Molecular Basis of Angiogenesis and its Application
Keio J Med. 2024;73(1):12. doi: 10.2302/kjm.ABSTRACT_73_1-1.ABSTRACTAngiogenesis, the development of new blood vessels, is a fundamental physiological process. In addition, angiogenesis plays a key role in the pathogenesis of several disorders, including cancer and eye disorders such as diabetic retinopathy and age-related macular degeneration (AMD). However, identifying the regulators of angiogenesis proved challenging. Numerous factors that stimulated angiogenesis in various bioassays were identified, but their pathophysiological role remained unclear. In 1989, we reported the isolation and cloning of vascular endothelia...
Source: The Keio Journal of Medicine - March 24, 2024 Category: Universities & Medical Training Authors: Napoleone Ferrara Source Type: research

Elucidation of molecular mechanism of the unfolded protein response
Keio J Med. 2024;73(1):13. doi: 10.2302/kjm.ABSTRACT_73_1-2.ABSTRACTThe endoplasmic reticulum (ER), where newly synthesized secretory and transmembrane proteins are folded and assembled, has the ability to discriminate folded proteins from unfolded proteins and controls the quality of synthesized proteins. Only correctly folded molecules are allowed to move along the secretory pathway, whereas unfolded proteins are retained in the ER.The ER contains a number of molecular chaperones and folding enzymes (ER chaperones hereafter), which assist productive folding of proteins, and therefore newly synthesized proteins usually ga...
Source: The Keio Journal of Medicine - March 24, 2024 Category: Universities & Medical Training Authors: Kazutoshi Mori Source Type: research

Molecular Basis of Angiogenesis and its Application
Keio J Med. 2024;73(1):12. doi: 10.2302/kjm.ABSTRACT_73_1-1.ABSTRACTAngiogenesis, the development of new blood vessels, is a fundamental physiological process. In addition, angiogenesis plays a key role in the pathogenesis of several disorders, including cancer and eye disorders such as diabetic retinopathy and age-related macular degeneration (AMD). However, identifying the regulators of angiogenesis proved challenging. Numerous factors that stimulated angiogenesis in various bioassays were identified, but their pathophysiological role remained unclear. In 1989, we reported the isolation and cloning of vascular endothelia...
Source: The Keio Journal of Medicine - March 24, 2024 Category: Universities & Medical Training Authors: Napoleone Ferrara Source Type: research

Elucidation of molecular mechanism of the unfolded protein response
Keio J Med. 2024;73(1):13. doi: 10.2302/kjm.ABSTRACT_73_1-2.ABSTRACTThe endoplasmic reticulum (ER), where newly synthesized secretory and transmembrane proteins are folded and assembled, has the ability to discriminate folded proteins from unfolded proteins and controls the quality of synthesized proteins. Only correctly folded molecules are allowed to move along the secretory pathway, whereas unfolded proteins are retained in the ER.The ER contains a number of molecular chaperones and folding enzymes (ER chaperones hereafter), which assist productive folding of proteins, and therefore newly synthesized proteins usually ga...
Source: The Keio Journal of Medicine - March 24, 2024 Category: Universities & Medical Training Authors: Kazutoshi Mori Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research

Incidence of Radiation-induced Nausea and Vomiting: A Prospective Single-institution Pilot Study
Keio J Med. 2024 Feb 23. doi: 10.2302/kjm.2023-0021-OA. Online ahead of print.ABSTRACTRadiation-induced nausea and vomiting (RINV) is a frequent adverse event that occurs in patients undergoing radiotherapy. However, research on RINV is underrepresented. This prospective single-institution exploratory pilot study investigated the incidence of RINV according to the irradiation site and observed the efficacy of symptomatic antiemetic treatment in controlling symptoms of RINV. The primary outcomes were the proportions of emesis-free days and nausea-free days. The secondary endpoints included the time to the first episode of R...
Source: The Keio Journal of Medicine - February 25, 2024 Category: Universities & Medical Training Authors: Kayo Yoshida Takashi Hanada Junichi Fukada Mariko Kawamura Naoyuki Shigematsu Source Type: research