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Therapy: Stem Cell Therapy
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Total 2351 results found since Jan 2013.
Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2
Ischemic stroke is a frequently occurring cerebrovascular disease (CVD) linked to high mortality, disability, and incidence rates, and the second factor causing global mortality41,3. There are two common sources of embolism in ischamic strokes: large artery atherosclerosis and small artery atherosclerosis. Ischemic stroke can be treated clinically with thrombolytic therapy4. Although ischemic stroke is treatable, post-cerebral ischemia blood reperfusion frequently induces inflammation, oxidative stress (OS) or additional unfavorable events that may exacerbate brain injury20,24.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2023 Category: Neurology Authors: Yingju Wang, Hongping Chen, Xuehui Fan, Chen Xu, Meng Li, Hongxue Sun, Jihe Song, Feihong Jia, Wan Wei, Fangchao Jiang, Guozhong Li, Di Zhong Source Type: research
Stem Cells Aid In The Brain's Recovery After Stroke
A specific MicroRNA, a short set of RNA (ribonuclease) sequences, naturally packaged into minute (50 nanometers) lipid containers called exosomes, are released by stem cells after a stroke and contribute to better neurological recovery according to a new animal study by Henry Ford Hospital researchers. The important role of a specific microRNA transferred from stem cells to brain cells via the exosomes to enhance functional recovery after a stroke was shown in lab rats...
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
Vascular and parenchymal lesions along with enhanced neurogenesis characterize the brain of asymptomatic stroke-prone spontaneous hypertensive rats
Conclusion:Appearance of vascular changes in SHRSPs, before any MRI-detectable brain lesion, is coupled to active neural proliferation in the SVZ. With disease progression, only newborn astrocytes can survive, likely because of the neurotoxicity triggered by brain oedema and oxidative stress.
Source: Journal of Hypertension - July 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research
Stem cell discovery: Astrocytes could repair stroke brain damage
Stem cell researchers have discovered that astrocytes may prove useful against stroke and other brain disorders. Astrocytes - neural cells that form the blood-brain barrier and so control what can and cannot enter the brain from the blood supply - have previously been overlooked in this area of stroke research. A collaborative study published in Nature Communications suggests that astrocytes can do far more than simply support nerve cells (neurons)...
Source: Health News from Medical News Today - July 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
Novel treatment for stroke and possibly other neurological diseases
In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease," says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute. The new study is published online in the current issue of Journal of Cerebral Blood Flow and Metabolism...
Source: Health News from Medical News Today - August 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
Reparative Therapy for Acute Ischemic Stroke with Allogeneic Mesenchymal Stem Cells from Adipose Tissue: A Safety Assessment
Few studies have evaluated the possible beneficial effect of the administration of stem cells in the early stages of stroke. Intravenous administration of allogeneic mesenchymal stem cells (MSCs) from adipose tissue in patients with acute stroke could be a safe therapy for promoting neurovascular unit repair, consequently supporting better functional recovery. We aim to assess the safety and efficacy of MSC administration and evaluate its potential as a treatment for cerebral protection and repair.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2014 Category: Neurology Authors: Exuperio Díez-Tejedor, María Gutiérrez-Fernández, Patricia Martínez-Sánchez, Berta Rodríguez-Frutos, Gerardo Ruiz-Ares, Manuel Lara Lara, Blanca Fuentes Gimeno Source Type: research
Stem Cell-Based Tissue Replacement After Stroke: Factual Necessity or Notorious Fiction? Topical Reviews
Source: Stroke - July 27, 2015 Category: Neurology Authors: Janowski, M., Wagner, D.-C., Boltze, J. Tags: Cerebrovascular disease/stroke, Cell biology/structural biology, Acute Cerebral Infarction, Neuroprotectors, Other Stroke Treatment - Medical Topical Reviews Source Type: research
MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats Basic Sciences
Conclusions—Our data suggest that treatment of stroke with tailored exosomes enriched with the miR-17–92 cluster increases neural plasticity and functional recovery after stroke, possibly via targeting phosphatase and tensin homolog to activate the PI3K/protein kinase B/mechanistic target of rapamycin/glycogen synthase kinase 3β signaling pathway.
Source: Stroke - February 26, 2017 Category: Neurology Authors: Hongqi Xin, Mark Katakowski, Fengjie Wang, Jian-Yong Qian, Xian Shuang Liu, Meser M. Ali, Benjamin Buller, Zheng Gang Zhang, Michael Chopp Tags: Animal Models of Human Disease, Cell Signaling/Signal Transduction, Cell Therapy, Stem Cells, Translational Studies Original Contributions Source Type: research
Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell
AbstractStem cell therapy for ischemic stroke has widely been explored. Results from both preclinical and clinical studies have immensely supported the judicious use of stem cells as therapy. These provide an attractive means for preserving and replacing the damaged brain tissues following an ischemic attack. Since the past few years, researchers have used various types of stem cells to replenish insulted neuronal and glial cells in neurological disorders. In the present review, we discuss different types of stem cells employed for the treatment of ischemic stroke and mechanisms and challenges these cells face once introdu...
Source: Translational Stroke Research - October 26, 2017 Category: Neurology Source Type: research
Cell Therapy in Stroke —Cautious Steps Towards a Clinical Treatment
AbstractIn the future, stroke patients may receive stem cell therapy as this has the potential to restore lost functions. However, the development of clinically deliverable therapy has been slower and more challenging than expected. Despite recommendations by STAIR and STEPS consortiums, there remain flaws in experimental studies such as lack of animals with comorbidities, inconsistent approaches to experimental design, and concurrent rehabilitation that might lead to a bias towards positive results. Clinical studies have typically been small, lacking control groups as well as often without clear biological hypotheses to g...
Source: Translational Stroke Research - November 17, 2017 Category: Neurology Source Type: research
NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons
Developing new medicines is a complex process where understanding the reasons for both failure and success takes us forward. One gap in our understanding of most candidate stroke drugs before clinical trial is whether they have a protective effect on human tissues. NXY-059 is a spin-trap reagent hypothesized to have activity against the damaging oxidative biology which accompanies ischemic stroke. Re-examination of the preclinical in vivo dataset for this agent in the wake of the failed SAINT-II RCT highlighted the presence of a range of biases leading to overestimation of the magnitude of NXY-059's effects in laboratory animals.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2018 Category: Neurology Authors: Ana Antonic, Mirella Dottori, Malcolm R. Macleod, Geoffrey A. Donnan, David W. Howells Source Type: research
Hydrogel Scaffolds: Towards Restitution of Ischemic Stroke-Injured Brain
AbstractChronic brain injury following cerebral ischemia is a severe debilitating neurological condition, where clinical intervention is well known to decrease morbidity and mortality. Despite the development of several therapeutic strategies, clinical outcome in the majority of patients could be better improved, since many still face life-long neurological deficits. Among the several strategic options that are currently being pursued, tissue engineering provides much promise for neural tissue salvage and regeneration in brain ischemia. Specifically, hydrogel biomaterials have been utilized to docket biomolecules, adhesion...
Source: Translational Stroke Research - August 27, 2018 Category: Neurology Source Type: research
Mesenchymal Stem Cells: The Potential Therapeutic Cell Therapy to Reduce Brain Stroke Side Effects
Tissue plasminogen activator (tPA) is the gold standard treatment for ischemic stroke in the time window of 3-4.5 hours after the onset of symptoms. However, tPA administration is associated with inflammation and neurotoxic effects. Mesenchymal stem cells (MSC)-based therapy is emerging as a promising therapeutic strategy to control different inflammatory conditions. This project was designed to examine the protective role of MSC administration alone or in combination with royal jelly (RJ) five hours after stroke onset.
Source: Journal of Stroke and Cerebrovascular Diseases - February 23, 2021 Category: Neurology Authors: Ahmad Shabanizadeh, Mohammad Reza Rahmani, Aliakbar Yousefi-Ahmadipour, Fatemeh Asadi, Mohammad Kazemi Arababadi Source Type: research
Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke
AbstractCompromised adult human mesenchymal stem cells (hMSC) can impair cell therapy efficacy and further reverse ischemic recovery. However, in vitro assays require extended passage to characterize cells, limiting rapid assessment for therapeutic potency. Multinuclear magnetic resonance imaging and spectroscopy (MRI/S) provides near real-time feedback on disease progression and tissue recovery. Applied to ischemic stroke,23Na MRI evaluates treatment efficacy within 24 h after middle cerebral artery occlusion, showing recovery of sodium homeostasis and lesion reduction in specimens treated with hMSC while1H MRS identifi...
Source: Translational Stroke Research - July 28, 2022 Category: Neurology Source Type: research
