Utilizing network pharmacology, molecular docking, and animal models to explore the therapeutic potential of the WenYang FuYuan recipe for cerebral ischemia-reperfusion injury through AGE-RAGE and NF- κB/p38MAPK signaling pathway modulation
CONCLUSION: This study utilized network pharmacology, molecular docking, and animal experiments to identify the potential mechanism of the WenYang FuYuan recipe, which may be associated with the regulation of the AGE-RAGE signaling pathway and the inhibition of target proteins and mRNAs in the downstream NF-kB/p38MAPK pathway.PMID:38697555 | DOI:10.1016/j.exger.2024.112448 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 2, 2024 Category: Geriatrics Authors: Ding Zhang Hongling Qin Wei Chen Junjun Xiang Minghe Jiang Ling Zhang Keqing Zhou Yueqiang Hu Source Type: research
IL-1 β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice
CONCLUSIONS: Taken together, IL-1β appears to be required for the maintenance of standard laboratory diet-induced reductions in plaque burden and increases in multiple indices of plaque stability.PMID:38695167 | DOI:10.1161/ATVBAHA.124.320800 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Santosh Karnewar Vaishnavi Karnewar Rebecca Deaton Laura S Shankman Ernest D Benavente Corey M Williams Xenia Bradley Gabriel F Alencar Gamze B Bulut Sara Kirmani Richard A Baylis Eli R Zunder Hester M den Ruijter Gerard Pasterkamp Gary K Owens Source Type: research
Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research
A "dual-key-and-lock" platform for distinguishing autophagy during neuroinflammation
Biosens Bioelectron. 2024 Apr 27;258:116344. doi: 10.1016/j.bios.2024.116344. Online ahead of print.ABSTRACTAutophagy is an essential degradative process that governs the renewal of organelle and maintains the homeostasis of cellular microenvironment. Its dysregulation has been demonstrated to be an indicator for neuroinflammation. To elucidate the interrelationship between neuroinflammation and autophagy, optical probes are ideal tools as they offer a number of advantages such as high spatiotemporal resolution and non-invasive sensing, which help to visualize the physiological and pathological functions of interested anal...
Source: Biosensors and Bioelectronics - May 2, 2024 Category: Biotechnology Authors: Shuyang Zhai Wei Hu Zhihong Liu Yingbin Liu Source Type: research
Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research
Atrial fibrillation incidence after coronary artery bypass graft surgery and percutaneous coronary intervention: the prospective AFAF cohort study
Conclusion. New-onset atrial fibrillation during 30 days of follow-up was rare after percutaneous coronary intervention but common after coronary artery bypass grafting. A prolonged uninterrupted heart rhythm monitoring strategy identified additional patients in both groups with new-onset atrial fibrillation after discharge.PMID:38695238 | DOI:10.1080/14017431.2024.2347297 (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - May 2, 2024 Category: Cardiology Authors: Anders Wickbom Espen Fengsrud Joakim Alfredsson Johan Engdahl Torbj örn Kalm Anders Ahlsson Source Type: research
Comparison of aspiration catheter performance using adaptive pulsatile aspiration in an < em > in vitro < /em > thrombectomy model
CONCLUSION: APA via the Von Vascular, Inc. ALGO® pump achieved a high success rate in an in vitro MT model. All catheters tested with the pump achieved complete reperfusion in all trials, and complete clot ingestion into the pump was seen in a majority of trials. The promising in vitro performance of APA using multiple catheters warrants future in vivo investigation.PMID:38693768 | DOI:10.1177/15910199241250082 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - May 2, 2024 Category: Radiology Authors: Michael A Silva Sai Sanikommu Pedro Bartkevitch Rodrigues Manning Hanser Ryan Ortiz Victor Gamez Robert M Starke Source Type: research
Health-care-seeking behaviour in patients with hypertension: experience from a dedicated hypertension centre in Bangladesh
Conclusions: Raising awareness among patients and proper referral to specialised hypertension centres could promulgate the patients towards appropriate behaviour.PMID:38696746 | DOI:10.1080/08037051.2024.2339434 (Source: Blood Pressure)
Source: Blood Pressure - May 2, 2024 Category: Hematology Authors: Mohammad Jahid Hasan Md Zakir Hossain Md Anwar Hossain Koustuv Dalal Md Abdul Baset Probal Sutradhar Mahabubul Alam Tamanna Tabassum Jannatul Fardous Paramita Zaman Md Abdur Rafi Md Abdullah Saeed Khan Mohammad Delwer Hossain Hawlader Source Type: research
The possible causal relationship between COVID-19 and imaging markers of cerebral small vessel disease: a Mendelian randomization study
This study aims to explore the causal correlation between COVID-19 and the imaging markers of CSVD using Mendelian randomization (MR) methods.METHODS: Summary-level genome-wide association study (GWAS) statistics for COVID-19 susceptibility, hospitalization, and severity were utilized as proxies for exposure. Large-scale meta-analysis GWAS data on three neuroimaging markers of white matter hyperintensity, lacunar stroke, and brain microbleeds, were employed as outcomes. Our primary MR analysis employed the inverse variance weighted (IVW) approach, supplemented by MR-Egger, weighted median, and MR-PRESSO methods. We also co...
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Jiahao Song Da Zhou Lina Jia Mengqi Wang Duo Lan Jingrun Li Fatime Zara Hassan Hamit Yuchuan Ding Xunming Ji Ran Meng Source Type: research
Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research
Theoretically Based Factors Associated With Stroke Family Caregiver Health
The objective of this study is to determine theoretically based factors associated with unhealthy days in stroke family caregivers.RESEARCH DESIGN AND METHODS: Secondary data analysis was conducted using baseline data from a large randomized controlled clinical trial testing the Telephone Assessment and Skill-Building Kit program with 254 family caregivers of persons who have had strokes. Guided by a conceptual model derived from Lazarus' transactional approach to stress, data were analyzed using multiple regression with unhealthy days as the dependent variable and theoretically based factors as independent variables.RESUL...
Source: Rehabilitation Nursing - May 2, 2024 Category: Rehabilitation Authors: Cleopatra Kum Holly J Jones Elaine L Miller Natalie Kreitzer Tamilyn Bakas Source Type: research
Theoretically Based Factors Associated With Stroke Family Caregiver Health
Rehabil Nurs. 2024 May-Jun 01;49(3):E9-E10. doi: 10.1097/RNJ.0000000000000462.NO ABSTRACTPMID:38696436 | DOI:10.1097/RNJ.0000000000000462 (Source: Rehabilitation Nursing)
Source: Rehabilitation Nursing - May 2, 2024 Category: Rehabilitation Source Type: research
Visual imagery deficits in posterior cortical atrophy
Cogn Neuropsychol. 2024 May 2:1-16. doi: 10.1080/02643294.2024.2346362. Online ahead of print.ABSTRACTVisual imagery has a close overlapping relationship with visual perception. Posterior cortical atrophy (PCA) is a neurodegenerative syndrome marked by early impairments in visuospatial processing and visual object recognition. We asked whether PCA would therefore also be marked by deficits in visual imagery, tested using objective forced-choice questionnaires, and whether imagery deficits would be selective for certain properties. We recruited four patients with PCA and a patient with integrative visual agnosia due to bila...
Source: Cognitive Neuropsychology - May 2, 2024 Category: Psychiatry & Psychology Authors: Connor D Dietz Andrea Albonico Jeremy J Tree Jason J S Barton Source Type: research
Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research
Are we ready for new strategies to prevent stroke in children with sickle cell disease?
Haematologica. 2024 May 2. doi: 10.3324/haematol.2024.285328. Online ahead of print.ABSTRACTNot available.PMID:38695140 | DOI:10.3324/haematol.2024.285328 (Source: Haematologica)
Source: Haematologica - May 2, 2024 Category: Hematology Authors: Giovanna Russo Raffaella Colombatti Source Type: research
