Development and Multi-Scale Validation of a Finite Element Football Helmet Model.
Abstract Head injury is a growing concern within contact sports, including American football. Computational tools such as finite element (FE) models provide an avenue for researchers to study, and potentially optimize safety tools, such as helmets. The goal of this study was to develop an accurate representative helmet model that could be used in further study of head injury to mitigate the toll of concussions in contact sports. An FE model of a Schutt Air XP Pro football helmet was developed through three major steps: geometry development, material characterization, and model validation. The fully assembled helme...
Source: Annals of Biomedical Engineering - September 13, 2019 Category: Biomedical Engineering Authors: Decker W, Baker A, Ye X, Brown P, Stitzel J, Gayzik FS Tags: Ann Biomed Eng Source Type: research

A Biomarker for Discriminating Between Migraine With and Without Aura: Machine Learning on Functional Connectivity on Resting-State EEGs.
Abstract Advanced analyses of electroencephalography (EEG) are rapidly becoming an important tool in understanding the brain's processing of pain. To date, it appears that none have been explored as a way of distinguishing between migraine patients with aura (MWA) vs. those without aura (MWoA). In this work, we apply a mixture of predictive, e.g., classification methods and attribute-selection techniques, and traditional explanatory, e.g., statistical, analyses on functional connectivity measures extracted from EEG signal acquired from at-rest participants (N = 52) during their interictal period and ...
Source: Annals of Biomedical Engineering - September 13, 2019 Category: Biomedical Engineering Authors: Frid A, Shor M, Shifrin A, Yarnitsky D, Granovsky Y Tags: Ann Biomed Eng Source Type: research

Membrane Deformation of Endothelial Surface Layer Interspersed with Syndecan-4: A Molecular Dynamics Study.
Abstract The lipid membrane of endothelial cells plays a pivotal role in maintaining normal circulatory system functions. To investigate the response of the endothelial cell membrane to changes in vascular conditions, an atomistic model of the lipid membrane interspersed with Syndecan-4 core protein was established based on experimental observations and a series of molecular dynamics simulations were undertaken. The results show that flow results in continuous deformation of the lipid membrane, and the degree of membrane deformation is not in monotonic relationship with the environmental changes (either the change...
Source: Annals of Biomedical Engineering - September 13, 2019 Category: Biomedical Engineering Authors: Jiang XZ, Guo L, Luo KH, Ventikos Y Tags: Ann Biomed Eng Source Type: research

Statistical Shape Modeling Approach to Predict Missing Scapular Bone.
Abstract Prediction of complete and premorbid scapular anatomy is an important aspect of successful shoulder arthroplasty surgeries to treat glenohumeral arthritis and which remains elusive in the current literature. We proposed to build a statistical shape model (SSM) of the scapula and use it to build a framework to predict a complete scapular shape from virtually created scapular bone defects. The bone defects were synthetically created to imitate bone loss in the glenoid region and missing bony part in inferior and superior scapular regions. Sixty seven dry scapulae were used to build the SSM while ten externa...
Source: Annals of Biomedical Engineering - September 11, 2019 Category: Biomedical Engineering Authors: Salhi A, Burdin V, Boutillon A, Brochard S, Mutsvangwa T, Borotikar B Tags: Ann Biomed Eng Source Type: research

In Vitro Calcification of Bioprosthetic Heart Valves: Investigation of Test Fluids.
Abstract Calcification is a major reason for the failure of bioprosthetic heart valves. Therefore, several attempts towards an accelerated in vitro model were undertaken in order to provide a cost- and time-saving method for the analysis of calcification processes. Due to the problem of superficial or spontaneous precipitation, which occurred in the fluids applied, we focused our study on the development of a near-physiological calcification fluid. The desired fluid should not precipitate spontaneously and should neither promote nor inhibit calcification. Eleven different fluid compositions were tested without con...
Source: Annals of Biomedical Engineering - September 6, 2019 Category: Biomedical Engineering Authors: Kiesendahl N, Schmitz C, Von Berg A, Menne M, Schmitz-Rode T, Arens J, Steinseifer U Tags: Ann Biomed Eng Source Type: research

State-of-the-Art Modeling and Simulation of the Brain's Response to Mechanical Loads.
PMID: 31485874 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - September 4, 2019 Category: Biomedical Engineering Authors: Horstemeyer MF, Panzer MB, Prabhu RK Tags: Ann Biomed Eng Source Type: research

An Integrated Sensor-Model Approach for Haptic Feedback of Flexible Endoscopic Robots.
Abstract Haptic feedback for flexible endoscopic surgical robots is challenging due to space constraints for sensors and shape-dependent force hysteresis of tendon-sheath mechanisms (TSMs). This paper proposes (1) a single-axis fiber Bragg grating (FBG)-based force sensor for a TSM of a robotic arm and (2) an integrated sensor-model approach to estimate forces on other TSMs of that arm. With a robust and simple structure, a temperature-compensated sensor can be mounted on the distal sheath to measure forces applied by the TSM. This proposed sensor was integrated with a Ø4.2 mm articulated robotic arm d...
Source: Annals of Biomedical Engineering - September 4, 2019 Category: Biomedical Engineering Authors: Lai W, Cao L, Tan RX, Tan YC, Li X, Phan PT, Tiong AMH, Tjin SC, Phee SJ Tags: Ann Biomed Eng Source Type: research

ECM in Differentiation: A Review of Matrix Structure, Composition and Mechanical Properties.
Abstract Stem cell regenerative potential owing to the capacity to self-renew as well as differentiate into other cell types is a promising avenue in regenerative medicine. Stem cell niche not only provides physical scaffolding but also possess instructional capacity as it provides a milieu of biophysical and biochemical cues. Extracellular matrix (ECM) has been identified as a major dictator of stem cell lineage, thus understanding the structure of in vivo ECM pertaining to specific tissue differentiation will aid in devising in vitro strategies to improve the differentiation efficiency. In this review, we summar...
Source: Annals of Biomedical Engineering - September 4, 2019 Category: Biomedical Engineering Authors: Padhi A, Nain AS Tags: Ann Biomed Eng Source Type: research

In Vivo MRI Assessment of Blood Flow in Arteries and Veins from Head-to-Toe Across Age and Sex in C57BL/6 Mice.
Abstract Although widely used as a preclinical model for studying cardiovascular diseases, there is a scarcity of in vivo hemodynamic measurements of the naïve murine system in multiple arterial and venous locations, from head-to-toe, and across sex and age. The purpose of this study is to quantify cardiovascular hemodynamics in mice at different locations along the vascular tree while evaluating the effects of sex and age. Male and female, adult and aged mice were anesthetized and underwent magnetic resonance imaging. Data were acquired from four co-localized vessel pairs (carotid/jugular, suprarenal and inf...
Source: Annals of Biomedical Engineering - August 27, 2019 Category: Biomedical Engineering Authors: Crouch AC, Cao AA, Scheven UM, Greve JM Tags: Ann Biomed Eng Source Type: research

Scaffold Free Microtissue Formation for Enhanced Cartilage Repair.
This study demonstrates 3D cartilage mimics that could have a potential application in the next generation of Autologous Chondrocyte Implantation procedures. Moreover, spheroids can be used as building blocks to create cartilage constructs by bioprinting in the future. PMID: 31451988 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - August 26, 2019 Category: Biomedical Engineering Authors: De Moor L, Beyls E, Declercq H Tags: Ann Biomed Eng Source Type: research

An Effective CNN Method for Fully Automated Segmenting Subcutaneous and Visceral Adipose Tissue on CT Scans.
This study demonstrates considerable improvement in feasibility and reliability for the fully automated recognition of abdominal CT slices and segmentation of selected abdominal CT in subcutaneous and visceral adipose tissue, and it has a high agreement with a manually annotated biomarker. PMID: 31451989 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - August 26, 2019 Category: Biomedical Engineering Authors: Wang Z, Meng Y, Weng F, Chen Y, Lu F, Liu X, Hou M, Zhang J Tags: Ann Biomed Eng Source Type: research

Development of a Bioactive Polymeric Drug Eluting Coronary Stent Coating Using Electrospraying.
Abstract Drug-eluting stents are now routinely used in the treatment of acute coronary syndromes caused by coronary artery disease. Whilst the sustained release of anti-proliferative drugs from these devices has greatly reduced the need for repeat revascularisation procedures, this approach is not suitable for all patients and appears to delay regrowth of the endothelium, necessitating the use of prolonged dual anti-platelet therapy. Although the development of more advanced stent platforms and drug coatings has produced modest improvements in performance, these devices have not fully addressed the limitations exp...
Source: Annals of Biomedical Engineering - August 22, 2019 Category: Biomedical Engineering Authors: McKittrick CM, Cardona MJ, Black RA, McCormick C Tags: Ann Biomed Eng Source Type: research

Head Impact Biomechanics Differ Between Girls and Boys Youth Ice Hockey Players.
Abstract The influence of sex on head impact biomechanics is unknown for youth ice hockey. We sought to determine sex differences in head impact severity and frequency in youth ice hockey players. Male (n = 110) and female (n = 25) players (13-16 years old) were recruited from a local hockey organization. Players wore helmets instrumented with the Head Impact Telemetry System for all competitions and practices throughout the season. Seven team-seasons were captured. Random intercepts general mixed linear models determined whether linear acceleration and rotational acceleration differed ...
Source: Annals of Biomedical Engineering - August 21, 2019 Category: Biomedical Engineering Authors: Mihalik JP, Wasserman EB, Teel EF, Marshall SW Tags: Ann Biomed Eng Source Type: research

Correction to: Material Mapping of QCT-Derived Scapular Models: A Comparison with Micro-CT Loaded Specimens Using Digital Volume Correlation.
Abstract The article Material Mapping of QCT-Derived Scapular Models: A Comparison with Micro-CT Loaded Specimens Using Digital Volume Correlation, written by Knowles et al, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 11 July 2019 without open access. With the author(s)' decision to opt for Open Choice the copyright of the article changed on [August 30] to © The Author(s) 2019 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ), which per...
Source: Annals of Biomedical Engineering - August 20, 2019 Category: Biomedical Engineering Authors: Knowles NK, Kusins J, Faieghi M, Ryan M, Dall'Ara E, Ferreira LM Tags: Ann Biomed Eng Source Type: research

Clinical Applicability of an Existing Proportionality Scheme in Three-Segment Kinetic Foot Models.
Abstract An important methodological challenge in multi-segment kinetic foot models is to partition the total ground reaction force across different foot segments. Several studies applied a proportionality scheme based on the combination of a pressure- and force platform. A recent study highlighted distinct errors in the partitioning of shear forces when using this proportionality scheme. To date, the impact of this shear force partitioning error analysis on joint moment calculations using inverse dynamic calculations in pathological gait is not known. Hence, the goal of this study was to investigate the clinical ...
Source: Annals of Biomedical Engineering - August 20, 2019 Category: Biomedical Engineering Authors: Eerdekens M, Staes F, Giovanni MA, Deschamps K Tags: Ann Biomed Eng Source Type: research

Authors' Response to Drs. Ece Salihoglu and Ziya Salihoglu's Letter to the Editor.
D: 31410712 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - August 13, 2019 Category: Biomedical Engineering Authors: Authors' Response to Drs. Ece Salihoglu and Ziya Salihoglu's Letter to the Editor. Tags: Ann Biomed Eng Source Type: research

Shear-Induced Encapsulation into Red Blood Cells: A New Microfluidic Approach to Drug Delivery.
Abstract Encapsulating molecules into red blood cells (RBCs) is a challenging topic for drug delivery in clinical practice, allowing to prolong the residence time in the body and to avoid toxic residuals. Fluidic shear stress is able to temporary open the membrane pores of RBCs, thus allowing for the diffusion of a drug in solution with the cells. In this paper, both a computational and an experimental approach were used to investigate the mechanism of shear-induced encapsulation in a microchannel. By means of a computational fluid dynamic model of a cell suspension, it was possible to calculate an encapsulation i...
Source: Annals of Biomedical Engineering - August 13, 2019 Category: Biomedical Engineering Authors: Piergiovanni M, Casagrande G, Taverna F, Corridori I, Frigerio M, Bianchi E, Arienti F, Mazzocchi A, Dubini G, Costantino ML Tags: Ann Biomed Eng Source Type: research

Difference in Bicarbonate Calculation Algorithm by Manufacturer Alters Diagnosis of Acid-Base Disorders.
PMID: 31399880 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - August 9, 2019 Category: Biomedical Engineering Authors: Tanemoto M, Kimura T, Yamada S, Yokoyama T, Okazaki Y Tags: Ann Biomed Eng Source Type: research

Correction to: Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization.
This article was corrected to add a permissions credit to Fig 3 legend. PMID: 31388848 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - August 6, 2019 Category: Biomedical Engineering Authors: Adams S, Wuescher LM, Worth R, Yildirim-Ayan E Tags: Ann Biomed Eng Source Type: research

Repetitive Head Impact Exposure in College Football Following an NCAA Rule Change to Eliminate Two-A-Day Preseason Practices: A Study from the NCAA-DoD CARE Consortium.
The objective of this study was to quantify head impact exposure during the preseason and regular season in Division I college football athletes to determine whether the 2017 NCAA ruling decreased head impact exposure. 342 unique athletes from five NCAA Division I Football Bowl Subdivision (FBS) programs were consented and enrolled. Head impacts were recorded using the Head Impact Telemetry (HIT) System during the entire fall preseasons and regular seasons in 2016 and 2017. Despite the elimination of two-a-day practices, the number of preseason contact days increased in 2017, with an increase in average hourly impact expos...
Source: Annals of Biomedical Engineering - August 6, 2019 Category: Biomedical Engineering Authors: Stemper BD, Shah AS, Harezlak J, Rowson S, Duma S, Mihalik JP, Riggen LD, Brooks A, Cameron KL, Giza CC, Houston MN, Jackson J, Posner MA, McGinty G, DiFiori J, Broglio SP, McAllister TW, McCrea M, And the CARE Consortium Investigators Tags: Ann Biomed Eng Source Type: research

Burst & High-Frequency Spinal Cord Stimulation Differentially Effect Spinal Neuronal Activity After Radiculopathy.
Burst & High-Frequency Spinal Cord Stimulation Differentially Effect Spinal Neuronal Activity After Radiculopathy. Ann Biomed Eng. 2019 Aug 05;: Authors: Kent AR, Weisshaar CL, Venkatesan L, Winkelstein BA Abstract Although burst and high-frequency (HF) spinal cord stimulation (SCS) relieve neuropathic pain, their effects on neuronal hyperexcitability have not been compared. Specifically, it is unknown how the recharge components of burst SCS-either actively balanced or allowed to passively return-and/or different frequencies of HF SCS compare in altering neuronal activity. Neuronal firing rates w...
Source: Annals of Biomedical Engineering - August 5, 2019 Category: Biomedical Engineering Authors: Kent AR, Weisshaar CL, Venkatesan L, Winkelstein BA Tags: Ann Biomed Eng Source Type: research

Advances in Human Induced Pluripotent Stem Cell-Derived Hepatocytes for Use in Toxicity Testing.
Abstract Induced pluripotent stem cells (iPSCs) can be differentiated into multiple cell types in the body while maintaining proliferative capabilities. The generation of hepatocyte-like cells (HLCs) from iPSCs has resulted in a new source for liver cells. Since healthy primary human hepatocytes and hepatic cells are difficult to obtain, HLCs are gaining attention. HLCs can be obtained from a continuous, stable source while maintaining their original donor genotype, which opens new avenues into patient-specific testing and therapeutics. Studies have utilized HLCs for toxicity testing to further understand their dr...
Source: Annals of Biomedical Engineering - August 1, 2019 Category: Biomedical Engineering Authors: Wills LR, Rajagopalan P Tags: Ann Biomed Eng Source Type: research

A Mechanical Brain Damage Framework Used to Model Abnormal Brain Tau Protein Accumulations of National Football League Players.
Abstract A mechanics-based brain damage framework is used to model the abnormal accumulation of hyperphosphorylated p-tau associated with chronic traumatic encephalopathy within the brains of deceased National Football League (NFL) players studied at Boston University and to provide a framework for understanding the damage mechanisms. p-tau damage is formulated as the multiplicative decomposition of three independently evolving damage internal state variables (ISVs): nucleation related to number density, growth related to the average area, and coalescence related to the nearest neighbor distance. The ISVs evolve u...
Source: Annals of Biomedical Engineering - August 1, 2019 Category: Biomedical Engineering Authors: Horstemeyer MF, Berthelson PR, Moore J, Persons AK, Dobbins A, Prabhu RK Tags: Ann Biomed Eng Source Type: research

Development of the STAR Evaluation System for Assessing Bicycle Helmet Protective Performance.
Abstract Cycling is a leading cause of mild traumatic brain injury in the US. While bicycle helmets help protect cyclists who crash, limited biomechanical data exist differentiating helmet protective capabilities. This paper describes the development of a bicycle helmet evaluation scheme based in real-world cyclist accidents and brain injury mechanisms. Thirty helmet models were subjected to oblique impacts at six helmet locations and two impact velocities. The summation of tests for the analysis of risk (STAR) equation, which condenses helmet performance from a range of tests into a single value, was used to summ...
Source: Annals of Biomedical Engineering - August 1, 2019 Category: Biomedical Engineering Authors: Bland ML, McNally C, Zuby DS, Mueller BC, Rowson S Tags: Ann Biomed Eng Source Type: research

Review of Robotic Needle Guide Systems for Percutaneous Intervention.
Abstract Numerous research groups in the past have designed and developed robotic needle guide systems that improve the targeting accuracy and precision by either providing a physical guidance for manual insertion or enabling a complete automated intervention. Here we review systems that have been reported in the last 11 years and limited to straight line needle interventions. Most systems fall under the category of image guided systems as they either use magnetic resonance image, computed tomography, ultrasound or a combination of these modalities for real time image feedback of the intervention pa...
Source: Annals of Biomedical Engineering - July 31, 2019 Category: Biomedical Engineering Authors: Kulkarni P, Sikander S, Biswas P, Frawley S, Song SE Tags: Ann Biomed Eng Source Type: research

Encapsulation of Mesenchymal Stem Cells in 3D Ovarian Cell Constructs Promotes Stable and Long-Term Hormone Secretion with Improved Physiological Outcomes in a Syngeneic Rat Model.
In this report, we examined if hormone secretion from cHT constructs is impacted by incorporation of bone marrow-derived mesenchymal stem cells (BMSC) since these cells contain regulatory factors such as aromatase necessary for estrogen production. Incorporation of BMSCs led to enhanced estrogen secretion in vitro. Moreover, cHT constructs with BMSCs achieved estrogen secretion levels significantly greater than constructs without BMSCs in ovariectomized rats from 70 to 90 days after implantation, while also regulating pituitary hormones. cHT constructs with BMSC ameliorated estrogen deficiency-induced uterine atrophy ...
Source: Annals of Biomedical Engineering - July 31, 2019 Category: Biomedical Engineering Authors: Sittadjody S, Enck KM, Wells A, Yoo JJ, Atala A, Saul JM, Opara EC Tags: Ann Biomed Eng Source Type: research

Evolution and Current Applications of Robot-Assisted Fracture Reduction: A Comprehensive Review.
Abstract Robots in orthopedic surgery have been developed rapidly for decades and bring significant benefits to the patients and healthcare providers. However, robotics in fracture reduction remains at the infant stage. As essential components of the current robotic system, external fixators were used in fracture reduction, including the unilateral and Ilizarov-like ring fixators. With emerging of the industrial robots and mechanical arms, their sterilized variants were developed as the serial robots, including the traction device and robotic arm, for fracture reduction. Besides, parallel robots (e.g., Gough-Stewa...
Source: Annals of Biomedical Engineering - July 29, 2019 Category: Biomedical Engineering Authors: Zhao JX, Li C, Ren H, Hao M, Zhang LC, Tang PF Tags: Ann Biomed Eng Source Type: research

Reproducibility and Radiation Effect of High-Resolution In Vivo Micro Computed Tomography Imaging of the Mouse Lumbar Vertebra and Long Bone.
Abstract A moderate radiation dose, in vivo µCT scanning protocol was developed and validated for long-term monitoring of multiple skeletal sites (femur, tibia, vertebra) in mice. A customized, 3D printed mouse holder was designed and utilized to minimize error associated with animal repositioning, resulting in good to excellent reproducibility in most cortical and trabecular bone microarchitecture and density parameters except for connectivity density. Repeated in vivo µCT scans of mice were performed at the right distal femur and the 4th lumbar vertebra every 3 weeks until euthanized at 9 w...
Source: Annals of Biomedical Engineering - July 29, 2019 Category: Biomedical Engineering Authors: Zhao H, Chang CC, Liu Y, Yang Y, Tseng WJ, de Bakker CM, Chung R, Ghosh P, Deng L, Liu XS Tags: Ann Biomed Eng Source Type: research

Acoustic Emissions as a Non-invasive Biomarker of the Structural Health of the Knee.
Abstract The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation. In this paper, we investigate that mechanism using an injury model in human lower-limb cadavers, and relate AEs to joint kinematics. Using our custom joint sound recording system, we recorded the AEs from nine cadaver legs in four stages: at baseline, after a sham surgery, after a meniscus ...
Source: Annals of Biomedical Engineering - July 26, 2019 Category: Biomedical Engineering Authors: Whittingslow DC, Jeong HK, Ganti VG, Kirkpatrick NJ, Kogler GF, Inan OT Tags: Ann Biomed Eng Source Type: research

Accounting for Variance in Concussion Tolerance Between Individuals: Comparing Head Accelerations Between Concussed and Physically Matched Control Subjects.
In this study, we identified control subjects for our concussed subjects who demonstrated traits we believed were correlated to factors thought to affect injury tolerance, including height, mass, age, race, and concussion history. A total of 502 college football players were instrumented with helmet-mounted accelerometer arrays and provided complete baseline assessment data, 44 of which sustained a total of 49 concussion. Biomechanical measures quantifying impact frequency and acceleration magnitude were compared between groups. On average, we found that concussed subjects experienced 93.8 more head impacts (p =&thi...
Source: Annals of Biomedical Engineering - July 24, 2019 Category: Biomedical Engineering Authors: Rowson S, Campolettano ET, Duma SM, Stemper B, Shah A, Harezlak J, Riggen L, Mihalik JP, Guskiewicz KM, Giza C, Brooks A, Cameron K, McAllister T, Broglio SP, McCrea M Tags: Ann Biomed Eng Source Type: research

A Concentric Tube Robot System for Rigid Bronchoscopy: A Feasibility Study on Central Airway Obstruction Removal.
In this study, we used an ex vivo ovine airway model to demonstrate the ability of a physician using the robotic system to efficiently remove tissue and restore the airway. Pre- and post-operative CT scans showed that the robot was able to reduce the degree of airway obstruction stenosis from 75 to 14% on average for five CAO resections performed in an ex vivo animal model. Using cadaver experiments, we demonstrated the potential of the robotic system to substantially reduce the intraoperative forces applied to the patient's head and neck (from 80.6 to 4.1 N). These preliminary results illustrate that CAO removal is feasib...
Source: Annals of Biomedical Engineering - July 24, 2019 Category: Biomedical Engineering Authors: Gafford JB, Webster S, Dillon N, Blum E, Hendrick R, Maldonado F, Gillaspie EA, Rickman OB, Herrell SD, Webster RJ Tags: Ann Biomed Eng Source Type: research

Impact Performance Comparison of Advanced Bicycle Helmets with Dedicated Rotation-Damping Systems.
In conclusion, results revealed significant differences in the effectiveness between rotation-damping systems, whereby some rotation-damping systems significantly reduced rotational head acceleration and associated TBI risk. PMID: 31342338 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - July 24, 2019 Category: Biomedical Engineering Authors: Bottlang M, Rouhier A, Tsai S, Gregoire J, Madey SM Tags: Ann Biomed Eng Source Type: research

The Role of Recovery Lower Limb Segments in Post-Slip Determination of Falls Due to Instability or Limb Collapse.
Abstract Slip-related falls can be induced by instability or limb collapse, but the key factors that determine these two fall causations remain unknown. The purpose of this study was to investigate the factors that contribute towards instability-induced and limb-collapse-induced slip-related falls by investigating 114 novel slip trials. The segment angles and moments of the recovery limb after slip-onset from pre-left-touchdown (pre-LTD) to post-left-touchdown (post-LTD) were calculated, and logistic regression was used to detect which variable contributed most to instability-induced and limb-collapse-induced fall...
Source: Annals of Biomedical Engineering - July 23, 2019 Category: Biomedical Engineering Authors: Wang S, Bhatt T, Liu X, Pai YC Tags: Ann Biomed Eng Source Type: research

Human Factors and User Experience Issues with Ventricular Assist Device Wearable Components: A Systematic Review.
Abstract Ventricular Assist Devices (VADs) provide continuous mechanical circulatory support during in- and out-of-hospital care. However, limitations of the external wearable components influence patient quality of life. There is insufficient understanding of the issues with such components that combines a holistic viewpoint from both human factors and user (including patient and caregiver) experience perspectives. This paper comprehensively details the issues with VAD wearable systems and proposes a way for human-centered design to bridge the gap, addressing such issues synergistically. Through the review t...
Source: Annals of Biomedical Engineering - July 23, 2019 Category: Biomedical Engineering Authors: Dunn JL, Nusem E, Straker K, Gregory S, Wrigley C Tags: Ann Biomed Eng Source Type: research

Cortical and Trabecular Bone Fracture Characterisation in the Vertebral Body Using Acoustic Emission.
In this study, high rate axial compression tests were performed on twenty sets of three-vertebra lumbar spine specimens. Acoustic Emission (AE) sensor measurements of sound wave pressure were used to classify isolated trabecular fractures and severe compressive fractures of vertebral body cortical and trabecular bone. Fracture detection using standard AE parameters was compared to that of traditional mechanical parameters obtained from load cell and displacement readings. Results indicated that the AE parameters achieved slightly enhanced classification of isolated trabecular fractures, whereas the mechanical parameters be...
Source: Annals of Biomedical Engineering - July 23, 2019 Category: Biomedical Engineering Authors: Robinson DL, Tse KM, Franklyn M, Zhang J, Ackland D, Lee PVS Tags: Ann Biomed Eng Source Type: research

Evaluation of a New Approach for Modeling Full Ring Stent Bundles with the Inclusion of Manufacturing Strains.
Abstract Ring stent bundles have been used in several biomedical stent-graft devices for decades, yet in the published literature, the numerical models of these structures always present significant simplifications. In this paper, a finite element (FE) ring stent bundle has been developed and evaluated with a combination of beam and surface elements. With this approach, the shape, the global stiffness and the strains of the structure can all be well predicted at a low computational cost while the approach is suitable for application to non-symmetrical, patient-specific implant simulations. The model has been valid...
Source: Annals of Biomedical Engineering - July 17, 2019 Category: Biomedical Engineering Authors: Kyriakou F, Bow D, Dempster W, Brodie R, Nash D Tags: Ann Biomed Eng Source Type: research

An Evaluation of the Influence of Coronary Flow on Transcatheter Heart Valve Neo-Sinus Flow Stasis.
Abstract Transcatheter heart valve (THV) leaflet thrombosis in the neo-sinus and associated reduced leaflet motion is of clinical concern due to risks of embolism and worsened valve hemodynamics. Flow stasis in the neo-sinus (the space between the native and THV leaflets) is a known risk factor, but the role of proximal coronary flow is yet to be investigated. We tested two replicas of FDA approved commercial THVs-intra-annular and supra-annular (similar to the SAPIEN 3 and CoreValve families)-in a left heart simulator with coronary flow. Velocity fields in the left coronary cusp (LCC) and non (NCC) neo-sinus were...
Source: Annals of Biomedical Engineering - July 16, 2019 Category: Biomedical Engineering Authors: Madukauwa-David ID, Sadri V, Midha PA, Babaliaros V, Aidun C, Yoganathan AP Tags: Ann Biomed Eng Source Type: research

The Influence of Shear Anisotropy in mTBI: A White Matter Constitutive Model.
Abstract We examine the influence of shear anisotropy of brain tissue on the potential for mild traumatic brain injury. First we develop a new constitutive description for the white matter in the brain that can capture the anisotropic behavior of the white matter in both tension and shear. The material parameters for the models are determined using a set of three experiments already published in the literature. The calibrated and parameterized model is then implemented in a computational (finite element) model of the head. This computational model is two-dimensional and is used to simulate a previously published i...
Source: Annals of Biomedical Engineering - July 15, 2019 Category: Biomedical Engineering Authors: Madouh FA, Ramesh KT Tags: Ann Biomed Eng Source Type: research

Evaluation of Local Tissue Reaction After the Application of a 3D Printed Novel Holdfast Device for Left Atrial Appendage Exclusion.
Abstract The left atrial appendage (LAA) is a small, finger-like extension of the left atrium and its exclusion is used as a treatment strategy to prevent ischemic stroke. Existing holdfast devices may damage the tissue, are unisized and not adjustable. A novel holdfast device for LAA exclusion devoid of these shortcomings was designed and 3D-printed using the Selective Laser Sintering (SLS) technology with polyamide powder and tested it on animal model. We selected the SLS 3D printing technology due to its wid14e availability and low production costs which could provide on-site 3D printing for specific patient. T...
Source: Annals of Biomedical Engineering - July 15, 2019 Category: Biomedical Engineering Authors: Brzeziński M, Sejda A, Pęksa R, Pawlak M, Bury K, Adamiak Z, Kowalik M, Jagielak D, Bartus K, Hołda MK, Litwinowicz R, Rogowski J Tags: Ann Biomed Eng Source Type: research

Material Mapping of QCT-Derived Scapular Models: A Comparison with Micro-CT Loaded Specimens Using Digital Volume Correlation.
This study utilized volumetric imaging combined with mechanical loading to derive full-field experimental measurements to evaluate various density-modulus relationships required for QCT-FEMs applied to whole-bone scapular loading. The results suggest that elemental and nodal material mapping strategies are both able to simultaneously replicate experimental full-field displacements and reactions forces dependent on the density-modulus relationship used. PMID: 31297723 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - July 11, 2019 Category: Biomedical Engineering Authors: Knowles NK, Kusins J, Faieghi M, Ryan M, Dall'Ara E, Ferreira LM Tags: Ann Biomed Eng Source Type: research

Development, Validation and Pilot Field Deployment of a Custom Mouthpiece for Head Impact Measurement.
The objective of this study was to develop a mouthpiece sensor with improved head kinematic measurement for use in non-helmeted and helmeted sports through laboratory validation and pilot field deployment in female youth soccer. For laboratory validation, data from the mouthpiece sensor was compared to standard sensors mounted in a headform at the center of gravity as the headform was struck with a swinging pendulum. Linear regression between peak kinematics measured from the mouthpiece and headform showed strong correlation, with r2 values of 0.95 (slope = 1.02) for linear acceleration, 1.00 (slope = 1.00) for angular vel...
Source: Annals of Biomedical Engineering - July 11, 2019 Category: Biomedical Engineering Authors: Rich AM, Filben TM, Miller LE, Tomblin BT, Van Gorkom AR, Hurst MA, Barnard RT, Kohn DS, Urban JE, Stitzel JD Tags: Ann Biomed Eng Source Type: research

EMG-Informed Musculoskeletal Modeling to Estimate Realistic Knee Anterior Shear Force During Drop Vertical Jump in Female Athletes.
The objective of this study was to develop electromyography-informed musculoskeletal simulations of the drop vertical jump motor task and assess the contribution of knee muscle forces to tibial anterior shear force. In this cross-sectional study, musculoskeletal simulations were used to estimate the muscle forces of thirteen female athletes performing a drop vertical jump using an electromyography-informed method. Muscle activation and knee loads that resulted from these simulations were compared to the results obtained with the more common approach of minimization of muscle effort (optimization-based method). Quadriceps-h...
Source: Annals of Biomedical Engineering - July 9, 2019 Category: Biomedical Engineering Authors: Navacchia A, Ueno R, Ford KR, DiCesare CA, Myer GD, Hewett TE Tags: Ann Biomed Eng Source Type: research

Contribution of Human Hair in Solar UV Transmission in Skin: Implications for Melanoma Development.
Abstract Melanoma is the deadliest type of skin cancer with its prevalence on the rise. Recently, the melanocyte stem cells in hair follicles have been identified as the possible origin of melanoma upon exposure to ultraviolet radiation (UVR) through skin. It is hypothesized that colourless vellus hair (predominant in childhood) can serve as an alternative pathway in transmitting these ultraviolet (UV) photons to the stem cells. To investigate this, we have used the CRAIC microspectrophotometer to investigate the optical properties of 'vellus-like' hairs and terminal hairs of different colours using UV-VIS-NIR lig...
Source: Annals of Biomedical Engineering - July 9, 2019 Category: Biomedical Engineering Authors: Huang X, Protheroe MD, Al-Jumaily AM, Paul SP, Chalmers AN, Wang S, Diwu J, Liu W Tags: Ann Biomed Eng Source Type: research

Magnetic Resonance Navigation for Targeted Embolization in a Two-Level Bifurcation Phantom.
Soulez G Abstract This work combines a particle injection system with our proposed magnetic resonance navigation (MRN) sequence with the intention of validating MRN in a two-bifurcation phantom for endovascular treatment of hepatocellular carcinoma (HCC). A theoretical physical model used to calculate the most appropriate size of the magnetic drug-eluting bead (MDEB, 200 μm) aggregates was proposed. The aggregates were injected into the phantom by a dedicated particle injector while a trigger signal was automatically sent to the MRI to start MRN which consists of interleaved tracking and steering sequence...
Source: Annals of Biomedical Engineering - July 9, 2019 Category: Biomedical Engineering Authors: Li N, Jiang Y, Plantefève R, Michaud F, Nosrati Z, Tremblay C, Saatchi K, Häfeli UO, Kadoury S, Moran G, Joly F, Martel S, Soulez G Tags: Ann Biomed Eng Source Type: research

In Vivo Measurement of Plantar Tissue Characteristics and Its Indication for Foot Modeling.
The objective of the present study is to combine in vivo experimental measurements and finite element modelling of the foot to investigate the influences of stiffness and thickness variation of individual plantar tissues especially the heel pad on deformation behaviours of the human foot. The stiffness and thickness variance of individuals were measured through supersonic shear wave elastography considering detailed heel pad layers refered to in literature as: dermis, stiffer micro-chamber layer, softer macro-chamber layer. A corresponding foot model with separated heel pad layers was established and used to a sensitivity ...
Source: Annals of Biomedical Engineering - July 1, 2019 Category: Biomedical Engineering Authors: Mo F, Li J, Yang Z, Zhou S, Behr M Tags: Ann Biomed Eng Source Type: research

Analysis of Inlet Velocity Profiles in Numerical Assessment of Fontan Hemodynamics.
This study implements real, patient-specific velocity profiles for numerical assessment of Fontan hemodynamics using CFD simulations. Four additional, artificial velocity profiles were used for comparison: (1) flat, (2) parabolic, (3) Womersley, and (4) parabolic with inlet extensions [to develop flow before entering the total cavopulmonary connection (TCPC)]. The differences arising from the five velocity profiles, as well as discrepancies between the real and each of the artificial velocity profiles, were quantified by examining clinically important metrics in TCPC hemodynamics: power loss (PL), viscous dissipation rate ...
Source: Annals of Biomedical Engineering - June 24, 2019 Category: Biomedical Engineering Authors: Wei ZA, Huddleston C, Trusty PM, Singh-Gryzbon S, Fogel MA, Veneziani A, Yoganathan AP Tags: Ann Biomed Eng Source Type: research

Technical Note on the Reliability of the PowerLift App for Velocity-Based Resistance Training Purposes: Response.
;lez-Badillo JJ, Pallarés JG PMID: 31240509 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - June 24, 2019 Category: Biomedical Engineering Authors: Courel-Ibáñez J, Martínez-Cava A, Hernández-Belmonte A, González-Badillo JJ, Pallarés JG Tags: Ann Biomed Eng Source Type: research

Factors Affecting Head Impact Exposure in College Football Practices: A Multi-Institutional Study.
This study sought to specifically quantify the factors that contribute towards player head impact exposure in college football practices. All players included in this study were outfitted with football helmets instrumented with accelerometer arrays (Head Impact Telemetry System). Head impact exposure was defined by the number of head impacts each player experienced in practice, the number of practice head impacts normalized by the number of practice sessions (practice head impact rate), and the 95th percentile linear and rotational resultant head impact accelerations. Practice head impact rate was observed to vary signific...
Source: Annals of Biomedical Engineering - June 19, 2019 Category: Biomedical Engineering Authors: Campolettano ET, Rowson S, Duma SM, Stemper B, Shah A, Harezlak J, Riggen LD, Mihalik J, Brooks A, Cameron K, Giza CC, McAllister T, Broglio SP, McCrea M Tags: Ann Biomed Eng Source Type: research

Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization.
Abstract In recent years, biomaterial- and scaffold-based immunomodulation strategies were implemented in tissue regeneration efforts for manipulating macrophage polarization (a.k.a. phenotype or lineage commitment, or differentiation). Yet, most of our understanding of macrophage phenotype commitment and phagocytic capacity is limited to how physical cues (extracellular matrix stiffness, roughness, and topography) and soluble chemical cues (cytokines and chemokines released from the scaffold) influence macrophage polarization. In the context of immune response-tissue interaction, the mechanical cues experienced b...
Source: Annals of Biomedical Engineering - June 19, 2019 Category: Biomedical Engineering Authors: Adams S, Wuescher LM, Worth R, Yildirim-Ayan E Tags: Ann Biomed Eng Source Type: research

Experimental and Computational Investigation of the IDDSI Flow Test of Liquids Used in Dysphagia Management.
This study assesses how the IDDSI test relates to rheology and clinical knowledge of physiological flows during swallowing. With no pre-existing analytical solution for internal flow through the syringe, a computational model was designed, incorporating rheometry data from a variety of Newtonian and non-Newtonian liquids. The computational model was validated experimentally across the range of liquids but the technique showed limitations in simulating dripping and cohesiveness. Gum-based liquids which were strongly shear-thinning (0.12
Source: Annals of Biomedical Engineering - June 19, 2019 Category: Biomedical Engineering Authors: Hanson B, Jamshidi R, Redfearn A, Begley R, Steele CM Tags: Ann Biomed Eng Source Type: research