206 SAFFRON: Savolitinib + Osimertinib vs Chemotherapy in EGFRm NSCLC with MET Overexpression/Amplification Post-Osimertinib
Osimertinib, a potent, third-generation, oral EGFR-TKI is the preferred first-line treatment in EGFRm advanced NSCLC. However, tumours eventually develop resistance and METoverexpression and/or amplification is the most common acquired resistance mechanism. Savolitinib is an oral, potent, and highly selective MET-TKI. Savolitinib +osimertinib has been investigated in the Ph1B TATTON (NCT02143466)/Ph2 SAVANNAH (NCT03778229) studies. SAFFRON (NCT05261399) aims to assess efficacy/safety of savolitinib+osimertinib vs platinum-based chemotherapy in adult patients with EGFRm, MET-overexpressed and/or -amplified, locally advanced...
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Colin Lindsay, Wanning Xu, Aino Telaranta-Keerie, Nan Jia, Ryan J Hartmaier, Shun Lu Tags: Trials in progress Source Type: research
[Corrigendum] Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL ‑6‑stimulated liver cancer cells
Oncol Rep. 2024 May;51(5):68. doi: 10.3892/or.2024.8727. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1E on p. 1885, the STAT3 blots shown for the A549 and A2780 cell lines were strikingly similar, such that these data were possibly derived from the same original source where the panels were intended to show the results from differently performed experiments. Upon examining their original data, the authors have realized that an inadvertent error was made in assembling the data in the figure, and the STAT3 data shown correctly for ...
Source: Oncology Reports - March 29, 2024 Category: Cancer & Oncology Authors: Buyun Kim Byoungduck Park Source Type: research
Molecular interactions with bilayer membrane stacks using neutron and X-ray diffraction
Adv Colloid Interface Sci. 2024 Mar 15;326:103134. doi: 10.1016/j.cis.2024.103134. Online ahead of print.ABSTRACTLamellar unit cell reconstruction from neutron and X-ray diffraction data provides information about the disposition and position of molecules and molecular segments with respect to the bilayer. When supplemented with the judicious use of molecular deuteration, the technique probes the molecular interactions and conformations within the bilayer membrane and the water layer which constitute the crystallographic unit cell. The perspective is model independent, and potentially, with a higher degree of resolution th...
Source: Adv Data - March 22, 2024 Category: Epidemiology Authors: Saffron J Bryant Christopher J Garvey Tamim A Darwish Robert Georgii Gary Bryant Source Type: research
Molecular interactions with bilayer membrane stacks using neutron and X-ray diffraction
Adv Colloid Interface Sci. 2024 Mar 15;326:103134. doi: 10.1016/j.cis.2024.103134. Online ahead of print.ABSTRACTLamellar unit cell reconstruction from neutron and X-ray diffraction data provides information about the disposition and position of molecules and molecular segments with respect to the bilayer. When supplemented with the judicious use of molecular deuteration, the technique probes the molecular interactions and conformations within the bilayer membrane and the water layer which constitute the crystallographic unit cell. The perspective is model independent, and potentially, with a higher degree of resolution th...
Source: Advances in Colloid and Interface Science - March 22, 2024 Category: Chemistry Authors: Saffron J Bryant Christopher J Garvey Tamim A Darwish Robert Georgii Gary Bryant Source Type: research
Functional analysis and comparative genomics of Rahnella perminowiae S11P1 and Variovorax sp. S12S4, two plant growth-promoting rhizobacteria isolated from Crocus sativus L. (saffron) rhizosphere
Rahnella perminowiae S11P1 and Variovorax sp. S12S4 are two plant growth-promoting rhizobacteria that were previously isolated from the rhizosphere of Crocus sativus L. (saffron), and have demonstrated interestin... (Source: BMC Genomics)
Source: BMC Genomics - March 18, 2024 Category: Genetics & Stem Cells Authors: Rahma ZOUAGUI, Houda ZOUAGUI, Jamal AURAG, Azeddine IBRAHIMI and Laila SBABOU Tags: Research Source Type: research
The protective effect of traditional Chinese medicine Jinteng Qingbi granules on rats with rheumatoid arthritis
Conclusion: Our findings demonstrated that JTQBG was effective against RA by alleviating synovial inflammation, synovial hyperplasia, and joint destruction. The anti-RA properties of JTQBG were likely attributed to the inhibition of the NF-κB pathway and the regulation of serum metabolite disorders. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Enhancing the purification of crocin-I from saffron through the combination of multicolumn countercurrent chromatography and green solvents
In conclusion, this study presents the MCSGP as a reliable, simple, and economical technique for purifying crocin-I from saffron extract, demonstrating for the first time that it can be effectively applied as a powerful approach for process intensification in the purification of natural products from complex matrices.PMID:38459965 | DOI:10.1007/s00216-024-05228-6 (Source: Analytical and Bioanalytical Chemistry)
Source: Analytical and Bioanalytical Chemistry - March 9, 2024 Category: Chemistry Authors: Mohammad Hooshyari Ardakani Chiara Nosengo Simona Felletti Martina Catani Alberto Cavazzini Chiara De Luca Hassan Rezadoost Source Type: research
Enhancing the purification of crocin-I from saffron through the combination of multicolumn countercurrent chromatography and green solvents
In conclusion, this study presents the MCSGP as a reliable, simple, and economical technique for purifying crocin-I from saffron extract, demonstrating for the first time that it can be effectively applied as a powerful approach for process intensification in the purification of natural products from complex matrices.PMID:38459965 | DOI:10.1007/s00216-024-05228-6 (Source: Analytical and Bioanalytical Chemistry)
Source: Analytical and Bioanalytical Chemistry - March 9, 2024 Category: Chemistry Authors: Mohammad Hooshyari Ardakani Chiara Nosengo Simona Felletti Martina Catani Alberto Cavazzini Chiara De Luca Hassan Rezadoost Source Type: research
Crocetin protects mouse brain from apoptosis in traumatic brain injury model through activation of autophagy
CONCLUSION: Crocetin alleviates TBI by inhibiting neuronal apoptosis and neuroinflammation and activating autophagy.PMID:38433503 | DOI:10.1080/02699052.2024.2324022 (Source: Brain Injury)
Source: Brain Injury - March 4, 2024 Category: Neurology Authors: Shan Chen Xinghong Luo Liu Yang Liang Luo Zhen Hu Jianglan Wang Source Type: research
