Hepatoprotective Effect of Medicine Food Homology Flower Saffron against CCl < sub > 4 < /sub > -Induced Liver Fibrosis in Mice via the Akt/HIF-1 α/VEGF Signaling Pathway
Molecules. 2023 Oct 24;28(21):7238. doi: 10.3390/molecules28217238.ABSTRACTLiver fibrosis refers to a complex inflammatory response caused by multiple factors, which is a known cause of liver cirrhosis and even liver cancer. As a valuable medicine food homology herb, saffron has been widely used in the world. Saffron is commonly used in liver-related diseases and has rich therapeutic and health benefits. The therapeutic effect is satisfactory, but its mechanism is still unclear. In order to clarify these problems, we planned to determine the pharmacological effects and mechanisms of saffron extract in preventing and treati...
Source: Atherosclerosis - November 14, 2023 Category: Cardiology Authors: Huajuan Jiang Xulong Huang Jiaxin Wang Yongfeng Zhou Chaoxiang Ren Tao Zhou Jin Pei Source Type: research
Hepatoprotective Effect of Medicine Food Homology Flower Saffron against CCl < sub > 4 < /sub > -Induced Liver Fibrosis in Mice via the Akt/HIF-1 α/VEGF Signaling Pathway
Molecules. 2023 Oct 24;28(21):7238. doi: 10.3390/molecules28217238.ABSTRACTLiver fibrosis refers to a complex inflammatory response caused by multiple factors, which is a known cause of liver cirrhosis and even liver cancer. As a valuable medicine food homology herb, saffron has been widely used in the world. Saffron is commonly used in liver-related diseases and has rich therapeutic and health benefits. The therapeutic effect is satisfactory, but its mechanism is still unclear. In order to clarify these problems, we planned to determine the pharmacological effects and mechanisms of saffron extract in preventing and treati...
Source: Atherosclerosis - November 14, 2023 Category: Cardiology Authors: Huajuan Jiang Xulong Huang Jiaxin Wang Yongfeng Zhou Chaoxiang Ren Tao Zhou Jin Pei Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
