Current Challenges for Imaging of Hypoxia in 2019

1128Introduction: Tissues with low levels of oxygen often respond poorly to radiation therapy and chemo / immune therapies. Hypoxia in tumor bearing tissue is associated with worse clinical outcome and this has been known for over 50 years. Alterations to radiation therapy planning via providing localized boost to hypoxic tissues cannot be made without knowing exactly where hypoxia exists. However, there is no FDA approved agent to assess for hypoxia in tumor tissues, there is no accepted standard methodology for measuring hypoxia in patients, nor are there FDA approved agents for treating hypoxia. There are multiple PET imaging agents that can find areas of hypoxia in tumors .These include 18F MISO (which becomes irreversibly bound to hypoxic cells and trapped over time) and 18F FAZA (newer and has more ideal imaging qualities, though uptake could in part be flow related). Both of these agents require cells to be viable as part of uptake. There are several copper containing PET imaging compounds such as 62Cu-ATSM which become trapped due to the redox environment of hypoxic tissues. Cu-ATSM uptake can be associated with over expression of VEGF. However, radiation dose from the copper containing compounds is about 2X that of 18F MISO. Distribution of Cu-ATSM is not the same as FMISO, and the role for Cu-ATSM compounds vs FMISO is not clear. There also are also several MRI techniques such as OE, DCE, BOLD, qBOLD, and TOLD that can be used to assess for hypoxia. None have achiev...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibit Posters Source Type: research

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This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We reported a case of carotid artery stenosis with stroke symptoms detected in a patient with lung cancer after radiotherapy. The patient was a 58-year-old male with a complaint of \"a single episode of temporary amaurosis in the right eye for 10 minutes". The clinical diagnosis at admission, after consideration of the patient's age, medical history, and auxiliary examination results, was as follows: lung cancer; right common carotid artery stenosis; left common carotid artery stenosis; left vertebral artery stenosis; and right subclavian artery occlusion with right subclavian steal syndrome (Grade 3). Carot...
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
We present a contemporary analysis of risk of fatal stroke among more than 7.5 million cancer patients and report that stroke risk varies as a function of disease site, age, gender, marital status, and time after diagnosis. The risk of stroke among cancer patients is two times that of the general population and rises with longer follow-up time. The relative risk of fatal stroke, versus the general population, is highest in those with cancers of the brain and gastrointestinal tract. The plurality of strokes occurs in patients older than 40 years of age with cancers of the prostate, breast, and colorectum. Patients of any ag...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Radiation therapy can cause cerebral arteriopahty, resulting in ischemic stroke. We document late-delayed cerebral arteriopathy by high-resolution magnetic resonance imaging (HR-MRI) in a middle aged man who h...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
The purpose of this case report is to document a protracted course of recovery and the deficits exhibited by a person with SMART syndrome.
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Source Type: research
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract PURPOSE: To identify genetic risk factors associated with risk of stroke among survivors of childhood cancer treated with cranial radiation therapy (CRT). EXPERIMENTAL DESIGN: We analyzed whole-genome sequencing (36.8-fold) data of 686 childhood cancer survivors of European ancestry [median (range): 40.4 (12.4-64.7) years old; 54% male] from the St. Jude Lifetime Cohort study treated with CRT, of whom 116 (17%) had clinically-diagnosed stroke. Association analyses (single-variant and Burden/SKAT tests) were performed, adjusting for demographic characteristics and childhood cancer treatment exposures....
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
AbstractPurpose of ReviewTo review the latest information about the interactions between cancer and cerebrovascular disease.Recent FindingsAdditional data support the finding that both ischemic and hemorrhagic stroke are important complications of cancer or its treatment. Reperfusion therapy is being given successfully to patients with stroke complicating cancer.SummaryHemorrhagic stroke may occur with metastatic disease to the brain, coagulopathies from cancer, in particular leukemia, or as complications of chemotherapy. Ischemic stroke also may be a complication of metastatic disease with local invasion of vessels, a pro...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Radiation therapy can cause arteries to scar or thicken, leading to blockages that can result in heart attacks and strokes. Statins work by keeping plaques from building up in blood vessels, preventing blockages.
Source: WebMD Health - Category: Consumer Health News Source Type: news
WEDNESDAY, June 19, 2019 -- For cardiac patients with thorax and head or neck cancer, statin use after radiation therapy is associated with a significant reduction in stroke incidence and a trend toward reduced cardiovascular and cerebrovascular...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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