Selective Partitioned Regression for Accurate Kidney Health Monitoring
Ann Biomed Eng. 2024 Feb 27. doi: 10.1007/s10439-024-03470-8. Online ahead of print.ABSTRACTThe number of people diagnosed with advanced stages of kidney disease have been rising every year. Early detection and constant monitoring are the only minimally invasive means to prevent severe kidney damage or kidney failure. We propose a cost-effective machine learning-based testing system that can facilitate inexpensive yet accurate kidney health checks. Our proposed framework, which was developed into an iPhone application, uses a camera-based bio-sensor and state-of-the-art classical machine learning and deep learning techniqu...
Source: Annals of Biomedical Engineering - February 27, 2024 Category: Biomedical Engineering Authors: Alex Whelan Ragwa Elsayed Alessandro Bellofiore David C Anastasiu Source Type: research

Quantitative and Visual Analysis of Data Augmentation and Hyperparameter Optimization in Deep Learning-Based Segmentation of Low-Grade Glioma Tumors Using Grad-CAM
This study executes a quantitative and visual investigation on the effectiveness of data augmentation and hyperparameter optimization on the accuracy of deep learning-based segmentation of LGG tumors. The study employed the MobileNetV2 and ResNet backbones with atrous convolution in DeepLabV3+ structure. The Grad-CAM tool was also used to interpret the effect of augmentation and network optimization on segmentation performance. A wide investigation was performed to optimize the network hyperparameters. In addition, the study examined 35 different models to evaluate different data augmentation techniques. The results of the...
Source: Annals of Biomedical Engineering - February 27, 2024 Category: Biomedical Engineering Authors: Fereshteh Khodadadi Shoushtari Azimeh N V Dehkordi Sedigheh Sina Source Type: research

Quantifying Imaging Agent Binding and Dissociation in 3-D Cancer Spheroid Tissue Culture Using Paired-Agent Principles
Ann Biomed Eng. 2024 Feb 26. doi: 10.1007/s10439-024-03476-2. Online ahead of print.ABSTRACTBinding kinetics play an important role in cancer diagnosis and therapeutics. However, current methods of quantifying binding kinetics fail to consider the three-dimensional environment that drugs and imaging agents experience in biological tissue. In response, a methodology to assay agent binding and dissociation in 3-D tissue culture was developed using paired-agent molecular imaging principles. To test the methodology, the uptakes of ABY-029 (an IRDye 800CW-labeled epidermal growth factor receptor (EGFR)-targeted antibody mimetic...
Source: Annals of Biomedical Engineering - February 27, 2024 Category: Biomedical Engineering Authors: Chengyue Li Cody C Rounds Veronica C Torres Yusheng He Xiaochun Xu Georgia Papavasiliou Kimberley S Samkoe Jovan G Brankov Kenneth M Tichauer Source Type: research

Sterilization of Human Amniotic Membrane Using an Ozone Hydrodynamic System
Ann Biomed Eng. 2024 Feb 27. doi: 10.1007/s10439-024-03467-3. Online ahead of print.ABSTRACTHuman amniotic membrane (hAM) is an important biomaterial for Tissue Engineering, due to its great regenerative properties and potential use as a scaffold. The most used procedure to sterilize biomaterials is gamma-irradiation, but this method can affect several properties, causing damage to the structure and reducing the growth factors. The present work evaluated the efficiency of a new method based on ozonated dynamic water for hAM sterilization. HAM fragments were experimentally contaminated with Staphylococcus aureus, Escherichi...
Source: Annals of Biomedical Engineering - February 27, 2024 Category: Biomedical Engineering Authors: T úlia Botelho Bianca Akemi Kawata Silvia M óbille Awoyama Pedro Augusto Laurindo Igreja Marrafa Henrique Cunha Carvalho Carlos Jos é de Lima Adriana Barrinha Fernandes Source Type: research

Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction
Ann Biomed Eng. 2024 Feb 26. doi: 10.1007/s10439-024-03463-7. Online ahead of print.ABSTRACTAn in silico study is performed to investigate fluid dynamic effects of central venous catheter (CVC) placement within patient-specific cavo-atrial junctions. Prior studies show the CVC infusing a liquid, but this study focuses on the placement without any liquid emerging from the CVC. A 7 or 15-French double-lumen CVC is placed virtually in two patient-specific models; the CVC tip location is altered to understand its effect on the venous flow field. Results show that the CVC impact is trivial on flow in the superior vena cava when...
Source: Annals of Biomedical Engineering - February 26, 2024 Category: Biomedical Engineering Authors: Boyang Su Hannah Palahnuk Thaddeus Harbaugh Elias Rizk Will Hazard Angel Chan Jonathan Bernstein Jonathan W Weinsaft Keefe B Manning Source Type: research

Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction
Ann Biomed Eng. 2024 Feb 26. doi: 10.1007/s10439-024-03463-7. Online ahead of print.ABSTRACTAn in silico study is performed to investigate fluid dynamic effects of central venous catheter (CVC) placement within patient-specific cavo-atrial junctions. Prior studies show the CVC infusing a liquid, but this study focuses on the placement without any liquid emerging from the CVC. A 7 or 15-French double-lumen CVC is placed virtually in two patient-specific models; the CVC tip location is altered to understand its effect on the venous flow field. Results show that the CVC impact is trivial on flow in the superior vena cava when...
Source: Annals of Biomedical Engineering - February 26, 2024 Category: Biomedical Engineering Authors: Boyang Su Hannah Palahnuk Thaddeus Harbaugh Elias Rizk Will Hazard Angel Chan Jonathan Bernstein Jonathan W Weinsaft Keefe B Manning Source Type: research

Choosing Optimal Cutoff Frequencies for Filtering Linear Acceleration and Angular Velocity Signals Associated with Head Impacts Measured by Instrumented Mouthguards
This study sought optimal filter cutoff frequencies for six-degree-of-freedom measurements made at the teeth using instrumented mouthguards. We collected linear acceleration and angular velocity signals at the head center of gravity (CG) using laboratory-grade instrumentation. We also collected and filtered similar six-degree-of-freedom measurements from an instrumented mouthguard using 24 cutoff frequencies, from 25 to 600 Hz. We transformed the measurements to linear acceleration at the center of gravity of the head (CG) using all kinematic variables at the teeth, optimizing linear and angular mouthguard cutoff frequenci...
Source: Annals of Biomedical Engineering - February 25, 2024 Category: Biomedical Engineering Authors: Ryan Gellner Mark Begonia Steve Rowson Source Type: research

Mild Traumatic Brain Injury and  Career Stage Associate with Visible Perivascular Spaces in Special Operations Forces Soldiers
Ann Biomed Eng. 2024 Feb 23. doi: 10.1007/s10439-024-03468-2. Online ahead of print.ABSTRACTMild traumatic brain injury (mTBI) and occupational blast exposure in military Service Members may lead to impaired brain waste clearance which increases neurological disease risk. Perivascular spaces (PVS) are a key part of the glymphatic system which supports brain waste clearance, preferentially during sleep. Visible PVS on clinical magnetic resonance imaging have been previously observed in patients with neurodegenerative diseases and animal neurotrauma models. The purpose of this study was to determine associations between PVS ...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Jacob R Powell Xiaopeng Zong Joshua M Weinstein Stephen M DeLellis Shawn F Kane Gary E Means Jason P Mihalik Source Type: research

Deep Learning for Perfusion Cerebral Blood Flow (CBF) and Volume (CBV) Predictions and Diagnostics
Ann Biomed Eng. 2024 Feb 24. doi: 10.1007/s10439-024-03471-7. Online ahead of print.ABSTRACTDynamic susceptibility contrast magnetic resonance perfusion (DSC-MRP) is a non-invasive imaging technique for hemodynamic measurements. Various perfusion parameters, such as cerebral blood volume (CBV) and cerebral blood flow (CBF), can be derived from DSC-MRP, hence this non-invasive imaging protocol is widely used clinically for the diagnosis and assessment of intracranial pathologies. Currently, most institutions use commercially available software to compute the perfusion parametric maps. However, these conventional methods oft...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Salmonn Talebi Siyu Gai Aaron Sossin Vivian Zhu Elizabeth Tong Mohammad R K Mofrad Source Type: research

Modification of Woven Endo-Bridge After Intracranial Aneurysm Treatment: A Methodology for Three-Dimensional Analysis of Shape and Relative Position Changes
We present a methodology to quantify the morphology and position of the WEB device in relation to the vascular anatomy. Three-dimensional rotational angiography (3DRA) images of seven aneurysms patients treated with WEBs were used, which also accompanied by a post-treatment 3DRA image and a follow-up 3DRA image. The device was manually segmented, obtaining the 3D models after treatment and at the follow-up. Volume, surface area, height, maximum diameter and WSM ratio of both surfaces were calculated. Position changes were evaluated measuring WEB axis and relative position between post-treatment and follow-up. Changes in WE...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Romina Mu ñoz Nicol ás Dazeo Santiago Estevez-Areco Kevin Janot Ana Paula Narata Aymeric Rouchaud Ignacio Larrabide Source Type: research

An EM-Tracked Approach for Calibrating the 3D Pose of Flexible Endoscopes
Ann Biomed Eng. 2024 Feb 24. doi: 10.1007/s10439-024-03469-1. Online ahead of print.ABSTRACTFlexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to simplify the calibration process, we propose an electromagnetic (EM)-tracked calibration approach that does not require any predefined poses of the EM sensor. A three-stage calibration protocol was presented in an extensor. First, the orientation of the endoscope tube was derived by con...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Zhongjie Long Yongting Chi Xianbo Zhang Hongbing Li Dejin Yang Diangeng Li Zhouxiang Jiang Source Type: research

Mild Traumatic Brain Injury and  Career Stage Associate with Visible Perivascular Spaces in Special Operations Forces Soldiers
Ann Biomed Eng. 2024 Feb 23. doi: 10.1007/s10439-024-03468-2. Online ahead of print.ABSTRACTMild traumatic brain injury (mTBI) and occupational blast exposure in military Service Members may lead to impaired brain waste clearance which increases neurological disease risk. Perivascular spaces (PVS) are a key part of the glymphatic system which supports brain waste clearance, preferentially during sleep. Visible PVS on clinical magnetic resonance imaging have been previously observed in patients with neurodegenerative diseases and animal neurotrauma models. The purpose of this study was to determine associations between PVS ...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Jacob R Powell Xiaopeng Zong Joshua M Weinstein Stephen M DeLellis Shawn F Kane Gary E Means Jason P Mihalik Source Type: research

Deep Learning for Perfusion Cerebral Blood Flow (CBF) and Volume (CBV) Predictions and Diagnostics
Ann Biomed Eng. 2024 Feb 24. doi: 10.1007/s10439-024-03471-7. Online ahead of print.ABSTRACTDynamic susceptibility contrast magnetic resonance perfusion (DSC-MRP) is a non-invasive imaging technique for hemodynamic measurements. Various perfusion parameters, such as cerebral blood volume (CBV) and cerebral blood flow (CBF), can be derived from DSC-MRP, hence this non-invasive imaging protocol is widely used clinically for the diagnosis and assessment of intracranial pathologies. Currently, most institutions use commercially available software to compute the perfusion parametric maps. However, these conventional methods oft...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Salmonn Talebi Siyu Gai Aaron Sossin Vivian Zhu Elizabeth Tong Mohammad R K Mofrad Source Type: research

Modification of Woven Endo-Bridge After Intracranial Aneurysm Treatment: A Methodology for Three-Dimensional Analysis of Shape and Relative Position Changes
We present a methodology to quantify the morphology and position of the WEB device in relation to the vascular anatomy. Three-dimensional rotational angiography (3DRA) images of seven aneurysms patients treated with WEBs were used, which also accompanied by a post-treatment 3DRA image and a follow-up 3DRA image. The device was manually segmented, obtaining the 3D models after treatment and at the follow-up. Volume, surface area, height, maximum diameter and WSM ratio of both surfaces were calculated. Position changes were evaluated measuring WEB axis and relative position between post-treatment and follow-up. Changes in WE...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Romina Mu ñoz Nicol ás Dazeo Santiago Estevez-Areco Kevin Janot Ana Paula Narata Aymeric Rouchaud Ignacio Larrabide Source Type: research

An EM-Tracked Approach for Calibrating the 3D Pose of Flexible Endoscopes
Ann Biomed Eng. 2024 Feb 24. doi: 10.1007/s10439-024-03469-1. Online ahead of print.ABSTRACTFlexible endoscopes are ideal instruments for visualizing and diagnosing the inner surfaces of organs via a minimally invasive incision. Calibrating a flexible endoscope is a troublesome yet inevitable process in image-based tools tracking. Aiming to simplify the calibration process, we propose an electromagnetic (EM)-tracked calibration approach that does not require any predefined poses of the EM sensor. A three-stage calibration protocol was presented in an extensor. First, the orientation of the endoscope tube was derived by con...
Source: Annals of Biomedical Engineering - February 24, 2024 Category: Biomedical Engineering Authors: Zhongjie Long Yongting Chi Xianbo Zhang Hongbing Li Dejin Yang Diangeng Li Zhouxiang Jiang Source Type: research