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Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models
Exp Eye Res. 2023 Dec 12:109751. doi: 10.1016/j.exer.2023.109751. Online ahead of print.ABSTRACTChoroidal neovascularization (CNV) is the primary pathogenic process underlying wet age-related macular degeneration, leading to severe vision loss. Despite current anti-vascular endothelial growth factor (VEGF) therapies, several limitations persist. Crocetin, a major bioactive constituent of saffron, exhibits multiple pharmacological activities, yet its role and mechanism in CNV remain unclear. Here, we investigated the potential effects of crocetin on CNV using in vitro and in vivo models. In human umbilical vein endothelial ...
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Caixia Wang Xuejing Li Jing Su Jialiang Duan Yimin Yao Qingli Shang Source Type: research

Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models
Exp Eye Res. 2023 Dec 13;238:109751. doi: 10.1016/j.exer.2023.109751. Online ahead of print.ABSTRACTChoroidal neovascularization (CNV) is the primary pathogenic process underlying wet age-related macular degeneration, leading to severe vision loss. Despite current anti-vascular endothelial growth factor (VEGF) therapies, several limitations persist. Crocetin, a major bioactive constituent of saffron, exhibits multiple pharmacological activities, yet its role and mechanism in CNV remain unclear. Here, we investigated the potential effects of crocetin on CNV using in vitro and in vivo models. In human umbilical vein endothel...
Source: Experimental Eye Research - December 14, 2023 Category: Opthalmology Authors: Caixia Wang Xuejing Li Jing Su Jialiang Duan Yimin Yao Qingli Shang Source Type: research

Saffron reduces the liver fibrosis in mice by inhibiting the JAK/STAT3 pathway
CONCLUSIONS: Saffron can attenuate liver fibrosis by inhibiting the JAK/STAT3 pathway and the activation of hepatic stellate cell, providing a theoretical basis for the development of new anti-fibrotic drugs.PMID:38055395 | PMC:PMC10691186 | DOI:10.1590/acb385823 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - December 6, 2023 Category: Surgery Authors: Lijuan Huang Yan Han Zhi Wang Qiao Qiu Sichen Yue Qingmin Zhou Wei Su Jianhui Yan Source Type: research