Fingerprints of Chalcogen Bonding Revealed Through 77Se-NMR
Chemistry. 2024 Mar 20:e202400385. doi: 10.1002/chem.202400385. Online ahead of print.ABSTRACT77Se-NMR is used to characterise several chalcogen bonded complexes of derivatives of the organoselenium drug ebselen, exploring a range of electron demand. NMR titration experiments support the intuitive understanding that chalcogen bond donors bearing more electron withdrawing substituents give rise stronger chalcogen bonds. The chemical shift of the selenium nucleus is also shown to move upfield as it participates in a chalcogen bond. Solid-state NMR is used to explore chalcogen bonding in co-crystals. Due to the lack of molec...
Source: Chemistry - March 20, 2024 Category: Chemistry Authors: Thomas Fellowes Marc Antoine Sani Jonathan White Source Type: research
Tumor Microenvironment-Triggered Self-Adaptive Polymeric Photosensitizers for Enhanced Photodynamic Therapy
Biomacromolecules. 2024 Mar 20. doi: 10.1021/acs.biomac.3c01150. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT) employs photosensitizers to convert nearby oxygen into toxic singlet oxygen (1O2) upon laser light irradiation, showing great potential as a noninvasive approach for tumor ablation. However, the therapeutic efficacy of PDT is essentially impeded by π-π stacking and the aggregation of photosensitizers. Herein, we propose a tumor microenvironment-triggered self-adaptive nanoplatform to weaken the aggregation of photosensitizers by selenium-based oxidation at the tumor site. The selenide units in a selen...
Source: Biomacromolecules - March 20, 2024 Category: Biochemistry Authors: Zepeng Cui Ruqian Ji Jun Xie Chao Wang Jia Tian Weian Zhang Source Type: research
Protective effect of thyroid and restores of ovarian function of Buzhong Yiqi granule on experimental autoimmune thyroiditis in female rats
CONCLUSIONS: BZYQ granule could regulate the thyroid function of EAT rats, reduce thyroid antibody titers, then act on the ovarian function, regulate hormone disorders, and alleviate the pathological damage of rat's ovarian tissues. The effect of high dose Buzhong Yiqi granule is the best.PMID:38504537 | PMC:PMC10927403 | DOI:10.19852/j.cnki.jtcm.20240203.008 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Wang Yuezhu Zhang Yuyang Qiao Jiajun L U Yuyuan Xia Zhongyuan Source Type: research
The interaction effect of dietary selenium intake and the < em > IL10 < /em > rs1800871 polymorphism on the risk of colorectal cancer: a case ‒control study in Korea
Br J Nutr. 2024 Mar 21:1-23. doi: 10.1017/S0007114524000345. Online ahead of print.ABSTRACTThe importance of selenium in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of selenium was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary selenium. Our study aimed to explore whether selenium potentially reduces CRC risk and whether the IL10 rs1800871 polymorphism has an effec...
Source: The British Journal of Nutrition - March 20, 2024 Category: Nutrition Authors: Tao Thi Tran Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim Source Type: research
Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study
CONCLUSIONS This study supports findings from previous studies that low serum selenium levels are associated with colorectal cancer and that selenium deficiency may be a risk factor for colorectal cancer.PMID:38504430 | DOI:10.12659/MSM.942882 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 20, 2024 Category: Research Authors: Micha ł Chalcarz Beniamin Oskar Grabarek Mateusz de Mezer Piotr Krokowicz Janusz Patera Krzysztof Czupryna Jakub Żurawski Source Type: research
Fingerprints of Chalcogen Bonding Revealed Through 77Se-NMR
Chemistry. 2024 Mar 20:e202400385. doi: 10.1002/chem.202400385. Online ahead of print.ABSTRACT77Se-NMR is used to characterise several chalcogen bonded complexes of derivatives of the organoselenium drug ebselen, exploring a range of electron demand. NMR titration experiments support the intuitive understanding that chalcogen bond donors bearing more electron withdrawing substituents give rise stronger chalcogen bonds. The chemical shift of the selenium nucleus is also shown to move upfield as it participates in a chalcogen bond. Solid-state NMR is used to explore chalcogen bonding in co-crystals. Due to the lack of molec...
Source: Chemistry - March 20, 2024 Category: Chemistry Authors: Thomas Fellowes Marc Antoine Sani Jonathan White Source Type: research
Tumor Microenvironment-Triggered Self-Adaptive Polymeric Photosensitizers for Enhanced Photodynamic Therapy
Biomacromolecules. 2024 Mar 20. doi: 10.1021/acs.biomac.3c01150. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT) employs photosensitizers to convert nearby oxygen into toxic singlet oxygen (1O2) upon laser light irradiation, showing great potential as a noninvasive approach for tumor ablation. However, the therapeutic efficacy of PDT is essentially impeded by π-π stacking and the aggregation of photosensitizers. Herein, we propose a tumor microenvironment-triggered self-adaptive nanoplatform to weaken the aggregation of photosensitizers by selenium-based oxidation at the tumor site. The selenide units in a selen...
Source: Biomacromolecules - March 20, 2024 Category: Biochemistry Authors: Zepeng Cui Ruqian Ji Jun Xie Chao Wang Jia Tian Weian Zhang Source Type: research
Protective effect of thyroid and restores of ovarian function of Buzhong Yiqi granule on experimental autoimmune thyroiditis in female rats
CONCLUSIONS: BZYQ granule could regulate the thyroid function of EAT rats, reduce thyroid antibody titers, then act on the ovarian function, regulate hormone disorders, and alleviate the pathological damage of rat's ovarian tissues. The effect of high dose Buzhong Yiqi granule is the best.PMID:38504537 | PMC:PMC10927403 | DOI:10.19852/j.cnki.jtcm.20240203.008 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Wang Yuezhu Zhang Yuyang Qiao Jiajun L U Yuyuan Xia Zhongyuan Source Type: research
The interaction effect of dietary selenium intake and the < em > IL10 < /em > rs1800871 polymorphism on the risk of colorectal cancer: a case ‒control study in Korea
Br J Nutr. 2024 Mar 21:1-23. doi: 10.1017/S0007114524000345. Online ahead of print.ABSTRACTThe importance of selenium in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of selenium was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary selenium. Our study aimed to explore whether selenium potentially reduces CRC risk and whether the IL10 rs1800871 polymorphism has an effec...
Source: The British Journal of Nutrition - March 20, 2024 Category: Nutrition Authors: Tao Thi Tran Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim Source Type: research
Protective effect of thyroid and restores of ovarian function of Buzhong Yiqi granule on experimental autoimmune thyroiditis in female rats
CONCLUSIONS: BZYQ granule could regulate the thyroid function of EAT rats, reduce thyroid antibody titers, then act on the ovarian function, regulate hormone disorders, and alleviate the pathological damage of rat's ovarian tissues. The effect of high dose Buzhong Yiqi granule is the best.PMID:38504537 | PMC:PMC10927403 | DOI:10.19852/j.cnki.jtcm.20240203.008 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Wang Yuezhu Zhang Yuyang Qiao Jiajun L U Yuyuan Xia Zhongyuan Source Type: research
The interaction effect of dietary selenium intake and the < em > IL10 < /em > rs1800871 polymorphism on the risk of colorectal cancer: a case ‒control study in Korea
Br J Nutr. 2024 Mar 21:1-23. doi: 10.1017/S0007114524000345. Online ahead of print.ABSTRACTThe importance of selenium in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of selenium was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary selenium. Our study aimed to explore whether selenium potentially reduces CRC risk and whether the IL10 rs1800871 polymorphism has an effec...
Source: The British Journal of Nutrition - March 20, 2024 Category: Nutrition Authors: Tao Thi Tran Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim Source Type: research
Protective effect of thyroid and restores of ovarian function of Buzhong Yiqi granule on experimental autoimmune thyroiditis in female rats
CONCLUSIONS: BZYQ granule could regulate the thyroid function of EAT rats, reduce thyroid antibody titers, then act on the ovarian function, regulate hormone disorders, and alleviate the pathological damage of rat's ovarian tissues. The effect of high dose Buzhong Yiqi granule is the best.PMID:38504537 | PMC:PMC10927403 | DOI:10.19852/j.cnki.jtcm.20240203.008 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Wang Yuezhu Zhang Yuyang Qiao Jiajun L U Yuyuan Xia Zhongyuan Source Type: research
The interaction effect of dietary selenium intake and the < em > IL10 < /em > rs1800871 polymorphism on the risk of colorectal cancer: a case ‒control study in Korea
Br J Nutr. 2024 Mar 21:1-23. doi: 10.1017/S0007114524000345. Online ahead of print.ABSTRACTThe importance of selenium in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of selenium was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary selenium. Our study aimed to explore whether selenium potentially reduces CRC risk and whether the IL10 rs1800871 polymorphism has an effec...
Source: The British Journal of Nutrition - March 20, 2024 Category: Nutrition Authors: Tao Thi Tran Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim Source Type: research
Protective effect of thyroid and restores of ovarian function of Buzhong Yiqi granule on experimental autoimmune thyroiditis in female rats
CONCLUSIONS: BZYQ granule could regulate the thyroid function of EAT rats, reduce thyroid antibody titers, then act on the ovarian function, regulate hormone disorders, and alleviate the pathological damage of rat's ovarian tissues. The effect of high dose Buzhong Yiqi granule is the best.PMID:38504537 | PMC:PMC10927403 | DOI:10.19852/j.cnki.jtcm.20240203.008 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Wang Yuezhu Zhang Yuyang Qiao Jiajun L U Yuyuan Xia Zhongyuan Source Type: research
The interaction effect of dietary selenium intake and the < em > IL10 < /em > rs1800871 polymorphism on the risk of colorectal cancer: a case ‒control study in Korea
Br J Nutr. 2024 Mar 21:1-23. doi: 10.1017/S0007114524000345. Online ahead of print.ABSTRACTThe importance of selenium in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of selenium was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary selenium. Our study aimed to explore whether selenium potentially reduces CRC risk and whether the IL10 rs1800871 polymorphism has an effec...
Source: The British Journal of Nutrition - March 20, 2024 Category: Nutrition Authors: Tao Thi Tran Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim Source Type: research
