Synthesis and mechanistic study of 2-(trifluoromethyl)-10H-phenoselenazine from double cross coupling reaction

An Acad Bras Cienc. 2024 Apr 5;96(1):e20230745. doi: 10.1590/0001-3765202420230745. eCollection 2024.ABSTRACTPhenoselenazines are nitrogen and selenium-based heterocyclic compounds that have important biological activities. However, their preparation methods are scarce and difficult to handle. The synthesis of a phenoselenazine from a simple and robust CuO nanoparticle catalyzed methodology, using bis-aniline-diselenide and 1,2-dihalobenzenes under microwave irradiation. Also, the double-cross-coupling reaction mechanism for C-Se and C-N bond formation, including the observation of a reaction intermediate by mass spectrometry have been studied.PMID:38597492 | DOI:10.1590/0001-3765202420230745
Source: An Acad Bras Cienc - Category: Science Authors: Source Type: research