A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis
In this study, we present an in vitro fibrin clot model that mimics clot accumulation in PHVs under relevant hydrodynamic conditions while allowing real-time imaging. We created 3D-printed mechanical aortic valve models that were inserted into a transparent glass aorta model and connected to a system that simulates human aortic flow pulse and pressures. Thrombin was gradually injected into a circulating fibrinogen solution to induce fibrin clot formation, and clot accumulation was quantified via image analysis. The results of valves positioned in a normal versus a tilted configuration showed that clot accumulation correlat...
Source: Annals of Biomedical Engineering - March 8, 2024 Category: Biomedical Engineering Authors: Yevgeniy Kreinin Yahel Talmon Moran Levi Maria Khoury Itay Or Mahli Raad Gil Bolotin Josu é Sznitman Netanel Korin Source Type: research
Microfluidic Diffusional Sizing (MDS) Measurements of Secretory Neutralizing Antibody Affinity Against SARS-CoV-2
Ann Biomed Eng. 2024 Mar 8. doi: 10.1007/s10439-024-03478-0. Online ahead of print.ABSTRACTSARS-CoV-2 has rampantly spread around the globe and continues to cause unprecedented loss through ongoing waves of (re)infection. Increasing our understanding of the protection against infection with SARS-CoV-2 is critical to ending the pandemic. Serological assays have been widely used to assess immune responses, but secretory antibodies, the essential first line of defense, have been studied to only a limited extent. Of particular interest and importance are neutralizing antibodies, which block the binding of the spike protein of ...
Source: Annals of Biomedical Engineering - March 8, 2024 Category: Biomedical Engineering Authors: Cara O'Mahoney Ian Watt Sebastian Fiedler Sean Devenish Sujata Srikanth Erica Justice Tristan Dover Delphine Dean Congyue Peng Source Type: research
A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis
In this study, we present an in vitro fibrin clot model that mimics clot accumulation in PHVs under relevant hydrodynamic conditions while allowing real-time imaging. We created 3D-printed mechanical aortic valve models that were inserted into a transparent glass aorta model and connected to a system that simulates human aortic flow pulse and pressures. Thrombin was gradually injected into a circulating fibrinogen solution to induce fibrin clot formation, and clot accumulation was quantified via image analysis. The results of valves positioned in a normal versus a tilted configuration showed that clot accumulation correlat...
Source: Annals of Biomedical Engineering - March 8, 2024 Category: Biomedical Engineering Authors: Yevgeniy Kreinin Yahel Talmon Moran Levi Maria Khoury Itay Or Mahli Raad Gil Bolotin Josu é Sznitman Netanel Korin Source Type: research
A Finite Element Model to Investigate the Stability of Osteochondral Grafts Within a Human Tibiofemoral Joint
Ann Biomed Eng. 2024 Mar 6. doi: 10.1007/s10439-024-03464-6. Online ahead of print.ABSTRACTOsteochondral grafting has demonstrated positive outcomes for treating articular cartilage defects by replacing the damaged region with a cylindrical graft consisting of bone with a layer of cartilage. However, factors that cause graft subsidence are not well understood. The aim of this study was to develop finite element (FE) models of osteochondral grafts within a tibiofemoral joint, suitable for an investigation of parameters affecting graft stability. Cadaveric femurs were used to experimentally calibrate the bone properties and ...
Source: Annals of Biomedical Engineering - March 6, 2024 Category: Biomedical Engineering Authors: Gavin A Day Alison C Jones Marl ène Mengoni Ruth K Wilcox Source Type: research
A Finite Element Model to Investigate the Stability of Osteochondral Grafts Within a Human Tibiofemoral Joint
Ann Biomed Eng. 2024 Mar 6. doi: 10.1007/s10439-024-03464-6. Online ahead of print.ABSTRACTOsteochondral grafting has demonstrated positive outcomes for treating articular cartilage defects by replacing the damaged region with a cylindrical graft consisting of bone with a layer of cartilage. However, factors that cause graft subsidence are not well understood. The aim of this study was to develop finite element (FE) models of osteochondral grafts within a tibiofemoral joint, suitable for an investigation of parameters affecting graft stability. Cadaveric femurs were used to experimentally calibrate the bone properties and ...
Source: Annals of Biomedical Engineering - March 6, 2024 Category: Biomedical Engineering Authors: Gavin A Day Alison C Jones Marl ène Mengoni Ruth K Wilcox Source Type: research
A Finite Element Model to Investigate the Stability of Osteochondral Grafts Within a Human Tibiofemoral Joint
Ann Biomed Eng. 2024 Mar 6. doi: 10.1007/s10439-024-03464-6. Online ahead of print.ABSTRACTOsteochondral grafting has demonstrated positive outcomes for treating articular cartilage defects by replacing the damaged region with a cylindrical graft consisting of bone with a layer of cartilage. However, factors that cause graft subsidence are not well understood. The aim of this study was to develop finite element (FE) models of osteochondral grafts within a tibiofemoral joint, suitable for an investigation of parameters affecting graft stability. Cadaveric femurs were used to experimentally calibrate the bone properties and ...
Source: Annals of Biomedical Engineering - March 6, 2024 Category: Biomedical Engineering Authors: Gavin A Day Alison C Jones Marl ène Mengoni Ruth K Wilcox Source Type: research
The Effect of Simulated Obstructive Apneas on Mechanical Characteristics of Lower Airways in Individuals with Asthma
Ann Biomed Eng. 2024 Mar 3. doi: 10.1007/s10439-024-03475-3. Online ahead of print.ABSTRACTIncreased negative intrathoracic pressure that occurs during pharyngeal obstruction can increase thoracic fluid volume that may contribute to lower airway narrowing in individuals with obstructive sleep apnea (OSA) and asthma. Our previous study showed that fluid accumulation in the thorax induced by simulated OSA can increase total respiratory resistance. However, the effect of fluid shift on lower airway narrowing has not been investigated. To examine the effect of fluid accumulation in the thorax on the resistance of the lower air...
Source: Annals of Biomedical Engineering - March 3, 2024 Category: Biomedical Engineering Authors: Nasim Montazeri Ghahjaverestan Shaghayegh Chavoshian Xiaoshu Cao T Douglas Bradley Susan M Tarlo Matthew Stanbrook Kenneth R Chapman Azadeh Yadollahi Source Type: research
The Effect of Simulated Obstructive Apneas on Mechanical Characteristics of Lower Airways in Individuals with Asthma
Ann Biomed Eng. 2024 Mar 3. doi: 10.1007/s10439-024-03475-3. Online ahead of print.ABSTRACTIncreased negative intrathoracic pressure that occurs during pharyngeal obstruction can increase thoracic fluid volume that may contribute to lower airway narrowing in individuals with obstructive sleep apnea (OSA) and asthma. Our previous study showed that fluid accumulation in the thorax induced by simulated OSA can increase total respiratory resistance. However, the effect of fluid shift on lower airway narrowing has not been investigated. To examine the effect of fluid accumulation in the thorax on the resistance of the lower air...
Source: Annals of Biomedical Engineering - March 3, 2024 Category: Biomedical Engineering Authors: Nasim Montazeri Ghahjaverestan Shaghayegh Chavoshian Xiaoshu Cao T Douglas Bradley Susan M Tarlo Matthew Stanbrook Kenneth R Chapman Azadeh Yadollahi Source Type: research
The Effect of Simulated Obstructive Apneas on Mechanical Characteristics of Lower Airways in Individuals with Asthma
Ann Biomed Eng. 2024 Mar 3. doi: 10.1007/s10439-024-03475-3. Online ahead of print.ABSTRACTIncreased negative intrathoracic pressure that occurs during pharyngeal obstruction can increase thoracic fluid volume that may contribute to lower airway narrowing in individuals with obstructive sleep apnea (OSA) and asthma. Our previous study showed that fluid accumulation in the thorax induced by simulated OSA can increase total respiratory resistance. However, the effect of fluid shift on lower airway narrowing has not been investigated. To examine the effect of fluid accumulation in the thorax on the resistance of the lower air...
Source: Annals of Biomedical Engineering - March 3, 2024 Category: Biomedical Engineering Authors: Nasim Montazeri Ghahjaverestan Shaghayegh Chavoshian Xiaoshu Cao T Douglas Bradley Susan M Tarlo Matthew Stanbrook Kenneth R Chapman Azadeh Yadollahi Source Type: research
The Influence of Headform Friction and Inertial Properties on Oblique Impact Helmet Testing
This study aimed to quantify the influence of headform coefficient of friction (COF) and inertial properties on oblique impact response. The static COF of each headform condition (EN960, Hybrid III, NOCSAE, Hybrid III with a skull cap, NOCSAE with a skull cap) was measured against the helmet lining material used in a KASK prototype helmet. Each headform condition was tested with the same helmet model at two speeds (4.8 & 7.3 m/s) and two primary orientations (y-axis and x-axis rotation) with 5 repetitions, totaling 100 tests. The influence of impact location, inertial properties, and friction on linear and rotational i...
Source: Annals of Biomedical Engineering - February 29, 2024 Category: Biomedical Engineering Authors: Nicole E-P Stark Mark Begonia Luca Viano Steven Rowson Source Type: research
Muscle Morphology Does Not Solely Determine Knee Flexion Weakness After Anterior Cruciate Ligament Reconstruction with a Semitendinosus Tendon Graft: A Combined Experimental and Computational Modeling Study
Ann Biomed Eng. 2024 Feb 29. doi: 10.1007/s10439-024-03455-7. Online ahead of print.ABSTRACTThe distal semitendinosus tendon is commonly harvested for anterior cruciate ligament reconstruction, inducing substantial morbidity at the knee. The aim of this study was to probe how morphological changes of the semitendinosus muscle after harvest of its distal tendon for anterior cruciate ligament reconstruction affects knee flexion strength and whether the knee flexor synergists can compensate for the knee flexion weakness. Ten participants 8-18 months after anterior cruciate ligament reconstruction with an ipsilateral distal se...
Source: Annals of Biomedical Engineering - February 29, 2024 Category: Biomedical Engineering Authors: Adam Kositsky Lauri Stenroth Rod S Barrett Rami K Korhonen Christopher J Vertullo Laura E Diamond David J Saxby Source Type: research
Sustained Physiological Stretch Induces Abdominal Skin Growth in Pregnancy
Ann Biomed Eng. 2024 Feb 29. doi: 10.1007/s10439-024-03472-6. Online ahead of print.ABSTRACTSupraphysiological stretches are exploited in skin expanders to induce tissue growth for autologous implants. As pregnancy is associated with large levels of sustained stretch, we investigated whether skin growth occurs in pregnancy. Therefore, we combined a mechanical model of skin and the observations from suction experiments on several body locations of five pregnant women at different gestational ages. The measurements show a continuous increase in stiffness, with the largest change observed during the last trimester. A comparis...
Source: Annals of Biomedical Engineering - February 29, 2024 Category: Biomedical Engineering Authors: David Sachs Raphael Jakob Bettina Thumm Michael Bajka Alexander E Ehret Edoardo Mazza Source Type: research
The Influence of Headform Friction and Inertial Properties on Oblique Impact Helmet Testing
This study aimed to quantify the influence of headform coefficient of friction (COF) and inertial properties on oblique impact response. The static COF of each headform condition (EN960, Hybrid III, NOCSAE, Hybrid III with a skull cap, NOCSAE with a skull cap) was measured against the helmet lining material used in a KASK prototype helmet. Each headform condition was tested with the same helmet model at two speeds (4.8 & 7.3 m/s) and two primary orientations (y-axis and x-axis rotation) with 5 repetitions, totaling 100 tests. The influence of impact location, inertial properties, and friction on linear and rotational i...
Source: Annals of Biomedical Engineering - February 29, 2024 Category: Biomedical Engineering Authors: Nicole E-P Stark Mark Begonia Luca Viano Steven Rowson Source Type: research
Muscle Morphology Does Not Solely Determine Knee Flexion Weakness After Anterior Cruciate Ligament Reconstruction with a Semitendinosus Tendon Graft: A Combined Experimental and Computational Modeling Study
Ann Biomed Eng. 2024 Feb 29. doi: 10.1007/s10439-024-03455-7. Online ahead of print.ABSTRACTThe distal semitendinosus tendon is commonly harvested for anterior cruciate ligament reconstruction, inducing substantial morbidity at the knee. The aim of this study was to probe how morphological changes of the semitendinosus muscle after harvest of its distal tendon for anterior cruciate ligament reconstruction affects knee flexion strength and whether the knee flexor synergists can compensate for the knee flexion weakness. Ten participants 8-18 months after anterior cruciate ligament reconstruction with an ipsilateral distal se...
Source: Annals of Biomedical Engineering - February 29, 2024 Category: Biomedical Engineering Authors: Adam Kositsky Lauri Stenroth Rod S Barrett Rami K Korhonen Christopher J Vertullo Laura E Diamond David J Saxby Source Type: research
Sustained Physiological Stretch Induces Abdominal Skin Growth in Pregnancy
Ann Biomed Eng. 2024 Feb 29. doi: 10.1007/s10439-024-03472-6. Online ahead of print.ABSTRACTSupraphysiological stretches are exploited in skin expanders to induce tissue growth for autologous implants. As pregnancy is associated with large levels of sustained stretch, we investigated whether skin growth occurs in pregnancy. Therefore, we combined a mechanical model of skin and the observations from suction experiments on several body locations of five pregnant women at different gestational ages. The measurements show a continuous increase in stiffness, with the largest change observed during the last trimester. A comparis...
Source: Annals of Biomedical Engineering - February 29, 2024 Category: Biomedical Engineering Authors: David Sachs Raphael Jakob Bettina Thumm Michael Bajka Alexander E Ehret Edoardo Mazza Source Type: research
