Preparation, characterization and cytotoxicity assessment of a novel selenized polysaccharide from Morchella sextelata
This study suggested that SeMSP-4 could be utilized as a potential selenium source with antioxidant, antitumor, and immunostimulatory activities.PMID:38521308 | DOI:10.1016/j.ijbiomac.2024.131100 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 23, 2024 Category: Biochemistry Authors: Jie Deng Jinying Min Yang Zhang Rumeng You Zuo Zhang Yili Hu Xiaoling Chen Shuiyuan Cheng Xiaolong Ma Shaopeng Zhang Source Type: research
Multifunctional Inorganic-Organic Composite Carriers for Synergistic Dual Therapy of Melanoma
ACS Biomater Sci Eng. 2024 Mar 23. doi: 10.1021/acsbiomaterials.4c00156. Online ahead of print.ABSTRACTMany methods for cancer treatment have been developed. Among them photothermal therapy (PTT) has drawn the most significant attention due to its noninvasiveness, remote control activation, and low side effects. However, a limited depth of light penetration of PTT is the main drawback. To improve the therapeutic efficiency, the development of combined PTT with other therapeutic agents is highly desirable. In this work, we have designed multifunctional composite carriers based on polylactic acid (PLA) particles decorated wi...
Source: Cancer Control - March 23, 2024 Category: Cancer & Oncology Authors: Kseniya A Mitusova Darya R Akhmetova Anna Rogova Timofey E Karpov Yulia A Tishchenko Daler R Dadadzhanov Anna O Matyushevskaya Nina V Gavrilova Evgeny E Priakhin Alexander S Timin Source Type: research
Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study
CONCLUSION: This research highlights the complex relationship between HMM exposure and liver health in Chinese adults, particularly emphasizing metals like manganese, thallium, and selenium. The results suggest a need for public health attention to low dose HMM exposure and underscore the potential benefits of selenium for liver health. Further studies are essential to establish causality.PMID:38518907 | DOI:10.1016/j.envres.2024.118653 (Source: Environmental Research)
Source: Environmental Research - March 22, 2024 Category: Environmental Health Authors: Shiyu Wang Yuebin Lyu Saisai Ji Nankun Liu Bing Wu Feng Zhao Zheng Li Yingli Qu Yuanduo Zhu Linna Xie Yawei Li Zheng Zhang Haocan Song Xiaojian Hu Yidan Qiu Xulin Zheng Wenli Zhang Yanwei Yang Fangyu Li Jiayi Cai Ying Zhu Zhaojin Cao Feng Tan Xiaoming Shi Source Type: research
Interplay between diphenyl diselenide and copper: Impact on D. melanogaster survival, behavior, and biochemical parameters
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 20:109899. doi: 10.1016/j.cbpc.2024.109899. Online ahead of print.ABSTRACTCopper (Cu2+) is a biologically essential element that participates in numerous physiological processes. However, elevated concentrations of copper have been associated with cellular oxidative stress and neurodegenerative diseases. Organo‑selenium compounds such as diphenyl diselenide (DPDS) have in vitro and in vivo antioxidant properties. Hence, we hypothesized that DPDS may modulate the toxicity of Cu2+ in Drosophila melanogaster. The acute effects (4 days of exposure) caused by a high concentra...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 22, 2024 Category: Biochemistry Authors: G S Rieder T Duarte C P Delgado A Rodighiero P A Nogara L Orian M Aschner C L Dalla Corte J B T Da Rocha Source Type: research
Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4
In conclusion, SBP1 plays a functional role in hypoxia-induced tubular cell death. Enhancing SBP1 expression is a potential therapeutic approach for the treatment of AKI.PMID:38518851 | DOI:10.1016/j.cbi.2024.110944 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - March 22, 2024 Category: Molecular Biology Authors: Weihao Zhao David J Nikolic-Paterson Ke Li Yan Li Yinhong Wang Xianghui Chen Zhaoyang Duan Yuzhan Zhang Pengfei Liu Shemin Lu Rongguo Fu Lifang Tian Source Type: research
Interplay between diphenyl diselenide and copper: Impact on D. melanogaster survival, behavior, and biochemical parameters
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 20:109899. doi: 10.1016/j.cbpc.2024.109899. Online ahead of print.ABSTRACTCopper (Cu2+) is a biologically essential element that participates in numerous physiological processes. However, elevated concentrations of copper have been associated with cellular oxidative stress and neurodegenerative diseases. Organo‑selenium compounds such as diphenyl diselenide (DPDS) have in vitro and in vivo antioxidant properties. Hence, we hypothesized that DPDS may modulate the toxicity of Cu2+ in Drosophila melanogaster. The acute effects (4 days of exposure) caused by a high concentra...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 22, 2024 Category: Biochemistry Authors: G S Rieder T Duarte C P Delgado A Rodighiero P A Nogara L Orian M Aschner C L Dalla Corte J B T Da Rocha Source Type: research
Turmeric Extract-loaded Selenium Nanoparticles Counter Doxorubicin-induced Hepatotoxicity in Mice via Repressing Oxidative Stress, Inflammatory Cytokines, and Cell Apoptosis
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Source: Anti-Cancer Agents in Medicinal Chemistry - March 22, 2024 Category: Cancer & Oncology Authors: ALRashdi, Barakat M. Hussein, Mohamed M. Mohammed, Rawan M. Abdelhamed, Nada W. Asaad, Maran E. Alruwaili, Mubarak Alrashidi, Saad M. Habotta, Ola A. Abdel Moneim, Ahmed E. Ramadan, Shimaa S. Tags: Research article Source Type: research
IJERPH, Vol. 21, Pages 381: Essential and Toxic Elements in Infant Cereal in Brazil: Exposure Risk Assessment
The objective of this study was to assess the cancer and non-cancer risk of exposure to essential and toxic elements in infant cereal in Brazil. In our analyses, we included data from 18 samples of infant cereals made from different raw materials and estimated the incremental lifetime cancer risks and non-cancer hazard quotients (HQs) for their consumption. Rice cereal is particularly concerning because it is immensely popular and usually contains high levels of inorganic arsenic. In addition to arsenic, we assessed aluminum, boron, barium, cadmium, chromium, copper, lead, manganese, nickel, selenium, silver, strontium, an...
Source: International Journal of Environmental Research and Public Health - March 22, 2024 Category: Environmental Health Authors: Michele C. Toledo Janice S. Lee Bruno Lemos Batista Kelly P. K. Olympio Adelaide C. Nardocci Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1418: Preparation, Characterization, and Bioactivities of Polysaccharide & ndash;Nano-Selenium and Selenized Polysaccharides from Acanthopanax senticosus
Molecules, Vol. 29, Pages 1418: Preparation, Characterization, and Bioactivities of Polysaccharide–Nano-Selenium and Selenized Polysaccharides from Acanthopanax senticosus
Molecules doi: 10.3390/molecules29071418
Authors:
Xiaoli Li
Ying Li
Xueyan Wang
Rui Zhang
Jiaojiao Xue
Yi Ding
Xiuling Chu
Jianqing Su
Acanthopanax senticosus polysaccharide–nano-selenium (ASPS-SENPS) and A. selenopanax selenized polysaccharides (Se-ASPS) were synthesized, and their characterization and biological properties were compared. The acid extraction method was used to extract the polysaccharides of ...
Source: Molecules - March 22, 2024 Category: Chemistry Authors: Xiaoli Li Ying Li Xueyan Wang Rui Zhang Jiaojiao Xue Yi Ding Xiuling Chu Jianqing Su Tags: Article Source Type: research
Uptake behavior of 73As, 75Se, 197mHg, 212Pb and 210Po on Eichrom pre-filter resin from HCl and HNO3
AbstractThe extraction of73As,75Se,197mHg,212Pb and210Po on Eichrom pre-filter resin was studied in HCl and HNO3 with batch uptake, kinetic and column experiments. There was significant extraction of mercury in HNO3 and HCl, and polonium and selenium in HCl. The kinetics are sufficient to allow for retention on pre-filter columns, and separations of73As from75Se and197mHg, and212Pb from210Po are demonstrated. This retention is important for the development of chemical separations as pre-filter resin is commonly used alongside extraction chromatography resins but its potential for uptake of metal ions is not well characteri...
Source: Journal of Radioanalytical and Nuclear Chemistry - March 22, 2024 Category: Nuclear Medicine Source Type: research
The effect of selenium supplementation on oxidative stress, clinical symptoms and mental health status in patients with migraine: a study protocol for a double-blinded randomized clinical trial
Despite a number of recommended strategies, effective treatment of migraine remains elusive. Given the role of oxidative stress in the pathogenesis of migraine, selenium, as an antioxidant nutrient, may have a... (Source: Trials)
Source: Trials - March 22, 2024 Category: General Medicine Authors: Arghavan Balali, Omid Sadeghi, Javad Anjom-Shoae, Mohammad Hossein Rouhani, Fariborz Khorvash and Gholamreza Askari Tags: Study protocol Source Type: research
Synthesis and characterisation of a nucleotide based pro-drug formulated with a peptide into a nano-chemotherapy for colorectal cancer
J Control Release. 2024 Mar 19:S0168-3659(24)00189-5. doi: 10.1016/j.jconrel.2024.03.036. Online ahead of print.ABSTRACTRecent studies in colorectal cancer patients (CRC) have shown that increased resistance to thymidylate synthase (TS) inhibitors such as 5-fluorouracil (5-FU), reduce the efficacy of standard of care (SoC) treatment regimens. The nucleotide pool cleanser dUTPase is highly expressed in CRC and is an attractive target for potentiating anticancer activity of chemotherapy. The purpose of the current work was to investigate the activity of P1, P4-di(2',5'-dideoxy-5'-selenouridinyl)-tetraphosphate (P4-SedU2), a ...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Jordan J Wilson Lindsey Bennie Olga Eguaogie Ahmed Elkashif Patrick F Conlon Lynn Jena Emma McErlean Niamh Buckley Klaudia Englert Nicholas J Dunne James H R Tucker Joseph S Vyle Helen O McCarthy Source Type: research
