Optical Elastography for Micropressure Characterization of Zebrafish Embryonic Cardiac Development
Ann Biomed Eng. 2023 Nov 30. doi: 10.1007/s10439-023-03413-9. Online ahead of print.ABSTRACTThe proper formation of the vertebrate embryonic heart relies on various mechanical forces which determine its form and function. Measuring these forces at the microscale of the embryo is a challenge. We propose a new tool utilizing high-resolution optical elastography and stiffness measurements of surrounding tissues to non-invasively track the changes in the pressure exerted by the heart on the neighboring yolk, as well as changes in contractile patterns during early cardiac growth in-vivo, using the zebrafish embryo as a model sy...
Source: Annals of Biomedical Engineering - November 30, 2023 Category: Biomedical Engineering Authors: Anand G Vaish Yuji Tomizawa David F Daggett Kazunori Hoshino Source Type: research
Optical Elastography for Micropressure Characterization of Zebrafish Embryonic Cardiac Development
Ann Biomed Eng. 2023 Nov 30. doi: 10.1007/s10439-023-03413-9. Online ahead of print.ABSTRACTThe proper formation of the vertebrate embryonic heart relies on various mechanical forces which determine its form and function. Measuring these forces at the microscale of the embryo is a challenge. We propose a new tool utilizing high-resolution optical elastography and stiffness measurements of surrounding tissues to non-invasively track the changes in the pressure exerted by the heart on the neighboring yolk, as well as changes in contractile patterns during early cardiac growth in-vivo, using the zebrafish embryo as a model sy...
Source: Annals of Biomedical Engineering - November 30, 2023 Category: Biomedical Engineering Authors: Anand G Vaish Yuji Tomizawa David F Daggett Kazunori Hoshino Source Type: research
Optical Elastography for Micropressure Characterization of Zebrafish Embryonic Cardiac Development
Ann Biomed Eng. 2023 Nov 30. doi: 10.1007/s10439-023-03413-9. Online ahead of print.ABSTRACTThe proper formation of the vertebrate embryonic heart relies on various mechanical forces which determine its form and function. Measuring these forces at the microscale of the embryo is a challenge. We propose a new tool utilizing high-resolution optical elastography and stiffness measurements of surrounding tissues to non-invasively track the changes in the pressure exerted by the heart on the neighboring yolk, as well as changes in contractile patterns during early cardiac growth in-vivo, using the zebrafish embryo as a model sy...
Source: Annals of Biomedical Engineering - November 30, 2023 Category: Biomedical Engineering Authors: Anand G Vaish Yuji Tomizawa David F Daggett Kazunori Hoshino Source Type: research
Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses
This study introduces a new method of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TM...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Zaid S Salameh Kenneth N Aycock Nastaran Alinezhadbalalami Khan Mohammad Imran Iain H McKillop Irving C Allen Rafael V Davalos Source Type: research
Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves
In this study, our key contributions include: (i) a first-of-its-kind demonstration of the BO method used for the AHV iFEA; and (ii) the evaluation of a candidate AHV in-silico modeling approach wherein the chordae could be substituted with equivalent displacement boundary conditions, rendering the better iFEA convergence and a smoother objective surface.PMID:37989903 | DOI:10.1007/s10439-023-03408-6 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Colton J Ross Devin W Laurence Ankush Aggarwal Ming-Chen Hsu Arshid Mir Harold M Burkhart Chung-Hao Lee Source Type: research
A Nonlinear Functional Link Multilayer Perceptron Using Volterra Series as an Adaptive Noise Canceler for the Extraction of Fetal Electrocardiogram
Ann Biomed Eng. 2023 Nov 21. doi: 10.1007/s10439-023-03409-5. Online ahead of print.ABSTRACTUninterrupted monitoring of fetal cardiac health is essential for the timely diagnosis of congenital diseases. The maternal Electrocardiogram (mECG), which has the most significant impact, always tampers with the signals collected from the pregnant woman's abdomen. So, an efficient nonlinear filtering network based on artificial neural network (ANN) is required to eliminate the maternal part from the abdominal Electrocardiogram (aECG) that is traveled from the thoracic of the mother to the abdomen following nonlinear dynamics. In th...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Bipin Samuel Malaya Kumar Hota Source Type: research
Region-Dependent Mechanical Properties of Human Brain Tissue Under Large Deformations Using Inverse Finite Element Modeling
This study aims to facilitate intracranial simulation of traumatic events by determining the mechanical properties of different anatomical structures of the brain. Our experimental indentation paradigm used fresh, post-operative human tissue, which is highly advantageous in determining mechanical properties without being affected by postmortem time. This study employed an inverse finite element approach coupled with experimental indentation data to characterize mechanical properties of the human hippocampus (CA1, CA3, dentate gyrus), cortex white matter, and cortex grey matter. We determined that an uncoupled viscoelastic ...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Andrew V Basilio Delin Zeng Leanne A Pichay Steve A Maas Sowmya N Sundaresh John D Finan Benjamin S Elkin Guy M McKhann Gerard A Ateshian Barclay Morrison Source Type: research
Effect of Membrane Permeance and System Parameters on the Removal of Protein-Bound Uremic Toxins in Hemodialysis
Ann Biomed Eng. 2023 Nov 22. doi: 10.1007/s10439-023-03397-6. Online ahead of print.ABSTRACTInadequate clearance of protein-bound uremic toxins (PBUTs) during dialysis is associated with morbidities in chronic kidney disease patients. The development of high-permeance membranes made from materials such as graphene raises the question whether they could enable the design of dialyzers with improved PBUT clearance. Here, we develop device-level and multi-compartment (body) system-level models that account for PBUT-albumin binding (specifically indoxyl sulfate and p-cresyl sulfate) and diffusive and convective transport of tox...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Chun Man Chow Aaron H Persad Rohit Karnik Source Type: research
Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses
This study introduces a new method of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TM...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Zaid S Salameh Kenneth N Aycock Nastaran Alinezhadbalalami Khan Mohammad Imran Iain H McKillop Irving C Allen Rafael V Davalos Source Type: research
Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves
In this study, our key contributions include: (i) a first-of-its-kind demonstration of the BO method used for the AHV iFEA; and (ii) the evaluation of a candidate AHV in-silico modeling approach wherein the chordae could be substituted with equivalent displacement boundary conditions, rendering the better iFEA convergence and a smoother objective surface.PMID:37989903 | DOI:10.1007/s10439-023-03408-6 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Colton J Ross Devin W Laurence Ankush Aggarwal Ming-Chen Hsu Arshid Mir Harold M Burkhart Chung-Hao Lee Source Type: research
A Nonlinear Functional Link Multilayer Perceptron Using Volterra Series as an Adaptive Noise Canceler for the Extraction of Fetal Electrocardiogram
Ann Biomed Eng. 2023 Nov 21. doi: 10.1007/s10439-023-03409-5. Online ahead of print.ABSTRACTUninterrupted monitoring of fetal cardiac health is essential for the timely diagnosis of congenital diseases. The maternal Electrocardiogram (mECG), which has the most significant impact, always tampers with the signals collected from the pregnant woman's abdomen. So, an efficient nonlinear filtering network based on artificial neural network (ANN) is required to eliminate the maternal part from the abdominal Electrocardiogram (aECG) that is traveled from the thoracic of the mother to the abdomen following nonlinear dynamics. In th...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Bipin Samuel Malaya Kumar Hota Source Type: research
Region-Dependent Mechanical Properties of Human Brain Tissue Under Large Deformations Using Inverse Finite Element Modeling
This study aims to facilitate intracranial simulation of traumatic events by determining the mechanical properties of different anatomical structures of the brain. Our experimental indentation paradigm used fresh, post-operative human tissue, which is highly advantageous in determining mechanical properties without being affected by postmortem time. This study employed an inverse finite element approach coupled with experimental indentation data to characterize mechanical properties of the human hippocampus (CA1, CA3, dentate gyrus), cortex white matter, and cortex grey matter. We determined that an uncoupled viscoelastic ...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Andrew V Basilio Delin Zeng Leanne A Pichay Steve A Maas Sowmya N Sundaresh John D Finan Benjamin S Elkin Guy M McKhann Gerard A Ateshian Barclay Morrison Source Type: research
Effect of Membrane Permeance and System Parameters on the Removal of Protein-Bound Uremic Toxins in Hemodialysis
Ann Biomed Eng. 2023 Nov 22. doi: 10.1007/s10439-023-03397-6. Online ahead of print.ABSTRACTInadequate clearance of protein-bound uremic toxins (PBUTs) during dialysis is associated with morbidities in chronic kidney disease patients. The development of high-permeance membranes made from materials such as graphene raises the question whether they could enable the design of dialyzers with improved PBUT clearance. Here, we develop device-level and multi-compartment (body) system-level models that account for PBUT-albumin binding (specifically indoxyl sulfate and p-cresyl sulfate) and diffusive and convective transport of tox...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Chun Man Chow Aaron H Persad Rohit Karnik Source Type: research
Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses
This study introduces a new method of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TM...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Zaid S Salameh Kenneth N Aycock Nastaran Alinezhadbalalami Khan Mohammad Imran Iain H McKillop Irving C Allen Rafael V Davalos Source Type: research
Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves
In this study, our key contributions include: (i) a first-of-its-kind demonstration of the BO method used for the AHV iFEA; and (ii) the evaluation of a candidate AHV in-silico modeling approach wherein the chordae could be substituted with equivalent displacement boundary conditions, rendering the better iFEA convergence and a smoother objective surface.PMID:37989903 | DOI:10.1007/s10439-023-03408-6 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Colton J Ross Devin W Laurence Ankush Aggarwal Ming-Chen Hsu Arshid Mir Harold M Burkhart Chung-Hao Lee Source Type: research
