Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes
In conclusion, crocetin exerted rapid antidepressant effects via suppressing the expression of inflammatory cytokines and the apoptosis of neuronal cells through PI3K/AKT signaling pathways. The rapid antidepressant effect of crocetin (40 mg/kg) could be maintained for at least 2 days after single treatment.PMID:37935859 | DOI:10.1007/s11064-023-04051-2 (Source: Neurochemical Research)
Source: Neurochemical Research - November 7, 2023 Category: Neuroscience Authors: Susu Lin Ziwei Chen Zhaoruncheng Wu Fei Fei Zijin Xu Yingpeng Tong Wenyu Sun Ping Wang Source Type: research
Sensors, Vol. 23, Pages 9015: Food Safety Issues in the Oltrep & ograve; Pavese Area: A SERS Sensing Perspective
Sensors, Vol. 23, Pages 9015: Food Safety Issues in the Oltrepò Pavese Area: A SERS Sensing Perspective
Sensors doi: 10.3390/s23229015
Authors:
Benedetta Albini
Pietro Galinetto
Serena Schiavi
Enrico Giulotto
Handly and easy-to-use optical instrumentation is very important for food safety monitoring, as it provides the possibility to assess law and health compliances at every stage of the food chain. In particular, the Surface-enhanced Raman Scattering (SERS) method appears highly promising because the intrinsic drawback of Raman spectroscopy, i.e., the natural weakness of the effect and, in turn, ...
Source: Sensors - November 7, 2023 Category: Biotechnology Authors: Benedetta Albini Pietro Galinetto Serena Schiavi Enrico Giulotto Tags: Review Source Type: research
Effect of safranal or candesartan on 3-nitropropionicacid-induced biochemical, behavioral and histological alterations in a rat model of Huntington ’s disease
In conclusion, Safr and Cands may prevent or delay the progression of HD and its associated impairments through their antioxidant, anti-inflammatory, anti-apoptotic and neuromodulator effects. (Source: PLoS One)
Source: PLoS One - November 1, 2023 Category: Biomedical Science Authors: Nagwa Ibrahim Shehata Source Type: research
Small Airway Dysfunction (SAD) in older patients: analysing lung function data from the SAFFRON study
Discussion:There is no evidence of emphysema or hyperinflation on lung function in disCOPD patients, despite the presence of SAD, highlighting the potential for misdiagnosis of early COPD due to silent SAD. Radiology, blood biomarker and functional capacity data, collected as part of the SAFFRON study, will be of benefit.Ref 1: 10.1136/thx.2008.098483 (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Thomas, M., Mansfield, A., Armitage, M., Patel, K., Krishnan, A., Ho, E., Kershaw, M., Chukowry, P., Turner, A. Tags: Monitoring airway disease Source Type: research
Sinomenine Ameliorates IL-1 β-Induced Intervertebral Disc Degeneration in Rats Through Suppressing Inflammation and Oxidative Stress via Keap1/Nrf2/NF-κB Signaling Pathways
CONCLUSION: SN can prevent IL-1β-induced apoptosis of NPCs and ameliorate IDD by activating the Keap1/Nrf2 pathway and inhibiting the NF-κB signaling pathway.PMID:37881650 | PMC:PMC10596063 | DOI:10.2147/JIR.S430423 (Source: Cell Research)
Source: Cell Research - October 26, 2023 Category: Cytology Authors: Gongbiao Lu Cunxin Zhang Kang Li Kai Gao Maoqing Fu Chaoliang Lyu Zhengxue Quan Source Type: research
The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review
Curr Radiopharm. 2023 Oct 24. doi: 10.2174/0118744710268127231020083505. Online ahead of print.ABSTRACTCrocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in tr...
Source: Current Radiopharmaceuticals - October 25, 2023 Category: Radiology Authors: Natalia S Klunko Harun Achmad Tamara Muayad Abdullah Sami Mohammed Indranil Saha Khulood Saadoon Salim Rasha Fadhel Obaid Rosario Mireya Romero-Parra Shaker Shanawa Al-Hasnawi Wissam Hamid Al-Janabi Bagher Farhood Source Type: research
Molecules, Vol. 28, Pages 7238: Hepatoprotective Effect of Medicine Food Homology Flower Saffron against CCl4-Induced Liver Fibrosis in Mice via the Akt/HIF-1 & alpha;/VEGF Signaling Pathway
Molecules, Vol. 28, Pages 7238: Hepatoprotective Effect of Medicine Food Homology Flower Saffron against CCl4-Induced Liver Fibrosis in Mice via the Akt/HIF-1α/VEGF Signaling Pathway
Molecules doi: 10.3390/molecules28217238
Authors:
Huajuan Jiang
Xulong Huang
Jiaxin Wang
Yongfeng Zhou
Chaoxiang Ren
Tao Zhou
Jin Pei
Liver fibrosis refers to a complex inflammatory response caused by multiple factors, which is a known cause of liver cirrhosis and even liver cancer. As a valuable medicine food homology herb, saffron has been widely used in the world. Saffron is commonly used in liver-related disea...
Source: Molecules - October 24, 2023 Category: Chemistry Authors: Huajuan Jiang Xulong Huang Jiaxin Wang Yongfeng Zhou Chaoxiang Ren Tao Zhou Jin Pei Tags: Article Source Type: research
The effects of Crocus sativus extract on inhaled paraquat-induced lung inflammation, oxidative stress, pathological changes and tracheal responsiveness in rats
Toxicon. 2023 Oct 10:107316. doi: 10.1016/j.toxicon.2023.107316. Online ahead of print.ABSTRACTParaquat is a green liquid toxin that is used in agriculture and can induce multi-organ including lung injury. Various pharmacological effects of Crocus sativus (C. sativus) were indicated in previous studies. In this research, the effects of C. sativus extract and pioglitazone on inhaled paraquat-induced lung inflammation, oxidative stress, pathological changes, and tracheal responsiveness were studied in rats. Eight groups of rats (n = 7 in each) including control (Ctrl), untreated paraquat aerosol exposed group (54 mg/m3, 8 ti...
Source: Toxicon - October 12, 2023 Category: Toxicology Authors: Arghavan Memarzia Seyedeh Zahra Ghasemi Sepideh Behrouz Mohammad Hossein Boskabady Source Type: research
The effects of Crocus sativus extract on inhaled paraquat-induced lung inflammation, oxidative stress, pathological changes and tracheal responsiveness in rats
Toxicon. 2023 Oct 10:107316. doi: 10.1016/j.toxicon.2023.107316. Online ahead of print.ABSTRACTParaquat is a green liquid toxin that is used in agriculture and can induce multi-organ including lung injury. Various pharmacological effects of Crocus sativus (C. sativus) were indicated in previous studies. In this research, the effects of C. sativus extract and pioglitazone on inhaled paraquat-induced lung inflammation, oxidative stress, pathological changes, and tracheal responsiveness were studied in rats. Eight groups of rats (n = 7 in each) including control (Ctrl), untreated paraquat aerosol exposed group (54 mg/m3, 8 ti...
Source: Toxicon - October 12, 2023 Category: Toxicology Authors: Arghavan Memarzia Seyedeh Zahra Ghasemi Sepideh Behrouz Mohammad Hossein Boskabady Source Type: research
Antimicrobial and anti-aflatoxigenic activities of nanoemulsions based on Achillea millefolium and Crocus sativus flower extracts as green promising agents for food preservatives
Although the mechanism of action of nanoemulsion is still unclear, the modern use of nanoemulsions made from natural extracts as antimicrobial and anti-aflatoxigenic agents represents a potential food preserva... (Source: BMC Microbiology)
Source: BMC Microbiology - October 7, 2023 Category: Microbiology Authors: Feriala A. Abu Safe, Ahmed N. Badr, Mohamed G. Shehata and Gharieb S. El-Sayyad Tags: Research Source Type: research
