Obesity and Hypertension Mediate the Effect of Education on Deep Intracerebral Hemorrhage: A Mendelian Randomization Study
Educational attainment (EA) as a stable indicator of socioeconomic status has been confirmed to affect intracerebral hemorrhage (ICH), but the mechanism relating EA and ICH is still unknown. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2024 Category: Neurology Authors: Hao Sun, Yuan Zhong, Lixian Liao, Jujiang Wu, Hongwu Xu, Junqiang Ma Source Type: research

Paul Coyne, DNP, MBA, MS, APRN, AGPCNP-BC
Paul Coyne is a distinguished figure in the realm of health care, currently serving as the Senior Vice President and Chief Nurse Executive at the Hospital for Special Surgery (HSS), the world ’s leading academic medical center focused on musculoskeletal health. His journey from a financial analyst at Goldman Sachs to a luminary in nursing and health care leadership is not just a career transition but a narrative of overcoming personal health challenges, including hypertrophic cardiomyo pathy, a stroke, and the profound vulnerabilities these experiences entailed. (Source: Nurse Leader)
Source: Nurse Leader - May 3, 2024 Category: Nursing Authors: Reynaldo R. Rivera Tags: Leader to Watch Source Type: research

Neuroendovascular Rescue 2025
Neuroendovascular rescue of patients with acute ischemic stroke caused by a large arterial occlusion has evolved throughout the first quarter of the present century, and continues to do so. Starting with the intra-arterial instillation of thrombolytic agents via microcatheters to dissolve occluding thromboembolic material, the current status is one that includes a variety of different techniques such as direct aspiration of thrombus, removal by stent retriever, adjuvant techniques such as balloon angioplasty, stenting, and tactical intra-arterial instillation of thrombolytic agents in smaller branches to treat no-reflow ph...
Source: Neurologic Clinics - May 3, 2024 Category: Neurology Authors: Camilo R. Gomez, Brandi R. French, Francisco E. Gomez, Adnan I. Qureshi Source Type: research

Early vs Late Anticoagulation in Acute Ischemic Stroke with Indications Outside Atrial Fibrillation
Current literature lacks guidance on the safety of administering anticoagulation in acute ischemic stroke with emergent indications that require anticoagulation other than atrial fibrillation. Therefore, we tend to rely on studies investigating acute ischemic stroke in atrial fibrillation for anticoagulation recommendations. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2024 Category: Neurology Authors: Ammar Jumah, Siyuan Fu, Abdalla Jamal Albanna, Utkarsh Agarwal, Michael Fana, Omar Choudhury, Anas Idris, Abdelrahman Elfaham, Zahid Iqbal, Lonni Schultz, Katie Latack, Megan Brady, Dawn Scozzari, Ahmad Riad Ramadan Source Type: research

The impact of sex on epidemiology, management, and outcome of spontaneous intracerebral hemorrhage (sICH)
Data on sex differences in spontaneous intracerebral hemorrhages are limited. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2024 Category: Neurology Authors: Andrea Sterenstein, Rajeev Garg Source Type: research

Sensors, Vol. 24, Pages 2925: Rehabilitation Assessment System for Stroke Patients Based on Fusion-Type Optoelectronic Plethysmography Device and Multi-Modality Fusion Model: Design and Validation
This study aimed to propose a portable and intelligent rehabilitation evaluation system for digital stroke-patient rehabilitation assessment. Specifically, the study designed and developed a fusion device capable of emitting red, green, and infrared lights simultaneously for photoplethysmography (PPG) acquisition. Leveraging the different penetration depths and tissue reflection characteristics of these light wavelengths, the device can provide richer and more comprehensive physiological information. Furthermore, a Multi-Channel Convolutional Neural Network–Long Short-Term Memory–Attention (MCNN...
Source: Sensors - May 3, 2024 Category: Biotechnology Authors: Liangwen Yan Ze Long Jie Qian Jianhua Lin Sheng Quan Xie Bo Sheng Tags: Article Source Type: research

Bilateral cochlear implants in a MELAS patient
ConclusionsMELAS patients receiving bilateral CIs can attain satisfactory post-CI speech recognition, spatial hearing, and sound qualities. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - May 2, 2024 Category: ENT & OMF Source Type: research

Visual imagery deficits in posterior cortical atrophy
Cogn Neuropsychol. 2024 May 2:1-16. doi: 10.1080/02643294.2024.2346362. Online ahead of print.ABSTRACTVisual imagery has a close overlapping relationship with visual perception. Posterior cortical atrophy (PCA) is a neurodegenerative syndrome marked by early impairments in visuospatial processing and visual object recognition. We asked whether PCA would therefore also be marked by deficits in visual imagery, tested using objective forced-choice questionnaires, and whether imagery deficits would be selective for certain properties. We recruited four patients with PCA and a patient with integrative visual agnosia due to bila...
Source: Cognitive Neuropsychology - May 2, 2024 Category: Psychiatry & Psychology Authors: Connor D Dietz Andrea Albonico Jeremy J Tree Jason J S Barton Source Type: research

Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research

Are we ready for new strategies to prevent stroke in children with sickle cell disease?
Haematologica. 2024 May 2. doi: 10.3324/haematol.2024.285328. Online ahead of print.ABSTRACTNot available.PMID:38695140 | DOI:10.3324/haematol.2024.285328 (Source: Haematologica)
Source: Haematologica - May 2, 2024 Category: Hematology Authors: Giovanna Russo Raffaella Colombatti Source Type: research

Utilizing network pharmacology, molecular docking, and animal models to explore the therapeutic potential of the WenYang FuYuan recipe for cerebral ischemia-reperfusion injury through AGE-RAGE and NF- κB/p38MAPK signaling pathway modulation
CONCLUSION: This study utilized network pharmacology, molecular docking, and animal experiments to identify the potential mechanism of the WenYang FuYuan recipe, which may be associated with the regulation of the AGE-RAGE signaling pathway and the inhibition of target proteins and mRNAs in the downstream NF-kB/p38MAPK pathway.PMID:38697555 | DOI:10.1016/j.exger.2024.112448 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 2, 2024 Category: Geriatrics Authors: Ding Zhang Hongling Qin Wei Chen Junjun Xiang Minghe Jiang Ling Zhang Keqing Zhou Yueqiang Hu Source Type: research

IL-1 β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice
CONCLUSIONS: Taken together, IL-1β appears to be required for the maintenance of standard laboratory diet-induced reductions in plaque burden and increases in multiple indices of plaque stability.PMID:38695167 | DOI:10.1161/ATVBAHA.124.320800 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2024 Category: Cardiology Authors: Santosh Karnewar Vaishnavi Karnewar Rebecca Deaton Laura S Shankman Ernest D Benavente Corey M Williams Xenia Bradley Gabriel F Alencar Gamze B Bulut Sara Kirmani Richard A Baylis Eli R Zunder Hester M den Ruijter Gerard Pasterkamp Gary K Owens Source Type: research

Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research

A "dual-key-and-lock" platform for distinguishing autophagy during neuroinflammation
Biosens Bioelectron. 2024 Apr 27;258:116344. doi: 10.1016/j.bios.2024.116344. Online ahead of print.ABSTRACTAutophagy is an essential degradative process that governs the renewal of organelle and maintains the homeostasis of cellular microenvironment. Its dysregulation has been demonstrated to be an indicator for neuroinflammation. To elucidate the interrelationship between neuroinflammation and autophagy, optical probes are ideal tools as they offer a number of advantages such as high spatiotemporal resolution and non-invasive sensing, which help to visualize the physiological and pathological functions of interested anal...
Source: Biosensors and Bioelectronics - May 2, 2024 Category: Biotechnology Authors: Shuyang Zhai Wei Hu Zhihong Liu Yingbin Liu Source Type: research

Combining echocardiography and fluoroscopy imaging in real time for left atrial appendage occlusion - single center experience from Poland
CONCLUSIONS: This study marks the inaugural application of FI in Polish LAAO procedures. FI, offering enhanced visualization and reduced procedure times, holds promise in improving patient safety and treatment efficacy. We recommend its consideration as a standard visualization technique for LAAO procedures.PMID:38693977 | PMC:PMC11059017 | DOI:10.5114/kitp.2024.138575 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marian Burysz Jakub Batko Michalina Helena Malec-Litwinowicz Mariusz Kowalewski Rados ław Adam Litwinowicz Aleksandra Burysz Łukasz Graczykowski Wojciech Olejek Source Type: research