Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction
Ann Biomed Eng. 2024 Feb 26. doi: 10.1007/s10439-024-03463-7. Online ahead of print.ABSTRACTAn in silico study is performed to investigate fluid dynamic effects of central venous catheter (CVC) placement within patient-specific cavo-atrial junctions. Prior studies show the CVC infusing a liquid, but this study focuses on the placement without any liquid emerging from the CVC. A 7 or 15-French double-lumen CVC is placed virtually in two patient-specific models; the CVC tip location is altered to understand its effect on the venous flow field. Results show that the CVC impact is trivial on flow in the superior vena cava when...
Source: Annals of Biomedical Engineering - February 26, 2024 Category: Biomedical Engineering Authors: Boyang Su Hannah Palahnuk Thaddeus Harbaugh Elias Rizk Will Hazard Angel Chan Jonathan Bernstein Jonathan W Weinsaft Keefe B Manning Source Type: research
Choosing Optimal Cutoff Frequencies for Filtering Linear Acceleration and Angular Velocity Signals Associated with Head Impacts Measured by Instrumented Mouthguards
This study sought optimal filter cutoff frequencies for six-degree-of-freedom measurements made at the teeth using instrumented mouthguards. We collected linear acceleration and angular velocity signals at the head center of gravity (CG) using laboratory-grade instrumentation. We also collected and filtered similar six-degree-of-freedom measurements from an instrumented mouthguard using 24 cutoff frequencies, from 25 to 600 Hz. We transformed the measurements to linear acceleration at the center of gravity of the head (CG) using all kinematic variables at the teeth, optimizing linear and angular mouthguard cutoff frequenci...
Source: Annals of Biomedical Engineering - February 25, 2024 Category: Biomedical Engineering Authors: Ryan Gellner Mark Begonia Steve Rowson Source Type: research
Mild Traumatic Brain Injury and Career Stage Associate with Visible Perivascular Spaces in Special Operations Forces Soldiers
Ann Biomed Eng. 2024 Feb 23. doi: 10.1007/s10439-024-03468-2. Online ahead of print.ABSTRACTMild traumatic brain injury (mTBI) and occupational blast exposure in military Service Members may lead to impaired brain waste clearance which increases neurological disease risk. Perivascular spaces (PVS) are a key part of the glymphatic system which supports brain waste clearance, preferentially during sleep. Visible PVS on clinical magnetic resonance imaging have been previously observed in patients with neurodegenerative diseases and animal neurotrauma models. The purpose of this study was to determine associations between PVS ...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Jacob R Powell Xiaopeng Zong Joshua M Weinstein Stephen M DeLellis Shawn F Kane Gary E Means Jason P Mihalik Source Type: research
Deep Learning for Perfusion Cerebral Blood Flow (CBF) and Volume (CBV) Predictions and Diagnostics
Ann Biomed Eng. 2024 Feb 24. doi: 10.1007/s10439-024-03471-7. Online ahead of print.ABSTRACTDynamic susceptibility contrast magnetic resonance perfusion (DSC-MRP) is a non-invasive imaging technique for hemodynamic measurements. Various perfusion parameters, such as cerebral blood volume (CBV) and cerebral blood flow (CBF), can be derived from DSC-MRP, hence this non-invasive imaging protocol is widely used clinically for the diagnosis and assessment of intracranial pathologies. Currently, most institutions use commercially available software to compute the perfusion parametric maps. However, these conventional methods oft...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Salmonn Talebi Siyu Gai Aaron Sossin Vivian Zhu Elizabeth Tong Mohammad R K Mofrad Source Type: research
Modification of Woven Endo-Bridge After Intracranial Aneurysm Treatment: A Methodology for Three-Dimensional Analysis of Shape and Relative Position Changes
We present a methodology to quantify the morphology and position of the WEB device in relation to the vascular anatomy. Three-dimensional rotational angiography (3DRA) images of seven aneurysms patients treated with WEBs were used, which also accompanied by a post-treatment 3DRA image and a follow-up 3DRA image. The device was manually segmented, obtaining the 3D models after treatment and at the follow-up. Volume, surface area, height, maximum diameter and WSM ratio of both surfaces were calculated. Position changes were evaluated measuring WEB axis and relative position between post-treatment and follow-up. Changes in WE...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Romina Mu ñoz Nicol ás Dazeo Santiago Estevez-Areco Kevin Janot Ana Paula Narata Aymeric Rouchaud Ignacio Larrabide Source Type: research
An EM-Tracked Approach for Calibrating the 3D Pose of Flexible Endoscopes
Ann Biomed Eng. 2024 Feb 24. doi: 10.1007/s10439-024-03469-1. Online ahead of print.ABSTRACTFlexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to simplify the calibration process, we propose an electromagnetic (EM)-tracked calibration approach that does not require any predefined poses of the EM sensor. A three-stage calibration protocol was presented in an extensor. First, the orientation of the endoscope tube was derived by con...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Zhongjie Long Yongting Chi Xianbo Zhang Hongbing Li Dejin Yang Diangeng Li Zhouxiang Jiang Source Type: research
Mild Traumatic Brain Injury and Career Stage Associate with Visible Perivascular Spaces in Special Operations Forces Soldiers
Ann Biomed Eng. 2024 Feb 23. doi: 10.1007/s10439-024-03468-2. Online ahead of print.ABSTRACTMild traumatic brain injury (mTBI) and occupational blast exposure in military Service Members may lead to impaired brain waste clearance which increases neurological disease risk. Perivascular spaces (PVS) are a key part of the glymphatic system which supports brain waste clearance, preferentially during sleep. Visible PVS on clinical magnetic resonance imaging have been previously observed in patients with neurodegenerative diseases and animal neurotrauma models. The purpose of this study was to determine associations between PVS ...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Jacob R Powell Xiaopeng Zong Joshua M Weinstein Stephen M DeLellis Shawn F Kane Gary E Means Jason P Mihalik Source Type: research
Deep Learning for Perfusion Cerebral Blood Flow (CBF) and Volume (CBV) Predictions and Diagnostics
Ann Biomed Eng. 2024 Feb 24. doi: 10.1007/s10439-024-03471-7. Online ahead of print.ABSTRACTDynamic susceptibility contrast magnetic resonance perfusion (DSC-MRP) is a non-invasive imaging technique for hemodynamic measurements. Various perfusion parameters, such as cerebral blood volume (CBV) and cerebral blood flow (CBF), can be derived from DSC-MRP, hence this non-invasive imaging protocol is widely used clinically for the diagnosis and assessment of intracranial pathologies. Currently, most institutions use commercially available software to compute the perfusion parametric maps. However, these conventional methods oft...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Salmonn Talebi Siyu Gai Aaron Sossin Vivian Zhu Elizabeth Tong Mohammad R K Mofrad Source Type: research
Modification of Woven Endo-Bridge After Intracranial Aneurysm Treatment: A Methodology for Three-Dimensional Analysis of Shape and Relative Position Changes
We present a methodology to quantify the morphology and position of the WEB device in relation to the vascular anatomy. Three-dimensional rotational angiography (3DRA) images of seven aneurysms patients treated with WEBs were used, which also accompanied by a post-treatment 3DRA image and a follow-up 3DRA image. The device was manually segmented, obtaining the 3D models after treatment and at the follow-up. Volume, surface area, height, maximum diameter and WSM ratio of both surfaces were calculated. Position changes were evaluated measuring WEB axis and relative position between post-treatment and follow-up. Changes in WE...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Romina Mu ñoz Nicol ás Dazeo Santiago Estevez-Areco Kevin Janot Ana Paula Narata Aymeric Rouchaud Ignacio Larrabide Source Type: research
An EM-Tracked Approach for Calibrating the 3D Pose of Flexible Endoscopes
Ann Biomed Eng. 2024 Feb 24. doi: 10.1007/s10439-024-03469-1. Online ahead of print.ABSTRACTFlexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to simplify the calibration process, we propose an electromagnetic (EM)-tracked calibration approach that does not require any predefined poses of the EM sensor. A three-stage calibration protocol was presented in an extensor. First, the orientation of the endoscope tube was derived by con...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Zhongjie Long Yongting Chi Xianbo Zhang Hongbing Li Dejin Yang Diangeng Li Zhouxiang Jiang Source Type: research
A Review of Machine Learning Algorithms for Biomedical Applications
Ann Biomed Eng. 2024 Feb 21. doi: 10.1007/s10439-024-03459-3. Online ahead of print.ABSTRACTAs the amount and complexity of biomedical data continue to increase, machine learning methods are becoming a popular tool in creating prediction models for the underlying biomedical processes. Although all machine learning methods aim to fit models to data, the methodologies used can vary greatly and may seem daunting at first. A comprehensive review of various machine learning algorithms per biomedical applications is presented. The key concepts of machine learning are supervised and unsupervised learning, feature selection, and e...
Source: Annals of Biomedical Engineering - February 22, 2024 Category: Biomedical Engineering Authors: V A Binson Sania Thomas M Subramoniam J Arun S Naveen S Madhu Source Type: research
Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia
Ann Biomed Eng. 2024 Feb 21. doi: 10.1007/s10439-024-03440-0. Online ahead of print.ABSTRACTSystemic hypertension is a strong risk factor for cardiovascular, neurovascular, and renovascular diseases. Central artery stiffness is both an initiator and indicator of hypertension, thus revealing a critical relationship between the wall mechanics and hemodynamics. Mice have emerged as a critical animal model for studying effects of hypertension and much has been learned. Regardless of the specific mouse model, data on changes in cardiac function and hemodynamics are necessarily measured under anesthesia. Here, we present a new e...
Source: Annals of Biomedical Engineering - February 22, 2024 Category: Biomedical Engineering Authors: S E Hopper D Weiss N Mikush B Jiang B Spronck C Cavinato J D Humphrey C A Figueroa Source Type: research
A Review of Machine Learning Algorithms for Biomedical Applications
Ann Biomed Eng. 2024 Feb 21. doi: 10.1007/s10439-024-03459-3. Online ahead of print.ABSTRACTAs the amount and complexity of biomedical data continue to increase, machine learning methods are becoming a popular tool in creating prediction models for the underlying biomedical processes. Although all machine learning methods aim to fit models to data, the methodologies used can vary greatly and may seem daunting at first. A comprehensive review of various machine learning algorithms per biomedical applications is presented. The key concepts of machine learning are supervised and unsupervised learning, feature selection, and e...
Source: Annals of Biomedical Engineering - February 22, 2024 Category: Biomedical Engineering Authors: V A Binson Sania Thomas M Subramoniam J Arun S Naveen S Madhu Source Type: research
Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia
Ann Biomed Eng. 2024 Feb 21. doi: 10.1007/s10439-024-03440-0. Online ahead of print.ABSTRACTSystemic hypertension is a strong risk factor for cardiovascular, neurovascular, and renovascular diseases. Central artery stiffness is both an initiator and indicator of hypertension, thus revealing a critical relationship between the wall mechanics and hemodynamics. Mice have emerged as a critical animal model for studying effects of hypertension and much has been learned. Regardless of the specific mouse model, data on changes in cardiac function and hemodynamics are necessarily measured under anesthesia. Here, we present a new e...
Source: Annals of Biomedical Engineering - February 22, 2024 Category: Biomedical Engineering Authors: S E Hopper D Weiss N Mikush B Jiang B Spronck C Cavinato J D Humphrey C A Figueroa Source Type: research
Biomechanical Remodeling of Aortic Valve Interstitial Cells During Calcified Lesion Formation In Vitro
Ann Biomed Eng. 2024 Feb 19. doi: 10.1007/s10439-024-03451-x. Online ahead of print.ABSTRACTHealthy aortic heart valves are essential to the regulation of unidirectional blood flow. Calcific aortic valve disease (CAVD) is an actively progressive disease that involves the disorganization of valve cells and accumulation of calcium deposits on the aortic valve leaflets. CAVD involves disruption of cell environment homeostasis that prior cell culture models have found difficult to portray and model. As it is still poorly understood how tissue stiffening associates with lesion formation, here, we implement a novel 3D culture pl...
Source: Annals of Biomedical Engineering - February 20, 2024 Category: Biomedical Engineering Authors: Justine Yushiuan Shih Terence Gee Gaetano Scuderi Jonathan Butcher Source Type: research
