Effect of Ascending Aortic Curvature on Flow in the Sinus and Neo-sinus Following TAVR: A Patient-Specific Study
Ann Biomed Eng. 2023 Nov 3. doi: 10.1007/s10439-023-03392-x. Online ahead of print.ABSTRACTPatient-specific aortic geometry and its influence on the flow in the vicinity of Transcatheter Aortic Valve (TAV) has been highlighted in numerous studies using both in silico and in vitro experiments. However, there has not yet been a detailed Particle Image Velocimetry (PIV) experiment conducted to quantify the relationship between the geometry, flow downstream of TAV, and the flow in the sinus and the neo-sinus. We tested six different patient-specific aorta models with a 26-mm SAPIEN 3 valve (Edwards Lifesciences, Irvine, CA, US...
Source: Annals of Biomedical Engineering - November 3, 2023 Category: Biomedical Engineering Authors: Jae Hyun Kim Vahid Sadri Huang Chen Sanchita Bhat Keshav Kohli Raj Makkar Vasilis C Babaliaros Rahul P Sharma Ajit P Yoganathan Source Type: research

Effect of Ascending Aortic Curvature on Flow in the Sinus and Neo-sinus Following TAVR: A Patient-Specific Study
Ann Biomed Eng. 2023 Nov 3. doi: 10.1007/s10439-023-03392-x. Online ahead of print.ABSTRACTPatient-specific aortic geometry and its influence on the flow in the vicinity of Transcatheter Aortic Valve (TAV) has been highlighted in numerous studies using both in silico and in vitro experiments. However, there has not yet been a detailed Particle Image Velocimetry (PIV) experiment conducted to quantify the relationship between the geometry, flow downstream of TAV, and the flow in the sinus and the neo-sinus. We tested six different patient-specific aorta models with a 26-mm SAPIEN 3 valve (Edwards Lifesciences, Irvine, CA, US...
Source: Annals of Biomedical Engineering - November 3, 2023 Category: Biomedical Engineering Authors: Jae Hyun Kim Vahid Sadri Huang Chen Sanchita Bhat Keshav Kohli Raj Makkar Vasilis C Babaliaros Rahul P Sharma Ajit P Yoganathan Source Type: research

Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling
Ann Biomed Eng. 2023 Nov 1. doi: 10.1007/s10439-023-03390-z. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is a massive clinical challenge, annually affecting millions of patients globally. VTE is a particularly consequential pathology, as incidence is correlated with extremely common risk factors, and a large cohort of patients experience recurrent VTE after initial intervention. Altered hemodynamics, hypercoagulability, and damaged vascular tissue cause deep-vein thrombosis and pulmonary embolism, the two permutations of VTE. Venous valves have been identified as likely locations for initial blood clot forma...
Source: Annals of Biomedical Engineering - November 2, 2023 Category: Biomedical Engineering Authors: Connor Watson Hicham Saaid Vijay Vedula Jessica C Cardenas Peter K Henke Franck Nicoud Xiao Yun Xu Beverley J Hunt Keefe B Manning Source Type: research

Correction: Evaluating the Intracranial Pressure Biofidelity and Response Repeatability of a Physical Head-Brain Model in Frontal Impacts
Ann Biomed Eng. 2023 Nov 2. doi: 10.1007/s10439-023-03395-8. Online ahead of print.NO ABSTRACTPMID:37917383 | DOI:10.1007/s10439-023-03395-8 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - November 2, 2023 Category: Biomedical Engineering Authors: Yizhao Li Paris Vakiel Kevin Adanty Simon Ouellet Albert H Vette Donald Raboud Christopher R Dennison Source Type: research

Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling
Ann Biomed Eng. 2023 Nov 1. doi: 10.1007/s10439-023-03390-z. Online ahead of print.ABSTRACTVenous thromboembolism (VTE) is a massive clinical challenge, annually affecting millions of patients globally. VTE is a particularly consequential pathology, as incidence is correlated with extremely common risk factors, and a large cohort of patients experience recurrent VTE after initial intervention. Altered hemodynamics, hypercoagulability, and damaged vascular tissue cause deep-vein thrombosis and pulmonary embolism, the two permutations of VTE. Venous valves have been identified as likely locations for initial blood clot forma...
Source: Annals of Biomedical Engineering - November 2, 2023 Category: Biomedical Engineering Authors: Connor Watson Hicham Saaid Vijay Vedula Jessica C Cardenas Peter K Henke Franck Nicoud Xiao Yun Xu Beverley J Hunt Keefe B Manning Source Type: research

Correction: Evaluating the Intracranial Pressure Biofidelity and Response Repeatability of a Physical Head-Brain Model in Frontal Impacts
Ann Biomed Eng. 2023 Nov 2. doi: 10.1007/s10439-023-03395-8. Online ahead of print.NO ABSTRACTPMID:37917383 | DOI:10.1007/s10439-023-03395-8 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - November 2, 2023 Category: Biomedical Engineering Authors: Yizhao Li Paris Vakiel Kevin Adanty Simon Ouellet Albert H Vette Donald Raboud Christopher R Dennison Source Type: research

A Comparative Study of Ex-Vivo Murine Pulmonary Mechanics Under Positive- and Negative-Pressure Ventilation
Ann Biomed Eng. 2023 Oct 31. doi: 10.1007/s10439-023-03380-1. Online ahead of print.ABSTRACTIncreased ventilator use during the COVID-19 pandemic resurrected persistent questions regarding mechanical ventilation including the difference between physiological and artificial breathing induced by ventilators (i.e., positive- versus negative-pressure ventilation, PPV vs NPV). To address this controversy, we compare murine specimens subjected to PPV and NPV in ex vivo quasi-static loading and quantify pulmonary mechanics via measures of quasi-static and dynamic compliances, transpulmonary pressure, and energetics when varying i...
Source: Annals of Biomedical Engineering - October 31, 2023 Category: Biomedical Engineering Authors: K A M Quiros T M Nelson A Ulu E C Dominguez T A Biddle D D Lo T M Nordgren M Eskandari Source Type: research

A Comparative Study of Ex-Vivo Murine Pulmonary Mechanics Under Positive- and Negative-Pressure Ventilation
Ann Biomed Eng. 2023 Oct 31. doi: 10.1007/s10439-023-03380-1. Online ahead of print.ABSTRACTIncreased ventilator use during the COVID-19 pandemic resurrected persistent questions regarding mechanical ventilation including the difference between physiological and artificial breathing induced by ventilators (i.e., positive- versus negative-pressure ventilation, PPV vs NPV). To address this controversy, we compare murine specimens subjected to PPV and NPV in ex vivo quasi-static loading and quantify pulmonary mechanics via measures of quasi-static and dynamic compliances, transpulmonary pressure, and energetics when varying i...
Source: Annals of Biomedical Engineering - October 31, 2023 Category: Biomedical Engineering Authors: K A M Quiros T M Nelson A Ulu E C Dominguez T A Biddle D D Lo T M Nordgren M Eskandari Source Type: research

Open-Source System for Real-Time Functional Assessment of In Vitro Filtration Barriers
We present an affordable, open-source platform for the real-time monitoring of functional filtration status in engineered microphysiological systems. Using readily available components, our assay can linearly detect real-time concentrations of two target molecules, FITC-labeled inulin and Texas Red-labeled human-serum albumin, within clinically relevant ranges, and it can be easily modified for different target molecules of varying sizes and tags. We demonstrate the platform's ability to determine the concentration of our target molecules automatically and consistently. We show through an acellular context that the platfor...
Source: Annals of Biomedical Engineering - October 30, 2023 Category: Biomedical Engineering Authors: Tess K Fallon Merve Zuvin Alan D Stern Nanditha Anandakrishnan Ilse S Daehn Evren U Azeloglu Source Type: research

Histological, Physiological and Biomechanical Effects of Low-Level Laser Therapy on Tendon Healing in Animals and Humans: A Systematic Review
Ann Biomed Eng. 2023 Oct 29. doi: 10.1007/s10439-023-03364-1. Online ahead of print.ABSTRACTLow-level Laser Therapy (LLLT) was widely used in clinical practice for tendon disorders. However, the underlying mechanisms and effectiveness of LLLT in treating tendon injury remain unclear. Therefore, the present study was conducted aiming to summarize the evidence regarding the histological, physiological, and biomechanical effects of LLLT on tendon healing in animal and human models. Four databases were searched for relevant literature. Four independent reviewers screened abstracts and full-text articles, extracted relevant dat...
Source: Annals of Biomedical Engineering - October 30, 2023 Category: Biomedical Engineering Authors: Kexu He Xuelian Zhou Feisheng Zheng Xiaojie Ju Siu-Ngor Fu Arnold Y L Wong Source Type: research

Open-Source System for Real-Time Functional Assessment of In Vitro Filtration Barriers
We present an affordable, open-source platform for the real-time monitoring of functional filtration status in engineered microphysiological systems. Using readily available components, our assay can linearly detect real-time concentrations of two target molecules, FITC-labeled inulin and Texas Red-labeled human-serum albumin, within clinically relevant ranges, and it can be easily modified for different target molecules of varying sizes and tags. We demonstrate the platform's ability to determine the concentration of our target molecules automatically and consistently. We show through an acellular context that the platfor...
Source: Annals of Biomedical Engineering - October 30, 2023 Category: Biomedical Engineering Authors: Tess K Fallon Merve Zuvin Alan D Stern Nanditha Anandakrishnan Ilse S Daehn Evren U Azeloglu Source Type: research

Histological, Physiological and Biomechanical Effects of Low-Level Laser Therapy on Tendon Healing in Animals and Humans: A Systematic Review
Ann Biomed Eng. 2023 Oct 29. doi: 10.1007/s10439-023-03364-1. Online ahead of print.ABSTRACTLow-level Laser Therapy (LLLT) was widely used in clinical practice for tendon disorders. However, the underlying mechanisms and effectiveness of LLLT in treating tendon injury remain unclear. Therefore, the present study was conducted aiming to summarize the evidence regarding the histological, physiological, and biomechanical effects of LLLT on tendon healing in animal and human models. Four databases were searched for relevant literature. Four independent reviewers screened abstracts and full-text articles, extracted relevant dat...
Source: Annals of Biomedical Engineering - October 30, 2023 Category: Biomedical Engineering Authors: Kexu He Xuelian Zhou Feisheng Zheng Xiaojie Ju Siu-Ngor Fu Arnold Y L Wong Source Type: research

Translating Cadaveric Injury Risk to Dummy Injury Risk at Iso-energy
Ann Biomed Eng. 2023 Oct 27. doi: 10.1007/s10439-023-03388-7. Online ahead of print.ABSTRACTInjury risk assessment based on cadaver data is essential for informing safety standards. The common 'matched-pair' method matches energy-based inputs to translate human response to anthropometric test devices (ATDs). However, this method can result in less conservative human injury risk curves due to intrinsic differences between human and ATDs. Generally, dummies are stiffer than cadavers, so force and displacement cannot be matched simultaneously. Differences in fracture tolerance further influence the dummy risk curve to be less...
Source: Annals of Biomedical Engineering - October 27, 2023 Category: Biomedical Engineering Authors: Maria Ortiz-Paparoni Concetta Morino Jefferson Bercaw Joost Op 't Eynde Roger Nightingale Cameron 'Dale' Bass Source Type: research

Translating Cadaveric Injury Risk to Dummy Injury Risk at Iso-energy
Ann Biomed Eng. 2023 Oct 27. doi: 10.1007/s10439-023-03388-7. Online ahead of print.ABSTRACTInjury risk assessment based on cadaver data is essential for informing safety standards. The common 'matched-pair' method matches energy-based inputs to translate human response to anthropometric test devices (ATDs). However, this method can result in less conservative human injury risk curves due to intrinsic differences between human and ATDs. Generally, dummies are stiffer than cadavers, so force and displacement cannot be matched simultaneously. Differences in fracture tolerance further influence the dummy risk curve to be less...
Source: Annals of Biomedical Engineering - October 27, 2023 Category: Biomedical Engineering Authors: Maria Ortiz-Paparoni Concetta Morino Jefferson Bercaw Joost Op 't Eynde Roger Nightingale Cameron 'Dale' Bass Source Type: research

Osteoporosis Prediction Using Machine-Learned Optical Bone Densitometry Data
Ann Biomed Eng. 2023 Oct 26. doi: 10.1007/s10439-023-03387-8. Online ahead of print.ABSTRACTOptical bone densitometry (OBD) has been developed for the early detection of osteoporosis. In recent years, machine learning (ML) techniques have been actively implemented for the areas of medical diagnosis and screening with the goal of improving diagnostic accuracy. The purpose of this study was to verify the feasibility of using the combination of OBD and ML techniques as a screening tool for osteoporosis. Dual energy X-ray absorptiometry (DXA) and OBD measurements were performed on 203 Thai subjects. From the OBD measurements a...
Source: Annals of Biomedical Engineering - October 26, 2023 Category: Biomedical Engineering Authors: Kaname Miura Shigeo M Tanaka Chanisa Chotipanich Thanapon Chobpenthai Attapon Jantarato Anak Khantachawana Source Type: research