Gut-gonad crosstalk in mice exposed to a "chemical cocktail" combining metabolomics and amplicon sequencing
Food Chem Toxicol. 2024 Mar 30:114627. doi: 10.1016/j.fct.2024.114627. Online ahead of print.ABSTRACTTestes are very prone to be damaged by environmental pollutants, but there is a lack of information about the impact of "chemical cocktails" (CC) on the testicular metabolome and the possible influence in the gut-gonad crosstalk. For this, BALB/c mice were given flumequine and diclofenac orally in food and potentially toxic trace elements (Cd, Hg, As) in drinking water. A mice group was supplemented with selenium, a well-known antagonist against many pollutants. Our results revealed that the steroid 5-alpha-androstan-17-bet...
Source: Food and Chemical Toxicology - April 1, 2024 Category: Food Science Authors: C Parra-Mart ínez M Selma-Royo B Callej ón-Leblic M C Collado N Abril T Garc ía-Barrera Source Type: research
Evaluation of biological selenium nanoparticles on growth performance, histopathology of vital organs and genotoxicity in Japanese quails ( < em > coturnix coturnix japonica) < /em >
Vet Q. 2024 Dec;44(1):1-10. doi: 10.1080/01652176.2024.2319830. Epub 2024 Apr 1.ABSTRACTResearch on the effects of selenium nanoparticles (Se-NPs), particularly in Japanese quails, is lacking, especially regarding the potential for DNA damage. Therefore, this study aimed to investigate the impact of administering 0.2 and 0.4 mg/kg of Se-NPs on the growth performance, DNA integrity, and histopathological alterations of the liver, lung, kidney, and heart in quails. A total of 480 one-day-old Japanese quails were divided into three experimental groups as follows: Group 1 served as the control and received only basic feed, whi...
Source: Veterinary Quarterly - April 1, 2024 Category: Veterinary Research Authors: Shabana Naz Gulnaz Bibi Rida Nadeem Ibrahim A Alhidary Sifa Dai Muhammad Israr Rifat Ullah Khan Source Type: research
The Role of Selenium Nanoparticles in Addressing Diabetic Complications: A Comprehensive Study
Curr Top Med Chem. 2024 Mar 29. doi: 10.2174/0115680266299494240326083936. Online ahead of print.ABSTRACTDiabetes, as an emerging epidemic, has put forward a significant spotlight on the evolving population worldwide grounded upon the remarkable affliction of healthcare along with economical conflict. Various studies suggested that, in modern society, lack of maintenance of a healthy life style leads to the occurrence of diabetes as insulin resistant, later having a damaging effect on the pancreatic β-cells, suggesting various complications. Furthermore, diabetes management is controversial owing to different opinions bas...
Source: Current Topics in Medicinal Chemistry - April 1, 2024 Category: Chemistry Authors: Siddharth Satpathy Lipsa Leena Panigrahi Manoranjan Arakha Source Type: research
Gut-gonad crosstalk in mice exposed to a "chemical cocktail" combining metabolomics and amplicon sequencing
Food Chem Toxicol. 2024 Mar 30:114627. doi: 10.1016/j.fct.2024.114627. Online ahead of print.ABSTRACTTestes are very prone to be damaged by environmental pollutants, but there is a lack of information about the impact of "chemical cocktails" (CC) on the testicular metabolome and the possible influence in the gut-gonad crosstalk. For this, BALB/c mice were given flumequine and diclofenac orally in food and potentially toxic trace elements (Cd, Hg, As) in drinking water. A mice group was supplemented with selenium, a well-known antagonist against many pollutants. Our results revealed that the steroid 5-alpha-androstan-17-bet...
Source: Food and Chemical Toxicology - April 1, 2024 Category: Food Science Authors: C Parra-Mart ínez M Selma-Royo B Callej ón-Leblic M C Collado N Abril T Garc ía-Barrera Source Type: research
Evaluation of biological selenium nanoparticles on growth performance, histopathology of vital organs and genotoxicity in Japanese quails ( < em > coturnix coturnix japonica) < /em >
Vet Q. 2024 Dec;44(1):1-10. doi: 10.1080/01652176.2024.2319830. Epub 2024 Apr 1.ABSTRACTResearch on the effects of selenium nanoparticles (Se-NPs), particularly in Japanese quails, is lacking, especially regarding the potential for DNA damage. Therefore, this study aimed to investigate the impact of administering 0.2 and 0.4 mg/kg of Se-NPs on the growth performance, DNA integrity, and histopathological alterations of the liver, lung, kidney, and heart in quails. A total of 480 one-day-old Japanese quails were divided into three experimental groups as follows: Group 1 served as the control and received only basic feed, whi...
Source: Veterinary Quarterly - April 1, 2024 Category: Veterinary Research Authors: Shabana Naz Gulnaz Bibi Rida Nadeem Ibrahim A Alhidary Sifa Dai Muhammad Israr Rifat Ullah Khan Source Type: research
[PERSPECTIVES] Iron, Copper, and Selenium: Cancer's Thing for Redox Bling
Cells require micronutrients for numerous basic functions. Among these, iron, copper, and selenium are particularly critical for redox metabolism, and their importance is heightened during oncogene-driven perturbations in cancer. In this review, which particularly focuses on iron, we describe how these micronutrients are carefully chaperoned about the body and made available to tissues, a process that is designed to limit the toxicity of free iron and copper or by-products of selenium metabolism. We delineate perturbations in iron metabolism and iron-dependent proteins that are observed in cancer, and describe the current ...
Source: Cold Spring Harbor perspectives in medicine - April 1, 2024 Category: Research Authors: Terzi, E. M., Possemato, R. Tags: Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities PERSPECTIVES Source Type: research
Preoperative serum selenium concentrations and disease-specific survival in patients with oral cancer: a long-term follow-up study
Serum selenium (Se) concentration has been reported to be associated with the incidence of oral cancer. The association between serum Se and long-term survival in oral cancer patients is still unclear. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - April 1, 2024 Category: ENT & OMF Authors: Xiaodan Bao, Fa Chen, Fengqiong Liu, Yu Qiu, Lisong Lin, Jing Wang, Baochang He Source Type: research
Recent Advances on Selenium Nutrition and Keshan Disease
Int Heart J. 2024;65(2):173-179. doi: 10.1536/ihj.23-628.ABSTRACTKeshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It is primarily found in areas in China with low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that selenium deficiency is a major factor in KD development. Selenium is important in removing free radicals and protecting cells and tissues from peroxide-induced damage. Thus, low environmental selenium may affect the selenium level within the human body, and selenium level differences are commonly observed between healthy peo...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Shu-Juan Li An-Wei Wang Kai-Lian Huang Ying Yang Source Type: research
