Knockdown of lncRNA AU020206 could inhibit microglia apoptosis in ischemic stroke
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):142-147. doi: 10.14715/cmb/2024.70.3.21.ABSTRACTThe diagnostic biomarkers associated with ischemic stroke (IS) that may have clinical utility remain elucidated. Thus, the potential functional lncRNAs in IS were explored. The Gene Expression Omnibus database provided the transcriptome profile of IS for download. WGCNA analysis and integrated bioinformatics were used to find genes that were differentially expressed (DEGs). The Starbase database created the lncRNA-based ceRNA network. In order to investigate the molecular mechanism and involved pathways of DEGs in IS, function...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Zhihua Chen Wei Hu Jiahong Wang Donggen Rao Jianming Zhu Source Type: research
Improvement in right heart function following kidney transplantation in esrd patients: insights from speckle tracking echocardiography analysis
This study aimed to evaluate the effects of KTx on the right heart chambers in ESRD patients. 57 adult KTx candidates were enrolled in this prospective longitudinal study, while 49 of them were included in the final assessment. Patients underwent a comprehensive cardiac assessment, including conventional echocardiography, speckle tracking echocardiography, and three-dimensional heart modeling both before and after surgery. Echocardiographic assessments showed significant increases in right ventricular (RV) ejection fraction, RV fractional area change (RVFAC), tricuspid annular plain systolic excursion, RV fractional shorte...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Mohammad Khani Amir Moradi Erfan Ghadirzadeh Seyed Pooria Salehi Mashhad Sari Tooba Akbari Source Type: research
Early and Long-Term Results of Simultaneous and Staged Revascularization of Coronary and Carotid Arteries
CONCLUSIONS: This study revealed no significant difference in the impact of simultaneous CABG + CEA or staged CABG/CEA on the incidence of death, stroke, MI, and MACEs over a 30-day and long-term follow-up period. Although the immediate results indicated an increased risk of a complicated course (attributable to overall complications) and more prolonged ventilation after simultaneous CABG + CEA compared with staged CABG/CEA, this did not lead to an increase in fatal complications. Therefore, the implementation of either tactic is considered eligible and appropriate following a thorough operative risk assessment.PMID:386514...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Elena Golukhova Igor Sigaev Milena Keren Inessa Slivneva Bektur Berdibekov Nina Sheikina Olga Kozlova Valery Arakelyan Irina Volkovskaya Tatiana Zavalikhina Susanna Avakova Source Type: research
Elevated gut microbiota metabolite bile acids confer protective effects on clinical prognosis in ischemic stroke patients
CONCLUSION: Serum TBA is an independent risk factor for disability and poor functional outcomes after AIS or TIA, and exerts a protective effects on brain.PMID:38650617 | PMC:PMC11033300 | DOI:10.3389/fnins.2024.1388748 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Zhaobin Wang Jing Li Yingxin Xu Ye Liu Zhe Zhang Qin Xu Jinxi Lin Yong Jiang Yongjun Wang Jing Jing Anxin Wang Xia Meng Source Type: research
Thrombus composition and regulatory T cell expression are associated with clinical outcomes in acute ischemic stroke patients with thrombectomy
CONCLUSIONS: There was no significant correlation between erythrocyte and fibrin/platelet components in thrombus and functional outcome, but increased expression of regulatory T cells was associated with good functional outcome.PMID:38650441 | DOI:10.3724/zdxbyxb-2023-0424 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Jia Luo Jun Ma Source Type: research
Relationship Between Hemorrhage Type and Development of Emotional and Behavioral Dyscontrol After Hemorrhagic Stroke
CONCLUSIONS: Patients with ICH and a low GCS score at admission are at increased risk of developing EBD 3 months after hemorrhagic stroke and may benefit from early intervention.PMID:38650464 | DOI:10.1176/appi.neuropsych.20230114 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - April 23, 2024 Category: Psychiatry Authors: Daniel Talmasov Sean Kelly Sarah Ecker Anlys Olivera Aaron Lord Lindsey Gurin Koto Ishida Kara Melmed Jose Torres Cen Zhang Jennifer Frontera Ariane Lewis Source Type: research
Added Clinical Value of Intraplaque Neovascularization Detection to Color Doppler Ultrasound for Assessing Ischemic Stroke Risk
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - April 23, 2024 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
The Influence of Primary Language on Postoperative Stroke Outcomes
Language barriers have the potential to influence acute stroke outcomes. Thus, we examined postoperative stroke outcomes among non-English primary language speakers. (Source: American Journal of Surgery)
Source: American Journal of Surgery - April 23, 2024 Category: Surgery Authors: Emna Bakillah, Adora Moneme, Danielle Brown, James Sharpe, Michael L. McGarvey, Rachel R. Kelz Source Type: research
A Systematic Review of the Epidemiology and The Public Health Implications of Stroke in Sub-Saharan Africa
With approximately 11 million strokes occurring annually worldwide, and over 6.5 million deaths annually, stroke has made its place as one of the major killers in the world. Although developing countries make up more than 4/5 of the global stroke burden, well-grounded information on stroke epidemiology remains lacking there. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2024 Category: Neurology Authors: Gisele Abissegue, Seidina Iliasu Yakubu, Aiswarya Seema Ajay, Faatihah Niyi-Odumosu Source Type: research
A promising frontier: targeting NETs for stroke treatment breakthroughs
Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and subsequently generate and r... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 23, 2024 Category: Molecular Biology Authors: Huijie Fang, Yunfei Bo, Zhongfei Hao, Ge Mang, Jiaqi Jin and Hongjun Wang Tags: Review Source Type: research
Correction: Emergent carotid stenting versus no stenting for acute ischemic stroke due to tandem occlusion: a meta-analysis
Diana F, Romoli M, Toccaceli G, et al.Emergent carotid stenting versus no stenting for acute ischemic stroke due to tandem occlusion: a meta-analysis. J NeuroIntervent Surg 2023;15:428–433.
Since this paper was first published, figure 3 has been updated, because an article was wrongly included in the analysis. The OR, 95 CI and weight categories have been updated. However, point estimate remains unchanged, and only a minor change to 95%CI emerged. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - April 23, 2024 Category: Neurosurgery Tags: Correction Source Type: research
Mechanical thrombectomy in patients with acute ischemic stroke in the USA before and after time window expansion
Conclusions
The window expansion for mechanical thrombectomy for patients with acute ischemic stroke was associated with an increase in the numbers of mechanical thrombectomy procedures and performing hospitals with a reduction of in-hospital mortality in the USA. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - April 23, 2024 Category: Neurosurgery Authors: Kwok, C. S., Gillani, S. A., Bains, N. K., Gomez, C. R., Hanley, D. F., Ford, D. E., Hassan, A. E., Nguyen, T. N., Siddiq, F., Spiotta, A. M., Qureshi, A. I. Tags: Ischemic stroke Source Type: research
Cost-effectiveness of endovascular therapy for acute ischemic stroke with large infarct in China
Conclusions
Endovascular therapy for acute ischemic stroke with large infarction could be cost-effective in China. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - April 23, 2024 Category: Neurosurgery Authors: Pan, Y., Huo, X., Jin, A., Nguyen, T. N., Ma, G., Tong, X., Zhang, X., Gao, F., Ma, N., Mo, D., Ren, Z., Wang, Y., Miao, Z. Tags: Ischemic stroke Source Type: research
How much of the outcome improvement after successful recanalization is explained by follow-up infarct volume reduction?
Conclusion
56% (95% CI 38% to 78%) of outcome improvement after successful recanalization was explained by FIV reduction. Results corroborate pathophysiological assumptions and confirm the value of FIV as an imaging endpoint in clinical trials. 44% (95% CI 22% to 62%) of the improvement in outcome was not explained by FIV reduction and reflects the remaining mismatch between radiological and clinical outcome measures. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - April 23, 2024 Category: Neurosurgery Authors: Kniep, H., Meyer, L., Broocks, G., Bechstein, M., Austein, F., McDonough, R. V., Brekenfeld, C., Flottmann, F., Deb-Chatterji, M., Alegiani, A., Hanning, U., Thomalla, G., Fiehler, J., Gellissen, S. Tags: Ischemic stroke Source Type: research
Clot composition and recanalization outcomes in mechanical thrombectomy
Conclusions
Despite the lack of correlation between clot histology and FPE, our study adds to the growing evidence supporting the notion that clot composition influences recanalization treatment strategy outcomes. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - April 23, 2024 Category: Neurosurgery Authors: Nogueira, R. G., Pinheiro, A., Brinjikji, W., Abbasi, M., Al-Bayati, A. R., Mohammaden, M. H., Souza Viana, L., Ferreira, F., Abdelhamid, H., Bhatt, N. R., Kvamme, P., Layton, K. F., Delgado Almandoz, J. E., Hanel, R. A., Mendes Pereira, V., Almekhlafi, M Tags: Ischemic stroke Source Type: research
