Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development
Ann Biomed Eng. 2023 Dec 11. doi: 10.1007/s10439-023-03414-8. Online ahead of print.ABSTRACTInterest in studying neonatal development and the improved healing response observed in neonates is increasing, with the goal of using this work to create better therapeutics for tendon injury. Decorin and biglycan are two small leucine-rich proteoglycans that play important roles in collagen fibrillogenesis to develop, maintain, and repair tendon structure. However, little is known about the roles of decorin and biglycan in early neonatal development and healing. The goal of this study was to determine the effects of decorin and bi...
Source: Annals of Biomedical Engineering - December 11, 2023 Category: Biomedical Engineering Authors: Zakary M Beach Courtney A Nuss Stephanie N Weiss Louis J Soslowsky Source Type: research
Super-Resolution Reconstruction of CT Images Based on Multi-scale Information Fused Generative Adversarial Networks
Ann Biomed Eng. 2023 Dec 8. doi: 10.1007/s10439-023-03412-w. Online ahead of print.ABSTRACTThe popularization and widespread use of computed tomography (CT) in the field of medicine evocated public attention to the potential radiation exposure endured by patients. Reducing the radiation dose may lead to scattering noise and low resolution, which can adversely affect the radiologists' judgment. Hence, this paper introduces a new network called PANet-UP-ESRGAN (PAUP-ESRGAN), specifically designed to obtain low-dose CT (LDCT) images with high peak signal-to-noise ratio (PSNR) and high resolution (HR). The model was trained on...
Source: Annals of Biomedical Engineering - December 8, 2023 Category: Biomedical Engineering Authors: Xiaobao Liu Shuailin Su Wenjuan Gu Tingqiang Yao Jihong Shen Yin Mo Source Type: research
Super-Resolution Reconstruction of CT Images Based on Multi-scale Information Fused Generative Adversarial Networks
Ann Biomed Eng. 2023 Dec 8. doi: 10.1007/s10439-023-03412-w. Online ahead of print.ABSTRACTThe popularization and widespread use of computed tomography (CT) in the field of medicine evocated public attention to the potential radiation exposure endured by patients. Reducing the radiation dose may lead to scattering noise and low resolution, which can adversely affect the radiologists' judgment. Hence, this paper introduces a new network called PANet-UP-ESRGAN (PAUP-ESRGAN), specifically designed to obtain low-dose CT (LDCT) images with high peak signal-to-noise ratio (PSNR) and high resolution (HR). The model was trained on...
Source: Annals of Biomedical Engineering - December 8, 2023 Category: Biomedical Engineering Authors: Xiaobao Liu Shuailin Su Wenjuan Gu Tingqiang Yao Jihong Shen Yin Mo Source Type: research
Super-Resolution Reconstruction of CT Images Based on Multi-scale Information Fused Generative Adversarial Networks
Ann Biomed Eng. 2023 Dec 8. doi: 10.1007/s10439-023-03412-w. Online ahead of print.ABSTRACTThe popularization and widespread use of computed tomography (CT) in the field of medicine evocated public attention to the potential radiation exposure endured by patients. Reducing the radiation dose may lead to scattering noise and low resolution, which can adversely affect the radiologists' judgment. Hence, this paper introduces a new network called PANet-UP-ESRGAN (PAUP-ESRGAN), specifically designed to obtain low-dose CT (LDCT) images with high peak signal-to-noise ratio (PSNR) and high resolution (HR). The model was trained on...
Source: Annals of Biomedical Engineering - December 8, 2023 Category: Biomedical Engineering Authors: Xiaobao Liu Shuailin Su Wenjuan Gu Tingqiang Yao Jihong Shen Yin Mo Source Type: research
Optimization of the IntraVascular Oxygenator Catheter Using Angular Oscillation
Ann Biomed Eng. 2023 Dec 7. doi: 10.1007/s10439-023-03411-x. Online ahead of print.ABSTRACTWe demonstrate a methodology which both improves oxygen transport and reduces or eliminates bubble formation in a novel hyperbaric membrane oxygenator catheter model system. Angular oscillations were introduced to a bundle of hollow fiber membranes (HFMs) supplied with hyperbaric 100% oxygen at average gauge pressures up to 0.35 barg. Oscillating bundles enabled delivery of an oxygen flux of up to 400 mL min-1 m-2 in an aqueous solution, a doubling over a previous non-oscillating setup. Similarly, the addition of angular oscillations...
Source: Annals of Biomedical Engineering - December 7, 2023 Category: Biomedical Engineering Authors: Stewart Farling Bruce Klitzman Travis P Vesel Ira M Cheifetz Tobias L Straube Marc A Deshusses Source Type: research
Treatment with PB125 < sup > ® < /sup > Increases Femoral Long Bone Strength in 15-Month-Old Female Hartley Guinea Pigs
Ann Biomed Eng. 2023 Dec 3. doi: 10.1007/s10439-023-03415-7. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor-2 (Nrf2) is a transcription factor that serves as a master regulator of anti-inflammatory agents, phase I xenobiotic, and phase II antioxidant enzymes, all of which provide a cytoprotective role during disease progression. We hypothesized that oral administration of a purported phytochemical Nrf2-activator, PB125®, would increase long bone strength in aging Hartley guinea pigs, a model prone to musculoskeletal decline. Male (N = 56) and female (N = 56) guinea pigs were randomly assigned to r...
Source: Annals of Biomedical Engineering - December 3, 2023 Category: Biomedical Engineering Authors: K M Andrie D R Palmer O Wahl S Bork M Campbell M A Walsh J Sanford R V Musci Karyn L Hamilton Kelly S Santangelo Christian M Puttlitz Source Type: research
Treatment with PB125 < sup > ® < /sup > Increases Femoral Long Bone Strength in 15-Month-Old Female Hartley Guinea Pigs
Ann Biomed Eng. 2023 Dec 3. doi: 10.1007/s10439-023-03415-7. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor-2 (Nrf2) is a transcription factor that serves as a master regulator of anti-inflammatory agents, phase I xenobiotic, and phase II antioxidant enzymes, all of which provide a cytoprotective role during disease progression. We hypothesized that oral administration of a purported phytochemical Nrf2-activator, PB125®, would increase long bone strength in aging Hartley guinea pigs, a model prone to musculoskeletal decline. Male (N = 56) and female (N = 56) guinea pigs were randomly assigned to r...
Source: Annals of Biomedical Engineering - December 3, 2023 Category: Biomedical Engineering Authors: K M Andrie D R Palmer O Wahl S Bork M Campbell M A Walsh J Sanford R V Musci Karyn L Hamilton Kelly S Santangelo Christian M Puttlitz Source Type: research
Treatment with PB125 < sup > ® < /sup > Increases Femoral Long Bone Strength in 15-Month-Old Female Hartley Guinea Pigs
Ann Biomed Eng. 2023 Dec 3. doi: 10.1007/s10439-023-03415-7. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor-2 (Nrf2) is a transcription factor that serves as a master regulator of anti-inflammatory agents, phase I xenobiotic, and phase II antioxidant enzymes, all of which provide a cytoprotective role during disease progression. We hypothesized that oral administration of a purported phytochemical Nrf2-activator, PB125®, would increase long bone strength in aging Hartley guinea pigs, a model prone to musculoskeletal decline. Male (N = 56) and female (N = 56) guinea pigs were randomly assigned to r...
Source: Annals of Biomedical Engineering - December 3, 2023 Category: Biomedical Engineering Authors: K M Andrie D R Palmer O Wahl S Bork M Campbell M A Walsh J Sanford R V Musci Karyn L Hamilton Kelly S Santangelo Christian M Puttlitz Source Type: research
Treatment with PB125 < sup > ® < /sup > Increases Femoral Long Bone Strength in 15-Month-Old Female Hartley Guinea Pigs
Ann Biomed Eng. 2023 Dec 3. doi: 10.1007/s10439-023-03415-7. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor-2 (Nrf2) is a transcription factor that serves as a master regulator of anti-inflammatory agents, phase I xenobiotic, and phase II antioxidant enzymes, all of which provide a cytoprotective role during disease progression. We hypothesized that oral administration of a purported phytochemical Nrf2-activator, PB125®, would increase long bone strength in aging Hartley guinea pigs, a model prone to musculoskeletal decline. Male (N = 56) and female (N = 56) guinea pigs were randomly assigned to r...
Source: Annals of Biomedical Engineering - December 3, 2023 Category: Biomedical Engineering Authors: K M Andrie D R Palmer O Wahl S Bork M Campbell M A Walsh J Sanford R V Musci Karyn L Hamilton Kelly S Santangelo Christian M Puttlitz Source Type: research
Fibrin Hydrogel Layer-Anchored Pericardial Matrix Prevents Epicardial Adhesion in the Severe Heart Adhesion-Induced Miniature Pig Model
Ann Biomed Eng. 2023 Dec 2. doi: 10.1007/s10439-023-03373-0. Online ahead of print.ABSTRACTPostoperative adhesion is a very common and serious complication that occurs frequently in cardiac surgery. The purpose of this study was to evaluate the efficacy of a fibrin hydrogel layer-anchored decellularized pericardial matrix in preventing pericardial adhesions in a miniature pig model with a myocardial injury. Fibrin hydrogel layer-anchored decellularized pericardial matrix was prepared by spraying a mixture of fibrinogen and thrombin on a fibrinogen-doped decellularized pericardium. Cardiac injury was generated by abrading a...
Source: Annals of Biomedical Engineering - December 2, 2023 Category: Biomedical Engineering Authors: Yoshihide Hashimoto Akitatsu Yamashita Masaki Tabuchi Yongwei Zhang Seiichi Funamoto Akio Kishida Source Type: research
Optical Elastography for Micropressure Characterization of Zebrafish Embryonic Cardiac Development
Ann Biomed Eng. 2023 Nov 30. doi: 10.1007/s10439-023-03413-9. Online ahead of print.ABSTRACTThe proper formation of the vertebrate embryonic heart relies on various mechanical forces which determine its form and function. Measuring these forces at the microscale of the embryo is a challenge. We propose a new tool utilizing high-resolution optical elastography and stiffness measurements of surrounding tissues to non-invasively track the changes in the pressure exerted by the heart on the neighboring yolk, as well as changes in contractile patterns during early cardiac growth in-vivo, using the zebrafish embryo as a model sy...
Source: Annals of Biomedical Engineering - November 30, 2023 Category: Biomedical Engineering Authors: Anand G Vaish Yuji Tomizawa David F Daggett Kazunori Hoshino Source Type: research
Optical Elastography for Micropressure Characterization of Zebrafish Embryonic Cardiac Development
Ann Biomed Eng. 2023 Nov 30. doi: 10.1007/s10439-023-03413-9. Online ahead of print.ABSTRACTThe proper formation of the vertebrate embryonic heart relies on various mechanical forces which determine its form and function. Measuring these forces at the microscale of the embryo is a challenge. We propose a new tool utilizing high-resolution optical elastography and stiffness measurements of surrounding tissues to non-invasively track the changes in the pressure exerted by the heart on the neighboring yolk, as well as changes in contractile patterns during early cardiac growth in-vivo, using the zebrafish embryo as a model sy...
Source: Annals of Biomedical Engineering - November 30, 2023 Category: Biomedical Engineering Authors: Anand G Vaish Yuji Tomizawa David F Daggett Kazunori Hoshino Source Type: research
Optical Elastography for Micropressure Characterization of Zebrafish Embryonic Cardiac Development
Ann Biomed Eng. 2023 Nov 30. doi: 10.1007/s10439-023-03413-9. Online ahead of print.ABSTRACTThe proper formation of the vertebrate embryonic heart relies on various mechanical forces which determine its form and function. Measuring these forces at the microscale of the embryo is a challenge. We propose a new tool utilizing high-resolution optical elastography and stiffness measurements of surrounding tissues to non-invasively track the changes in the pressure exerted by the heart on the neighboring yolk, as well as changes in contractile patterns during early cardiac growth in-vivo, using the zebrafish embryo as a model sy...
Source: Annals of Biomedical Engineering - November 30, 2023 Category: Biomedical Engineering Authors: Anand G Vaish Yuji Tomizawa David F Daggett Kazunori Hoshino Source Type: research
Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses
This study introduces a new method of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TM...
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Zaid S Salameh Kenneth N Aycock Nastaran Alinezhadbalalami Khan Mohammad Imran Iain H McKillop Irving C Allen Rafael V Davalos Source Type: research
Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves
In this study, our key contributions include: (i) a first-of-its-kind demonstration of the BO method used for the AHV iFEA; and (ii) the evaluation of a candidate AHV in-silico modeling approach wherein the chordae could be substituted with equivalent displacement boundary conditions, rendering the better iFEA convergence and a smoother objective surface.PMID:37989903 | DOI:10.1007/s10439-023-03408-6 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - November 22, 2023 Category: Biomedical Engineering Authors: Colton J Ross Devin W Laurence Ankush Aggarwal Ming-Chen Hsu Arshid Mir Harold M Burkhart Chung-Hao Lee Source Type: research
