Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
Preventive effects of crocin, a natural compound from saffron, against nicotine ‑induced oxidative stress and neurobehavioral disturbances
In this study, we explore the neuroprotective effects of crocin, a bioactive agent commonly found in saffron - a spice derived from the flower of Crocus sativus - using a rat model. The dose‑dependent effects of crocin were evaluated in nicotine‑induced neurodegeneration and compared with a control group. Neurobehavioral changes, assessed through the elevated plus maze, the open field test, the forced swim test, and the Morris water maze, as well as oxidative stress in the hippocampus, were evaluated. Interestingly, nicotine administration resulted in depression, anxiety, and abnormal motor and cognitive functions, whi...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Majid Motaghinejad Manijeh Motevalian Antoni Sureda Source Type: research
The immunoregulatory property of mesenchymal stem cells in Crocin treatment by expression modulation of microRNA-155, microRNA-21, microRNA-23b, microRNA-126a, and their target inflammatory genes
In conclusion, Crocin could control essential signaling pathways related to the inflammation by regulating the expression of related- miRNAs genes that play a key function in the immune regulation pathways in MSCs. Our findings can give an understanding of the mechanisms by which Crocin enhances the immunomodulatory feature of MSCs. According to the research findings, DP-SCs are probably a better immunomodulator in Crocin treatment than Ad-SCs and it may be helpful for MSCs selection in clinical applications for modulation or treatment of autoimmune disorders.PMID:38583816 | DOI:10.1016/j.gene.2024.148446 (Source: Gene)
Source: Gene - April 7, 2024 Category: Genetics & Stem Cells Authors: Zeinab Rostami Mansoore Saharkhiz Mohsen Khorashadizadeh Malaksima Ayadilord Mohsen Naseri Source Type: research
The immunoregulatory property of mesenchymal stem cells in Crocin treatment by expression modulation of microRNA-155, microRNA-21, microRNA-23b, microRNA-126a, and their target inflammatory genes
In conclusion, Crocin could control essential signaling pathways related to the inflammation by regulating the expression of related- miRNAs genes that play a key function in the immune regulation pathways in MSCs. Our findings can give an understanding of the mechanisms by which Crocin enhances the immunomodulatory feature of MSCs. According to the research findings, DP-SCs are probably a better immunomodulator in Crocin treatment than Ad-SCs and it may be helpful for MSCs selection in clinical applications for modulation or treatment of autoimmune disorders.PMID:38583816 | DOI:10.1016/j.gene.2024.148446 (Source: Gene)
Source: Gene - April 7, 2024 Category: Genetics & Stem Cells Authors: Zeinab Rostami Mansoore Saharkhiz Mohsen Khorashadizadeh Malaksima Ayadilord Mohsen Naseri Source Type: research
Analysis of green word-of-mouth advertising behavior of organic food consumers
In this study, 400 organic saffron consumers were grouped using a self-organizing map (SOM) neural network based on consumer neobehavioristic theory, and then, using decision trees, consumer behavior rules were extracted for participating in the WOM for each group. According to the results, less than fifty percent of consumers in each of the four market segments are willing to participate in WOM advertising for organic saffron. A lack of awareness of the characteristics of organic saffron is also found to be the main reason for consumers' reluctance to recommend organic saffron to others. Mass-media advertising is an effec...
Source: Appetite - April 6, 2024 Category: Nutrition Authors: Flavio Boccia Amirhossein Tohidi Source Type: research
Analysis of green word-of-mouth advertising behavior of organic food consumers
In this study, 400 organic saffron consumers were grouped using a self-organizing map (SOM) neural network based on consumer neobehavioristic theory, and then, using decision trees, consumer behavior rules were extracted for participating in the WOM for each group. According to the results, less than fifty percent of consumers in each of the four market segments are willing to participate in WOM advertising for organic saffron. A lack of awareness of the characteristics of organic saffron is also found to be the main reason for consumers' reluctance to recommend organic saffron to others. Mass-media advertising is an effec...
Source: Appetite - April 6, 2024 Category: Nutrition Authors: Flavio Boccia Amirhossein Tohidi Source Type: research
Analysis of green word-of-mouth advertising behavior of organic food consumers
In this study, 400 organic saffron consumers were grouped using a self-organizing map (SOM) neural network based on consumer neobehavioristic theory, and then, using decision trees, consumer behavior rules were extracted for participating in the WOM for each group. According to the results, less than fifty percent of consumers in each of the four market segments are willing to participate in WOM advertising for organic saffron. A lack of awareness of the characteristics of organic saffron is also found to be the main reason for consumers' reluctance to recommend organic saffron to others. Mass-media advertising is an effec...
Source: Appetite - April 6, 2024 Category: Nutrition Authors: Flavio Boccia Amirhossein Tohidi Source Type: research
206 SAFFRON: Savolitinib + Osimertinib vs Chemotherapy in EGFRm NSCLC with MET Overexpression/Amplification Post-Osimertinib
Osimertinib, a potent, third-generation, oral EGFR-TKI is the preferred first-line treatment in EGFRm advanced NSCLC. However, tumours eventually develop resistance and METoverexpression and/or amplification is the most common acquired resistance mechanism. Savolitinib is an oral, potent, and highly selective MET-TKI. Savolitinib +osimertinib has been investigated in the Ph1B TATTON (NCT02143466)/Ph2 SAVANNAH (NCT03778229) studies. SAFFRON (NCT05261399) aims to assess efficacy/safety of savolitinib+osimertinib vs platinum-based chemotherapy in adult patients with EGFRm, MET-overexpressed and/or -amplified, locally advanced...
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Colin Lindsay, Wanning Xu, Aino Telaranta-Keerie, Nan Jia, Ryan J Hartmaier, Shun Lu Tags: Trials in progress Source Type: research
