Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice

CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337

Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research