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Therapy: Stem Cell Therapy

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Total 2351 results found since Jan 2013.

Multipotent Adult Progenitor Cells Enhance Recovery After Stroke by Modulating the Immune Response from the Spleen
Abstract Stem cell therapy modulates not only the local microenvironment of the brain but also the systemic immune responses. We explored the impact of human multipotent adult progenitor cells (MAPC) modulating splenic activation and peripheral immune responses after ischemic stroke. Hundred twenty‐six Long‐Evans adult male rats underwent middle cerebral artery occlusion. Twenty‐four hours later, they received IV MAPC or saline treatment. At 3 days after infusion, RNA was isolated from the injured cortex and spleen for microarray analysis. Spleen mass, splenocyte phenotype, and releasing cytokines were measured. Seru...
Source: Stem Cells - March 5, 2017 Category: Stem Cells Authors: Bing Yang, Jason A. Hamilton, Krystal S. Valenzuela, Annelies Bogaerts, XiaoPei Xi, Jaroslaw Aronowski, Robert W. Mays, Sean I. Savitz Tags: Regenerative Medicine Source Type: research

Stem Cell Therapy for Abrogating Stroke-Induced Neuroinflammation and Relevant Secondary Cell Death Mechanisms
Publication date: Available online 23 July 2017 Source:Progress in Neurobiology Author(s): Connor Stonesifer, Sydney Corey, Shaila Ghanekar, Zachary Diamandis, Sandra A. Acosta, Cesar V. Borlongan Ischemic stroke is a leading cause of death worldwide. A key secondary cell death mechanism mediating neurological damage following the initial episode of ischemic stroke is the upregulation of endogenous neuroinflammatory processes to levels that destroy hypoxic tissue local to the area of insult, induce apoptosis, and initiate a feedback loop of inflammatory cascades that can expand the region of damage. Stem cell therapy has ...
Source: Progress in Neurobiology - July 23, 2017 Category: Neuroscience Source Type: research

Regenerative medicine: Stroke survivor and carer views and motivations towards a proposed stem cell clinical trial using placebo neurosurgery
ConclusionStroke survivor views and motivations reflect anticipation of the personal and future benefits of regenerative medicine. Partners/carers sought to balance the value of stroke survivor hope with carrying the weight of hope as carer, a conflict burden adding to known caregiver burden. All participants expressed the need for during and post‐trial psychological support. This study provides a rare opportunity to explore the prospective views and motivations of stroke survivors and their partners/carers towards a proposed Phase III 2‐arm RCT. This adds weight to qualitative evidence exploring capacity, consent, dec...
Source: Health Expectations - October 1, 2017 Category: Health Management Authors: Nicola A. Cunningham, Purva Abhyankar, Julie Cowie, Jayne Galinsky, Karen Methven Tags: ORIGINAL RESEARCH PAPER Source Type: research

Clinical Outcomes of Repeated Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Chronic Haemorrhagic Stroke. A One-Year Follow Up.
Conclusion: Intraventricular transplantation of BM-MSCs has shown benefits in improving the functional status of post-haemorrhagic stroke patients with no adverse effect. PMID: 29290837 [PubMed]
Source: The Open Neurology Journal - January 3, 2018 Category: Neurology Tags: Open Neurol J Source Type: research

Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow-derived mesenchymal stem cells (SB623): a phase 1/2a study.
CONCLUSIONSIn this completed 2-year phase 1/2a study, implantation of SB623 cells in patients with stable chronic stroke was safe and was accompanied by improvements in clinical outcomes.Clinical trial registration no.: NCT01287936 (clinicaltrials.gov). PMID: 30497166 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 1, 2018 Category: Neurosurgery Tags: J Neurosurg Source Type: research

Human stem cells transplanted into the rat stroke brain migrate to spleen via lymphatic and inflammation pathways.
This study is the first to demonstrate brain-to-periphery migration of stem cells, advancing the novel concept of harnessing the lymphatic system in mobilizing stem cells to sequester peripheral inflammation as a brain repair strategy. PMID: 30514806 [PubMed - as supplied by publisher]
Source: Haematologica - December 4, 2018 Category: Hematology Authors: Xu K, Lee JY, Kaneko Y, Tuazon JP, Vale F, van Loveren H, Borlongan CV Tags: Haematologica Source Type: research

Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function
Transplanted neural stem cells (NSCs) have demonstrated multimodal therapeutic function after stroke. In preclinical stroke models, NSCs have been shown to modulate inflammation, foster neuroplasticity, and neural reorganization; promote angiogenesis; and act as a cellular replacement by differentiating into mature neural cell types. Understanding the key factors involved in NSC ‐mediated tissue recovery and addressing the current translational barriers may lead to clinical success of NSC therapy and a first‐in‐class restorative therapy for stroke patients. AbstractIntroductionNeural stem cells (NSCs) have demonstrat...
Source: Brain and Behavior - February 12, 2019 Category: Neurology Authors: Emily W. Baker, Holly A. Kinder, Franklin D. West Tags: REVIEW Source Type: research

Exosomes from miRNA-126-modified ADSCs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation.
Authors: Geng W, Tang H, Luo S, Lv Y, Liang D, Kang X, Hong W Abstract Although adipose derived stem cells (ADSCs) exert their therapeutic potential in ischemic stroke, the migration of ADSCs in injured area is not apparently observed after intravenous administration. ADSCs are an important source of exosomes which hold great promise as an endogenous drug delivery system for the treatment of cerebral ischemia given their ability to cross the blood-brain barrier. Here we investigated whether ADSCs-derived exosomes mediated miRNAs transfer and thus promoted neurological recovery after stroke. We first proved that miR...
Source: American Journal of Translational Research - March 24, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Exosomes Secreted by the Cocultures of Normal and Oxygen –Glucose-Deprived Stem Cells Improve Post-stroke Outcome
AbstractEmerging stroke literature suggests that treatment of experimentally induced stroke with stem cells offered post-stroke neuroprotection via exosomes produced by these cells. Treatment with exosomes has great potential to overcome the limitations associated with cell-based therapies. However, in our preliminary studies, we noticed that the exosomes released from human umbilical cord blood-derived mesenchymal stem cells (MSCs) under standard culture conditions did not improve the post-stroke neurological outcome. Because of this apparent discrepancy, we hypothesized that exosome characteristics vary with the conditio...
Source: NeuroMolecular Medicine - May 9, 2019 Category: Neurology Source Type: research

Efficacy of Stem Cell-Based Therapies for Stroke.
Abstract Stroke remains a prevalent disease with limited treatment options. Available treatments offer little in the way of enhancing neurogenesis and recovery. Because of the limitations of available treatments, new therapies for stroke are needed. Stem cell-based therapies for stroke offer promise because of their potential to provide neurorestorative benefits. Stem cell-based therapies aim to promote neurogenesis and replacement of lost neurons or protect surviving neurons in order to improve neurological recovery. The mechanism through which stem cell treatments mediate their therapeutic effect is largely depe...
Source: Brain Research - August 1, 2019 Category: Neurology Authors: Chrostek MR, Fellows EG, Crane AT, Grande AW, Low WC Tags: Brain Res Source Type: research

Adult Stem Cells and Induced Pluripotent Stem Cells for Stroke Treatment
Stroke is the main cause of disability and death in the world within neurological diseases. Despite such a huge impact, enzymatic or mechanical recanalization are the only treatments available so far for ischemic stroke, but only less than 20% of patients can benefit from them. The use of stem cells as a possible cell therapy in stroke has been tested for years. The results obtained from these studies, although conflicting or controversial in some aspects, are promising. In the last years, the recent development of the induced pluripotent stem cells has opened new possibilities to find new cell therapies against stroke. In...
Source: Frontiers in Neurology - August 27, 2019 Category: Neurology Source Type: research

Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors.
CONCLUSION: TAOK1 protected MCAO-induced cerebral ischemic stroke by decreasing the pro-inflammatory factors and apoptosis via PI3K/AKT and MAPK signaling pathways. PMID: 31652447 [PubMed - in process]
Source: Bioscience Reports - October 29, 2019 Category: Biomedical Science Authors: Li J, Liu Z, Wang L, Xu H, Wang Y Tags: Biosci Rep Source Type: research

Mitochondria as a therapeutic target for ischemic stroke.
Abstract Stroke is the leading cause of death and physical disability worldwide. Mitochondrial dysfunction has been considered as one of the hallmarks of ischemic stroke and contributes to the pathology of ischemia and reperfusion. Mitochondria is essential in promoting neural survival and neurological improvement following ischemic stroke. Therefore, mitochondria represent an important drug target for stroke treatment. This review discusses the mitochondrial molecular mechanisms underlying cerebral ischemia and involved in reactive oxygen species generation, mitochondrial electron transport dysfunction, mitochond...
Source: Free Radical Biology and Medicine - November 4, 2019 Category: Biology Authors: He Z, Ning N, Zhou Q, Khoshnam SE, Farzaneh M Tags: Free Radic Biol Med Source Type: research

Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain.
Abstract Due to the limitation in treatment window of the rtPA (recombinant tissue plasminogen activator), the development of delayed treatment for stroke is needed. We previously reported that there is a difference in neurogenesis and neuroblast migration patterns in different mouse stroke models (proximal and distal middle cerebral artery occlusion models, pMCAo or dMCAo). Specifically, compared to robust neurogenesis and substantial migration of newly born neuroblasts in pMCAo model, dMCAo only illicit limited neurogenesis and migration of neuroblasts towards ischemic area. One potential reason for this differe...
Source: Experimental Neurology - January 1, 2020 Category: Neurology Authors: Luo F, Zhang Z, Barnett A, Bellinger TJ, Turcato F, Schmidt K, Luo Y Tags: Exp Neurol Source Type: research

Challenges and Improvements of Novel Therapies for Ischemic Stroke
Stroke is the third most common disease all over the world, which is regarded as a hotspot in medical research because of its high mortality and morbidity. Stroke, especially ischemic stroke, causes severe neural cell death, and no effective therapy is currently available for neuroregeneration after stroke. Although many therapies have been shown to be effective in preclinical studies of ischemic stroke, almost none of them passed clinical trials, and the reasons for most failures have not been well identified. In this review, we focus on several novel methods, such as traditional Chinese medicine, stem cell therapy, and e...
Source: Frontiers in Pharmacology - September 30, 2021 Category: Drugs & Pharmacology Source Type: research