A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
This study poses the basis for investigating how time-dependent changes in the vasculature affect the haemodynamics across the whole CoW in patients with stable and growing aneurysms.PMID:38616236 | DOI:10.1007/s10439-024-03493-1 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 14, 2024 Category: Biomedical Engineering Authors: Alberto Coccarelli Raoul Van Loon Aichi Chien Source Type: research
A Computational Pipeline to Investigate Longitudinal Blood Flow Changes in the Circle of Willis of Patients with Stable and Growing Aneurysms
This study poses the basis for investigating how time-dependent changes in the vasculature affect the haemodynamics across the whole CoW in patients with stable and growing aneurysms.PMID:38616236 | DOI:10.1007/s10439-024-03493-1 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 14, 2024 Category: Biomedical Engineering Authors: Alberto Coccarelli Raoul Van Loon Aichi Chien Source Type: research
Cryoablation with KCl Solution Enhances Necrosis and Apoptosis of HepG2 Liver Cancer Cells
In conclusion, the results of this study demonstrate the effectiveness of KCl solution in promoting cryoablation and describe a novel therapeutic model for the treatment of liver cancer that may distinguish between cancer and normal cells.PMID:38615077 | DOI:10.1007/s10439-024-03512-1 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 13, 2024 Category: Biomedical Engineering Authors: Mu Chen Wei Liu Baolin Liu Source Type: research
In Vitro Comparison of a Closed and Semi-closed Leaflet Design for Adult and Pediatric Transcatheter Heart Valves
Ann Biomed Eng. 2024 Apr 13. doi: 10.1007/s10439-024-03502-3. Online ahead of print.ABSTRACTTranscatheter heart valve replacements (TVR) are mostly designed in a closed position (c) with leaflets coaptating. However, recent literature suggests fabricating valves in semi-closed (sc) position to minimize pinwheeling. With about 100,000 children in need of a new pulmonary valve each year worldwide, this study evaluates both geometrical approaches in adult as well as pediatric size and condition. Three valves of each geometry were fabricated in adult (30 mm) and pediatric (15 mm) size, using porcine pericardium. To evaluate pe...
Source: Annals of Biomedical Engineering - April 13, 2024 Category: Biomedical Engineering Authors: Alexander Breitenstein-Attach Marvin Steitz Xiaolin Sun Yimeng Hao Jonathan Kiekenap Jasper Emeis Sugat Ratna Tuladhar Felix Berger Boris Schmitt Source Type: research
Ethical Considerations of Neuralink and Brain-Computer Interfaces: Balancing Innovation and Responsibility
Ann Biomed Eng. 2024 Apr 11. doi: 10.1007/s10439-024-03511-2. Online ahead of print.ABSTRACTNeuralink is a neurotechnology company founded by Elon Musk in 2016, which has been quietly developing revolutionary technology allowing for ultra-high precision bidirectional communication between external devices and the brain. In this paper, we explore the multifaceted ethical considerations surrounding neural interfaces, analyzing potential societal impacts, risks, and call for a need for responsible innovation. Despite the technological, medical, medicolegal, and ethical challenges ahead, neural interface technology remains ext...
Source: Annals of Biomedical Engineering - April 11, 2024 Category: Biomedical Engineering Authors: Ethan Waisberg Joshua Ong Andrew G Lee Source Type: research
Ethical Considerations of Neuralink and Brain-Computer Interfaces: Balancing Innovation and Responsibility
Ann Biomed Eng. 2024 Apr 11. doi: 10.1007/s10439-024-03511-2. Online ahead of print.ABSTRACTNeuralink is a neurotechnology company founded by Elon Musk in 2016, which has been quietly developing revolutionary technology allowing for ultra-high precision bidirectional communication between external devices and the brain. In this paper, we explore the multifaceted ethical considerations surrounding neural interfaces, analyzing potential societal impacts, risks, and call for a need for responsible innovation. Despite the technological, medical, medicolegal, and ethical challenges ahead, neural interface technology remains ext...
Source: Annals of Biomedical Engineering - April 11, 2024 Category: Biomedical Engineering Authors: Ethan Waisberg Joshua Ong Andrew G Lee Source Type: research
Ethical Considerations of Neuralink and Brain-Computer Interfaces: Balancing Innovation and Responsibility
Ann Biomed Eng. 2024 Apr 11. doi: 10.1007/s10439-024-03511-2. Online ahead of print.ABSTRACTNeuralink is a neurotechnology company founded by Elon Musk in 2016, which has been quietly developing revolutionary technology allowing for ultra-high precision bidirectional communication between external devices and the brain. In this paper, we explore the multifaceted ethical considerations surrounding neural interfaces, analyzing potential societal impacts, risks, and call for a need for responsible innovation. Despite the technological, medical, medicolegal, and ethical challenges ahead, neural interface technology remains ext...
Source: Annals of Biomedical Engineering - April 11, 2024 Category: Biomedical Engineering Authors: Ethan Waisberg Joshua Ong Andrew G Lee Source Type: research
Computational Investigation of Vessel Injury Due to Catheter Tracking During Transcatheter Aortic Valve Replacement
In this study, we investigate the role that catheter design and aorta and plaque mechanical properties have on the risk of plaque rupture during TAVR catheter delivery. We report that, for trackability testing, a rigid test model provides a reasonable estimation of the peak reaction forces experienced during catheter tracking within compliant vessels. We investigated the risk of rupture of both the aortic tissue and calcified plaques. We report that there was no risk of diseased aortic tissue rupture based on an accepted aortic tissue stress threshold (4.2 MPa). However, we report that both the aortic and plaque tissue exc...
Source: Annals of Biomedical Engineering - April 8, 2024 Category: Biomedical Engineering Authors: David G Symes Laoise M McNamara Claire Conway Source Type: research
Computational Investigation of Vessel Injury Due to Catheter Tracking During Transcatheter Aortic Valve Replacement
In this study, we investigate the role that catheter design and aorta and plaque mechanical properties have on the risk of plaque rupture during TAVR catheter delivery. We report that, for trackability testing, a rigid test model provides a reasonable estimation of the peak reaction forces experienced during catheter tracking within compliant vessels. We investigated the risk of rupture of both the aortic tissue and calcified plaques. We report that there was no risk of diseased aortic tissue rupture based on an accepted aortic tissue stress threshold (4.2 MPa). However, we report that both the aortic and plaque tissue exc...
Source: Annals of Biomedical Engineering - April 8, 2024 Category: Biomedical Engineering Authors: David G Symes Laoise M McNamara Claire Conway Source Type: research
Computational Investigation of Vessel Injury Due to Catheter Tracking During Transcatheter Aortic Valve Replacement
In this study, we investigate the role that catheter design and aorta and plaque mechanical properties have on the risk of plaque rupture during TAVR catheter delivery. We report that, for trackability testing, a rigid test model provides a reasonable estimation of the peak reaction forces experienced during catheter tracking within compliant vessels. We investigated the risk of rupture of both the aortic tissue and calcified plaques. We report that there was no risk of diseased aortic tissue rupture based on an accepted aortic tissue stress threshold (4.2 MPa). However, we report that both the aortic and plaque tissue exc...
Source: Annals of Biomedical Engineering - April 8, 2024 Category: Biomedical Engineering Authors: David G Symes Laoise M McNamara Claire Conway Source Type: research
Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease
In conclusion, the simulations suggest that time-averaged total stress along the fiber direction and time-averaged intracellular myofiber passive stress can be used to drive concentric and eccentric growth in simulations of valve disease.PMID:38564074 | DOI:10.1007/s10439-024-03497-x (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 2, 2024 Category: Biomedical Engineering Authors: Hossein Sharifi Mohammad Mehri Charles K Mann Kenneth S Campbell Lik Chuan Lee Jonathan F Wenk Source Type: research
Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease
In conclusion, the simulations suggest that time-averaged total stress along the fiber direction and time-averaged intracellular myofiber passive stress can be used to drive concentric and eccentric growth in simulations of valve disease.PMID:38564074 | DOI:10.1007/s10439-024-03497-x (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 2, 2024 Category: Biomedical Engineering Authors: Hossein Sharifi Mohammad Mehri Charles K Mann Kenneth S Campbell Lik Chuan Lee Jonathan F Wenk Source Type: research
Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease
In conclusion, the simulations suggest that time-averaged total stress along the fiber direction and time-averaged intracellular myofiber passive stress can be used to drive concentric and eccentric growth in simulations of valve disease.PMID:38564074 | DOI:10.1007/s10439-024-03497-x (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 2, 2024 Category: Biomedical Engineering Authors: Hossein Sharifi Mohammad Mehri Charles K Mann Kenneth S Campbell Lik Chuan Lee Jonathan F Wenk Source Type: research
Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease
In conclusion, the simulations suggest that time-averaged total stress along the fiber direction and time-averaged intracellular myofiber passive stress can be used to drive concentric and eccentric growth in simulations of valve disease.PMID:38564074 | DOI:10.1007/s10439-024-03497-x (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 2, 2024 Category: Biomedical Engineering Authors: Hossein Sharifi Mohammad Mehri Charles K Mann Kenneth S Campbell Lik Chuan Lee Jonathan F Wenk Source Type: research
Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease
In conclusion, the simulations suggest that time-averaged total stress along the fiber direction and time-averaged intracellular myofiber passive stress can be used to drive concentric and eccentric growth in simulations of valve disease.PMID:38564074 | DOI:10.1007/s10439-024-03497-x (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 2, 2024 Category: Biomedical Engineering Authors: Hossein Sharifi Mohammad Mehri Charles K Mann Kenneth S Campbell Lik Chuan Lee Jonathan F Wenk Source Type: research
