Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model
Curr Issues Mol Biol. 2023 Jun 30;45(7):5558-5574. doi: 10.3390/cimb45070351.ABSTRACTDespite the existence of effective drugs used to treat inflammatory bowel disease (IBD), many patients fail to respond or lose response over time. Further, many drugs can carry serious adverse effects, including increased risk of infections and malignancies. Saffron (Crocus sativus) has been reported to have anti-inflammatory properties. Its protective role in IBD and how the microbiome and metabolome play a role has not been explored extensively. We aimed to establish whether saffron treatment modulates the host microbiome and metabolic p...
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Gulshan Singh Hassan Brim Yeneneh Haileselassie Sudhir Varma Aida Habtezion Mudasir Rashid Sidhartha R Sinha Hassan Ashktorab Source Type: research
Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model
Curr Issues Mol Biol. 2023 Jun 30;45(7):5558-5574. doi: 10.3390/cimb45070351.ABSTRACTDespite the existence of effective drugs used to treat inflammatory bowel disease (IBD), many patients fail to respond or lose response over time. Further, many drugs can carry serious adverse effects, including increased risk of infections and malignancies. Saffron (Crocus sativus) has been reported to have anti-inflammatory properties. Its protective role in IBD and how the microbiome and metabolome play a role has not been explored extensively. We aimed to establish whether saffron treatment modulates the host microbiome and metabolic p...
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Gulshan Singh Hassan Brim Yeneneh Haileselassie Sudhir Varma Aida Habtezion Mudasir Rashid Sidhartha R Sinha Hassan Ashktorab Source Type: research
Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model
Curr Issues Mol Biol. 2023 Jun 30;45(7):5558-5574. doi: 10.3390/cimb45070351.ABSTRACTDespite the existence of effective drugs used to treat inflammatory bowel disease (IBD), many patients fail to respond or lose response over time. Further, many drugs can carry serious adverse effects, including increased risk of infections and malignancies. Saffron (Crocus sativus) has been reported to have anti-inflammatory properties. Its protective role in IBD and how the microbiome and metabolome play a role has not been explored extensively. We aimed to establish whether saffron treatment modulates the host microbiome and metabolic p...
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Gulshan Singh Hassan Brim Yeneneh Haileselassie Sudhir Varma Aida Habtezion Mudasir Rashid Sidhartha R Sinha Hassan Ashktorab Source Type: research
Membrane vesicles from Lactobacillus johnsonii delay osteoarthritis progression via modulating macrophage glutamine synthetase/mTORC1 axis
Biomed Pharmacother. 2023 Jul 25;165:115204. doi: 10.1016/j.biopha.2023.115204. Online ahead of print.ABSTRACTAIMS: The manipulation of macrophage recruitment and their shift in the M1/M2 ratio is a promising approach to mitigate osteoarthritis (OA). Nevertheless, the current clinical medication available for OA is only palliative and may result in undesirable outcomes. Hence, it is urgent to explore alternative disease-modifying drug supplement that are both safer and more effective in OA treatment, like probiotic and probiotic-derived membrane vesicles.METHODS: The synovial inflammation and cartilage damage in collagenas...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 27, 2023 Category: Drugs & Pharmacology Authors: Rangru Liu Yue Zhou Huanxiong Chen Haixia Xu Min Zuo Bo Chen Hua Wang Source Type: research
A novel multi-hyphenated approach to screen and character the xanthine oxidase inhibitors from saffron floral bio-residues
In this study, an integrated approach combining two-dimensional liquid chromatography, surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) was developed to online screen and character the potential XOD inhibitors from SFB. The two-dimensional liquid chromatography consisted of affinity chromatography and reverse phase chromatography (2D-AR), in which an XOD column, an inactive XOD column, and a control column were used in the first dimensional liquid chromatography to avoid phenomena of "false positive" and "missing screen of compounds with weak affinity to XOD" that often occur in the screening proc...
Source: International Journal of Biological Macromolecules - July 27, 2023 Category: Biochemistry Authors: Ran Wang Xingnan Yue Guangzhi Shan Xiaodan Qiu Lan Wang Li Yang Jiaqi Li Bin Yang Source Type: research
Membrane vesicles from Lactobacillus johnsonii delay osteoarthritis progression via modulating macrophage glutamine synthetase/mTORC1 axis
Biomed Pharmacother. 2023 Jul 25;165:115204. doi: 10.1016/j.biopha.2023.115204. Online ahead of print.ABSTRACTAIMS: The manipulation of macrophage recruitment and their shift in the M1/M2 ratio is a promising approach to mitigate osteoarthritis (OA). Nevertheless, the current clinical medication available for OA is only palliative and may result in undesirable outcomes. Hence, it is urgent to explore alternative disease-modifying drug supplement that are both safer and more effective in OA treatment, like probiotic and probiotic-derived membrane vesicles.METHODS: The synovial inflammation and cartilage damage in collagenas...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 27, 2023 Category: Drugs & Pharmacology Authors: Rangru Liu Yue Zhou Huanxiong Chen Haixia Xu Min Zuo Bo Chen Hua Wang Source Type: research
A novel multi-hyphenated approach to screen and character the xanthine oxidase inhibitors from saffron floral bio-residues
In this study, an integrated approach combining two-dimensional liquid chromatography, surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) was developed to online screen and character the potential XOD inhibitors from SFB. The two-dimensional liquid chromatography consisted of affinity chromatography and reverse phase chromatography (2D-AR), in which an XOD column, an inactive XOD column, and a control column were used in the first dimensional liquid chromatography to avoid phenomena of "false positive" and "missing screen of compounds with weak affinity to XOD" that often occur in the screening proc...
Source: International Journal of Biological Macromolecules - July 27, 2023 Category: Biochemistry Authors: Ran Wang Xingnan Yue Guangzhi Shan Xiaodan Qiu Lan Wang Li Yang Jiaqi Li Bin Yang Source Type: research
The role of saffron ( L) on testosterone and depression in andropause middle-aged and elderly men: a systematic review
This study provides researchers with an additional perspective for conducting clinical trials on the use of saffron to enhance the mood of elderly men with testosterone deficiency. (Source: Nutrition and Food Science)
Source: Nutrition and Food Science - July 19, 2023 Category: Nutrition Authors: Shirin Amini Houra Mohseni Behnaz Abiri Sima Jafarirad Source Type: research
Anti-tumor effect of Crocus sativus petals polysaccharides by reconstructing tumor microenvironment
In this study, PCSPB was evaluated for the anti-tumor activity and explored its immunological mechanisms based on tumor microenvironment (TME) using S180 sarcoma-bearing mice. Although PCSPB showed the lower toxicity to a series of tumor cells, it significantly and dose-dependently suppressed the growth of S180 sarcomas transplanted in mice. HE staining, immunohistochemical analysis, and TUNEL assay revealed that PCSPB significantly induced tumor cell necrosis, apoptosis, and vessel disruption in sarcoma tissues. Meanwhile, PCSPB markedly decreased the levels of inflammatory factors TGF-β, IFN-γ, IL-10 and TNF-α and dow...
Source: International Journal of Biological Macromolecules - July 19, 2023 Category: Biochemistry Authors: Jue Tu Yanfei He Huifang Zhang Juanjuan Wang Zhenhao Li Hongxiang Sun Source Type: research
Anti-tumor effect of Crocus sativus petals polysaccharides by reconstructing tumor microenvironment
In this study, PCSPB was evaluated for the anti-tumor activity and explored its immunological mechanisms based on tumor microenvironment (TME) using S180 sarcoma-bearing mice. Although PCSPB showed the lower toxicity to a series of tumor cells, it significantly and dose-dependently suppressed the growth of S180 sarcomas transplanted in mice. HE staining, immunohistochemical analysis, and TUNEL assay revealed that PCSPB significantly induced tumor cell necrosis, apoptosis, and vessel disruption in sarcoma tissues. Meanwhile, PCSPB markedly decreased the levels of inflammatory factors TGF-β, IFN-γ, IL-10 and TNF-α and dow...
Source: International Journal of Biological Macromolecules - July 19, 2023 Category: Biochemistry Authors: Jue Tu Yanfei He Huifang Zhang Juanjuan Wang Zhenhao Li Hongxiang Sun Source Type: research
Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.)
AbstractSafranal is one flavor component of saffron, which is used as a spice, food additive, and crude drug. In ISO3632, safranal is defined as the compound that contributes to the quality of saffron, and many quantitative determination methods for safranal have been reported. However, safranal is volatile and degrades easily during storage, and an analytical standard with an exact known purity is not commercially available, making it difficult to quantify accurately the content of safranal in saffron. Here, we developed a method for quantifying safranal using relative molar sensitivity (RMS), called the RMS method, using...
Source: Journal of Natural Medicines - July 14, 2023 Category: Drugs & Pharmacology Source Type: research
Effects of Aqueous Saffron Extract on Glucoregulation as Well as Hepatic Agt and TNF- α Gene Expression in Rats Subjected to Sub-Chronic Stress
CONCLUSION: Saffron treatment after sub-chronic stress not only did not improve glucose tolerance but also enhanced insulin resistance. It indicated the interaction of saffron and sub-chronic stress to promote renin-angiotensin system activity. In addition, the saffron treatment decreased TNF-α gene expression after sub-chronic stress. The synergistic stimulating effect of saffron and sub-chronic stress on gene expression of hepatic Agt led to insulin resistance and hyperglycemia.PMID:37434936 | PMC:PMC10331535 | DOI:10.4103/abr.abr_51_22 (Source: Biomed Res)
Source: Biomed Res - July 12, 2023 Category: Research Authors: Yeganeh Yazdani Maryam Radahmadi Roshanak Roustazade Source Type: research
Effects of Aqueous Saffron Extract on Glucoregulation as Well as Hepatic Agt and TNF- α Gene Expression in Rats Subjected to Sub-Chronic Stress
CONCLUSION: Saffron treatment after sub-chronic stress not only did not improve glucose tolerance but also enhanced insulin resistance. It indicated the interaction of saffron and sub-chronic stress to promote renin-angiotensin system activity. In addition, the saffron treatment decreased TNF-α gene expression after sub-chronic stress. The synergistic stimulating effect of saffron and sub-chronic stress on gene expression of hepatic Agt led to insulin resistance and hyperglycemia.PMID:37434936 | PMC:PMC10331535 | DOI:10.4103/abr.abr_51_22 (Source: Cell Research)
Source: Cell Research - July 12, 2023 Category: Cytology Authors: Yeganeh Yazdani Maryam Radahmadi Roshanak Roustazade Source Type: research
Effects of Aqueous Saffron Extract on Glucoregulation as Well as Hepatic Agt and TNF- α Gene Expression in Rats Subjected to Sub-Chronic Stress
CONCLUSION: Saffron treatment after sub-chronic stress not only did not improve glucose tolerance but also enhanced insulin resistance. It indicated the interaction of saffron and sub-chronic stress to promote renin-angiotensin system activity. In addition, the saffron treatment decreased TNF-α gene expression after sub-chronic stress. The synergistic stimulating effect of saffron and sub-chronic stress on gene expression of hepatic Agt led to insulin resistance and hyperglycemia.PMID:37434936 | PMC:PMC10331535 | DOI:10.4103/abr.abr_51_22 (Source: Biomed Res)
Source: Biomed Res - July 12, 2023 Category: Research Authors: Yeganeh Yazdani Maryam Radahmadi Roshanak Roustazade Source Type: research
Effects of Aqueous Saffron Extract on Glucoregulation as Well as Hepatic Agt and TNF- α Gene Expression in Rats Subjected to Sub-Chronic Stress
CONCLUSION: Saffron treatment after sub-chronic stress not only did not improve glucose tolerance but also enhanced insulin resistance. It indicated the interaction of saffron and sub-chronic stress to promote renin-angiotensin system activity. In addition, the saffron treatment decreased TNF-α gene expression after sub-chronic stress. The synergistic stimulating effect of saffron and sub-chronic stress on gene expression of hepatic Agt led to insulin resistance and hyperglycemia.PMID:37434936 | PMC:PMC10331535 | DOI:10.4103/abr.abr_51_22 (Source: Biomed Res)
Source: Biomed Res - July 12, 2023 Category: Research Authors: Yeganeh Yazdani Maryam Radahmadi Roshanak Roustazade Source Type: research
