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Total 256 results found since Jan 2013.

Statins May Be Beneficial After Radiation to Thorax, Head, Neck
WEDNESDAY, June 19, 2019 -- For cardiac patients with thorax and head or neck cancer, statin use after radiation therapy is associated with a significant reduction in stroke incidence and a trend toward reduced cardiovascular and cerebrovascular...
Source: Drugs.com - Pharma News - June 19, 2019 Category: Pharmaceuticals Source Type: news

Delayed radiation-induced stroke mimics recurrent tumor in and adolescent with remote history of low-grade brainstem glioma
A 13-year-old female was diagnosed with a ponto- medullary brainstem glioma and following unsuccessful treatment with chemotherapy, underwent focal photon intensity modulated radiation therapy that resulted in a favorable response. Ten years later, the patient presented with acute onset left-sided hemiplegia and headaches. Magnetic resonance imaging (MRI) at presentation showed a large contrast- enhancing lesion with surrounding vasogenic edema and reduced diffusivity on diffusion- weighted imaging most concerning for a high grade secondary malignancy (Figure 1).
Source: Pediatric Neurology - June 4, 2019 Category: Neurology Authors: Lianne Q. Chau, Michael L. Levy, John Ross Crawford Tags: Short Communication Source Type: research

Delayed Radiation-Induced Stroke Mimics Recurrent Tumor in an Adolescent With Remote History of Low-Grade Brainstem Glioma
This 13-year-old girl was diagnosed with a ponto-medullary brainstem glioma, and following unsuccessful treatment with chemotherapy, she underwent focal photon intensity-modulated radiation therapy that resulted in a favorable response. Ten years later, she presented with acute left hemiplegia and headaches. Magnetic resonance imaging (MRI) at presentation showed a large contrast-enhancing lesion with surrounding vasogenic edema and reduced diffusivity on diffusion-weighted imaging, most concerning for a high-grade secondary malignancy (Fig 1).
Source: Pediatric Neurology - June 4, 2019 Category: Neurology Authors: Lianne Q. Chau, Michael L. Levy, John R. Crawford Tags: Clinical Letter Source Type: research

Current Challenges for Imaging of Hypoxia in 2019
1128Introduction: Tissues with low levels of oxygen often respond poorly to radiation therapy and chemo / immune therapies. Hypoxia in tumor bearing tissue is associated with worse clinical outcome and this has been known for over 50 years. Alterations to radiation therapy planning via providing localized boost to hypoxic tissues cannot be made without knowing exactly where hypoxia exists. However, there is no FDA approved agent to assess for hypoxia in tumor tissues, there is no accepted standard methodology for measuring hypoxia in patients, nor are there FDA approved agents for treating hypoxia. There are multiple PET i...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Rodgers, B., Kotlyarov, E. Tags: Educational Exhibit Posters Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Stroke and thromboembolic events in men with prostate cancer treated with definitive radiation therapy with or without androgen deprivation therapy
Stroke and thromboembolic events in men with prostate cancer treated with definitive radiation therapy with or without androgen deprivation therapy, Published online: 15 April 2019; doi:10.1038/s41391-019-0150-5Stroke and thromboembolic events in men with prostate cancer treated with definitive radiation therapy with or without androgen deprivation therapy
Source: Prostate Cancer and Prostatic Diseases - April 14, 2019 Category: Urology & Nephrology Authors: Rishi Deka Daniel R. Simpson Matthew S. Panizzon Richard L. Hauger Paul Riviere Vinit Nalawade Rana McKay James D. Murphy Brent S. Rose Source Type: research

Left Thalamus Arteriovenous Malformation Secondary to Radiation Therapy of Original Vermian Arteriovenous Malformation: Case Report
A 70-year-old gentleman with history of hypothyroidism, hyperlipidemia, hypertension, and right superior cerebellar aneurysm presented to the neurosurgery service in 2008 with vertigo. Diagnostic cerebral angiography performed that year demonstrated a vermian arteriovenous malformations (AVM). The patient underwent stereotactic proton beam radiosurgery, which resulted in a decrease in flow and size of the lesion, and the patient was lost to follow-up. Now at the age of 80, the patient presented with acute gait instability.
Source: Journal of Stroke and Cerebrovascular Diseases - April 7, 2019 Category: Neurology Authors: Carlos Torres-Quinones, Matthew J. Koch, Scott B. Raymond, Aman Patel Tags: Case Report Source Type: research

Stroke-like migraine attacks after radiation therapy (SMART) syndrome
ABSTRACT The present article provides the historical background of the Sociedade Brasileira de Doen ças Cerebrovasculares (Brazilian Society for Cerebrovascular Diseases), including details on its function, structure, challenges and main achievements.RESUMO O presente texto apresenta um relato hist órico da Sociedade Brasileira de Doenças Cerebrovasculares, incluindo detalhes da sua fundação, estruturação, dificuldades e principais realizações.
Source: Arquivos de Neuro-Psiquiatria - April 4, 2019 Category: Neurology Source Type: research

Genetic variant linked to increased stroke risk in childhood cancer survivors treated with CRT
(American Association for Cancer Research) A common single nucleotide polymorphism (SNP) was associated with increased risk for developing stroke in childhood survivors who received cranial radiation therapy (CRT) for their primary cancer, according to results presented at the AACR Annual Meeting 2019, March 29-April 3.
Source: EurekAlert! - Cancer - April 2, 2019 Category: Cancer & Oncology Source Type: news

Surgical Management of Deep-Seated Metastatic Brain Tumors Using Minimally Invasive Approaches
Conclusion This minimally invasive approach can be used to achieve extensive resection with minimal morbidity for arguably the highest risk metastatic brain tumors. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - March 19, 2019 Category: Neurosurgery Authors: Gassie, Kelly Alvarado-Estrada, Keila Bechtle, Perry Chaichana, Kaisorn L. Tags: Original Article Source Type: research

Study unveils a blueprint for treating a deadly brain tumor
(NIH/National Institute of Neurological Disorders and Stroke) In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others. The results suggested that certain patients' tumor cells are less aggressive and much better at repairing DNA than others but are difficult to kill with radiation. The researchers then showed that combining radiation therapy with cancer drugs designed to block DNA repair may be an effective treatment strategy.
Source: EurekAlert! - Cancer - February 19, 2019 Category: Cancer & Oncology Source Type: news

Increased Risk of Lymphoid Malignancy in Patients with Herpes Zoster: A Longitudinal Follow-up Study Using a National Cohort Study
Conclusion: Our study demonstrates that herpes zoster infection increases the risk of subsequent lymphoid malignancies irrespective of age and gender in the Korean population.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Lee, Y. K., Kim, M., Kim, H. J., Lim, H., Choi, H. G. Tags: 902. Health Services Research-Malignant Diseases: Quality Of Life Studies Source Type: research

Medical Conditions Among Survivors of Adolescent and Young Adult Non-Hodgkin Lymphoma (NHL), Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML)
Conclusion: This study found that sociodemographic factors were associated with the risk of developing medical conditions in AYA NHL, ALL and AML survivors. As expected, the risk of medical conditions varied by cancer type and treatment, with those undergoing SCT having a higher risk of medical conditions regardless of cancer type. NHL and ALL survivors who were uninsured or publicly insured were at a consistently higher risk of developing medical conditions, as were Hispanic ALL survivors and Black AML survivors. Our findings highlight the higher burden of medical conditions in subgroups of cancer survivors that may relat...
Source: Blood - November 21, 2018 Category: Hematology Authors: Keegan, T. H. M., Muffly, L. S., Li, Q., Alvarez, E., Brunson, A. M., Malogolowkin, M., Wun, T. Tags: 904. Outcomes Research-Malignant Conditions: Real World Outcomes Source Type: research

CAR 2. Results of Carotid Artery Stenting in a Belgian “Real-World” Practice
Carotid artery stenting (CAS) is a valuable solution for the treatment of carotid artery stenosis in a population of patients at high risk for carotid endarterectomy (CEA). This high-risk population includes patients with recurrent stenosis after CEA, high/low lesion, contralateral laryngeal nerve palsy, previous radical neck surgery, cervical radiation therapy, and tracheostomy. In the European Society for Vascular Surgery guidelines, however, the authors were concerned about the death and stroke rates of CAS in “real-world” practice.
Source: Journal of Vascular Surgery - October 22, 2018 Category: Surgery Authors: Laura Kerselaers, Sarah Gallala, Dimitri Aerden, Karl Von Kemp, Erik Debing Source Type: research

SMART - Not Always Only "Stroke-Like".
Abstract Stroke-like migraine attacks after radiation therapy (SMART) is a syndrome observed in a delayed fashion in patients following brain radiation therapy. It is a rare but important differential diagnosis of migraine in these patients, often presenting with migraine-like headache. In addition, there may be focal neurological deficits or seizures. In general, it is regarded as a reversible condition, therefore termed stroke-like. Our case illustrates that there may also be ischemic stroke associated with SMART leading to an unfavorable course, even after prior remission. PMID: 30311189 [PubMed - as supplied by publisher]
Source: Headache - October 12, 2018 Category: Neurology Authors: Haller V, Dashti D, Peters N Tags: Headache Source Type: research