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Total 256 results found since Jan 2013.

Upregulation of Connexin-43 is critical for irradiation-induced neuroinflammation.
Conclusion Cx-43 expression level may play an important role in the inflammation-related neural damage after irradiation-induced ischemia stroke. PMID: 29984671 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - July 6, 2018 Category: Drugs & Pharmacology Authors: Wei C, Tong W, Guo Y, He B, Chen L, Yang W, Wu C, Ren D, Zheng P, Feng J Tags: CNS Neurol Disord Drug Targets Source Type: research

Seizures with Migraine-like Attacks after Radiation Therapy (SMART): A new meaning of an old acronym
We describe two patients with SMART presenting with focal status epilepticus and headache. We believe that SMART is a misnomer that misjudge seizures among clinical features and we suggest to rename this entity as " Seizure with Migraine-like Attacks after Radiation Therapy". The new acronym, modified in its meaning but not in its form (SMART), better reflects the main clinical features and may allow neurologists to recognize this condition more easily.
Source: Seizure: European Journal of Epilepsy - June 15, 2018 Category: Neurology Authors: Edoardo Ferlazzo, Michele Ascoli, Sara Gasparini, Vittoria Cianci, Damiano Branca, Chiara Sueri, Umberto Aguglia Tags: Short communication Source Type: research

Seizures with Migraine-like Attacks after Radiation Therapy (SMART) A new meaning of an old acronym
Stroke-like migraine attacks after radiation therapy (SMART) is a late-onset complication of cranial irradiation, clinically characterized by headache, seizures and focal deficits, with suggestive MRI changes. Clinical and neuroimaging findings typically resolve after a few weeks [1]. Seizures or status epilepticus are reported in 69% of SMART patients [2,3].
Source: Seizure: European Journal of Epilepsy - June 15, 2018 Category: Neurology Authors: Edoardo Ferlazzo, Michele Ascoli, Sara Gasparini, Vittoria Cianci, Damiano Branca, Chiara Sueri, Umberto Aguglia Tags: Short communication Source Type: research

A Reanalysis of Predictors for the Risk of Hemorrhage in Brain Arteriovenous Malformation
Brain arteriovenous malformation (BAVM) is a congenital cerebral vascular disease that characterized with intracranial hemorrhage and epilepsy. It has some risk in current treatments including microsurgery, endovascular, and radiation therapy. Some patients with bAVMs may keep unruptured in their whole life. Whether it should be treated depends on the evaluation of the hemorrhage risk of bAVM. Although previous studies gave many significant predictors, we tried to find some new and more significant predictors in 173 patients with bAVMS by retrospective analysis.
Source: Journal of Stroke and Cerebrovascular Diseases - April 2, 2018 Category: Neurology Authors: Zheng Huang, Kang Peng, Changqing Chen, Feiyue Zeng, Junyu Wang, Fenghua Chen Source Type: research

Surgical management of giant sphenoid wing meningiomas encasing major cerebral arteries.
CONCLUSIONS Although these giant lesions encasing major cerebral arteries are particularly treacherous for surgery, this series demonstrates that it is possible to safely achieve radical removal and at times even gross-total resection. However, the risk of recurrence remains high and larger studies are needed to see if and how improvement can be achieved, whether in surgical technique or technological advances, and by determining the timing and modality of adjuvant radiation therapy. PMID: 29606042 [PubMed - in process]
Source: Neurosurgical Focus - April 1, 2018 Category: Neurosurgery Authors: Champagne PO, Lemoine E, Bojanowski MW Tags: Neurosurg Focus Source Type: research

A Case of Stroke-like Migraine Attacks after Radiation Therapy (SMART) Syndrome Followed by Cerebral Infarction.
Authors: Takahashi H, Kimura T, Yuki N, Yoshioka A Abstract A 36-year-old man with a history of irradiation for acute lymphoblastic leukemia developed headache with cortical dysfunction lasting for 4 weeks. The clinical features were consistent with stroke-like migraine attacks after radiation therapy (SMART) syndrome. Six months later, he developed cerebral infarction due to occlusions of the left anterior and middle cerebral arteries. This is the first case report describing SMART syndrome followed by severe cerebral infarction. Although an association between the two episodes was not assumed, this case indicates...
Source: Internal Medicine - March 3, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Radiotherapy in acromegaly: long-term brain parenchymal and vascular magnetic resonance changes
Conclusions RT seems to have created a cohort of patients with brain parenchymal changes whose clinical and cognitive impact is still unknown. These patients might require a prolonged MRI and MRA follow-up to promptly detect delayed RT-related complications and minimize their clinical consequences.
Source: Journal of Neuroradiology - March 2, 2018 Category: Radiology Source Type: research

In Regard to Sanford et  al
To the Editor: We read with interest Sanford et  al's report (1) on their prospective study examining fractionated radiation therapy (RT) for residual/recurrent benign meningioma after resection; we applaud the authors for being the first to conduct such a study and for demonstrating the integrity and courage to present their complications whole heartedly. Although the 98% 10-year and 90% 15-year local control rates are impressive, we were particularly alarmed at the more than 20% stroke rate at the authors' median 17-year follow up (along with the near 60% rate of grade 2+ toxicity).
Source: International Journal of Radiation Oncology * Biology * Physics - January 31, 2018 Category: Radiology Authors: Shearwood McClelland, Timur Mitin, Jeremy N. Ciporen Tags: Comment Source Type: research

Pathologic Findings of Symptomatic Carotid Artery Stenosis Several Decades after Radiation Therapy: A Case Report
Improved long-term survival of malignancy has drawn increased attention to late cerebrovascular toxicity after neck radiotherapy. Recently, neck radiotherapy has been found as a significant risk factor of carotid artery stenosis and ischemic stroke; however, long-term adverse effects of radiation in large arteries remain unknown. Here, we described an autopsied case with recurrent ischemic stroke associated with ipsilateral carotid artery stenosis several decades after neck radiation therapy. Pathologically, there were intima-media fibrosis, endothelial cell loss, and decreased expression of thrombomodulin in irradiated ca...
Source: Journal of Stroke and Cerebrovascular Diseases - January 11, 2018 Category: Neurology Authors: Shuichi Tonomura, Keiji Shimada, Naoko Funatsu, Yoshiaki Kakehi, Hisao Shimizu, Nobuyuki Takahashi Tags: Case Studies Source Type: research

Stroke ‐like migraine attacks after radiation therapy: A misnomer?
Summary ObjectiveTo understand the frequency of electrographic and clinical seizures in patients with stroke‐like migraine attacks after radiation therapy (SMART), and determine whether SMART warrants comprehensive electroencephalographic (EEG) monitoring and aggressive seizure management. MethodsWe searched our magnetic resonance brain imaging report database for all patients between January 2013 and December 2015 for suspected SMART syndrome. Clinical inclusion criteria were further applied as follows: inpatient adults (>18 years of age) with history of cranial radiation presenting with acute neurologic deficits as ...
Source: Epilepsia - November 23, 2017 Category: Neurology Authors: Emily Peien Fan, Gabriel Heiber, Elizabeth E. Gerard, Stephan Schuele Tags: FULL ‐LENGTH ORIGINAL RESEARCH Source Type: research

Long ‐term safety of growth hormone—A combined registry analysis
ConclusionsPatients with risk factors for malignancy or type 2 diabetes should be treated with caution and monitored during follow‐up, but current published data provide reassurance on the long‐term safety profile of GH in patients receiving GH treatment.
Source: Clinical Endocrinology - November 20, 2017 Category: Endocrinology Authors: Kirstine Stochholm, Wieland Kiess Tags: UNSOLICITED REVIEW Source Type: research

Mortality following benign sacral insufficiency fracture and associated risk factors
ConclusionsLike other types of osteoporotic fractures, sacral insufficiency fractures are associated with increased mortality.
Source: Archives of Orthopaedic and Trauma Surgery - November 9, 2017 Category: Orthopaedics Source Type: research

Long ‐Term Safety of Growth Hormone – A Combined Registry Analysis
ConclusionsPatients with risk factors for malignancy or type 2 diabetes should be treated with caution and monitored during follow‐up, but current published data provide reassurance on the long‐term safety profile of GH in patients receiving GH treatment.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - October 21, 2017 Category: Endocrinology Authors: Kirstine Stochholm, Wieland Kiess Tags: Unsolicited Review Source Type: research

Efficacy and safety in frameless robot-assisted stereo-electroencephalography (SEEG) for drug-resistant epilepsy.
CONCLUSION: Frameless robot-assisted SEEG appears to be a safe procedure, providing sufficient accuracy in order to delineate the epileptogenic zone and represents a helpful tool in the pre-surgical management of refractory epilepsy. PMID: 28882607 [PubMed - as supplied by publisher]
Source: Neuro-Chirurgie - September 4, 2017 Category: Neurosurgery Authors: Ollivier I, Behr C, Cebula H, Timofeev A, Benmekhbi M, Valenti MP, Staack AM, Scholly J, Kehrli P, Hirsch E, Proust F Tags: Neurochirurgie Source Type: research