Filtered By:
Therapy: Stem Cell Therapy

This page shows you your search results in order of relevance. This is page number 20.

Order by Relevance | Date

Total 2351 results found since Jan 2013.

Protective Effects of Mesenchymal Stem Cells Overexpressing Extracellular Regulating Kinase 1/2 Against Stroke in Rats.
CONCLUSION: ERK/MSCs transplantation showed better functional recovery after stroke in rats, likely in part through enhancing survival of MSCs and possibly by modulating the proliferation, neuronal de-differentiation and neuroinflammation. PMID: 31002912 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - April 15, 2019 Category: Neurology Authors: Gao X, Wu D, Dou L, Zhang H, Huang L, Zeng J, Zhang Y, Yang C, Li H, Liu L, Ma B, Yuan Q Tags: Brain Res Bull Source Type: research

Heat shock protein 27 as a neuroprotective biomarker and a suitable target for stem cell therapy and pharmacotherapy in ischemic stroke.
This article is protected by copyright. All rights reserved. PMID: 31502740 [PubMed - as supplied by publisher]
Source: Cell Biology International - September 9, 2019 Category: Cytology Authors: Behdarvandy M, Karimian M, Atlasi MA, Tameh AA Tags: Cell Biol Int Source Type: research

Intra-arterial Stem Cell Therapy Diminishes Inflammasome Activation After Ischemic Stroke: a Possible Role of Acid Sensing Ion Channel 1a
This study offers a preliminary evidence of the role of IA MSCs in regulating inflammasome by modulating ASIC1a.
Source: Journal of Molecular Neuroscience - December 8, 2019 Category: Neuroscience Source Type: research

Early Transplantation of Human Cranial Bone-derived Mesenchymal Stem Cells Enhances Functional Recovery in Ischemic Stroke Model Rats.
Authors: Oshita J, Okazaki T, Mitsuhara T, Imura T, Nakagawa K, Otsuka T, Kurose T, Tamura T, Abiko M, Takeda M, Kawahara Y, Yuge L, Kurisu K Abstract We analyzed the cell characteristics, neuroprotective, and transplantation effects of human cranial bone-derived mesenchymal stem cells (hcMSCs) in ischemic stroke model rats compared with human iliac bone-derived mesenchymal stem cells (hiMSCs). The expressions of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF ) as neurotrophic factors were analyzed in both MSCs. hiMSCs or hcMSCs were intravenously administered into ischemic st...
Source: Neurologia Medico-Chirurgica - January 22, 2020 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke.
CONCLUSION: These findings highlight the therapeutic effects of EPI-NCSCs transplantation, probably through simultaneous induction of neuronal and glial formation, as well as Bdnf over-expression in a rat model of ischemic stroke. PMID: 32281225 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - April 11, 2020 Category: Neuroscience Authors: Salehi MS, Pandamooz S, Safari A, Jurek B, Tamadon A, Namavar MR, Dianatpour M, Dargahi L, Azarpira N, Fattahi S, Shid Moosavi SM, Keshavarz S, Khodabandeh Z, Zare S, Nazari S, Heidari M, Izadi S, Poursadeghfard M, Borhani-Haghighi A Tags: CNS Neurosci Ther Source Type: research

hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke
In this study, we found that innate immune memory is detrimental in stroke, because it promotes the acute immune response and exacerbates ischemic infarcts. Mesenchymal stem cell therapy has been widely studied for its therapeutic potential in various diseases including stroke, but whether it diminishes innate immune memory has not been studied. Here, our study demonstrates that, after the activation of innate immune memory by lipopolysaccharide, mesenchymal stem cell therapy can diminish innate immune memory though down-regulation of H3 methylation and subsequently protect against stroke. Our results demonstrate that inna...
Source: Frontiers in Immunology - September 10, 2020 Category: Allergy & Immunology Source Type: research

Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute ischemia stroke rat model.
Abstract Acute ischemia stroke (AIS) is one of the leading causes of mortality and disability worldwide, and its neurological impacts are devastating and permanent. There is no efficient and real treatment for acute ischemia stroke so far. Therefore, development of efficient therapeutic strategies is under focus of investigations by basic and clinical scientists. Brain is one of the organs with high energy consumption and metabolism. Hence, its functionality is highly dependent on mitochondrial activity and integrity. Therefore, mitochondria play a vital homeostatic role in neurons physiology and mitochondrial dys...
Source: Brain Research Bulletin - September 29, 2020 Category: Neurology Authors: Pourmohammadi-Bejarpasi Z, Roushandeh AM, Saberi A, Kheirandish-Rostami M, Toosi SMR, Jahanian-Najafabadi A, Tomita K, Kuwahara Y, Sato T, Roudkenar MH Tags: Brain Res Bull Source Type: research

A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review.
Authors: Park YJ, Farooq J, Cho J, Cozene B, Gonzales-Portillo B, Sadanandan N, Saft M, Lee JY, Borlongan CV Abstract Stem cell-based therapy stands as a robust experimental treatment for ischemic stroke. Stem cells derived from fetal, embryonic, and adult tissues serve as potential sources for transplantable cells in the setting of ischemic stroke. However, the search continues for finding an optimal cell line for clinical use. Muse cells, a distinct subset of mesenchymal stem cells found sporadically in the connective tissue of nearly every organ, may be a suitable candidate due to its safety and accessibility. T...
Source: Advances in Experimental Medicine and Biology - November 11, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Delayed Treatment with Human Dental Pulp Stem Cells Accelerates Functional Recovery and Modifies Responses of Peri-Infarct Astrocytes Following Photothrombotic Stroke in Rats.
Abstract Dental pulp contains multipotent mesenchymal stem cells that improve outcomes when administered early after temporary middle cerebral artery occlusion in rats. To further assess the therapeutic potential of these cells, we tested whether functional recovery following stroke induced by photothrombosis could be modified by a delayed treatment that was initiated after the infarct attained maximal volume. Photothrombosis induces permanent focal ischemia resulting in tissue changes that better reflect key aspects of the many human strokes in which early restoration of blood flow does not occur. Human dental pu...
Source: Cell Transplantation - January 1, 2021 Category: Cytology Authors: Yew WP, Djukic ND, Jayaseelan JSP, Kaidonis X, Kremer KL, Choy FC, Woodman RJ, Koblar SA, Sims NR Tags: Cell Transplant Source Type: research

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke.
Abstract To investigate the therapeutic mechanism of action of transplanted stem cells and develop exosome-based nanotherapeutics for ischemic stroke, we assessed the effect of exosomes (Exos) produced by human umbilical cord mesenchymal stem cells (hUMSCs) on microglia-mediated neuroinflammation after ischemic stroke. Our results found that injected hUMSC-Exos were able to access the site of ischemic damage and could be internalized by cells both in vivo and in vitro. In vitro, treatment with hUMSC-Exos attenuated microglia-mediated inflammation after oxygen-glucose deprivation (OGD). In vivo results demonstrated...
Source: Aging - January 21, 2021 Category: Biomedical Science Authors: Zhang Z, Zou X, Zhang R, Xie Y, Feng Z, Li F, Han J, Sun H, Ouyang Q, Hua S, Lv B, Hua T, Liu Z, Cai Y, Zou Y, Tang Y, Jiang X Tags: Aging (Albany NY) Source Type: research

Coding and non-coding nucleotides': The future of stroke gene therapeutics
Genomics. 2021 Mar 4:S0888-7543(21)00084-7. doi: 10.1016/j.ygeno.2021.03.003. Online ahead of print.ABSTRACTStroke is the foremost cause of death ranked after heart disease and cancer. It is the fatal life-threatening event that requires immediate medical admissions to overcome following morbidity and mortality. The therapeutic advances in stroke therapy have been manipulated with diverse paths for last 5 years. Recent research and clinical trials have investigated a variety of anti-stroke agents including anti-coagulants, cerebro-protective agents, antiplatelet therapy, stem-cell therapy, and specified gene therapy. In re...
Source: Genomics - March 7, 2021 Category: Genetics & Stem Cells Authors: Vishal Chavda Kajal Madhwani Source Type: research

Mesenchymal stem cell-derived exosomes for treatment of ischemic stroke
Curr Stem Cell Res Ther. 2021 Aug 12. doi: 10.2174/1574888X16666210812151003. Online ahead of print.ABSTRACTStroke is a life-threatening disease and one of the leading causes of death and physical disability worldwide. Currently, no drugs on the market promote neural recovery after stroke insult, and spontaneous remodeling processes are limited to induce recovery in the ischemic regions. Therefore, promoting a cell-based therapy has been needed to elevate the endogenous recovery process. Mesenchymal stem cells (MSCs) have been regarded as candidate cell sources for therapeutic purposes of ischemic stroke, which their thera...
Source: Cell Research - August 13, 2021 Category: Cytology Authors: Rucheng Liu Yi Zhang Yundi Zhang Maryam Farzaneh Seyed Esmaeil Khoshnam Source Type: research