Authors: Nippolainen E, Shaikh R, Virtanen V, Rieppo L, Saarakkala S, Töyräs J, Afara IO Tags: Ann Biomed Eng Source Type: research

Quantifying the Multidimensional Impedance of the Shoulder During Volitional Contractions.
Abstract The neuromuscular control of the shoulder requires regulation of 3D joint mechanics, but it is unknown how these mechanics vary during tasks that load the shoulder in different directions. The purpose of this study was to quantify how the 3D mechanics of the shoulder change with voluntary torque production. Eleven participants produced voluntary isometric torques in one of six directions along three measurement axes. Impedance was estimated by applying small, pseudorandom angular perturbations about the shoulder as participants maintained steady state torques. The nonparametric impedance frequency respons...
Source: Annals of Biomedical Engineering - April 16, 2020 Category: Biomedical Engineering Authors: Lipps DB, Baillargeon EM, Ludvig D, Perreault EJ Tags: Ann Biomed Eng Source Type: research

Biomaterials and Culture Systems for Development of Organoid and Organ-on-a-Chip Models.
Abstract The development of novel 3D tissue culture systems has enabled the in vitro study of in vivo processes, thereby overcoming many of the limitations of previous 2D tissue culture systems. Advances in biomaterials, including the discovery of novel synthetic polymers has allowed for the generation of physiologically relevant in vitro 3D culture models. A large number of 3D culture systems, aided by novel organ-on-a-chip and bioreactor technologies have been developed to improve reproducibility and scalability of in vitro organ models. The discovery of induced pluripotent stem cells (iPSCs) and the increasing ...
Source: Annals of Biomedical Engineering - April 13, 2020 Category: Biomedical Engineering Authors: D'Costa K, Kosic M, Lam A, Moradipour A, Zhao Y, Radisic M Tags: Ann Biomed Eng Source Type: research

Comparative Study of Electrospun Scaffolds Containing Native GAGs and a GAG Mimetic for Human Mesenchymal Stem Cell Chondrogenesis.
This study evaluated the chondrogenic differentiation of human mesenchymal stem cells (MSCs) on gelatin-based scaffolds containing partially sulfated cellulose (pSC), a GAG mimetic derived from cellulose, in comparison to native GAGs, chondroitin sulfate-A (CS-A) and chondroitin sulfate-C (CS-C), where pSC has similarity to CS-C in terms of degree and pattern of sulfation. Scaffolds were prepared by electrospinning gelatin with pSC or the native GAGs. All scaffolds consist of fibers having average diameters of approximately 3 μm and inter-fiber spacing of approximately 30 μm and were hydrolytically stable t...
Source: Annals of Biomedical Engineering - April 13, 2020 Category: Biomedical Engineering Authors: Menezes R, Arinzeh TL Tags: Ann Biomed Eng Source Type: research

Perception-to-Image: Reconstructing Natural Images from the Brain Activity of Visual Perception.
Abstract The reappearance of human visual perception is a challenging topic in the field of brain decoding. Due to the complexity of visual stimuli and the constraints of fMRI data collection, the present decoding methods can only reconstruct the basic outline or provide similar figures/features of the perceived natural stimuli. To achieve a high-quality and high-resolution reconstruction of natural images from brain activity, this paper presents an end-to-end perception reconstruction model called the similarity-conditions generative adversarial network (SC-GAN), where visually perceptible images are reconstructe...
Source: Annals of Biomedical Engineering - April 13, 2020 Category: Biomedical Engineering Authors: Huang W, Yan H, Wang C, Li J, Zuo Z, Zhang J, Shen Z, Chen H Tags: Ann Biomed Eng Source Type: research