Developing and Validating a Model of Humeral Stem Primary Stability, Intended for In Silico Clinical Trials
Ann Biomed Eng. 2024 Feb 15. doi: 10.1007/s10439-024-03452-w. Online ahead of print.ABSTRACTIn silico clinical trials (ISCT) can contribute to demonstrating a device's performance via credible computational models applied on virtual cohorts. Our purpose was to establish the credibility of a model for assessing the risk of humeral stem loosening in total shoulder arthroplasty, based on a twofold validation scheme involving both benchtop and clinical validation activities, for ISCT applications. A finite element model computing bone-implant micromotion (benchtop model) was quantitatively compared to a bone foam micromotion t...
Source: Annals of Biomedical Engineering - February 16, 2024 Category: Biomedical Engineering Authors: Ghislain Maquer Christine Mueri Adam Henderson Jeff Bischoff Philippe Favre Source Type: research
Cardiorespiratory Sensors and Their Implications for Out-of-Hospital Cardiac Arrest Detection: A Systematic Review
Ann Biomed Eng. 2024 Feb 15. doi: 10.1007/s10439-024-03442-y. Online ahead of print.ABSTRACTOut-of-hospital cardiac arrest (OHCA) is a major health problem, with a poor survival rate of 2-11%. For the roughly 75% of OHCAs that are unwitnessed, survival is approximately 2-4.4%, as there are no bystanders present to provide life-saving interventions and alert Emergency Medical Services. Sensor technologies may reduce the number of unwitnessed OHCAs through automated detection of OHCA-associated physiological changes. However, no technologies are widely available for OHCA detection. This review identifies research and commerc...
Source: Annals of Biomedical Engineering - February 15, 2024 Category: Biomedical Engineering Authors: Saud Lingawi Jacob Hutton Mahsa Khalili Babak Shadgan Jim Christenson Brian Grunau Calvin Kuo Source Type: research
Preparation of Decellularized Tissue as Dual Cell Carrier Systems: A Step Towards Facilitating Re-epithelization and Cell Encapsulation for Tracheal Reconstruction
This study underscores the versatility of the trachea in producing two distinct cell carriers-decellularized scaffold and hydrogel-both containing the native biochemical niche essential for tracheal tissue engineering applications.PMID:38353908 | DOI:10.1007/s10439-024-03448-6 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - February 14, 2024 Category: Biomedical Engineering Authors: Pensuda Sompunga Watchareewan Rodprasert Sayamon Srisuwatanasagul Somporn Techangamsuwan Sirinee Jirajessada Rattanavinan Hanchaina Thaned Kangsamaksin Supansa Yodmuang Chenphop Sawangmake Source Type: research
Computational Analysis of the Effects of Fiber Deformation on the Microstructure and Permeability of Blood Oxygenator Bundles
Ann Biomed Eng. 2024 Feb 13. doi: 10.1007/s10439-024-03446-8. Online ahead of print.ABSTRACTMechanical loads on the polymeric fibers of oxygenating bundles are commonly present due to bundle press-fitting during device assembly and blood pressure load. However, computational fluid dynamics (CFD) simulations for fiber bundle optimization neglect possible changes in microstructure due to such deformations. The aim of this study is to investigate the impact of fiber deformability on bundle microstructure and fluid dynamics mainly in terms of permeability. Fibers from commercial mats typically used for blood oxygenators were m...
Source: Annals of Biomedical Engineering - February 13, 2024 Category: Biomedical Engineering Authors: Gianluca Poletti Davide Ninarello Giancarlo Pennati Source Type: research
On the Impact of Residual Strains in the Stress Analysis of Patient-Specific Atherosclerotic Carotid Vessels: Predictions Based on the Homogenous Stress Hypothesis
In conclusion, the incorporation of residual strains in biomechanical studies of atherosclerotic carotids may be important for a reliable assessment of fibrous plaque cap stress.PMID:38349443 | DOI:10.1007/s10439-024-03458-4 (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - February 13, 2024 Category: Biomedical Engineering Authors: Alessandro Mastrofini Michele Marino Eva Karl öf Ulf Hedin T Christian Gasser Source Type: research
Non-invasive Estimation of Pressure Drop Across Aortic Coarctations: Validation of 0D and 3D Computational Models with In Vivo Measurements
The objective of this study was to evaluate the accuracy of [Formula: see text] estimates derived non-invasively using patient-specific 0D and 3D deformable wall simulations. Medical imaging and routine clinical measurements were used to create patient-specific models of patients with CoA (N = 17). 0D simulations were performed first and used to tune boundary conditions and initialize 3D simulations. [Formula: see text] across the CoA estimated using both 0D and 3D simulations were compared to invasive catheter-based pressure measurements for validation. The 0D simulations were extremely efficient ([Formula: see text] 15 s...
Source: Annals of Biomedical Engineering - February 10, 2024 Category: Biomedical Engineering Authors: Priya J Nair Martin R Pfaller Seraina A Dual Doff B McElhinney Daniel B Ennis Alison L Marsden Source Type: research
Personalized Pressure Conditions and Calibration for a Predictive Computational Model of Coronary and Myocardial Blood Flow
Ann Biomed Eng. 2024 Feb 9. doi: 10.1007/s10439-024-03453-9. Online ahead of print.ABSTRACTPredictive modeling of hyperemic coronary and myocardial blood flow (MBF) greatly supports diagnosis and prognostic stratification of patients suffering from coronary artery disease (CAD). In this work, we propose a novel strategy, using only readily available clinical data, to build personalized inlet conditions for coronary and MBF models and to achieve an effective calibration for their predictive application to real clinical cases. Experimental data are used to build personalized pressure waveforms at the aortic root, representat...
Source: Annals of Biomedical Engineering - February 9, 2024 Category: Biomedical Engineering Authors: Giovanni Montino Pelagi Andrea Baggiano Francesco Regazzoni Laura Fusini Marco Al ì Gianluca Pontone Giovanni Valbusa Christian Vergara Source Type: research
Characteristics of Acute Cartilage Response After Mechanical Loading in Patients with Early-Mild Knee Osteoarthritis
This study determined whether the acute cartilage response, assessed by cartilage thickness and echo intensity, differs between patients with early-mild knee osteoarthritis (OA) and healthy controls. We recruited 56 women aged ≥ 50 years with Kellgren-Lawrence (KL) grade ≤ 2 (age, 70.6 ± 7.4 years; height, 153.7 ± 5.2 cm; weight, 51.9 ± 8.2 kg). Based on KL grades and knee symptoms, the participants were classified into control (KL ≤ 1, asymptomatic, n = 27) and early-mild knee OA groups (KL 1 and symptomatic, KL 2, n = 29). Medial femoral cartilage thickness and echo intensity were assessed using ultrasonographic...
Source: Annals of Biomedical Engineering - February 8, 2024 Category: Biomedical Engineering Authors: Shogo Okada Masashi Taniguchi Masahide Yagi Yoshiki Motomura Sayaka Okada Kaede Nakazato Yoshihiro Fukumoto Masashi Kobayashi Kyoseki Kanemitsu Noriaki Ichihashi Source Type: research
Analysis of the Adherent Cell Response to the Substrate Stiffness Using Tensegrity
In this study, we are looking to examine the reaction of the cell to a variety of substrate stiffnesses and explain the relationship between cell behavior and substrate mechanical properties. However, which tensegrity structure is appropriate for modeling a living cell? Is the structure's complexity play a major role? We used two spherical tensegrities with different complexities to assess the impact of the structure on the cell's mechanical response versus substrate's stiffness. Six- and twelve-strut tensegrities together with membrane, cytoplasm, nucleoskeleton, and nucleus envelope were assembled in Abaqus package to cr...
Source: Annals of Biomedical Engineering - February 7, 2024 Category: Biomedical Engineering Authors: Gholamreza Mohammadi Khounsaraki Mehdi Movahedi Hanieh Niroomand Oscuii Arkady Voloshin Source Type: research
Shear Histories Alter Local Shear Effects on Thrombus Nucleation and Growth
Ann Biomed Eng. 2024 Feb 6. doi: 10.1007/s10439-023-03439-z. Online ahead of print.ABSTRACTOur goal was to determine the impact of physiological and pathological shear histories on platelet nucleation and thrombus growth at various local shear rates. We designed and characterized a microfluidic device capable of subjecting platelets to shear histories reaching as high as 6700 s[Formula: see text] in a single passage. Time-lapse videos of platelets and thrombi are captured using fluorescence microscopy. Thrombi are tracked, and the degree of thrombosis is evaluated through surface coverage, platelet nucleation maps, and ens...
Source: Annals of Biomedical Engineering - February 6, 2024 Category: Biomedical Engineering Authors: Junhyuk Kang Anjana Jayaraman James F Antaki Brian Kirby Source Type: research
Induced Current Electro-Thermal Imaging for Breast Tumor Detection: A Numerical and Experimental Study
This study proposes using magnetically induced currents in medical infrared imaging to increase the temperature contrast due to the electrical conductivity differences between tumors and healthy tissues. There are two objectives: (1) to investigate the feasibility of this active method for surface and deep tumors using numerical simulations, and (2) to demonstrate the use of this method through different experiments conducted with phantoms that mimic breast tissues. Tumorous breasts were numerically modeled and simulated in active and passive modes. At 750 kHz, the applied current was limited for breast tissue-tumor conduc...
Source: Annals of Biomedical Engineering - February 6, 2024 Category: Biomedical Engineering Authors: Volkan Tanr ıverdi Nevzat G Gen çer Source Type: research
Structural and Mechanical Properties of Human Superficial Femoral and Popliteal Arteries
Ann Biomed Eng. 2024 Feb 6. doi: 10.1007/s10439-023-03435-3. Online ahead of print.ABSTRACTThe femoropopliteal artery (FPA) is the main artery in the lower limb. It supplies blood to the leg muscles and undergoes complex deformations during limb flexion. Atherosclerotic disease of the FPA (peripheral arterial disease, PAD) is a major public health burden, and despite advances in surgical and interventional therapies, the clinical outcomes of PAD repairs continue to be suboptimal, particularly in challenging calcified lesions and biomechanically active locations. A better understanding of human FPA mechanical and structural...
Source: Annals of Biomedical Engineering - February 6, 2024 Category: Biomedical Engineering Authors: Ramin Shahbad Margarita Pipinos Majid Jadidi Anastasia Desyatova Jennifer Gamache Jason MacTaggart Alexey Kamenskiy Source Type: research
Large Language Models and Healthcare Alliance: Potential and Challenges of Two Representative Use Cases
Ann Biomed Eng. 2024 Feb 3. doi: 10.1007/s10439-024-03454-8. Online ahead of print.ABSTRACTLarge language models (LLMS) emerge as the most promising Natural Language Processing approach for clinical practice acceleration (i.e., diagnosis, prevention and treatment procedures). Similarly, intelligent conversational systems that leverage LLMS have disruptively become the future of therapy in the era of ChatGPT. Accordingly, this research addresses the application of LLMS in healthcare, paying particular attention to two relevant use cases: cognitive decline and depression, more specifically, postpartum depression. In the end,...
Source: Annals of Biomedical Engineering - February 3, 2024 Category: Biomedical Engineering Authors: Silvia Garc ía-Méndez Francisco de Arriba-P érez Source Type: research
An Assessment of Sikh Turban's Head Protection in Bicycle Incident Scenarios
Ann Biomed Eng. 2024 Feb 2. doi: 10.1007/s10439-023-03431-7. Online ahead of print.ABSTRACTDue to religious tenets, Sikh population wear turbans and are exempted from wearing helmets in several countries. However, the extent of protection provided by turbans against head injuries during head impacts remains untested. One aim of this study was to provide the first-series data of turbans' protective performance under impact conditions that are representative of real-world bicycle incidents and compare it with the performance of bicycle helmets. Another aim was to suggest potential ways for improving turban's protective perfo...
Source: Annals of Biomedical Engineering - February 2, 2024 Category: Biomedical Engineering Authors: Xiancheng Yu Gurpreet Singh Amritvir Kaur Mazdak Ghajari Source Type: research
Biomechanical Effectivity Evaluation of Single- and Double-Metal-Bar Methods with Rotation and Equilibrium Displacements in Nuss Procedure Simulations
Ann Biomed Eng. 2024 Feb 1. doi: 10.1007/s10439-024-03441-z. Online ahead of print.ABSTRACTSurgical treatment of the pectus excavatum has led to the introduction of the Nuss procedure, a minimally invasive surgical procedure that involves inserting a metal bar under the sternum through a small lateral thoracic incision. An additional metal bar was inserted in patients with pectus excavatum to improve the retention of the restored chest wall after the Nuss procedure. However, a need still exists to analyze the mechanistic advantages and disadvantages of the double-bar method owing to the increased surgical time and proficie...
Source: Annals of Biomedical Engineering - February 1, 2024 Category: Biomedical Engineering Authors: Beop-Yong Lim Hoseok I Chiseung Lee Source Type: research
