Synthesis of Bimetallic Palladium/Zinc Oxide Nanocomposites Using Crocus sativus and Its Anticancer Activity via the Induction of Apoptosis in Cervical Cancer
In this study, a straightforward and environmentally friendly method for creating bimetallic nanoparticles (NPs) by combining palladium (Pd) and zinc oxide (ZnO) using Crocus sativus extract (CS-Pd/ZnO NCs) was reported; the bio-synthesize bimetallic palladium/zinc oxide nanocomposites and their antioxidant and anti-cancer properties were assessed. The developed Pd/ZnO NPs were characterized using different approaches, including UV-vis, DLS, FTIR, EDX, and SEM analyses. The present investigation shows how nanocomposites are made, their distinctive properties, antioxidant activity, anticancer mechanisms, and their potential...
Source: Applied Biochemistry and Biotechnology - February 29, 2024 Category: Biochemistry Authors: Jun Feng Leilei He Jin Qing Hui Krishnamoorthy Kavithaa Zhengzheng Xu Source Type: research
An overview of pharmacological effects of Crocus sativous and its constituents
Iran J Basic Med Sci. 2024;27(4):391-417. doi: 10.22038/IJBMS.2023.73410.15950.ABSTRACTCrocus sativus L. was used for the treatment of a wide range of disorders in traditional medicine. Due to the extensive protective and treatment properties of C. sativus and its constituents in various diseases, the purpose of this review is to collect a summary of its effects, on experimental studies, both in vitro and in vivo. Databases such as PubMed, Science Direct, and Scopus were explored until January 2023 by employing suitable keywords. Several investigations have indicated that the therapeutic properties of C. sativus may be due...
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Saeideh Saadat Zahra Ghasemi Arghavan Memarzia Sepideh Behrouz Mohammad Reza Aslani Mohammad Hossein Boskabady Source Type: research
Synthesis of Bimetallic Palladium/Zinc Oxide Nanocomposites Using Crocus sativus and Its Anticancer Activity via the Induction of Apoptosis in Cervical Cancer
In this study, a straightforward and environmentally friendly method for creating bimetallic nanoparticles (NPs) by combining palladium (Pd) and zinc oxide (ZnO) using Crocus sativus extract (CS-Pd/ZnO NCs) was reported; the bio-synthesize bimetallic palladium/zinc oxide nanocomposites and their antioxidant and anti-cancer properties were assessed. The developed Pd/ZnO NPs were characterized using different approaches, including UV-vis, DLS, FTIR, EDX, and SEM analyses. The present investigation shows how nanocomposites are made, their distinctive properties, antioxidant activity, anticancer mechanisms, and their potential...
Source: Applied Biochemistry and Biotechnology - February 29, 2024 Category: Biochemistry Authors: Jun Feng Leilei He Jin Qing Hui Krishnamoorthy Kavithaa Zhengzheng Xu Source Type: research
Synthesis of Bimetallic Palladium/Zinc Oxide Nanocomposites Using Crocus sativus and Its Anticancer Activity via the Induction of Apoptosis in Cervical Cancer
In this study, a straightforward and environmentally friendly method for creating bimetallic nanoparticles (NPs) by combining palladium (Pd) and zinc oxide (ZnO) using Crocus sativus extract (CS-Pd/ZnO NCs) was reported; the bio-synthesize bimetallic palladium/zinc oxide nanocomposites and their antioxidant and anti-cancer properties were assessed. The developed Pd/ZnO NPs were characterized using different approaches, including UV-vis, DLS, FTIR, EDX, and SEM analyses. The present investigation shows how nanocomposites are made, their distinctive properties, antioxidant activity, anticancer mechanisms, and their potential...
Source: Applied Biochemistry and Biotechnology - February 29, 2024 Category: Biochemistry Authors: Jun Feng Leilei He Jin Qing Hui Krishnamoorthy Kavithaa Zhengzheng Xu Source Type: research
Synthesis of Bimetallic Palladium/Zinc Oxide Nanocomposites Using Crocus sativus and Its Anticancer Activity via the Induction of Apoptosis in Cervical Cancer
In this study, a straightforward and environmentally friendly method for creating bimetallic nanoparticles (NPs) by combining palladium (Pd) and zinc oxide (ZnO) using Crocus sativus extract (CS-Pd/ZnO NCs) was reported; the bio-synthesize bimetallic palladium/zinc oxide nanocomposites and their antioxidant and anti-cancer properties were assessed. The developed Pd/ZnO NPs were characterized using different approaches, including UV-vis, DLS, FTIR, EDX, and SEM analyses. The present investigation shows how nanocomposites are made, their distinctive properties, antioxidant activity, anticancer mechanisms, and their potential...
Source: Applied Biochemistry and Biotechnology - February 29, 2024 Category: Biochemistry Authors: Jun Feng Leilei He Jin Qing Hui Krishnamoorthy Kavithaa Zhengzheng Xu Source Type: research
NAMPT ‑NAD < sup > + < /sup > is involved in the senescence ‑delaying effects of saffron in aging mice
Exp Ther Med. 2024 Feb 1;27(3):123. doi: 10.3892/etm.2024.12411. eCollection 2024 Mar.ABSTRACTAs the proportion of the elderly population grows rapidly, the senescence-delaying effects of Traditional Chinese Medicine is being investigated. The aim of the present study was to investigate the senescence-delaying effects of saffron in naturally aging mice. The active ingredients in an aqueous saffron extract were determined using high-performance liquid chromatography (HPLC). Mice were divided into saffron (8- and 16-months-old) and control groups (3-, 8-, and 16-months-old), and saffron extract was administered to the former...
Source: Experimental and Therapeutic Medicine - February 27, 2024 Category: General Medicine Authors: Ling Xiao Runxuan Sun Yubin Han Linhan Xia Kexin Lin Wanyan Fu Kai Zhong Yilu Ye Source Type: research
Effect of vitamin E with and without saffron on the sexual function in women of reproductive age with sexual dysfunction: a randomized controlled trial
This study investigated the effect of the combined administratio... (Source: BMC Women's Health)
Source: BMC Women's Health - February 26, 2024 Category: OBGYN Authors: Saeideh Izadi, Sakineh Mohammad-Alizadeh-Charandabi, Parvin Yadollahi and Mojgan Mirghafourvand Tags: Research Source Type: research
Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma
Cancer Invest. 2024 Feb 22:1-10. doi: 10.1080/07357907.2024.2319754. Online ahead of print.ABSTRACTCrocin is the major active carotenoid of saffron (Crocus sativus L.). Its pluripotent effects have led to a growing body of literature investigating its antitumor properties as well as its diverse potentials for mood stabilization, normal tissue protection, and inflammation reduction; However, there is a gap in clinical trials testing this substance in cancer patients. In this randomized, double-blind, placebo-controlled clinical trial, patients with newly diagnosed esophageal squamous cell carcinoma were randomly assigned to...
Source: Cancer Investigation - February 22, 2024 Category: Cancer & Oncology Authors: Nima Ebrahimi Seyed Alireza Javadinia Roham Salek Azar Fanipakdel Samaneh Sepahi Mansoureh Dehghani Niloufar Valizadeh Seyed Ahmad Mohajeri Source Type: research
Benchtop volatilomics supercharged: How machine learning based design of experiment helps optimizing untargeted GC-IMS gas phase metabolomics
In this study, we propose a hybrid strategy, combining design of experiment (DOE) and machine learning (ML) for optimizing GC-IMS conditions in non-targeted volatilomic/flavoromic analysis, with saffron volatiles as a case study. To begin, a rotatable circumscribed central composite design (CCD) is used to define five influential GC-IMS factors of sample amount, headspace temperature, incubation time, injection volume, and split ratio. Subsequently, two ML models are utilized: multiple linear regression (MLR) as a linear model and Bayesian regularized-artificial neural network (BR-ANN) as a nonlinear model. These models ar...
Source: Talanta - February 21, 2024 Category: Chemistry Authors: Hadi Parastar Philipp Weller Source Type: research
L'effet du safran et de ses extraits sur le traitement du cancer du sein: une revue narrative
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00031-2. doi: 10.1016/j.pharma.2024.02.011. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit a...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Roya Mokhtarian Soodeh Rajabi Setareh Zahedian Saeideh Jafarinejad-Farsangi Morteza Hadizadeh Masoumeh Sadeghinejad Source Type: research
L'effet du safran et de ses extraits sur le traitement du cancer du sein: une revue narrative
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00031-2. doi: 10.1016/j.pharma.2024.02.011. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit a...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Roya Mokhtarian Soodeh Rajabi Setareh Zahedian Saeideh Jafarinejad-Farsangi Morteza Hadizadeh Masoumeh Sadeghinejad Source Type: research
L'effet du safran et de ses extraits sur le traitement du cancer du sein: une revue narrative
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00031-2. doi: 10.1016/j.pharma.2024.02.011. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit a...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Roya Mokhtarian Soodeh Rajabi Setareh Zahedian Saeideh Jafarinejad-Farsangi Morteza Hadizadeh Masoumeh Sadeghinejad Source Type: research
L'effet du safran et de ses extraits sur le traitement du cancer du sein: une revue narrative
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00031-2. doi: 10.1016/j.pharma.2024.02.011. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit a...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Roya Mokhtarian Soodeh Rajabi Setareh Zahedian Saeideh Jafarinejad-Farsangi Morteza Hadizadeh Masoumeh Sadeghinejad Source Type: research
