Synthesis and mechanistic study of 2-(trifluoromethyl)-10H-phenoselenazine from double cross coupling reaction
An Acad Bras Cienc. 2024 Apr 5;96(1):e20230745. doi: 10.1590/0001-3765202420230745. eCollection 2024.ABSTRACTPhenoselenazines are nitrogen and selenium-based heterocyclic compounds that have important biological activities. However, their preparation methods are scarce and difficult to handle. The synthesis of a phenoselenazine from a simple and robust CuO nanoparticle catalyzed methodology, using bis-aniline-diselenide and 1,2-dihalobenzenes under microwave irradiation. Also, the double-cross-coupling reaction mechanism for C-Se and C-N bond formation, including the observation of a reaction intermediate by mass spectrome...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: C ássio Siqueira Gianluca Ciancaleoni Sumbal Saba Antonio L Braga Jamal Rafique Giancarlo V Botteselle Source Type: research
Chitosan coated selenium: A versatile nano-delivery system for molecular cargoes
Int J Biol Macromol. 2024 Apr 8:131176. doi: 10.1016/j.ijbiomac.2024.131176. Online ahead of print.ABSTRACTThe use of nanoscale delivery platforms holds tremendous potential to overcome the current limitations associated with the conventional delivery of genetic materials and hydrophobic compounds. Therefore, there is an imperative need to develop a suitable alternative nano-enabled delivery platform to overcome these limitations. This work reports the first one-step hydrothermal synthesis of chitosan functionalized selenium nanoparticles (Selenium-chitosan, SeNP) that are capable of serving as a versatile nanodelivery pla...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Edwin Davidson Jorge Pereira Sebastian Leon Ernesto Navarro Saritha Raman Kavalappara Zachary Murphy Vasileios Anagnostopoulos Sudeep Bag Swadeshmukul Santra Source Type: research
Selenium, diabetes, and their intricate sex-specific relationship
Trends Endocrinol Metab. 2024 Apr 10:S1043-2760(24)00066-3. doi: 10.1016/j.tem.2024.03.004. Online ahead of print.ABSTRACTSelenium (Se) is an essential trace element, which is inserted as selenocysteine (Sec) into selenoproteins during biosynthesis, orchestrating their expression and activity. Se is associated with both beneficial and detrimental health effects; deficient supply or uncontrolled supplementation raises concerns. In particular, Se was associated with an increased incidence of type 2 diabetes (T2D) in a secondary analysis of a randomized controlled trial (RCT). In this review, we discuss the intricate relation...
Source: Trends in Endocrinology and Metabolism: TEM - April 10, 2024 Category: Endocrinology Authors: Kamil Demircan Thilo Samson Chillon Jeyoung Bang Vadim N Gladyshev Lutz Schomburg Source Type: research
Synthesis and mechanistic study of 2-(trifluoromethyl)-10H-phenoselenazine from double cross coupling reaction
An Acad Bras Cienc. 2024 Apr 5;96(1):e20230745. doi: 10.1590/0001-3765202420230745. eCollection 2024.ABSTRACTPhenoselenazines are nitrogen and selenium-based heterocyclic compounds that have important biological activities. However, their preparation methods are scarce and difficult to handle. The synthesis of a phenoselenazine from a simple and robust CuO nanoparticle catalyzed methodology, using bis-aniline-diselenide and 1,2-dihalobenzenes under microwave irradiation. Also, the double-cross-coupling reaction mechanism for C-Se and C-N bond formation, including the observation of a reaction intermediate by mass spectrome...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: C ássio Siqueira Gianluca Ciancaleoni Sumbal Saba Antonio L Braga Jamal Rafique Giancarlo V Botteselle Source Type: research
Synthesis and mechanistic study of 2-(trifluoromethyl)-10H-phenoselenazine from double cross coupling reaction
An Acad Bras Cienc. 2024 Apr 5;96(1):e20230745. doi: 10.1590/0001-3765202420230745. eCollection 2024.ABSTRACTPhenoselenazines are nitrogen and selenium-based heterocyclic compounds that have important biological activities. However, their preparation methods are scarce and difficult to handle. The synthesis of a phenoselenazine from a simple and robust CuO nanoparticle catalyzed methodology, using bis-aniline-diselenide and 1,2-dihalobenzenes under microwave irradiation. Also, the double-cross-coupling reaction mechanism for C-Se and C-N bond formation, including the observation of a reaction intermediate by mass spectrome...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: C ássio Siqueira Gianluca Ciancaleoni Sumbal Saba Antonio L Braga Jamal Rafique Giancarlo V Botteselle Source Type: research
Synthesis and mechanistic study of 2-(trifluoromethyl)-10H-phenoselenazine from double cross coupling reaction
An Acad Bras Cienc. 2024 Apr 5;96(1):e20230745. doi: 10.1590/0001-3765202420230745. eCollection 2024.ABSTRACTPhenoselenazines are nitrogen and selenium-based heterocyclic compounds that have important biological activities. However, their preparation methods are scarce and difficult to handle. The synthesis of a phenoselenazine from a simple and robust CuO nanoparticle catalyzed methodology, using bis-aniline-diselenide and 1,2-dihalobenzenes under microwave irradiation. Also, the double-cross-coupling reaction mechanism for C-Se and C-N bond formation, including the observation of a reaction intermediate by mass spectrome...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: C ássio Siqueira Gianluca Ciancaleoni Sumbal Saba Antonio L Braga Jamal Rafique Giancarlo V Botteselle Source Type: research
Selenium alloyed tellurium oxide for amorphous p-channel transistors
Nature, Published online: 10 April 2024; doi:10.1038/s41586-024-07360-wSelenium alloyed tellurium oxide for amorphous p-channel transistors (Source: Nature AOP)
Source: Nature AOP - April 10, 2024 Category: Research Authors: Ao Liu Yong-Sung Kim Min Gyu Kim Youjin Reo Taoyu Zou Taesu Choi Sai Bai Huihui Zhu Yong-Young Noh Source Type: research
Selenium suppressed growth of Ehrlich solid tumor and improved health of tumor-bearing mice
In conclusion, these findings suggest that Se therapy significantly suppressed solid tumor proliferation and growth while mitigating the health status of tumor-bearing mice.PMID:38591238 | DOI:10.1002/jez.2815 (Source: Cancer Control)
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Heba A Hekal Maggie E Amer Maher Amer Mohamed A El-Missiry Azza I Othman Source Type: research
Transforming Pharmaceutical Synthesis with Sein-E-B Nanocomposite Photocatalyst through 1,4-NAD(P)H Cofactor Regeneration and C-N Bond Activation
Chem Biodivers. 2024 Apr 8:e202400329. doi: 10.1002/cbdv.202400329. Online ahead of print.ABSTRACTThe need for sunlight chemical renewal and contemporary organic transformation has fostered the advancement of environmentally friendly photocatalytic techniques. For the first time, we report on the novel crafting of a bright future with selenium-infused Eosin-B (Sein-E-B) nanocomposite photocatalysts in this work. The Sein-E-B nanocomposite materials were created using a hydrothermal process for solar chemical regeneration and organic transformation under visible light. The synthesized samples were subjected to UV-DRS-visibl...
Source: Chemistry and Biodiversity - April 9, 2024 Category: Biochemistry Authors: Ravindra Shukla Rajesh Yadav Vitthal Gole Rajat Singhal Rehana Shahin Shaifali Mishra Satyam Singh Kanchan Sharma Jin-Ook Baeg Gamal El-Hiti Krishna Yadav Navneet Kumar Gupta Source Type: research
Selenomethionine preconditioned mesenchymal stem cells derived extracellular vesicles exert enhanced therapeutic efficacy in intervertebral disc degeneration
In conclusion, Se-Met facilitated the MSC-derived EVs production and increased miR-125a-5p delivery in Se-EVs, thereby improving the protective effects of MSC-derived EVs on alleviating NPCs senescence and attenuating IDD.PMID:38593507 | DOI:10.1016/j.intimp.2024.112028 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 9, 2024 Category: Allergy & Immunology Authors: Shengli Ma Rui Xue Haiyang Zhu Yu Han Xiang Ji Chaoyang Zhang Na Wei Jingjing Xu Feng Li Source Type: research
Transforming Pharmaceutical Synthesis with Sein-E-B Nanocomposite Photocatalyst through 1,4-NAD(P)H Cofactor Regeneration and C-N Bond Activation
Chem Biodivers. 2024 Apr 8:e202400329. doi: 10.1002/cbdv.202400329. Online ahead of print.ABSTRACTThe need for sunlight chemical renewal and contemporary organic transformation has fostered the advancement of environmentally friendly photocatalytic techniques. For the first time, we report on the novel crafting of a bright future with selenium-infused Eosin-B (Sein-E-B) nanocomposite photocatalysts in this work. The Sein-E-B nanocomposite materials were created using a hydrothermal process for solar chemical regeneration and organic transformation under visible light. The synthesized samples were subjected to UV-DRS-visibl...
Source: Chemistry and Biodiversity - April 9, 2024 Category: Biochemistry Authors: Ravindra Shukla Rajesh Yadav Vitthal Gole Rajat Singhal Rehana Shahin Shaifali Mishra Satyam Singh Kanchan Sharma Jin-Ook Baeg Gamal El-Hiti Krishna Yadav Navneet Kumar Gupta Source Type: research
Selenomethionine preconditioned mesenchymal stem cells derived extracellular vesicles exert enhanced therapeutic efficacy in intervertebral disc degeneration
In conclusion, Se-Met facilitated the MSC-derived EVs production and increased miR-125a-5p delivery in Se-EVs, thereby improving the protective effects of MSC-derived EVs on alleviating NPCs senescence and attenuating IDD.PMID:38593507 | DOI:10.1016/j.intimp.2024.112028 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 9, 2024 Category: Allergy & Immunology Authors: Shengli Ma Rui Xue Haiyang Zhu Yu Han Xiang Ji Chaoyang Zhang Na Wei Jingjing Xu Feng Li Source Type: research
Molecules, Vol. 29, Pages 1686: Herbal Polyphenols as Selenium Reducers in the Green Synthesis of Selenium Nanoparticles: Antibacterial and Antioxidant Capabilities of the Obtained SeNPs
In this study, herbal extracts were used in the green synthesis of SeNPs. The influence of herbal species, the ratio of the reagents, and post-reaction heating on the antibacterial and antioxidant properties of obtained SeNPs were investigated. The relationship between these properties and the physical parameters of obtained nanoparticles (e.g., size, shape) was also studied. It has been proven that SeNPs showed higher antioxidant and antibacterial properties in comparison to herbal extracts taken for their synthesis. Heating of the post-reaction mixture did not affect the SeNP size, shape, or other studied properties. (Source: Molecules)
Source: Molecules - April 9, 2024 Category: Chemistry Authors: Aleksandra Sentkowska Julia Konarska Jakub Szmytke Anna Grudniak Tags: Article Source Type: research
Selenium-modified activated coke: a high-capacity and facile designed Hg < sup > 0 < /sup > adsorbent for coal-fired flue gas
Environ Sci Pollut Res Int. 2024 Apr 8. doi: 10.1007/s11356-024-32995-7. Online ahead of print.ABSTRACTThe substantial amount of mercury emissions from coal-fired flue gas causes severe environmental contamination. With the Minamata Convention now officially in force, it is critical to strengthen mercury pollution control. Existing activated carbon injection technologies suffer from poor desulfurization performance and risk secondary-release risks. Therefore, considering the potential industrial application of adsorbents, we selected cost-effective and readily available activated coke (AC) as the carrier in this study. Fou...
Source: Environmental Science and Pollution Research International - April 8, 2024 Category: Environmental Health Authors: Yang Zheng Lin Zhang Xiaocong Wang Fenghui Guo Yi Xing Guoliang Li Tao Yue Source Type: research
Disease-modifying potential of diphenyl diselenide in an experimental osteoarthritis model
Biochem Biophys Res Commun. 2024 Apr 4;710:149885. doi: 10.1016/j.bbrc.2024.149885. Online ahead of print.ABSTRACTOxidative stress is a key factor in the disruption of cartilage homeostasis during the development of osteoarthritis (OA). Organic selenium (Se)-containing compounds such as diselenides have excellent antioxidant activity and may prevent related diseases. We aimed to examine the benefits of the synthetic small molecule diphenyl diselenide (DPDSe) in OA models in vitro and in vivo. Our findings showed that DPDSe could maintain extracellular matrix (ECM) homeostasis and inhibit reactive oxygen species (ROS) produ...
Source: Biochemical and Biophysical Research communications - April 8, 2024 Category: Biochemistry Authors: Li Qiao Zhiyao Li Peihua Shi Source Type: research
