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Therapy: Stem Cell Therapy

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Total 2351 results found since Jan 2013.

Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy
We examined hAMSC-secreted proteins obtained from serum-free culture medium by liquid chromatography-tandem mass spectrometry (LC-MS/MS), which identified several extracellular matrix proteins, supporting the well-known active paracrine function of hAMSCs. Subsequently, we performed label-free quantitative proteomic analysis on CSF samples from rat stroke models intravenously injected with hAMSC (experimental) or phosphate buffered saline (control). In total, 524 proteins were identified; among them, 125 and 91 proteins were increased and decreased with hAMSC treatment, respectively. Furthermore, gene set enrichment analys...
Source: Cell Transplantation - June 28, 2021 Category: Cytology Authors: Junseok W Hur Min-Sik Kim Se-Yeon Oh Ho-Young Kang Jingi Bae Hokeun Kim Hangyeore Lee Sang-Won Lee Dong-Hyuk Park Source Type: research

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke
This study aimed to investigate the microenvironmental changes in the subacute and chronic phases of ischemic stroke after stem cell transplantation. Herein, induced pluripotent stem cells (iPSCs) and neural stem cells (NSCs) were transplanted into the ischemic brain established by middle cerebral artery occlusion surgery. Positron emission tomography imaging and neurological tests were applied to evaluate the metabolic and neurofunctional alterations of rats transplanted with stem cells. Quantitative proteomics was employed to investigate the protein expression profiles in iPSCs-transplanted brain in the subacute and chro...
Source: Frontiers of Medicine - July 9, 2021 Category: General Medicine Source Type: research

Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy
We examined hAMSC-secreted proteins obtained from serum-free culture medium by liquid chromatography-tandem mass spectrometry (LC-MS/MS), which identified several extracellular matrix proteins, supporting the well-known active paracrine function of hAMSCs. Subsequently, we performed label-free quantitative proteomic analysis on CSF samples from rat stroke models intravenously injected with hAMSC (experimental) or phosphate buffered saline (control). In total, 524 proteins were identified; among them, 125 and 91 proteins were increased and decreased with hAMSC treatment, respectively. Furthermore, gene set enrichment analys...
Source: Cell Transplantation - June 28, 2021 Category: Cytology Authors: Junseok W Hur Min-Sik Kim Se-Yeon Oh Ho-Young Kang Jingi Bae Hokeun Kim Hangyeore Lee Sang-Won Lee Dong-Hyuk Park Source Type: research

NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment
CONCLUSIONS: NODDI compliments DTI metrics, enhances interpretation of tissue outcome in ischemic stroke following hMSC application, and may be useful in evaluating or predicting therapeutic response.PMID:34355818 | DOI:10.1002/mrm.28929
Source: Magnetic Resonance in Medicine - August 6, 2021 Category: Radiology Authors: F Andrew Bagdasarian Xuegang Yuan Jacob Athey Bruce A Bunnell Samuel C Grant Source Type: research

Allogeneic adipose tissue-derived mesenchymal stem cells in ischaemic stroke (AMASCIS-02): a phase IIb, multicentre, double-blind, placebo-controlled clinical trial protocol
Introduction Stroke is a serious public health problem, given it is a major cause of disability worldwide despite the spread of recanalisation therapies. Enhancement of brain plasticity with stem cell administration is a promising innovative therapy to reduce sequelae in these patients. Methods and analysis We have developed a phase IIb, multicentre, randomised, double-blind, placebo-controlled clinical trial protocol to evaluate the safety and efficacy of intravenous administration of allogeneic adipose tissue-derived mesenchymal stem cells (AD-MSCs) in patients with acute ischaemic stroke, concurrently with conventional...
Source: BMJ Open - August 9, 2021 Category: General Medicine Authors: de Celis-Ruiz, E., Fuentes, B., Moniche, F., Montaner, J., Borobia, A. M., Gutierrez-Fernandez, M., Diez-Tejedor, E. Tags: Open access, Neurology Source Type: research

Extracellular vesicles and their microRNA cargo in ischaemic stroke
This article is protected by copyright. All rights reserved.PMID:35421904 | DOI:10.1113/JP282050
Source: The Journal of Physiology - April 14, 2022 Category: Physiology Authors: Josie L Fullerton Caitlin C Cosgrove Rebecca A Rooney Lorraine M Work Source Type: research

Infarct-preconditioning exosomes of umbilical cord mesenchymal stem cells promoted vascular remodeling and neurological recovery after stroke in rats
CONCLUSIONS: Our results demonstrated that infarct-preconditioned exosomes promoted neurological recovery after stroke by enhancing vascular endothelial remodeling, suggested that infarct-preconditioned exosomes could be a novel way to alleviate brain damage following a stroke.PMID:35902882 | DOI:10.1186/s13287-022-03083-9
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Yi-Chao Ye Zhe-Han Chang Peng Wang You-Wei Wang Jun Liang Chong Chen Jing-Jing Wang Hong-Tao Sun Yi Wang Xiao-Hong Li Source Type: research

Modulatory effects of mesenchymal stem cells on microglia in ischemic stroke
Ischemic stroke accounts for 70–80% of all stroke cases. Immunity plays an important role in the pathophysiology of ischemic stroke. Microglia are the first line of defense in the central nervous system. Microglial functions are largely dependent on their pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotype. Modulating neuroinflammation via targeting microglia polarization toward anti-inflammatory phenotype might be a novel treatment for ischemic stroke. Mesenchymal stem cells (MSC) and MSC-derived extracellular vesicles (MSC-EVs) have been demonstrated to modulate microglia activation and phenotype polari...
Source: Frontiers in Neurology - January 18, 2023 Category: Neurology Source Type: research