Effects of Aqueous Saffron Extract on Glucoregulation as Well as Hepatic Agt and TNF- α Gene Expression in Rats Subjected to Sub-Chronic Stress

CONCLUSION: Saffron treatment after sub-chronic stress not only did not improve glucose tolerance but also enhanced insulin resistance. It indicated the interaction of saffron and sub-chronic stress to promote renin-angiotensin system activity. In addition, the saffron treatment decreased TNF-α gene expression after sub-chronic stress. The synergistic stimulating effect of saffron and sub-chronic stress on gene expression of hepatic Agt led to insulin resistance and hyperglycemia.PMID:37434936 | PMC:PMC10331535 | DOI:10.4103/abr.abr_51_22

Source: Biomed Res - July 12, 2023 Category: Research Authors: Yeganeh Yazdani Maryam Radahmadi Roshanak Roustazade Source Type: research