Filtered By:
Therapy: Stem Cell Therapy

This page shows you your search results in order of relevance. This is page number 15.

Order by Relevance | Date

Total 2351 results found since Jan 2013.

Mesenchymal Stem Cell Therapy for Ischemic Stroke.
Authors: Toyoshima A, Yasuhara T, Date I Abstract 　To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an impor...
Source: Acta Medica Okayama - August 22, 2017 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Stroke and the Cell Therapy Saga: Towards a Safe, Swift and Efficient Utilization of cells.
Abstract The first clinical trials of cell therapy in stroke were first published in the 2000s and consisted of neural stems cells transplanted via the intracerebral pathway. Since mesenchymal stem cells showed similar capacities to differentiate into neural cells and allowed autologous cell transplantation, they were then preferentially studied, including diabetes and hypertension. More recently, bone marrow derived mononuclear cells were successfully transplanted in stroke with no need of culture processing, and simple collection by density gradient centrifugation rendering them immediately ready for use. They i...
Source: The Keio Journal of Medicine - September 29, 2017 Category: Universities & Medical Training Authors: Kubis N Tags: Keio J Med Source Type: research

The beneficial role of early exercise training following stroke and possible mechanisms
Publication date: 1 April 2018 Source:Life Sciences, Volume 198 Author(s): Ying Xing, Si-Dong Yang, Fang Dong, Man-Man Wang, Ya-Shuo Feng, Feng Zhang Exercise training is a regular therapy for stroke patients in clinic. However, whether the early exercise is beneficial for stroke patients is still controversial. The review was performed in databases of OVID, PUBMED, and ISI Web of Science, from respective inception to December 2017. In this review, we summarize the effect of different exercise intensity, initiation time, and style on ischemic stroke. Moreover, the possible mechanism is also discussed. The conclusion is th...
Source: Life Sciences - February 15, 2018 Category: Biology Source Type: research

CXCR7+ and CXCR4+ stem cells and neuron specific enolase in acute ischemic stroke patients
In conclusion, in this study NSE indicated some activity of the CD45−CD34 + CXCR7+, CD45−CD34 + and CD45−CD34 + CXCR4+ stem/progenitor cells in the first 7 days after ischemic stroke. Additionally, this study supports the thesis that NSE might be a valuable prognostic marker in acute ischemic stroke.
Source: Neurochemistry International - August 17, 2018 Category: Neuroscience Source Type: research

Excitable Adult-Generated GABAergic Neurons Acquire Functional Innervation in the Cortex after Stroke
Publication date: Available online 8 November 2018Source: Stem Cell ReportsAuthor(s): Timal S. Kannangara, Anthony Carter, Yingben Xue, Jagroop S. Dhaliwal, Jean-Claude Béïque, Diane C. LagaceSummaryIschemic stroke enhances the proliferation of adult-generated precursor cells that ectopically migrate toward the infarct. Studies have correlated precursor cell proliferation and subsequent adult neurogenesis with enhanced stroke recovery, yet it remains unclear whether stroke can generate new neurons capable of functional integration into the injured cortex. Here, using single and bitransgenic reporter mice, we identify spa...
Source: Stem Cell Reports - November 9, 2018 Category: Stem Cells Source Type: research

Application of Muse Cell Therapy to Stroke.
Authors: Niizuma K, Borlongan CV, Tominaga T Abstract Stroke is defined as a sudden onset of neurologic deficits arising from cerebrovascular complications. It is the second common cause of death around the world and the major cause of disability. Because brain is an organ with complicated neural networks and neurons are highly differentiated, it has been traditionally considered to possess a limited potential for regeneration. The number of stroke patients is increasing, and stroke represents a serious problem from the viewpoint of the national medical economy. Even with the current sophisticated treatments, more ...
Source: Advances in Experimental Medicine and Biology - November 30, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

OCT4B-190 protects against ischemic stroke by modulating GSK-3 β/HDAC6.
OCT4B-190 protects against ischemic stroke by modulating GSK-3β/HDAC6. Exp Neurol. 2019 Apr 11;: Authors: Chen Y, Wu Z, Zhu X, Zhang M, Zang X, Li X, Xu Y Abstract OCT4 is a key regulator in maintaining the pluripotency and self-renewal of embryonic stem cells (ESCs). Human OCT4 gene has three mRNA isoforms, termed OCT4A, OCT4B and OCT4B1. The 190-amino-acid protein isoform (OCT4B-190) is one of the major products of OCT4B mRNA, the biological function of which is still not well defined. Recent evidence suggests that OCT4B-190 may function in the cellular stress response. The glycogen synthase kinase...
Source: Experimental Neurology - April 10, 2019 Category: Neurology Authors: Chen Y, Wu Z, Zhu X, Zhang M, Zang X, Li X, Xu Y Tags: Exp Neurol Source Type: research

Aggregation of human mesenchymal stem cells enhances survival and efficacy in stroke treatment
In this study, we report the effects of short-term preconditioning of hMSCs via three-dimensional (3D) aggregation on stroke lesion recovery after intra-arterial (IA) transplantation of 3D aggregate-derived hMSCs (Agg-D hMSCs) in a transient middle cerebral artery occlusion (MCAO) stroke model. Compared with two-dimensional (2D) monolayer culture, Agg-D hMSCs exhibited increased resistance to ischemic stress, secretory function and therapeutic outcome. Short-term preconditioning via 3D aggregation reconfigured hMSC energy metabolism and altered redox cycle, which activated the PI3K/AKT pathway and enhanced resistance to in...
Source: Cytotherapy - September 17, 2019 Category: Cytology Source Type: research

Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway
ConclusionAs IV stimulates hippocampal neurogenesis after stroke, thus potentially facilitates brain to remodel and repair by downregulating IL-17 expression via Wnt pathway.
Source: Frontiers in Pharmacology - April 2, 2020 Category: Drugs & Pharmacology Source Type: research

Blood-based biomarkers and stem cell therapy in human stroke: a systematic review.
Abstract Stroke is one of the main causes of death and disability worldwide. Cell therapy represents a promising therapeutic approach to improve stroke outcome. Measurement of blood-based biomarkers might serve as a proof-of-concept to monitor the mechanisms undergirding these treatments, and such compounds could be used as surrogate biomarkers to monitor the safety and efficacy of cell therapies in the future. Additionally, the measurement of biomarkers that correlate with circulating stem cells in observational studies might be of interest to improve the understanding of how these cells are spontaneously mobiliz...
Source: Molecular Biology Reports - July 6, 2020 Category: Molecular Biology Authors: Palà E, Bustamante A, Jolkkonen J, Hommel M, Rosell A, Montaner J Tags: Mol Biol Rep Source Type: research

Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy
We examined hAMSC-secreted proteins obtained from serum-free culture medium by liquid chromatography-tandem mass spectrometry (LC-MS/MS), which identified several extracellular matrix proteins, supporting the well-known active paracrine function of hAMSCs. Subsequently, we performed label-free quantitative proteomic analysis on CSF samples from rat stroke models intravenously injected with hAMSC (experimental) or phosphate buffered saline (control). In total, 524 proteins were identified; among them, 125 and 91 proteins were increased and decreased with hAMSC treatment, respectively. Furthermore, gene set enrichment analys...
Source: Cell Transplantation - June 28, 2021 Category: Cytology Authors: Junseok W Hur Min-Sik Kim Se-Yeon Oh Ho-Young Kang Jingi Bae Hokeun Kim Hangyeore Lee Sang-Won Lee Dong-Hyuk Park Source Type: research