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Therapy: Stem Cell Therapy

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Total 2351 results found since Jan 2013.

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke.
CONCLUSIONS: Our data suggest that timing and cell dose of transplantation determine the therapeutic effects after focal ischemia by modulating poststroke neuroinflammation. PMID: 24393245 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Wang LQ, Lin ZZ, Zhang HX, Shao B, Xiao L, Jiang HG, Zhuge QC, Xie LK, Wang B, Su DM, Jin KL Tags: CNS Neurosci Ther Source Type: research

Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis and hippocampal damage in brain of a spontaneously stroke model.
Abstract Stroke is the most common cause of motor disabilities and is a major cause of mortality worldwide. Adult stem cells have been shown to be effective against neuronal degeneration through mechanisms that include both the recovery of neurotransmitter activity and a decrease in apoptosis and oxidative stress. We chose the lineage Stroke Prone Spontaneously Hypertensive Rat (SHRSP) as a model for stem cells therapy. SHRSP can develop such severe hypertension that they generally suffer a stroke at approximately one year of age. The aims of this study were to evaluate whether mesenchymal stem cells (MSC) decreas...
Source: Free Radical Biology and Medicine - February 10, 2014 Category: Biology Authors: Longoni Calió M, Sousa Marinho D, Mi Ko G, Rodrigues R, Ferraz Carbonel A, Missae Oyama L, Ormanji M, Pinoti Guirao T, Luiz Calió P, Aparecida Reis L, de Jesus Simões M, Lisboa do Nascimento T, Teixeira Ferreira A, Rejane Antônio Bertoncini C Tags: Free Radic Biol Med Source Type: research

Transplantation of human dental pulp-derived stem cells protects against heat stroke in mice.
In conclusion, post-WBH treatment with SHED reduced induction of pro-inflammatory cytokines and oxidative radicals, enhanced plasma induction of both adrenocorticotrophic hormone and corticosterone, and improved lethality in mice heat stroke. The protective effect of SHED may be related to a decreased inflammatory response, a decreased oxidative stress, and an increased hypothalamo-pituitaryadrenocortical axis activity following the WBH injury. PMID: 24612725 [PubMed - as supplied by publisher]
Source: Cell Transplantation - March 7, 2014 Category: Cytology Authors: Tseng LS, Chen SH, Lin MT, Lin YC Tags: Cell Transplant Source Type: research

The Use of ADSCs as a Treatment for Chronic Stroke.
Abstract Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagic-induced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, ...
Source: Cell Transplantation - May 17, 2014 Category: Cytology Authors: Chan TM, Harn HJ, Lin HP, Chiu SC, Lin PC, Wang HI, Ho LI, Chuu CP, Chiou TW, Hsieh AC, Chen YW, Ho WY, Lin SZ Tags: Cell Transplant Source Type: research

Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells.
Conclusions: Ischemic stroke activates hematopoietic stem cells via increased sympathetic tone, leading to a myeloid bias of hematopoiesis and higher bone marrow output of inflammatory Ly6Chigh monocytes. PMID: 25362208 [PubMed - as supplied by publisher]
Source: Circulation Research - October 31, 2014 Category: Cardiology Authors: Courties G, Herisson F, Sager H, Heidt T, Ye Y, Ying W, Sun Y, Severe N, Dutta P, Scharff J, Scadden D, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Tags: Circ Res Source Type: research

Adipose tissue-derived stem cells in stroke treatment: from bench to bedside.
Authors: Gutiérrez-Fernández M, Rodríguez-Frutos B, Otero-Ortega L, Ramos-Cejudo J, Fuentes B, Díez-Tejedor E Abstract More recently, growing interests have brought cell therapy to the forefront of promising new approaches towards efficacious treatment for stroke. Of all cell-types, adipose tissue-derived mesenchymal stem cells (AD-MSC) are considered good candidates for stroke treatment because of their abundance and easy harvesting without invasive surgery from healthy donors. A wide number of experimental studies have demonstrated the potential of AD-MSC administration for improving functional deficits and h...
Source: Discovery Medicine - November 14, 2014 Category: Research Tags: Discov Med Source Type: research

Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke.
Abstract Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-ba...
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Tang YH, Ma YY, Zhang ZJ, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

Intranasal administration of Human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke.
In this study, we investigated whether intranasal administration of human umbilical cord mesenchymal stem cells (hUCMSCs)-CM has the therapeutic effects in rats after stroke. Adult male rats were subjected to middle cerebral artery occlusion (MCAo) and were treated by intranasal routine with or without hUCMSCs-CM (1ml/kg/d), starting 24h after MCAo and daily for 14 days. Neurological functional tests, blood brain barrier (BBB) leakage were measured. Angiogenesis and angiogenic factor expression were measured by immunohistochemistry, and Western blot, respectively. hUCMSCs-CM treatment of stroke by intranasal routine starti...
Source: Brain Research - August 13, 2015 Category: Neurology Authors: Zhao Q, Hu J, Xiang J, Gu Y, Jin P, Hua F, Zhang Z, Liu Y, Zan K, Zhang Z, Zu J, Yang X, Shi H, Zhu J, Xu Y, Cui G, Ye X Tags: Brain Res Source Type: research

MiR‐126 Contributes to Human Umbilical Cord Blood Cell Induced Neurorestorative Effects after Stroke in Type‐2 Diabetic Mice
This article is protected by copyright. All rights reserved.
Source: Stem Cells - August 24, 2015 Category: Stem Cells Authors: Jieli Chen, Ruizhuo Ning, Alex Zacharek, Chengcheng Cui, Xu Cui, Tao Yan, Poornima Venkat, Yi Zhang, Michael Chopp Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Transplantation of unique subpopulation of fibroblasts, Muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation
This article is protected by copyright. All rights reserved.
Source: Stem Cells - September 21, 2015 Category: Stem Cells Authors: Hiroki Uchida, Takahiro Morita, Kuniyasu Niizuma, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Hiroyuki Sakata, Yoshiya Matsuzaka, Hajime Mushiake, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Regenerative Medicine Source Type: research

Clinical Trials of Adult Stem Cell Therapy in Patients with Ischemic Stroke.
Authors: Bang OY Abstract Stem cell therapy is considered a potential regenerative strategy for patients with neurologic deficits. Studies involving animal models of ischemic stroke have shown that stem cells transplanted into the brain can lead to functional improvement. With current advances in the understanding regarding the effects of introducing stem cells and their mechanisms of action, several clinical trials of stem cell therapy have been conducted in patients with stroke since 2005, including studies using mesenchymal stem cells, bone marrow mononuclear cells, and neural stem/progenitor cells. In addition,...
Source: Journal of Clinical Neurology - November 30, 2015 Category: Neurology Tags: J Clin Neurol Source Type: research

MiR‐126 Contributes to Human Umbilical Cord Blood Cell‐Induced Neurorestorative Effects After Stroke in Type‐2 Diabetic Mice
Abstract Diabetes mellitus (DM) is a high risk factor for stroke and leads to more severe vascular and white‐matter injury than stroke in non‐DM. We tested the neurorestorative effects of delayed human umbilical cord blood cell (HUCBC) treatment of stroke in type‐2 diabetes (T2DM). db/db‐T2DM and db/+‐non‐DM mice were subjected to distal middle cerebral artery occlusion (dMCAo) and were treated 3 days after dMCAo with: (a) non‐DM + Phosphate buffered saline (PBS); (b) T2DM + PBS; (c) T2DM + naïve‐HUCBC; (d) T2DM + miR‐126−/−HUCBC. Functional evaluation, vascular and white‐matter cha...
Source: Stem Cells - January 13, 2016 Category: Stem Cells Authors: Jieli Chen, Ruizhuo Ning, Alex Zacharek, Chengcheng Cui, Xu Cui, Tao Yan, Poornima Venkat, Yi Zhang, Michael Chopp Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Intravenous injection of clinical grade human MSCs after experimental stroke: functional benefit and microvascular effect.
Abstract Stroke is the leading cause of disability in adults. Many current clinical trials use an intravenous (IV) administration of human mesenchymal stromal/stem cells (hMSCs). This autologous graft requires a delay for ex vivo expansion of cells. We followed microvascular effects and mechanisms of action involved after an IV injection of hMSCs at a subacute phase of stroke. Rats underwent a transient middle cerebral artery occlusion (MCAo) or a surgery without occlusion (sham) at day 0 (D0). At D8, rats received an IV injection of 3 million hMSCs or PBSglutamine. In a longitudinal behavioral follow-up, we showe...
Source: Cell Transplantation - February 26, 2016 Category: Cytology Authors: Moisan A, Favre I, Rome C, De Fraipont F, Grillon E, Coquery N, Mathieu H, Mayan V, Naegele B, Hommel M, Richard MJ, Barbier EL, Remy C, Detante O Tags: Cell Transplant Source Type: research

Neurorestoration after stroke.
Abstract Recent advancements in stem cell biology and neuromodulation have ushered in a battery of new neurorestorative therapies for ischemic stroke. While the understanding of stroke pathophysiology has matured, the ability to restore patients' quality of life remains inadequate. New therapeutic approaches, including cell transplantation and neurostimulation, focus on reestablishing the circuits disrupted by ischemia through multidimensional mechanisms to improve neuroplasticity and remodeling. The authors provide a broad overview of stroke pathophysiology and existing therapies to highlight the scientific and c...
Source: Neurosurgical Focus - April 30, 2016 Category: Neurosurgery Authors: Azad TD, Veeravagu A, Steinberg GK Tags: Neurosurg Focus Source Type: research

Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke: Mechanistic Determination of the Causal Link Between Neurovascular Regeneration and Motor Functional Recovery
This study provides novel insights into the development of new restorative strategies for stroke recovery.
Source: ASN Neuro - August 8, 2016 Category: Neuroscience Authors: Cui, L., Wang, D., McGillis, S., Kyle, M., Zhao, L.-R. Tags: Original Article Source Type: research