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A Comprehensive Review on GLP-1 Signaling Pathways in the Management of Diabetes Mellitus - Focus on the Potential Role of GLP-1 Receptors Agonists and Selenium Among Various Organ Systems
Curr Diabetes Rev. 2024 Apr 16. doi: 10.2174/0115733998287178240403055901. Online ahead of print.ABSTRACTDiabetes Mellitus develops when the body becomes unable to fuel its cells with glucose, which results in the accumulation of sugar excess in the bloodstream. Because it has diverse pathophysiological impacts on the body, diabetes mellitus represents a significant issue of concern in an attempt to find suitable treatment modalities and medications for afflicted diabetic patients. Glucagon-like peptide 1 (GLP-1) plays a pivotal role in the incretin effect, emerging as a prospective treatment for diabetes mellitus and a pr...
Source: Current Diabetes Reviews - April 17, 2024 Category: Endocrinology Authors: Ghinwa Barakat Ghaith Assi Hussein Khalil Sami El Khatib Source Type: research

Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females). In addition, trace element levels were analyzed in bone marrow samples from the patient gr...
Source: Clinical and Experimental Medicine - April 17, 2024 Category: Research Source Type: research

Room ‐Temperature High‐Performance Photodetector and Phototransistor Based on PdSe2/ZnIn2S4 Alloy Heterojunctions
PdSe2/sulfur vacancies-ZnIn2S4 (Sv-ZIS) alloy heterojunction connected by chemical bonding is proposed for realizing efficient photogenerated carrier transfer. Thanks to the tight interfacial contact and enhanced light absorption of the heterojunction, the as-fabricated photodetectors exhibit excellent performance in terms of photocurrent, switching ratio, responsivity, and detectivity. Moreover, the transistor with gate voltage modulation capability amplifies the photocurrent to the milliampere level and increases the responsivity. AbstractVarious semiconductor devices have been developed based on 2D heterojunction materi...
Source: Small - April 16, 2024 Category: Nanotechnology Authors: Mingchao Li, Wei Guan, Cihui Liu, Fangjian Xing, Yubin Zheng, Yunsong Di, Guiyuan Cao, Shibiao Wei, Ying Wang, Guofeng Yang, Liyan Yu, Zhixing Gan Tags: Research Article Source Type: research

Thyroid dysfunction due to trace element deficiency-not only selenium but also zinc
CONCLUSION: It is important to consider Se and Zn deficiencies when TSH and FT4 levels are elevated. It should also be noted that transient TSH elevation may be observed with Se supplementation.PMID:38625626 | DOI:10.1007/s42000-024-00550-1 (Source: Hormones)
Source: Hormones - April 16, 2024 Category: Endocrinology Authors: Kohei Nagano Yuma Motomura Hironori Bando Masaaki Yamamoto Keitaro Kanie Kei Yoshino Yushi Hirota Tomoko Yamada Michiko Takahashi Hidenori Fukuoka Wataru Ogawa Source Type: research

Unexpected Longer T1 Lifetime of 6-Sulfur Guanine than 6-Selenium Guanine: Solvent Effect from Hydrogen Bond to Brake the Triplet Decay
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D4CP00875H, PaperShaoting Liu, Yuhsuan Lee, Lingfang Chen, Jingheng Deng, Tongmei Ma, Mario Barbatti, Shuming Bai The decay of the T1 state to the ground state is an essential property of photosensitizers because it decides the lifetime of excited states and, thus, the time window for... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 15, 2024 Category: Chemistry Authors: Shaoting Liu Source Type: research

Achromobacter seleniivolatilans sp. nov. and Buttiauxella selenatireducens sp. nov., isolated from the rhizosphere of selenium hyperaccumulator Cardamine hupingshanesis 
Int J Syst Evol Microbiol. 2024 Apr;74(4). doi: 10.1099/ijsem.0.006334.ABSTRACTTwo Gram-stain-negative bacterial strains, R39T and R73T, were isolated from the rhizosphere soil of the selenium hyperaccumulator Cardamine hupingshanesis in China. Strain R39T transformed selenite into elemental and volatile selenium, whereas strain R73T transformed both selenate and selenite into elemental selenium. Phylogenetic and phylogenomic analyses indicated that strain R39T belonged to the genus Achromobacter, while strain R73T belonged to the genus Buttiauxella. Strain R39T (genome size, 6.68 Mb; G+C content, 61.6 mol%) showed the clo...
Source: International Journal of Systematic and Evolutionary Microbiology - April 15, 2024 Category: Microbiology Authors: Sasa Zhang Yi Liu Hao Wang Zhongnan Xu Jing Peng Qiaolin Xu Kui Li Haoyang Wang Yanbin Guo Source Type: research

Constructing network structures to enhance stability and target deposition of selenium nanoparticles via amphiphilic sodium alginate and alkyl glycosides
In this study, sodium alginate (SA) and lysozyme (LZ) were reacted via the wet-heat Maillard reaction (MR) to obtain amphiphilic alginate-based polymers (SA-LZ). Alkyl glycosides (APG) were introduced into SA-LZ to enhance the deposition of SeNPs in leaves. Thus, a renewable and degradable polysaccharide-based material (SA-LZ/APG) loaded with Se formed an amphiphilic alginate-based-based shell with a Se core. Notably, the encapsulation of SeNPs into a polysaccharide base (SA-LZ/APG) increased the stabilization of SeNPs and resulted in orange-red, zero-valent, monoclinic and spherical SeNPs with a mean diameter of approxima...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Xiaona Su Wenyan Liu Bei Yang Shujuan Yang Jinjian Hou Gaobo Yu Yuhong Feng Jiacheng Li Source Type: research

Optimization of CO fermentation by Clostridium carboxidivorans in batch reactors: effects of the medium composition
CONCLUSIONS: The optimization of the medium composition in CO fermentation by Clostridium carboxidivorans is crucial for cost-effective solvent production. Tuning the yeast extract (YE) concentration, using pure cysteine as the reducing agent and reducing trace metal concentration contribute to reasonable solvent production within a relatively short fermentation period. Tungsten is essential for cell growth and solvent production, while selenium is not required.PMID:38614289 | DOI:10.1016/j.anaerobe.2024.102855 (Source: Anaerobe)
Source: Anaerobe - April 13, 2024 Category: Microbiology Authors: F Lanzillo S Pisacane F Raganati M E Russo P Salatino A Marzocchella Source Type: research

Optimization of CO fermentation by Clostridium carboxidivorans in batch reactors: Effects of the medium composition
CONCLUSIONS: The optimization of the medium composition in CO fermentation by Clostridium carboxidivorans is crucial for cost-effective solvent production. Tuning the yeast extract (YE) concentration, using pure cysteine as the reducing agent and reducing trace metal concentration contribute to reasonable solvent production within a relatively short fermentation period. Tungsten is essential for cell growth and solvent production, while selenium is not required.PMID:38614289 | DOI:10.1016/j.anaerobe.2024.102855 (Source: Anaerobe)
Source: Anaerobe - April 13, 2024 Category: Microbiology Authors: F Lanzillo S Pisacane F Raganati M E Russo P Salatino A Marzocchella Source Type: research