Finite Element Model of the Shoulder with Active Rotator Cuff Muscles: Application to Wheelchair Propulsion
This study aimed to develop such a model to understand pathomechanisms associated with wheelchair propulsion. We developed an active muscle model associating a passive fiber-reinforced isotropic matrix with an activation law linking calcium ion concentration to tissue tension. This model was first evaluated against known physiological muscle behavior; then used to activate the rotator cuff during a wheelchair propulsion cycle. Here, experimental kinematics and electromyography data was used to drive a shoulder finite element model. Finally, we evaluated the importance of muscle activation by comparing the results of activa...
Source: Annals of Biomedical Engineering - February 20, 2024 Category: Biomedical Engineering Authors: Najoua Assila Micka ël Begon Sonia Duprey Source Type: research
Biomechanical Remodeling of Aortic Valve Interstitial Cells During Calcified Lesion Formation In Vitro
Ann Biomed Eng. 2024 Feb 19. doi: 10.1007/s10439-024-03451-x. Online ahead of print.ABSTRACTHealthy aortic heart valves are essential to the regulation of unidirectional blood flow. Calcific aortic valve disease (CAVD) is an actively progressive disease that involves the disorganization of valve cells and accumulation of calcium deposits on the aortic valve leaflets. CAVD involves disruption of cell environment homeostasis that prior cell culture models have found difficult to portray and model. As it is still poorly understood how tissue stiffening associates with lesion formation, here, we implement a novel 3D culture pl...
Source: Annals of Biomedical Engineering - February 20, 2024 Category: Biomedical Engineering Authors: Justine Yushiuan Shih Terence Gee Gaetano Scuderi Jonathan Butcher Source Type: research
Subject-Specific Geometry of FE Lumbar Spine Models for the Replication of Fracture Locations Using Dynamic Drop Tests
Ann Biomed Eng. 2024 Feb 19. doi: 10.1007/s10439-023-03402-y. Online ahead of print.ABSTRACTFor traumatic lumbar spine injuries, the mechanisms and influence of anthropometrical variation are not yet fully understood under dynamic loading. Our objective was to evaluate whether geometrically subject-specific explicit finite element (FE) lumbar spine models based on state-of-the-art clinical CT data combined with general material properties from the literature could replicate the experimental responses and the fracture locations via a dynamic drop tower-test setup. The experimental CT datasets from a dynamic drop tower-test ...
Source: Annals of Biomedical Engineering - February 20, 2024 Category: Biomedical Engineering Authors: Laura K Rieger Alok Shah Sylvia Schick Dustin B Draper Rachel Cutlan Steffen Peldschus Brian D Stemper Source Type: research
Finite Element Model of the Shoulder with Active Rotator Cuff Muscles: Application to Wheelchair Propulsion
This study aimed to develop such a model to understand pathomechanisms associated with wheelchair propulsion. We developed an active muscle model associating a passive fiber-reinforced isotropic matrix with an activation law linking calcium ion concentration to tissue tension. This model was first evaluated against known physiological muscle behavior; then used to activate the rotator cuff during a wheelchair propulsion cycle. Here, experimental kinematics and electromyography data was used to drive a shoulder finite element model. Finally, we evaluated the importance of muscle activation by comparing the results of activa...
Source: Annals of Biomedical Engineering - February 20, 2024 Category: Biomedical Engineering Authors: Najoua Assila Micka ël Begon Sonia Duprey Source Type: research
Clinical Super-Resolution Computed Tomography of Bone Microstructure: Application in Musculoskeletal and Dental Imaging
CONCLUSION: Model training with laboratory modalities could push the resolution limit beyond state-of-the-art clinical musculoskeletal and dental CBCT. A larger maxillofacial training dataset is recommended for dental applications.PMID:38361137 | DOI:10.1007/s10439-024-03450-y (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Santeri J O Rytky Aleksei Tiulpin Mikko A J Finnil ä Sakari S Karhula Annina Sipola V äinö Kurttila Maarit Valkealahti Petri Lehenkari Antti Joukainen Heikki Kr öger Rami K Korhonen Simo Saarakkala Jaakko Niinim äki Source Type: research
Developing and Validating a Model of Humeral Stem Primary Stability, Intended for In Silico Clinical Trials
Ann Biomed Eng. 2024 Feb 15. doi: 10.1007/s10439-024-03452-w. Online ahead of print.ABSTRACTIn silico clinical trials (ISCT) can contribute to demonstrating a device's performance via credible computational models applied on virtual cohorts. Our purpose was to establish the credibility of a model for assessing the risk of humeral stem loosening in total shoulder arthroplasty, based on a twofold validation scheme involving both benchtop and clinical validation activities, for ISCT applications. A finite element model computing bone-implant micromotion (benchtop model) was quantitatively compared to a bone foam micromotion t...
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Ghislain Maquer Christine Mueri Adam Henderson Jeff Bischoff Philippe Favre Source Type: research
Clinical Super-Resolution Computed Tomography of Bone Microstructure: Application in Musculoskeletal and Dental Imaging
CONCLUSION: Model training with laboratory modalities could push the resolution limit beyond state-of-the-art clinical musculoskeletal and dental CBCT. A larger maxillofacial training dataset is recommended for dental applications.PMID:38361137 | DOI:10.1007/s10439-024-03450-y (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Santeri J O Rytky Aleksei Tiulpin Mikko A J Finnil ä Sakari S Karhula Annina Sipola V äinö Kurttila Maarit Valkealahti Petri Lehenkari Antti Joukainen Heikki Kr öger Rami K Korhonen Simo Saarakkala Jaakko Niinim äki Source Type: research
Developing and Validating a Model of Humeral Stem Primary Stability, Intended for In Silico Clinical Trials
Ann Biomed Eng. 2024 Feb 15. doi: 10.1007/s10439-024-03452-w. Online ahead of print.ABSTRACTIn silico clinical trials (ISCT) can contribute to demonstrating a device's performance via credible computational models applied on virtual cohorts. Our purpose was to establish the credibility of a model for assessing the risk of humeral stem loosening in total shoulder arthroplasty, based on a twofold validation scheme involving both benchtop and clinical validation activities, for ISCT applications. A finite element model computing bone-implant micromotion (benchtop model) was quantitatively compared to a bone foam micromotion t...
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Ghislain Maquer Christine Mueri Adam Henderson Jeff Bischoff Philippe Favre Source Type: research
Clinical Super-Resolution Computed Tomography of Bone Microstructure: Application in Musculoskeletal and Dental Imaging
CONCLUSION: Model training with laboratory modalities could push the resolution limit beyond state-of-the-art clinical musculoskeletal and dental CBCT. A larger maxillofacial training dataset is recommended for dental applications.PMID:38361137 | DOI:10.1007/s10439-024-03450-y (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Santeri J O Rytky Aleksei Tiulpin Mikko A J Finnil ä Sakari S Karhula Annina Sipola V äinö Kurttila Maarit Valkealahti Petri Lehenkari Antti Joukainen Heikki Kr öger Rami K Korhonen Simo Saarakkala Jaakko Niinim äki Source Type: research
Developing and Validating a Model of Humeral Stem Primary Stability, Intended for In Silico Clinical Trials
Ann Biomed Eng. 2024 Feb 15. doi: 10.1007/s10439-024-03452-w. Online ahead of print.ABSTRACTIn silico clinical trials (ISCT) can contribute to demonstrating a device's performance via credible computational models applied on virtual cohorts. Our purpose was to establish the credibility of a model for assessing the risk of humeral stem loosening in total shoulder arthroplasty, based on a twofold validation scheme involving both benchtop and clinical validation activities, for ISCT applications. A finite element model computing bone-implant micromotion (benchtop model) was quantitatively compared to a bone foam micromotion t...
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Ghislain Maquer Christine Mueri Adam Henderson Jeff Bischoff Philippe Favre Source Type: research
Clinical Super-Resolution Computed Tomography of Bone Microstructure: Application in Musculoskeletal and Dental Imaging
CONCLUSION: Model training with laboratory modalities could push the resolution limit beyond state-of-the-art clinical musculoskeletal and dental CBCT. A larger maxillofacial training dataset is recommended for dental applications.PMID:38361137 | DOI:10.1007/s10439-024-03450-y (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Santeri J O Rytky Aleksei Tiulpin Mikko A J Finnil ä Sakari S Karhula Annina Sipola V äinö Kurttila Maarit Valkealahti Petri Lehenkari Antti Joukainen Heikki Kr öger Rami K Korhonen Simo Saarakkala Jaakko Niinim äki Source Type: research
Developing and Validating a Model of Humeral Stem Primary Stability, Intended for In Silico Clinical Trials
Ann Biomed Eng. 2024 Feb 15. doi: 10.1007/s10439-024-03452-w. Online ahead of print.ABSTRACTIn silico clinical trials (ISCT) can contribute to demonstrating a device's performance via credible computational models applied on virtual cohorts. Our purpose was to establish the credibility of a model for assessing the risk of humeral stem loosening in total shoulder arthroplasty, based on a twofold validation scheme involving both benchtop and clinical validation activities, for ISCT applications. A finite element model computing bone-implant micromotion (benchtop model) was quantitatively compared to a bone foam micromotion t...
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Ghislain Maquer Christine Mueri Adam Henderson Jeff Bischoff Philippe Favre Source Type: research
Cardiorespiratory Sensors and Their Implications for Out-of-Hospital Cardiac Arrest Detection: A Systematic Review
Ann Biomed Eng. 2024 Feb 15. doi: 10.1007/s10439-024-03442-y. Online ahead of print.ABSTRACTOut-of-hospital cardiac arrest (OHCA) is a major health problem, with a poor survival rate of 2-11%. For the roughly 75% of OHCAs that are unwitnessed, survival is approximately 2-4.4%, as there are no bystanders present to provide life-saving interventions and alert Emergency Medical Services. Sensor technologies may reduce the number of unwitnessed OHCAs through automated detection of OHCA-associated physiological changes. However, no technologies are widely available for OHCA detection. This review identifies research and commerc...
Source: Annals of Biomedical Engineering - February 15, 2024 Category: Biomedical Engineering Authors: Saud Lingawi Jacob Hutton Mahsa Khalili Babak Shadgan Jim Christenson Brian Grunau Calvin Kuo Source Type: research
Preparation of Decellularized Tissue as Dual Cell Carrier Systems: A Step Towards Facilitating Re-epithelization and Cell Encapsulation for Tracheal Reconstruction
This study underscores the versatility of the trachea in producing two distinct cell carriers-decellularized scaffold and hydrogel-both containing the native biochemical niche essential for tracheal tissue engineering applications.PMID:38353908 | DOI:10.1007/s10439-024-03448-6 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - February 14, 2024 Category: Biomedical Engineering Authors: Pensuda Sompunga Watchareewan Rodprasert Sayamon Srisuwatanasagul Somporn Techangamsuwan Sirinee Jirajessada Rattanavinan Hanchaina Thaned Kangsamaksin Supansa Yodmuang Chenphop Sawangmake Source Type: research
Computational Analysis of the Effects of Fiber Deformation on the Microstructure and Permeability of Blood Oxygenator Bundles
Ann Biomed Eng. 2024 Feb 13. doi: 10.1007/s10439-024-03446-8. Online ahead of print.ABSTRACTMechanical loads on the polymeric fibers of oxygenating bundles are commonly present due to bundle press-fitting during device assembly and blood pressure load. However, computational fluid dynamics (CFD) simulations for fiber bundle optimization neglect possible changes in microstructure due to such deformations. The aim of this study is to investigate the impact of fiber deformability on bundle microstructure and fluid dynamics mainly in terms of permeability. Fibers from commercial mats typically used for blood oxygenators were m...
Source: Annals of Biomedical Engineering - February 13, 2024 Category: Biomedical Engineering Authors: Gianluca Poletti Davide Ninarello Giancarlo Pennati Source Type: research
